Dynamics of axial separation in long rotating drums

We propose a continuum description for the axial separation of granular materials in a long rotating drum. The model, operating with two local variables, concentration difference and the dynamic angle of repose, describes both initial transient traveling wave dynamics and long-term segregation of the binary mixture. Segregation proceeds through ultra-slow logarithmic coarsening.Comment: 4 pages, 3 Postscript figures; submitted to PR

NASA Workshop on future directions in surface modeling and grid generation

Given here is a summary of the paper sessions and panel discussions of the NASA Workshop on Future Directions in Surface Modeling and Grid Generation held a NASA Ames Research Center, Moffett Field, California, December 5-7, 1989. The purpose was to assess U.S. capabilities in surface modeling and grid generation and take steps to improve the focus and pace of these disciplines within NASA. The organization of the workshop centered around overviews from NASA centers and expert presentations from U.S. corporations and universities. Small discussion groups were held and summarized by group leaders. Brief overviews and a panel discussion by representatives from the DoD were held, and a NASA-only session concluded the meeting. In the NASA Program Planning Session summary there are five recommended steps for NASA to take to improve the development and application of surface modeling and grid generation

Impact and key challenges of insider threats on organizations and critical businesses

The insider threat has consistently been identified as a key threat to organizations and governments. Understanding the nature of insider threats and the related threat landscape can help in forming mitigation strategies, including non-technical means. In this paper, we survey and highlight challenges associated with the identification and detection of insider threats in both public and private sector organizations, especially those part of a nation’s critical infrastructure. We explore the utility of the cyber kill chain to understand insider threats, as well as understanding the underpinning human behavior and psychological factors. The existing defense techniques are discussed and critically analyzed, and improvements are suggested, in line with the current state-of-the-art cyber security requirements. Finally, open problems related to the insider threat are identified and future research directions are discussed

Global Symposium on Women in Fisheries

All over the world, women contribute in multiple ways to the production, processing, marketing and management of fish and other living aquatic resources. The first ever Global Symposium on Women in Fisheries, held in Kaohsiung, Taiwan on 29 November 2001 generated the present collection of papers on women in fisheries. The reader of this volume will find in it a wealth of information, albeit in a very heterogeneous form, that the authors have had to draw from many different sources. Some are primary research studies whereas most are historical reviews from first hand experience of the authors or derived from other written materials, often contained in reports of fisheries development projects, newspapers and source materials well outside the fish sectors.Women, Participation, Sustainability, Poverty, Fisheries, Development projects, Fishery technology

Public health, pandemic response, and the 2020 US election

From a health perspective, the upcoming US election could be the most consequential in our lifetimes. The USA has underperformed globally in its pandemic response but still has unparalleled resources and potential. There are, roughly, two choices for the 2020 candidates. Either they can deny the effect of the COVID-19 pandemic, and both the immediate failures and structural forces that let it play out so disastrously in the USA, or they can accept that we need change and articulate a real plan for it. The USA can achieve global health excellence, but leadership is needed to guide the country away from counterproductive assumptions of US exceptionalism, recognising with humility where we fall short and where we have much to learn from countries that fare better in health outcomes, both before and in COVID times. We need to start rebuilding with a solid framework, one capable of sheltering every American individual's health and one that will stand strong through the next global health crisis

Nutrient Composition of Selected Cooked and Processed Snack Foods

Nutrient composition of 27 cooked snack foods and 19 processed snacks was determined. The cooked foods were mostly cereal based, made from wheat flour, rice or rice flour, and almost all of them were traditional Malaysian kuih or dishes. The processed snacks studied were chocolate, cereal, tuber, fish and prawn products. The levels of 19 nutrients were tabulated, expressed as per 100 g edible portion. Selected nutrients in each serving or packet of the foods were also presented. The paper is intended as a contribution to the knowledge on nutrient composition of local snack foods, for which information is still greatly lacking. The number of foods studied is only a fraction of the total number available. More work in this area will have to be carried out, to meet the increasing demand for such data

Anti-tumor activity mediated by protein and peptide transduction of HIV viral protein R (Vpr)

Peptides that are capable of traversing the cell membrane, via protein transduction domains (PTDs), are attractive either directly as drugs or indirectly as carriers for the delivery of therapeutic molecules. One such PTD, a HIV-1 Tat derived peptide has successfully delivered a variety of "cargoes" including proteins, peptides and nucleic acids into cells. There also exists other naturally occurring membrane permeable peptides which have potential as PTDs. Specifically, one of the accessory proteins of HIV (viral protein R; i.e., Vpr), which is important in controlling viral pathogenesis, possesses cell transduction domain characteristics. Related to these characteristics, Vpr has also been demonstrated to induce cell cycle arrest and host/target cell apoptosis, suggesting a potential anticancer activity for this protein. In this report we assessed the ability of Vpr protein or peptides, with or without conjugation to a PTD, to mediate anti-cancer activity against several tumor cell lines. Specifically, several Vpr peptides spanning carboxy amino acids 65-83 induced significant (i.e., greater than 50%) in vitro growth inhibition/toxicity of murine B16.F10 melanoma cells. Likewise, in in vitro experiments with other tumor cell lines, conjugation of Vpr to the Tat derived PTD and transfection of this construct into cells enhanced the induction of in vitro apoptosis by this protein when compared to the effects of transfection of cells with unconjugated Vpr. These results underscore the potential for Vpr based reagents as well as PTDs to enhance anti-tumor activity, and warrants further examination of Vpr protein and derived peptides as potential therapeutic agents against progressive cell proliferative diseases such as cancer. ©2009 Landes Bioscience

Cost-effectiveness analysis of preoperative transfusion in patients with sickle cell disease using evidence from the TAPS trial.

The study's objective was to assess the cost-effectiveness of preoperative transfusion compared with no preoperative transfusion in patients with sickle cell disease undergoing low- or medium-risk surgery. Seventy patients with sickle cell disease (HbSS/Sß(0) thal genotypes) undergoing elective surgery participated in a multicentre randomised trial, Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS). Here, a cost-effectiveness analysis based on evidence from that trial is presented. A decision-analytic model is used to incorporate long-term consequences of transfusions and acute chest syndrome. Costs and health benefits, expressed as quality-adjusted life years (QALYs), are reported from the 'within-trial' analysis and for the decision-analytic model. The probability of cost-effectiveness for each form of management is calculated taking into account the small sample size and other sources of uncertainty. In the range of scenarios considered in the analysis, preoperative transfusion was more effective, with the mean improvement in QALYs ranging from 0.018 to 0.206 per patient, and also less costly in all but one scenario, with the mean cost difference ranging from -£813 to £26. All scenarios suggested preoperative transfusion had a probability of cost-effectiveness >0.79 at a cost-effectiveness threshold of £20 000 per QALY

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres