Estructura cristalina de ADN y su utilización para la identificación de fármacos

Estructura cristalina de ADN y su utilización para la identificación de fármacos. La estructura cristalina que comprende un entrecruzamiento de tres cadenas de ADN está caracterizada porque: pertenece al grupo espacial P4(1)32 y tiene unas dimensiones de celda a=b=c=70,98 ± 0,7°A; todos los nucleótidos que constituyen dichas cadenas de ADN se encuentran emparejados; y dicho entrecruzamiento de tres cadenas de ADN alberga, en una cavidad hidrofóbica, una molécula. La estructura cristalina de la invención es una diana adecuada para el diseño de fármacos anti-ADN con una elevada especificidad.Peer reviewedConsejo Superior de Investigaciones Científicas (España)B1 Patente sin examen previ

Split-domain calibration of an ecosystem model using satellite ocean colour data

The application of satellite ocean colour data to the calibration of plankton ecosystem models for large geographic domains, over which their ideal parameters cannot be assumed to be invariant, is investigated. A method is presented for seeking the number and geographic scope of parameter sets which allows the best fit to validation data to be achieved. These are independent data not used in the parameter estimation process. The goodness-of-fit of the optimally calibrated model to the validation data is an objective measure of merit for the model, together with its external forcing data. Importantly, this is a statistic which can be used for comparative evaluation of different models. The method makes use of observations from multiple locations, referred to as stations, distributed across the geographic domain. It relies on a technique for finding groups of stations which can be aggregated for parameter estimation purposes with minimal increase in the resulting misfit between model and observations.The results of testing this split-domain calibration method for a simple zero dimensional model, using observations from 30 stations in the North Atlantic, are presented. The stations are divided into separate calibration and validation sets. One year of ocean colour data from each station were used in conjunction with a climatological estimate of the station’s annual nitrate maximum. The results demonstrate the practical utility of the method and imply that an optimal fit of the model to the validation data would be given by two parameter sets. The corresponding division of the North Atlantic domain into two provinces allows a misfit-based cost to be achieved which is 25% lower than that for the single parameter set obtained using all of the calibration stations. In general, parameters are poorly constrained, contributing to a high degree of uncertainty in model output for unobserved variables. This suggests that limited progress towards a definitive model calibration can be made without including other types of observations

Selbstbestimmt teilhaben in Altenpflegeeinrichtungen

Zusammenfassung Alte Menschen mit Hilfe- und Pflegebedarf, die in Altenpflegeeinrichtungen leben, haben nicht nur Anspruch auf eine qualitätsvolle medizinisch-pflegerische Versorgung, sondern explizit das Recht auf ein selbstbestimmtes Leben, das ihnen gesellschaftliche Teilhabe ermöglicht. Dazu verpflichten nicht zuletzt die Vorgaben der UN-Behindertenrechtskonvention. Das anwendungs-orientierte Forschungsprojekt „Selbstbestimmt teilhaben in Altenpflegeeinrichtungen“ hat Voraussetzungen zur Verwirklichung der selbstbestimmten Teilhabe von Bewohner*innen in stationären Einrichtungen der Altenhilfe analysiert. Im Rahmen einer sequentiellen Mixed-Methods-Studie wurden u. a. Interviews mit Bewohner*innen, Angehörigen und Mitarbeiter*innen sowie teilnehmende Beobachtungen in ausgewählten Einrichtungen und eine NRW-weite Online-Befragung durchgeführt. So konnten erstmals fördernde und hemmende Faktoren auf Ebene der Bewohner*innen, Mitarbeiter*innen und Einrichtung identifiziert und wichtige Anforderungen an die Teilhabeförderung praxisnah in einem Musterrahmenkonzept aufbereitet werden. Abstract Elderly residents of nursing homes do not only have the right to receive high-quality medical and nursing care, but also and explicitly to lead an autonomous life that enables them to partic-ipate in society. This right is not least stipulated in the UN Convention on the Rights of Persons with Disabilities. The application-based research project ‘Autonomous Participation in Residential Care Facilities for the Elderly’ analysed the prerequisites for realising elderly residents’ autonomous participation in their nursing homes. Within the framework of a sequential mixed methods study, the researchers conducted interviews with such residents, their relatives and care home staff, participatory observations in selected nursing homes and an online survey throughout North Rhine-Westphalia. As a result, they were able to identify factors which facilitate and restrict such participation from the perspectives of the residents, staff and the care home itself for the first time, and thus stipulate important requirements for the facilitation and implementation of participation within a framework model

Circulation characteristics in three eddy-permitting models of the North Atlantic

A systematic intercomparison of three realistic eddy-permitting models of the North Atlantic circulation has been performed. The models use different concepts for the discretization of the vertical coordinate, namely geopotential levels, isopycnal layers, terrain-following (sigma) coordinates, respectively. Although these models were integrated under nearly identical conditions, the resulting large-scale model circulations show substantial differences. The results demonstrate that the large-scale thermohaline circulation is very sensitive to the model representation of certain localised processes, in particular to the amount and water mass properties of the overflow across the Greenland-Scotland region, to the amount of mixing within a few hundred kilometers south of the sills, and to several other processes at small or sub-grid scales. The different behaviour of the three models can to a large extent be explained as a consequence of the different model representation of these processes