Reducing Road Wear While Ensuring Comfort and Charging Constraints for Dynamically Charged Passenger Vehicles Through Noise-Shaped Path Variations

Dynamically charged vehicles suffer from power loss during wireless power transfer due to receiver and transmitter coil misalignment while driving. Autonomous, dynamically charged vehicles can maximize wireless power transfer by minimizing the misalignment, but the repeated high-precision driving increases road wear. To avoid unnecessary road wear and rutting, a noise shaping filter is proposed that adds variability to a vehicle\u27s trajectory that complies with passenger acceleration and position constraints. However, introducing variability into an optimal charging path also risks depleting battery life prior to destination arrival. Therefore, a path planner is proposed that guarantees average charge within a specified probability and ensures rider comfort while reducing road wear

Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis

Reported associations between leukocyte telomere length (LTL) attrition, diet and cardiovascular disease (CVD) are inconsistent. This study explores effects of prolonged exposure to a high cholesterol high fat (HCHF) diet on LTL in a baboon model of atherosclerosis. We measured LTL by qPCR in pedigreed baboons fed a chow (n = 105) or HCHF (n = 106) diet for 2 years, tested for effects of diet on LTL, and association between CVD risk factors and atherosclerotic lesions with LTL. Though not different at baseline, after 2 years median LTL is shorter in HCHF fed baboons (P \u3c 0.0001). Diet predicts sex- and age-adjusted LTL and LTL attrition (P = 0.0009 and 0.0156, respectively). Serum concentrations of CVD biomarkers are associated with LTL at the 2-year endpoint and LTL accounts approximately 6% of the variance in aortic lesions (P = 0.04). Although heritable at baseline (h2 = 0.27, P = 0.027) and after 2 years (h2 = 0.46, P = 0.0038), baseline LTL does not predict lesion extent after 2 years. Atherogenic diet influences LTL, and LTL is a potential biomarker for early atherosclerosis. Prolonged exposure to an atherogenic diet decreases LTL and increases LTL attrition, and shortened LTL is associated with early-stage atherosclerosis in pedigreed baboons

A New Self-Adjusting CVT Configuration Using Compliant Mechanisms

ABSTRACT This paper introduces a new configuration of a Continuously Variable Transmission (CVT) that is self-adjusting and designed as a compliant mechanism. This new configuration is called the Pivot-Arm CVT. The criteria for classification as a Pivot-Arm CVT is discussed. An analytical model describing the performance of the Pivot-Arm CVT is developed. Special design considerations which may be useful in implementing Pivot-Arm CVTs are introduced and explained. The Pivot-Arm CVT model is validated through controlled testing of two Pivot-Arm CVT prototypes

Absolute Electron Emission Calibration: Round Robin Tests of Au and Polyimide

Accurate determination of the absolute electron yields of conducting and insulating materials are essential for models of spacecraft charging and related processes involving charge accumulation and emission due to electron beams and plasmas. Apparatus using low-fluence pulsed electron beam sources and various methods to minimize charge accumulation have been developed at facilities around the world. This study presents a round robin comparison of such tests performed in CSIC at Instituto de Ciencia de Materiales de Madrid, LaSeine at Kyushu Institute of Technology, DESSE at ONEREA, and the Space Environment Effects Materials (SEEM) test facility at Utah State University. The primary objectives of the study were to determine the consistency and uncertainties of these absolute yields measurements, and to investigate the effects of the similarities and differences of the diverse facilities. Measurements were made of the absolute total, secondary and backscattered electron yields at normal incidence over the full range of incident energies accessible with each group’s instrumentation (a full range of ~5 eV to ~30 keV). Electron emission spectra at specific incident electron energies were also measured. Measurements were made for identical samples with reproducible sample preparation of two standard materials: (1) the elemental conductor Au (25 μm thick 6N high purity Au foils) and (2) the polymeric insulator polyimide (25 μm thick Kapton HNTM). Studies of the effects on electron yield of Au surface contamination—as measured with Auger Electron Spectroscopy and other techniques—were made for samples: (1) as received, (2) subject to a simple standard cleaning procedure, (3) subsequently baked out under ultrahigh vacuum, and (4) after Ar ion sputter cleaning and thermal annealing. Similarly, studies of the effects of absorbed water and volatile compounds on electron yield were made for polyimide samples: (1) unbaked and (2) subjected to a vacuum bake out. An outline of measurement and analysis techniques used by each laboratory is presented, along with methods used to calibrate the incident energies and absolute yields measured with their different electron detectors. The effects of different charge minimization and neutralization methods are compared. Various empirical and physics-based models to characterize the electron yield curves are used to parameterize the yield data. The values determined at each laboratory for the maximum yield and energy at this yield, the first and second crossover energies, and the asymptotic yield at high energy are also compiled and compared

Introduction of Genetically Engineered Organisms - Draft Programmatic Environmental Impact Statement—July 2007

The U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) regulates the environmental introduction of genetically engineered (GE) organisms, including crop and noncrop plants, vertebrate and invertebrate animals, and micro-organisms. APHIS regulations are grounded in the most up-to-date science and are designed to provide a level of oversight appropriate for the safe introduction of GE organisms. APHIS is considering whether revisions to its regulations are necessary. One purpose of such revisions would be to address current and future technological trends resulting in GE plants with which the agency is less familiar, such as plants with environmental stress tolerance or enhanced nutrition, and plants engineered for new purposes such as biofuels or for production of pharmaceutical or industrial compounds. Additionally, the regulations would be revised to ensure a high level of environmental protection, to create regulatory processes that are transparent to stakeholders and the public, to consider the efficient use of agency resources, to ensure that the level of oversight is commensurate with the risk, and to ensure conformity with obligations under international treaties and agreements, such as World Trade Organization (WTO) agreements. To this end, this draft environmental impact statement (DEIS) was prepared to provide agency decisionmakers with a full range of regulatory alternatives and assist them in selecting a preferred alternative

Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics

Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout tropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p &lt; 5 × 10−8) and suggestive (p &lt; 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.</p

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden