97 research outputs found
Spectral simplicity and asymptotic separation of variables
We describe a method for comparing the real analytic eigenbranches of two
families of quadratic forms that degenerate as t tends to zero. One of the
families is assumed to be amenable to `separation of variables' and the other
one not. With certain additional assumptions, we show that if the families are
asymptotic at first order as t tends to 0, then the generic spectral simplicity
of the separable family implies that the eigenbranches of the second family are
also generically one-dimensional. As an application, we prove that for the
generic triangle (simplex) in Euclidean space (constant curvature space form)
each eigenspace of the Laplacian is one-dimensional. We also show that for all
but countably many t, the geodesic triangle in the hyperbolic plane with
interior angles 0, t, and t, has simple spectrum.Comment: 53 pages, 2 figure
Chaos assisted tunnelling with cold atoms
In the context of quantum chaos, both theory and numerical analysis predict
large fluctuations of the tunnelling transition probabilities when irregular
dynamics is present at the classical level. We consider here the
non-dissipative quantum evolution of cold atoms trapped in a time-dependent
modulated periodic potential generated by two laser beams. We give some precise
guidelines for the observation of chaos assisted tunnelling between invariant
phase space structures paired by time-reversal symmetry.Comment: submitted to Phys. Rev. E ; 16 pages, 13 figures; figures of better
quality can be found at http://www.phys.univ-tours.fr/~mouchet
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Epstein-Barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis
Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancie
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton’s tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS
The CALorimetric Electron Telescope (CALET) for high-energy astroparticle physics on the International Space Station
The CALorimetric Electron Telescope (CALET) is a space experiment, currently under development by Japan in collaboration with Italy and the United States, which will measure the flux of cosmic-ray electrons (and positrons) up to 20 TeV energy, of gamma rays up to 10 TeV, of nuclei with Z from 1 to 40 up to 1 PeV energy, and will detect gamma-ray bursts in the 7 keV to 20 MeV energy range during a 5 year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of CALET, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fibre planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch (expected in 2015) to the International Space Station ISS, for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF)
Measurement of the gamma ray background in the Davis Cavern at the Sanford Underground Research Facility
Deep underground environments are ideal for low background searches due to the attenuation of cosmic rays by passage through the earth. However, they are affected by backgrounds from γ-rays emitted by 40K and the 238U and 232Th decay chains in the surrounding rock. The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a liquid xenon TPC located within the Davis campus at the Sanford Underground Research Facility, Lead, South Dakota, at the 4,850-foot level. In order to characterise the cavern background, in-situ γ-ray measurements were taken with a sodium iodide detector in various locations and with lead shielding. The integral count rates (0--3300~keV) varied from 596~Hz to 1355~Hz for unshielded measurements, corresponding to a total flux in the cavern of 1.9±0.4~γ cm−2s−1. The resulting activity in the walls of the cavern can be characterised as 220±60~Bq/kg of 40K, 29±15~Bq/kg of 238U, and 13±3~Bq/kg of 232Th
The Calm before the storm! CAL in University Mathematics
A Computer Aided Learning project in Mathematics (the CALM Project) is based at the Heriot-Watt University in Edinburgh. It is one of the projects currently in receipt of funding from the Computer Board of the United Kingdom as part of the Computers in Teaching Initiative in British Universities.The CALM Project seeks to produce computer enhanced teaching packages which will back-up the conventional teaching of Calculus to large groups of first year engineering undergraduates at a typical Scottish University. The project has been underway for just over one year and some of the software prepared by the CALM team has been tested by one section of the class. During this testing period we have embarked on a formative evaluation of the software and of its impact on student learning practices.In this article the writers present an outline of the evaluation procedure. In addition, details are given of the software tools used to produce the CALM programs
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