COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends' gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied.S

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

Characterization of Zafarraya Polje geometry by gravity survey (Betic Cordillera)

The Zafarraya Polje is a Neogene endorheic basin, which lies on the contact between internal and external Zones of the Betic Cordillera. This basin limits on its southern boundary with the Ventas de Zafarraya fault, related to 1884 Andalusian earthquake. In this area a gravimetric survey was conducted in order to determine the geometrical characteristics of the basin infill. Bouguer, regional and residual anomaly maps have been calculated. Also, three residual anomaly profiles have been modeled and interpreted. All these results show the existence of horst and grabens in the substrate of the basin that determine thickness variations of the sedimentary infill. The up to now non-described blind faults have also been characterizedEl Polje de Zafarraya es una cuenca neógena endorreica que se sitúa sobre el contacto entre zonas internas y externas de la Cordillera Bética. Esta cuenca limita en su borde sur con la falla de Zafarraya, responsable del terremoto de Andalucía de 1884.Se ha realizado un estudio gravimétrico en el Polje para determinar las características geométricas del relleno sedimentario de la cuenca. Para ello, se han realizado mapas de anomalía Bouguer, regional y residual y se han interpretado 3 perfiles de anomalía residual con los que se ha podido observar la existencia de horsts y grabens en el substrato de la cuenca que condicionan la potencia del relleno detrítico. Del mismo modo también se ha podido caracterizar tanto fallas identificadas en superficie como fallas ciegas que no llegan a aflora

Improved Survival from Ovarian Cancer in Patients Treated in Phase III Trial Active Cancer Centres in the UK

Aims: Ovarian cancer is the principal cause of gynaecological cancer death in developed countries, yet overall survival in the UK has been reported as being inferior to that in some Western countries. As there is a range of survival across the UK we hypothesised that in major regional centres, outcomes are equivalent to the best internationally. Materials and methods: Data from patients treated in multicentre international and UK-based trials were obtained from three regional cancer centres in the UK; Manchester, University College London and Leeds (MUL). The median progression-free survival (PFS) and overall survival were calculated for each trial and compared with the published trial data. Normalised median survival values and the respective 95% confidence intervals (ratio of pooled MUL data to trial median survival) were calculated to allow inter-trial survival comparisons. This strategy then allowed a comparison of median survival across the UK, in three regional UK centres and in international centres. Results: The analysis showed that the trial-reported PFS was the same in the UK, in the MUL centres and in international centres for each of the trials included in the study. Overall survival was, however, 45% better in major regional centre-treated patients (95% confidence interval 9–73%) than the median overall survival reported in UK trials, whereas the median overall survival in MUL centres equated with that achieved in international centres. Conclusion: The data suggest that international survival statistics are achieved in UK regional cancer centres

Screening for hypertension in a primary care dental clinic

Objective: The aim of this study was to record blood pressure in patients during their visit to a dental clinic, with the aim of identifying those who have high blood pressure and are unaware of it, as well as those who are aware of their condition but do have their blood pressure under adequate control. Study design: We designed a cross-sectional study which included 154 patients who were seen for a dental checkup at the Primary Dental Care of the Gallician Health Service (SERGAS). All participants completed a standardized medical questionnaire after measuring their systolic blood pressure (SBP) and diastolic blood pressure (DBP), which was conducted using the protocol established by the Spanish Society of Hypertension-Spanish League for the Fight Against Hypertension (HTA). Results: In 45 patients (29%), the figures for blood pressure were recorded as SBP?140 mmHg and/or DBP ?90 mmHg, indicating that they may have hypertension. Only 12 of them had been previously diagnosed with hypertension, but did not have their blood pressure under adequate control. The remaining 33 had no history of hypertension and were referred to a family physician, but only 19 saw their doctor; 11 of these patients were given non-pharmacological treatment, 6 were prescribed drug treatment and no type of treatment was indicated for the other two patients. Conclusions: By screening for hypertension, especially among patients who are more than 40 years old, the dentist can play an important role in the early diagnosis

Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years.

Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients (n = 241 deceased, n = 239 survivors) was sequenced with the Myeloid Solutions™ panel of SOPHiA Genetics. The association between clonality and age and clonality and mortality was studied using logistic regression models adjusted for sex, ethnicity, and comorbidities. The association with mortality was performed with patients stratified into four groups of age according to the quartiles of the distribution: 60–74 years, 75–84 years, 85–91 years, and 92–101 years. Clonality was found in 38% of the cohort. The presence of CHIP variants, but not the number, significantly increased with age in the entire cohort of COVID-19 patients, as well as in the group of survivors (p < 0.001). When patients were stratified by age and the analysis adjusted, CHIP classified as pathogenic/likely pathogenic was significantly more represented in deceased patients compared with survivors in the group of 75–84 years (34.6% vs 13.7%, p = 0.020). We confirmed the well-established linear relationship between age and clonality in the cohort of COVID-19 patients and found a significant association between pathogenic/likely pathogenic CHIP and mortality in patients from 75 to 84 years that needs to be further validated.post-print1034 K

Defining the roadmap towards revision of ENCR coding standards and training for cancer registries

The European Network of Cancer Registries (ENCR) and the Joint Research Centre (JRC) jointly support harmonising the activities of the European population-based cancer registries (CR) in providing reliable and valid data on cancer. The process to supply valid, complete and comparable data in different European Countries, implies that CR implement common rules to define and code cancer and receive similar training. For this reason, one of the main activities of the ENCR-JRC is to provide CR staff with specific recommendations on coding along with training. For ENCR-JRC the objective of this workshop was to collate previous and current requests from CR and provide advice on the most pressing issues relating to recommendations and training. The workshop was planned during the ENCR Steering Committee (SC) meeting, which took place on November 2014, and JRC (the Secretariat of ENCR) was requested to organise it. A group of experts on cancer registration was identified. This group included the ENCR-SC members, representatives from Institutions and cancer research projects which collaborate with CR (i.e. IARC, Eurocare, Concord, Rarecare), representatives from national networks of CR, members of the Cancer Information group at the JRC, and other specialists in the field. Prior to the workshop, an anonymous questionnaire was sent to the group of experts. Moreover, all directors and staff of CR were invited to complete the questionnaire and provide comments in order for ENCR- JRC to get a more comprehensive overview of the situation. The questionnaire invited respondents to specify the five most urgent topics, to be addressed, on both recommendations and training. During the workshop, participants (around 30 people) were split into two groups: one to focus on recommendations and the other to focus on training. For each group a moderator facilitated the debate presented the responses to the questionnaire, which were discussed in detail using the Metaplan method. The results of the discussion were summarized in a final plenary section, where further clarifications were given and all the participants were involved in the discussion. In summary, the topics to be addressed by the ENCR-SC, in relation to recommendations, either as updates of current recommendations or for new specific ones, were: Multiple primary rules; Staging; Registration/reportability criteria; Death Certificate Only cases (DCO) – Death Certificate Notified cases (DCN); Date of incidence in relation to diagnosis; 'Complicated' cancers (e.g. bladder, etc.); Haematological cancers; and coding of borderline malignancies. The group on training suggested that all the issues that were raised (Cancer Registration; Haematological malignancies; Analysis; Stage; Quality; Multiple primaries; many on Specific cancer types; and Grading) should be addressed making available on the web high quality, reliable and training-oriented documentations. JRC offered to translate these documents, if necessary, into other European languages. For training on specific technical methodology (analysis, data quality) it was suggested that traditional face-to-face courses be provided. The workshop highlighted that recommendations and training are interlinked and this implies that, in the future, any new recommendation should be issued together with training documentation to explain its practical application. The technical proposals made at the workshop will help the ENCR-SC to prioritize the future supporting activities to the real needs of CR.JRC.I.2-Public Health Policy Suppor