Witches, 'Bitches' or Feminist Trailblazers? The Witch in Fold Horror Cinema

Witches have a long history in horror cinema but their status (feminist heroine or patriarchal monster?) continues to be the subject of critical debate. Barbara Creed’s seminal analysis notes that the witch is invariably represented as an old, ugly, crone. Elsewhere, Linda Williams’s suggestion that women and monsters share an affinity in horror film and pose a threat to vulnerable male power, has lead recent critics to consider depictions of the witch as offering a challenge to patriarchy. This article considers the genealogy of the witch in cinema through her depiction in folk horror, culminating in an analysis of Robert Eggers’s 2016 film, The Witch. Examining the debate around the feminist potential of the witch, the article concludes that she offers critics and viewers of horror cinema a troubling ambiguity that serves neither liberal nor conservative politics. The ambiguity of the witch means she can pressed in the service of competing discourses. Moreover, we cannot read the image of the witch independent of her origins in Early Modern history, nor of political and cultural contexts of these early decades of the twenty-first century. These contexts include the rise of the ‘Men’s Rights’ movement, a post-feminist backlash against women in authority, the creation of mainstream media platforms for misogynist ideas and rising economic and social inequalities that have disproportionately affected women. In these contexts, the figure of the witch looms large and ambiguity in itself is not necessarily subversion. As one reviewer of The Witch notes, the audience will see what they want to see

Nomadic intertextuality and postmillennial children's gothic fiction

Since the turn of the twenty first century, Gothic has emerged as one of the most popular forms in which to write for children. Although children’s literature critics and educational professionals were once dubious about the value of scary stories for children, postmillennial Gothic has begun to receive critical praise as well as mass market popularity. This thesis explores an emergent critical discourse that champions children’s Gothic alongside a variety of examples of the form. I argue that postmillennial children’s fiction employs metafictional reflexivity and explicit intertextuality, opening out into an expansive Gothic landscape. Unhoming its protagonists, readers and critics, postmillennial children’s Gothic challenges existing paradigms in both children’s literature criticism and Gothic Studies. Foremost, this fiction disrupts accounts of children’s literature that assign the form a pedagogical function, and that construct the child reader according to linear narratives of maturation offered by psychoanalysis and ego-relational psychology. In place of the ‘psychoanalytic child’, postmillennial children’s Gothic imagines a nomadic subject, constructing child protagonists and readers across a multiplicity of subject location and identities. There is not one child, but multiple figurations. The transgressive and liberating energies of Gothic play a part in this rejection of traditional figurations of the child. However, postmillennial children’s fiction also challenges critical commonplaces in Gothic Studies. The nomadic project of children’s Gothic runs counter to the melancholic figuration of subjectivity offered by a deconstructive psychoanalytic discourse that informs some analysis of Gothic literature. Unlike the tragic subjectivity of the Gothic wanderer, the nomad offers an affirmative figuration of being. The nomad is transformed through interrelationships with others, likewise transforming the locations through which it travels, suggesting new ways of reading Gothic. Taking its cue from Rosi Braidotti’s theory of nomadic subjectivity, this thesis engages productively with a variety of children’s texts published since 2000, reading them against existing criticism. I offer my analysis of these texts as part of a creative process that imagines non-unitary, non-binary figurations of subjectivity, and seeks to reformulate notions of reading and becoming

Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis

Minimal residual disease prior to allogeneic hematopoietic cell transplantation has been associated with increased risk of relapse and death in patients with acute myeloid leukemia, but detection methodologies and results vary widely. We performed a systematic review and meta-analysis evaluating the prognostic role of minimal residual disease detected by polymerase chain reaction or multiparametric flow cytometry before transplant. We identified 19 articles published between January 2005 and June 2016 and extracted hazard ratios for leukemia-free survival, overall survival, and cumulative incidences of relapse and non-relapse mortality. Pre-transplant minimal residual disease was associated with worse leukemia-free survival (HR=2.76 [1.90-4.00]), overall survival (HR=2.36 [1.73-3.22]), and cumulative incidence of relapse (HR=3.65 [2.53-5.27]), but not non-relapse mortality (HR=1.12 [0.81-1.55]). These associations held regardless of detection method, conditioning intensity, and patient age. Adverse cytogenetics was not an independent risk factor for death or relapse. There was more heterogeneity among studies using flow cytometry-based than WT1 polymerase chain reaction-based detection (I(2)=75.1% vs. <0.1% for leukemia-free survival, 67.8% vs. <0.1% for overall survival, and 22.1% vs. <0.1% for cumulative incidence of relapse). These results demonstrate a strong relationship between pre-transplant minimal residual disease and post-transplant relapse and survival. Outcome heterogeneity among studies using flow-based methods may underscore site-specific methodological differences or differences in test performance and interpretation

11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

Objective Inandnbsp;rheumatoid arthritis, theandnbsp;enzymeandnbsp;11 beta-hydroxysteroid dehydrogenase type 1(11andbeta;-HSD1) is highly expressed at sites ofandnbsp;inflammation, where it converts inactiveandnbsp;glucocorticoidsandnbsp;(GC) to their active counterparts. In conditions of GC excess it has been shown to be a critical regulator ofandnbsp;muscleandnbsp;wasting andandnbsp;bone loss. Here we examine the contribution of 11andbeta;-HSD1 to the pathology of persistent chronicandnbsp;inflammatory disease. Methods To determine the contribution of 11andbeta;-HSD1 toandnbsp;jointandnbsp;inflammation, destruction and systemicandnbsp;boneandnbsp;loss associated with persistent inflammatory arthritis, we generatedandnbsp;miceandnbsp;with global and mesenchymal specific 11andbeta;-HSD1 deletions in the TNF-transgenic (TNF-tg) model of chronic polyarthritis.andnbsp;Disease severityandnbsp;was determined by clinical scoring.andnbsp;Histologyandnbsp;was assessed inandnbsp;formalinandnbsp;fixed sections andandnbsp;fluorescence-activated cell sortingandnbsp;(FACS) analysis of synovialandnbsp;tissueandnbsp;was performed. Local and systemicandnbsp;boneandnbsp;loss were measured byandnbsp;micro computed tomography(micro-CT). Measures of inflammation andandnbsp;bone metabolismandnbsp;were assessed inandnbsp;serumandnbsp;and inandnbsp;tibiaandnbsp;mRNA. Results Global deletion of 11andbeta;-HSD1 drove an enhanced inflammatoryandnbsp;phenotype, characterised byandnbsp;floridandnbsp;synovitis,andnbsp;joint destructionandnbsp;and systemic bone loss. This was associated with increasedandnbsp;pannusandnbsp;invasion into subchondral bone, a markedandnbsp;polarisationandnbsp;towards pro-inflammatoryandnbsp;M1 macrophagesandnbsp;at sites of inflammation and increasedandnbsp;osteoclastandnbsp;numbers. Targeted mesenchymal deletion of 11andbeta;-HSD1 failed to recapitulate thisandnbsp;phenotypeandnbsp;suggesting that 11andbeta;-HSD1 withinandnbsp;leukocytesmediate its protective actions in vivo. Conclusions We demonstrate a fundamentalandnbsp;roleandnbsp;for 11andbeta;-HSD1 in the suppression ofandnbsp;synovitis, joint destruction, and systemic bone loss. Whilst aandnbsp;roleandnbsp;for 11andbeta;-HSD1 inhibitors has been proposed for metabolicandnbsp;complicationsandnbsp;in inflammatory diseases, our study suggests that this approach would greatly exacerbate disease severity.</p

Dalhousie dyspnea scales: construct and content validity of pictorial scales for measuring dyspnea

BACKGROUND: Because there are no child-friendly, validated, self-report measures of dyspnea or breathlessness, we developed, and provided initial validation, of three, 7-item, pictorial scales depicting three sub-constructs of dyspnea: throat closing, chest tightness, and effort. METHODS: We developed the three scales (Throat closing, Chest tightness, and Effort) using focus groups with 25 children. Subsequently, seventy-nine children (29 children with asthma, 30 children with cystic fibrosis. and 20 children who were healthy) aged 6 to 18 years rated each picture in each series, using a 0–10 scale. In addition, each child placed each picture in each series on a 100-cm long Visual Analogue Scale, with the anchors "not at all" and "a lot". RESULTS: Children aged eight years or older rated the scales in the correct order 75% to 98% correctly, but children less than 8 years of age performed unreliably. The mean distance between each consecutive item in each pictorial scale was equal. CONCLUSION: Preliminary results revealed that children aged 8 to 18 years understood and used these three scales measuring throat closing, chest tightness, and effort appropriately. The scales appear to accurately measure the construct of breathlessness, at least at an interval level. Additional research applying these scales to clinical situations is warranted

Fragmenting and becoming double": Supplementary twins and abject bodies in Helen Oyeyemi's the Icarus Girl

© 2016 SAGE Publications. This article uses readings of the abject body and writing as supplement in Helen Oyeyemi's novel, The Icarus Girl (2005) to argue against a critical trend that reads the postcolonial Bildungsroman as promising a positively transformed postcolonial identity. Through our reading of Oyeyemi's novel, we suggest that locating the debates and tropes conventionally mobilized within postcolonial gothic in the former colonial centre complicates subject formations and constructions of alterity. The Icarus Girl weaves together a Western literary tradition of gothic with the postcolonial Bildungsroman and we suggest that the interaction of these forms produces a reading focused on the abject, both in terms of physical abjection mapped onto bodies and places, and in the way writing functions as abject supplement. When bodies, borders, and writing disintegrate, the reading of the novel becomes a difficult process, one not easily co-opted into a critical discourse that tends to value a psycho-symbolic reading of the postcolonial gothic Bildungsroman and to promise a positively transformed postcolonial identity. Accordingly, we argue that The Icarus Girl is unable to find comforting resolutions, disrupt oppositional structures, and create a utopian hybrid space or to bring about a unified sense of self, meaning that it resists a redemptive or cathartic ending. We draw upon Kristeva's theories of the abject and Derrida's notion of the supplement in order to establish how Oyeyemi's novel resists the construction of a stable identity through its emphasis upon expulsion and disintegration. Unlike the majority of criticism on postcolonial gothic, which focuses on texts emanating from formerly colonized countries, this article considers what happens to postcolonial gothic when it is written within and about the former colonial centre. In The Icarus Girl the repercussions of the colonial period are experienced in the present day through experiences of racism, dislocation, and alienation within Britain

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Reading ‘Fundamental British Values’ Through Children’s Gothic: Imperialism, History, Pedagogy

This paper reads the U.K. Government’s “fundamental British values” project alongside two children’s Gothic novels, Coram Boy (2000) by Jamila Gavin and City of Ghosts (2009) by Bali Rai. In 2011 the U.K. Government outlined what it described as “fundamental British values” (FBV), making it a requirement for U.K. schools to promote these values. Many critics have shown that the root of FBV lies in Islamophobia and imperialist nostalgia and suggested that the promotion of “British” values in school will exclude minority groups already under siege from racist elements in contemporary Britain. Other critics argue that the promotion of FBV reduces opportunities to explore issues of belonging, belief, and nationhood in the classroom. This article argues that the Gothic fictions of Jamila Gavin and Bali Rai offer a space in which to critically examine British history (and so, its values) in a way that is acutely relevant to these education contexts. Coram Boy and City of Ghosts use the Gothic to interrogate aspects of British history elided by the FBV project. That is, they point to Britain’s imperial and colonial history and offer a rejoinder to the Government’s insistence that “British Values” equate to democracy, respect for the rule of law and mutual respect and tolerance of those from different faiths and religions. Furthermore, Gavin’s and Rai’s use of the Gothic creates a space in which the ambiguities and contradictions inherent in FBV can be explored. However, their “gothicized” histories of Britain do not render the idea of shared values invalid. The diversity and interconnectedness of the characters offer an alternative version of identity to the patronising and arrogant FBV project, which is aimed at promoting a national identity based on sameness and assimilation. Rai and Gavin look to Britain’s past through the lens of the Gothic not only to refute nationalism and racism, but also to offer a productive alternative that gestures towards a more cosmopolitan vision of identity

Multidisciplinary investigations of the diets of two post-medieval populations from London using stable isotopes and microdebris analysis

This paper presents the first multi-tissue study of diet in post-medieval London using both the stable light isotope analysis of carbon and nitrogen and analysis of microdebris in dental calculus. Dietary intake was explored over short and long timescales. Bulk bone collagen was analysed from humans from the Queen’s Chapel of the Savoy (QCS) (n = 66) and the St Barnabas/St Mary Abbots (SB) (n = 25). Incremental dentine analysis was performed on the second molar of individual QCS1123 to explore childhood dietary intake. Bulk hair samples (n = 4) were sampled from adults from QCS, and dental calculus was analysed from four other individuals using microscopy. In addition, bone collagen from a total of 46 animals from QCS (n = 11) and the additional site of Prescot Street (n = 35) was analysed, providing the first animal dietary baseline for post-medieval London. Overall, isotopic results suggest a largely C3-based terrestrial diet for both populations, with the exception of QCS1123 who exhibited values consistent with the consumption of C4 food sources throughout childhood and adulthood. The differences exhibited in δ15Ncoll across both populations likely reflect variations in diet due to social class and occupation, with individuals from SB likely representing wealthier individuals consuming larger quantities of animal and marine fish protein. Microdebris analysis results were limited but indicate the consumption of domestic cereals. This paper demonstrates the utility of a multidisciplinary approach to investigate diet across long and short timescales to further our understanding of variations in social status and mobility