Experience-based Auditory Predictions Modulate Brain Activity to Silence as do Real Sounds.

Interactions between stimuli's acoustic features and experience-based internal models of the environment enable listeners to compensate for the disruptions in auditory streams that are regularly encountered in noisy environments. However, whether auditory gaps are filled in predictively or restored a posteriori remains unclear. The current lack of positive statistical evidence that internal models can actually shape brain activity as would real sounds precludes accepting predictive accounts of filling-in phenomenon. We investigated the neurophysiological effects of internal models by testing whether single-trial electrophysiological responses to omitted sounds in a rule-based sequence of tones with varying pitch could be decoded from the responses to real sounds and by analyzing the ERPs to the omissions with data-driven electrical neuroimaging methods. The decoding of the brain responses to different expected, but omitted, tones in both passive and active listening conditions was above chance based on the responses to the real sound in active listening conditions. Topographic ERP analyses and electrical source estimations revealed that, in the absence of any stimulation, experience-based internal models elicit an electrophysiological activity different from noise and that the temporal dynamics of this activity depend on attention. We further found that the expected change in pitch direction of omitted tones modulated the activity of left posterior temporal areas 140-200 msec after the onset of omissions. Collectively, our results indicate that, even in the absence of any stimulation, internal models modulate brain activity as do real sounds, indicating that auditory filling in can be accounted for by predictive activity

Inter- and Intrahemispheric Dissociations in Ideomotor Apraxia: A Large-Scale Lesion-Symptom Mapping Study in Subacute Brain-Damaged Patients

Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal region

Numerical-Experimental characterization of honeycomb sandwich panel and numerical modal analysis of implemented delamination

The objective of this paper is to investigate the influence of the delamination on the vibration behavior of honeycomb sandwich panel, firstly, numerical characterization to provide the constant properties of the core only are performed using initial finite element model of Representative Volume Element (RVE) which does not take into account the double thickness wall existing in aluminum core structure. According to these initial parameters, finite element model of sandwich composite plate is constructed to extract its elasto-dynamic parameters. In order to validate the numerical results, Experimental Modal Analysis of sandwich plate specimens was performed. Secondly, the double thickness wall is selected to be introduced in the RVE because of important error between numerical and experimental achievements. Comparative study validates the improved mechanical characteristics. The knowledge of these constants is not sufficient and additional information about the delamination effects on the dynamical parameters of honeycomb composite panel is required. In present investigation this defect was implemented on the validated 3-D finite element model. The frequencies and associated modes shapes are obtained and analyzed

Successful neuropsychological rehabilitation in a patient with Cerebellar Cognitive Affective Syndrome

The objective of this case study was to describe the neuropsychological rehabilitation of a 16-year-old patient who presented a Cerebellar Cognitive Affective Syndrome (CCAS) following a bilateral cerebellar hemorrhage. The patient presented severe and diffuse cognitive deficits, massive behavioral disorders, and emotion regulation difficulties. The cognitive rehabilitation was performed in the chronic phase (one year after the onset of the hemorrhage) using a transdisciplinary neurobehavioral approach based on the patient's favorite interest (soccer). A significant behavioral and cognitive improvement was observed. The patient became progressively independent in all activities of daily living and was discharged home. The Functional Independence Measure at discharge was 124/126 (vs. 37/126 at entry). The patient was able to complete his schooling despite the mild cognitive and behavioral sequelae. This first description of the use of neurobehavioral therapy in a case of chronic CCAS suggests that (a) major clinical improvement can occur more than one year after the onset of the CCAS, showing the importance of long-term and intensive neurorehabilitation; and (b) when the cerebellum cannot properly play its regulator role in cognition, neuropsychological intervention through a behavioral and cognitive approach can be of great help by acting as an external modulator to help the patient regain control over himself

High and Low Stimulus-Driven Conflict Engage Segregated Brain Networks, Not Quantitatively Different Resources

Task-irrelevant information is constantly present in our environment and may interfere with the processing of the information necessary to achieve goal-directed behavior. While task goals determine which information must be suppressed, the demand for inhibitory control depends on the strength of the interference induced by incoming, task-irrelevant information. Whether the same or distinct inhibitory processes are engaged to suppress various degrees of interference from task-irrelevant information remains largely unresolved. We investigated this question by manipulating the strength of the conflict induced by automatic word reading in a classical color Stroop task. High conflict was induced by presenting words in participant's native language and low conflict by presenting words in a less familiar language. Behavioral performance and electrical neuroimaging analyses of event-related potentials to the words were analyzed following a two-by-two within-subject design with factors conflict strength (high; low) and color word/word ink congruency (congruent; incongruent). Behaviorally, we observed a significant conflict strength×congruency driven by a smaller Stroop effect in the low- than high conflict condition. Electrophysiologically, we observed a significant conflict strength×congruency interaction at the topographic level during the period of the N450 components, indicative of the engagement of distinct configurations of brain networks. No such interaction was found at the level of response strength. Electrical sources analyses localized the topographic effect within the anterior cingulate cortex and basal ganglia, left middle frontal and occipital areas. We interpret our results in terms of qualitatively distinct executive mechanisms for reactive inhibitory control in conditions of high versus low stimulus-driven conflict

Prediction of Cycle Life of Expansion Bellows for Fixed Tube sheet Heat Exchanger

Research on determining the lifetime of an expansion bellows designed to compensate the difference in expansion between the shell and the tubes in a fixed tube sheet heat exchanger has never ceased because of its Importance in a heat exchanger. The main function of the expansion bellows is to absorb the difference in expansion between the shell and the tube bundle while resisting the axial thermal deflection and the equivalent internal pressure on the shell side. TEMA-9 [1] edition attaches great importance to the finite element method in the case of an expansion bellows because of the disadvantages of the old design methods, which lead to overestimation and stress overload in the bellows. The objective of this work is to study the damage in the most stressed zone of the expansion bellows in order to construct a numerical simulation tool of the rupture to determine the lifetime that an expansion bellows can support during the operating conditions of a fixed tube heat exchanger. In a first step, the ANSYS FEM calculation code will allow the determination of the critical zone where the Von Mises is maximum and where potential cracks can develop. In a second step, a post-processor based on the concept of Continuum Damage Mechanics and using Newton's iterative method will be applied to this critical area for the determination of the bellows critical lifetime. The maximum lifetime will be the value of the number of cycles that corresponds to the critical value of the DC damage (crack initiation)

Are Endovascular Interventions for Central Vein Obstructions due to Cardiac Implanted Electronic Devices Effective?

<b>Objective:</b> One of the late-onset complications of cardiac implanted electronic devices (CIEDs) is central venous obstruction (CVO). The aim of this study was to investigate the feasibility, efficacy, and safety of endovascular treatment of CIED-related CVOs. <b>Methods:</b> Eighteen patients who underwent endovascular management of their device-related CVO were reviewed. Patients were classified into three groups: Group I patients were asymptomatic and needed lead replacement; Group II patients presented with symptomatic CVO without lead dysfunction, and Group III patients were referred with both symptomatic CVO and lead dysfunction. A treatment strategy involved recanalization and balloon angioplasty for Group I and angioplasty/stents for Groups II and III. Technical success, clinical success, complications, and long-term follow-up were assessed. <b>Results:</b> Thirteen patients were in Group I, four in Group II, and one in Group III. Technical and clinical success was achieved in 17 patients (94%). No major complications were reported. Restenosis was observed in two patients at 40 and 42 weeks of follow-up, and these patients were successfully treated with angioplasty. <b>Conclusion:</b> Endovascular management of CVO due to CIED is a safe and efficient technique. Plain balloon angioplasty is sufficient for lead replacement purposes, while stenting is needed for symptomatic CVO to achieve good long-term patency

Les rapports sols-sediments : le probleme de la retention continentale des elements majeurs et de leur liberation : exemple de l'Ordovicien superieur et du Silurien de Galice (Espagne)

T 55364 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc