Supporting Pre-Service Primary School Teachers with Hands-on-Science

The education that primary school students receive shapes their relationship with science. Elementary school teachers report they have low confidence and enthusiasm about teaching science. The Hands-on-Science Program at UT Austin was created to serve the unique needs of Applied Learning and Development majors. HoS consists of four required content courses: Physics, Chemistry & Geology, Biology, and Astronomy & Earth Climate. HoS classes differ from traditional science courses in two ways: (1) method of instruction, and (2) content. Our students attain higher learning gains and display improved attitudes towards learning science, compared to students who take traditional science classes

Relaxation Phenomena in a System of Two Harmonic Oscillators

We study the process by which quantum correlations are created when an interaction Hamiltonian is repeatedly applied to a system of two harmonic oscillators for some characteristic time interval. We show that, for the case where the oscillator frequencies are equal, the initial Maxwell-Boltzmann distributions of the uncoupled parts evolve to a new equilibrium Maxwell-Boltzmann distribution through a series of transient Maxwell-Boltzmann distributions. Further, we discuss why the equilibrium reached when the two oscillator frequencies are unequal, is not a thermal one. All the calculations are exact and the results are obtained through an iterative process, without using perturbation theory.Comment: 22 pages, 6 Figures, Added contents, to appear in PR

Interacting universes and the cosmological constant

We study some collective phenomena that may happen in a multiverse scenario. First, it is posed an interaction scheme between universes whose evolution is dominated by a cosmological constant. As a result of the interaction, the value of the cosmological constant of one of the universes becomes very close to zero at the expense of an increasing value of the cosmological constant of the partner universe. Second, we found normal modes for a 'chain' of interacting universes. The energy spectrum of the multiverse, being this taken as a collective system, splits into a large number of levels, some of which correspond to a value of the cosmological constant very close to zero. We finally point out that the multiverse may be much more than the mere sum of its parts.Comment: 7 page

Liquid Biopsy in Breast Cancer

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The evidence base for circulating tumour DNA blood-based biomarkers for the early detection of cancer: a systematic mapping review

Background: The presence of circulating cell-free DNA from tumours in blood (ctDNA) is of major importance to those interested in early cancer detection, as well as to those wishing to monitor tumour progression or diagnose the presence of activating mutations to guide treatment. In 2014, the UK Early Cancer Detection Consortium undertook a systematic mapping review of the literature to identify blood-based biomarkers with potential for the development of a non-invasive blood test for cancer screening, and which identified this as a major area of interest. This review builds on the mapping review to expand the ctDNA dataset to examine the best options for the detection of multiple cancer types. Methods: The original mapping review was based on comprehensive searches of the electronic databases Medline, Embase, CINAHL, the Cochrane library, and Biosis to obtain relevant literature on blood-based biomarkers for cancer detection in humans (PROSPERO no. CRD42014010827). The abstracts for each paper were reviewed to determine whether validation data were reported, and then examined in full. Publications concentrating on monitoring of disease burden or mutations were excluded. Results: The search identified 94 ctDNA studies meeting the criteria for review. All but 5 studies examined one cancer type, with breast, colorectal and lung cancers representing 60% of studies. The size and design of the studies varied widely. Controls were included in 77% of publications. The largest study included 640 patients, but the median study size was 65 cases and 35 controls, and the bulk of studies (71%) included less than 100 patients. Studies either estimated cfDNA levels non-specifically or tested for cancer-specific mutations or methylation changes (the majority using PCR-based methods). Conclusion: We have systematically reviewed ctDNA blood biomarkers for the early detection of cancer. Pre-analytical, analytical, and post-analytical considerations were identified which need to be addressed before such biomarkers enter clinical practice. The value of small studies with no comparison between methods, or even the inclusion of controls is highly questionable, and larger validation studies will be required before such methods can be considered for early cancer detection

Relaxation in harmonic oscillator systems and wave propagation in negative index materials

textThis dissertation is divided up into two parts, each examining a distinct theme. The rst part of our work concerns itself with open quantum systems and the relaxation phenomena arising from the repeated application of an interaction Hamiltonian on systems composed of quantum harmonic oscillators. For the second part of our work, we shift gears and investigate the wave propagation in left-handed media, or materials with simultaneously negative electric permeability and magnetic permeability . Each of these two parts is complete within its own context. In the rst part of this dissertation, we introduce a relaxation-generating model which we use to study the process by which quantum correlations are created when an interaction Hamiltonian is repeatedly applied to bipartite harmonic oscillator systems for some characteristic time interval . The two important time scales which enter our results are discussed in detail. We show that the relaxation time obtained by the application of this repeated interaction scheme is proportional to both the strength of interaction and to the characteristic time interval . Through discussing the implications of our model, we show that, for the case where the oscillator frequencies are equal, the initial Maxwell-Boltzmann distributions of the uncoupled parts evolve to a new Maxwell-Boltzmann distribution through a series of transient Maxwell-Boltzmann distributions, or quasi-stationary, non-equilibrium states. We further analyze the case in which the two oscillator frequencies are unequal and show how the application of the same model leads to a non-thermal steady state. The calculations are exact and the results are obtained through an iterative process, without using perturbation theory. In the second part of this dissertation, we examine the response of a plane wave incident on a at surface of a left-handed material, a medium characterized by simultaneously negative electric permittivity and magnetic permeability . We do this by solving Maxwell's equations explicitly. In the literature up to date, it has been assumed that negative refractive materials are necessarily frequency dispersive. We propose an alternative to this assumption by suggesting that the requirement of positive energy density can be relaxed, and discuss the implications of such a proposal. More speci cally, we show that once negative energy solutions are accepted, the requirement for frequency dispersion is no longer needed. We further argue that, for the purposes of discussing left-handed materials, the use of group velocity as the physically signi cant quantity is misleading, and suggest that any discussion involving it should be carefully reconsidered.Physic