786 research outputs found
Advanced real-time evaluation and data quality monitoring model integration with FPGAs for tokamak high-performance soft X-ray diagnostic system
Based on the publications regarding new or recent measurement systems for the tokamak plasma experiments, it can be found that the monitoring and quality validation of input signals for the computation stage is done in different, often simple, ways. In the paper is described the unique approach to implement the novel evaluation and data quality monitoring (EDQM) model for use in various measurement systems. The adaptation of the model is made for the GEM-based soft X-ray measurement system FPGA-based. The EDQM elements has been connected to the base firmware using PCI-E DMA real-time data streaming with minimal modification. As additional storage, on-board DDR3 memory has been used. Description of implemented elements is provided, along with designed data processing tools and advanced simulation environment based on Questa software
Interlayer Exchange Coupling in (Ga,Mn)As-based Superlattices
The interlayer coupling between (Ga,Mn)As ferromagnetic layers in
all-semiconductor superlattices is studied theoretically within a tight-binding
model, which takes into account the crystal, band and magnetic structure of the
constituent superlattice components. It is shown that the mechanism originally
introduced to describe the spin correlations in antiferromagnetic EuTe/PbTe
superlattices, explains the experimental results observed in ferromagnetic
semiconductor structures, i.e., both the antiferromagnetic coupling between
ferromagnetic layers in IV-VI (EuS/PbS and EuS/YbSe) superlattices as well as
the ferromagnetic interlayer coupling in III-V ((Ga,Mn)As/GaAs) multilayer
structures. The model allows also to predict (Ga,Mn)As-based structures, in
which an antiferromagnetic interlayer coupling could be expected.Comment: 4 pages, 3 figure
Π₯Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΡΠΈ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠ΅ΠΌ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠ΅
In this research we evaluated the nature of endothelial dysfunction and vascular adsorption-rheological properties
of serum in patients with ankylosing spondylitis, determined its characteristics in the presence of angiopathy and
established communication with the clinical and instrumental parameters of vascular disease and the state of immunity.
The study included 79 patients aged 15 to 66 years, among whom there were 95% of men and 5% of women. Endothelial
vessels dysfunction occurs in each second patient with ankylosing spondylitis, which in the presence of clinical and
instrumental vascular pathology accompanied by an increase in serum concentration of cyclic guanosine monophosphate
and even greater reduction in prostacyclinemia parameters. The severity of disorders of vascular endothelial function in
these patients is associated with disease duration, activity of the pathological process, the lesion of the peripheral nervous
system, the severity of spondylopathies and sacroiliitis.
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΈ Π°Π΄ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΡΠΎΠ²ΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠΈΠΌ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠΎΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π΅Π΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ
Π°Π½Π³ΠΈΠΎΠΏΠ°ΡΠΈΠΈ, ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ²ΡΠ·Ρ Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ
ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°. ΠΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ΠΌ Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΠΈΡΡ 79 Π±ΠΎΠ»ΡΠ½ΡΡ
Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 15 Π΄ΠΎ 66 Π»Π΅Ρ, ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π±ΡΠ»ΠΈ 95% ΠΌΡΠΆΡΠΈΠ½
ΠΈ 5% ΠΆΠ΅Π½ΡΠΈΠ½. ΠΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½Π°Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ² ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π²ΡΠΎΡΠΎΠ³ΠΎ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠΈΠΌ
ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠΎΠΌ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ
Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ΠΌ Π² ΠΊΡΠΎΠ²ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ΠΌΠΎΠ½ΠΎΡΠΎΡΡΠ°ΡΠ° ΠΈ Π΅ΡΠ΅ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ²
ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΠΈΠ½Π΅ΠΌΠΈΠΈ. Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² Ρ ΡΠ°ΠΊΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ²ΡΠ·Π°Π½Π°
Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ
ΡΠΈΡΡΠ΅ΠΌΡ, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΎΠΏΠ°ΡΠΈΠΈ ΠΈ ΡΠ°ΠΊΡΠΎΠΈΠ»Π΅ΠΈΡΠ°
Π’Π ΠΠΠ‘ΠΠ£ΠΠ¬Π’Π£Π ΠΠ ΠΠΠΠΠΠ¬ Π ΠΠΠΠΠ’ΠΠ£ Π‘Π£Π§ΠΠ‘ΠΠΠ ΠΠ£ΠΠ¬Π’Π£Π Π Π Π£ΠΠΠΠΠ₯ ΠΠΠΠΠΠΠΠΠΠ¦ΠΠ Π―Π ΠΠΠΠ ΠΠ‘ΠΠΠ‘ΠΠΠΠΠ― ΠΠ ΠΠΠΠΠΠ Π‘ΠΠΠΠΠΠΠΠΠ¨ΠΠΠΠ― Π£ΠΠΠ€ΠΠΠΠ¦ΠΠ Π’Π ΠΠΠΠΠΠΠΠΠ‘Π’ΠΠ (The transcultural model of modern cultureβs development in conditions of globalization as a new comprehension of problem of correlation between unitization and differences )
Π£ ΡΡΠ°ΡΡΡ ΠΏΠΎΠ΄Π°ΡΡΡΡΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ½Π΅ ΠΎΡΠΌΠΈΡΠ»Π΅Π½Π½Ρ ΡΡΠ°Π½ΡΠΊΡΠ»ΡΡΡΡΠ½ΠΎΡ
ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΡΡΠ°ΡΠ½ΠΎΡ ΠΊΡΠ»ΡΡΡΡΠΈ Π² ΡΠΌΠΎΠ²Π°Ρ
Π³Π»ΠΎΠ±Π°Π»ΡΠ·Π°ΡΡΡ. ΠβΡΡΠΎΠ²ΡΡΡΡΡΡ Π½Π΅Π΄ΠΎΠ»ΡΠΊΠΈ ΠΊΠΎΠ½ΡΠ΅ΠΏΡΡΠΉ ΠΌΡΠ»ΡΡΠΈΠΊΡΠ»ΡΡΡΡΠ°Π»ΡΠ·ΠΌΡ
ΡΠ°
ΠΊΡΠ»ΡΡΡΡΠ½ΠΎΠ³ΠΎ
Π³Π»ΠΎΠ±Π°Π»ΡΠ·ΠΌΡ
Ρ
Π²ΠΈΡΡΡΠ΅Π½Π½Ρ
ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΈ
ΡΠΏΡΠ²Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ
Π³Π»ΠΎΠ±Π°Π»ΡΠ½ΠΈΡ
ΡΠ° Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΈΡ
Π΅Π»Π΅ΠΌΠ΅Π½ΡΡΠ² Ρ ΠΊΡΠ»ΡΡΡΡΡ.
Π‘ΡΠ²Π΅ΡΠ΄ΠΆΡΡΡΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΡΡΠ°Π½ΡΠΊΡΠ»ΡΡΡΡΠ°ΡΡΡ
Ρ Π·ΠΎΠΊΡΠ΅ΠΌΠ° ΠΏΠΎΡΠΎΠ΄ΠΆΡΠ²Π°Π½ΠΎΡ Π½Π΅Ρ Π½ΠΎΠ²ΠΎΡ ΡΠΎΡΠΌΠΈ ΠΊΡΠ»ΡΡΡΡΠ½ΠΎΡ ΡΠ΄Π΅Π½ΡΠΈΡΠ½ΠΎΡΡΡ (The article is an attempt of theoretical comprehension
of transcultural model of development of modern culture in
the conditions of globalization. The lacks of conceptions of
multiculturalism and cultural globalism turn out in the decision
of problem of correlation between global and local elements in a
culture. Perspective of transculturation becomes firmly established
and, in particular, the new form of cultural identity generated by her
Disturbance of the muscoloskeletal system in juvenile ankylosing spondylitis and disease developed in the adulthood (involvement of spine and sacroiliac joints).
Background. Two forms of ankylosing spondylitis (AS) are distinguished: juvenile and adult, depending on debut age of the disease. The diagnosis of juvenile AS (JAS) is one of the most urgent problems in a pediatric rheumatology. The peculiarities of AS course that onsets in childhood and adulthood are manifested by differences in the nature of a spinal column disturbance. At the same time, the evolution of JAS in adulthood remains unexplored. The goals and objectives of research: to study clinical and X-ray symptoms of spondylopathy and sacroiliitis course, to assess their characteristics in the disease that onset in childhood and adulthood. Material and methods. 217 patients with AS (193 men and 24 women) with an average age of 38 years were examined. The fast-progressing course of the disease was detected in 21% of cases, moderate and high degree of activity β in 79% of cases, the ΠΠ-ΠΠΠ stage in 82%, and polyarthritis β in 65%. JAS was detected in 16% of cases (all boys), among them the third stage occurred twice more likely than among the other patients. Results. The clinical and radiologic signs of spondylopathy and sacroiliitis are observed in 95% and 97% of the total number of AS cases, respectively, among all patients with JAS lumbago was detected 4,3 times more frequently, sciatic muscles hypotrophy β 7,8 times, "the string symptom" - 2,9 times", the calcification of the spinal cord - 2,3 times, whereas the prevalence of spinal column injury, the severity of cervico-spondylopathy and sacroiliitis among patients with the disease debut in the adulthood is significantly greater, and the involvement in the process of the lumbar and thoracic spine are detected correspondingly twice as often and by 19%, occurrence of dorsalgia is 4 times as often, the limitation of body lateral bendover by 59%, while there are ambiguous dispersion-correlation links with extraarticular (systemic) manifestations of the disease, and the high prevalence of a peripheral articular syndrome regarding spondylopathy in JAS is a negative prognosis sign, and for the remaining patients there are indices of the Lansbury index and the index of arthroΒpathy progression. Conclusion: the onset of AS in adulthood is a risk factor for the severe course of spondylopathy
Does nitrate reductase play a key role in photoinduction of carotenoid synthesis in Neurospora crassa?
Does nitrate reductase play a key role in photoinduction of caroteniod synthesis in Neurospora crassa
Thermally activated decomposition of (Ga,Mn)As thin layer at medium temperature post growth annealing
The redistribution of Mn atoms in Ga1-xMnxAs layer during medium-temperature annealing, 250-450 oC, by Mn K-edge X-ray absorption fine structure (XAFS) recorded at ALBA facility, was studied. For this purpose Ga1-xMnxAs thin layer with x=0.01 was grown on AlAs buffer layer deposited on GaAs(100) substrate by molecular beam epitaxy (MBE) followed by annealing. The examined layer was detached from the substrate using a βlift-offβ procedure in order to eliminate elastic scattering in XAFS spectra. Fourier transform analysis of experimentally obtained EXAFS spectra allowed to propose a model which describes a redistribution/diffusion of Mn atoms in the host matrix. Theoretical XANES spectra, simulated using multiple scattering formalism (FEFF code) with the support of density functional theory (WIEN2k code), qualitatively describe the features observed in the experimental fine structure
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΊΠ° Π΄Π»Ρ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΡ ΠΆΠ°ΡΠΎΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π° ΠΠ‘32-ΠΠ
Objectives. To identify the regularities of electrochemical processing of the heat-resistant GS32-VI alloy in a sulfuric acid electrolyte with a concentration of 100 g/dm3 under the action of a pulsed current in a pulsed mode.Methods. Using the electrochemical technological complex EHK-1012 (developed by IP Tetran) and a non-compensatory method of measuring potential, polarization and depolarization curves with a change in pulse duration and a pause between them were recorded. The current pulses had an amplitude ranging from 0 to 3.5 A (when recording the polarization and depolarization curves), pulse durations ranging from 200 to 1200 ms, and a pause (delay) between pulses ranging from 50 to 500 ms. There were no reverse current pulses.Results. The parameters of the current program that provide the maximum values of the alloy dissolution rate and current output were determined: with a current pulse amplitude of 2 A, a current pulse duration of 500 ms, and a pause duration between pulses of 250 ms, the maximum dissolution rate of the alloy is 0.048 g/hΒ·cm2, while the current output for nickel is 61.6% with an anode area of 10 cm2. The basic technological scheme for processing the heat-resistant GS32-VI alloy, which includes anodic alloy dissolution in a pulsed mode, is proposed.Conclusions. Electrochemical dissolution of GS32-VI alloy under pulsed current action results in an optimal dissolution rate ratio of the alloy components, ensuring the production of a cathode precipitate with a total nickel and cobalt content of 97.5%.Π¦Π΅Π»ΠΈ. ΠΡΡΠ²ΠΈΡΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΆΠ°ΡΠΎΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π° ΠΠ‘32-ΠΠ, ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠΉ Π² ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅ Π² ΡΠ΅ΡΠ½ΠΎΠΊΠΈΡΠ»ΠΎΠΌ ΡΠ»Π΅ΠΊΡΡΠΎΠ»ΠΈΡΠ΅ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ 100 Π³/Π΄ΠΌ3 ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΊΠ°.ΠΠ΅ΡΠΎΠ΄Ρ. Π‘Π½ΡΡΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈ Π΄Π΅ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΡΠΈΠ²ΡΡ
Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠΌΠΏΡΠ»ΡΡΠ° ΠΈ ΠΏΠ°ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΈΠΌΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΠ₯Π-1012 (ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΠΠΠ ΠΠ Β«Π’Π΅ΡΡΠ°Π½Β»), ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΠ΅Π³ΠΎ Π½Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΡΠΏΠΎΡΠΎΠ± ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π°. ΠΠΌΠΏΠ»ΠΈΡΡΠ΄Π° ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² ΡΠΎΠΊΠ° Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»Π°ΡΡ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΎΡ 0 Π΄ΠΎ 3.5 Π (ΠΏΡΠΈ ΡΠ½ΡΡΠΈΠΈ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΈ Π΄Π΅ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΡΠΈΠ²ΡΡ
), Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠΌΠΏΡΠ»ΡΡΠΎΠ² ΠΈΠ·ΠΌΠ΅Π½ΡΠ»ΠΈΡΡ ΠΎΡ 200 Π΄ΠΎ 1200 ΠΌΡ, ΠΏΠ°ΡΠ·Π° (Π·Π°Π΄Π΅ΡΠΆΠΊΠ°) ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠΌΠΏΡΠ»ΡΡΠ°ΠΌΠΈ β ΠΎΡ 50 Π΄ΠΎ 500 ΠΌΡ, ΠΈΠΌΠΏΡΠ»ΡΡΡ ΡΠ΅Π²Π΅ΡΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠΎΠΊΠ° ΠΎΡΡΡΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΡΠΎΠΊΠΎΠ²ΠΎΠΉ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΡ, ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡΠΈΠ΅ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΡΠΎΡΡΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΡ ΡΠΏΠ»Π°Π²Π° ΠΈ Π²ΡΡ
ΠΎΠ΄Π° ΠΏΠΎ ΡΠΎΠΊΡ. ΠΡΠΈ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Π΅ ΠΈΠΌΠΏΡΠ»ΡΡΠ° ΡΠΎΠΊΠ° 2 Π, Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠΌΠΏΡΠ»ΡΡΠ° ΡΠΎΠΊΠ° 500 ΠΌΡ ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΠ°ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΈΠΌΠΏΡΠ»ΡΡΠ°ΠΌΠΈ 250 ΠΌΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½Π°Ρ ΡΠΊΠΎΡΠΎΡΡΡ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΡ ΡΠΏΠ»Π°Π²Π° 0.048 Π³/ΡΒ·ΡΠΌ2, ΠΏΡΠΈ ΡΡΠΎΠΌ Π²ΡΡ
ΠΎΠ΄ ΠΏΠΎ ΡΠΎΠΊΡ Π΄Π»Ρ Π½ΠΈΠΊΠ΅Π»Ρ ΡΠ°Π²Π΅Π½ 61.6% ΠΏΡΠΈ ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ Π°Π½ΠΎΠ΄Π° 10 ΡΠΌ2. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½Π°Ρ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡ
Π΅ΠΌΠ° ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΆΠ°ΡΠΎΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠ»Π°Π²Π° ΠΠ‘32-ΠΠ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ°Ρ Π°Π½ΠΎΠ΄Π½ΠΎΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠ»Π°Π²Π° Π² ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠΌ ΡΠ΅ΠΆΠΈΠΌΠ΅.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠ»Π°Π²Π° ΠΠ‘32-ΠΠ ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠΊΠ° ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΌΡ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΡΠΊΠΎΡΠΎΡΡΠ΅ΠΉ ΡΠ°ΡΡΠ²ΠΎΡΠ΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΡ
ΡΠΏΠ»Π°Π²Π°, ΡΡΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΎΡΠ°Π΄ΠΊΠ° Ρ ΡΡΠΌΠΌΠ°ΡΠ½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π½ΠΈΠΊΠ΅Π»Ρ ΠΈ ΠΊΠΎΠ±Π°Π»ΡΡΠ° 97.5%
Nature of endothelial dysfunction in ankylosing spondylitis
Π₯Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΡΠΈ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠ΅ΠΌ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠ΅. Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΈ Π°Π΄ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΡΠ΅ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΊΡΠΎΠ²ΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠΈΠΌ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠΎΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π΅Π΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ Π°Π½Π³ΠΈΠΎΠΏΠ°ΡΠΈΠΈ, ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΠ²ΡΠ·Ρ Ρ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°. ΠΠΎΠ΄ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ΠΌ Π½Π°Ρ
ΠΎΠ΄ΠΈΠ»ΠΈΡΡ 79 Π±ΠΎΠ»ΡΠ½ΡΡ
Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 15 Π΄ΠΎ 66 Π»Π΅Ρ, ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
Π±ΡΠ»ΠΈ 95% ΠΌΡΠΆΡΠΈΠ½ ΠΈ 5% ΠΆΠ΅Π½ΡΠΈΠ½. ΠΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½Π°Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ² ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π²ΡΠΎΡΠΎΠ³ΠΎ Π±ΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΠΊΠΈΠ»ΠΎΠ·ΠΈΡΡΡΡΠΈΠΌ
ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΈΡΠΎΠΌ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ΠΌ Π² ΠΊΡΠΎΠ²ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΡΠ°Π½ΠΎΠ·ΠΈΠ½ΠΌΠΎΠ½ΠΎΡΠΎΡΡΠ°ΡΠ° ΠΈ Π΅ΡΠ΅ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΏΡΠΎΡΡΠ°ΡΠΈΠΊΠ»ΠΈΠ½Π΅ΠΌΠΈΠΈ. Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠΎΡΡΠ΄ΠΎΠ² Ρ ΡΠ°ΠΊΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ²ΡΠ·Π°Π½Π° Ρ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ ΡΠΏΠΎΠ½Π΄ΠΈΠ»ΠΎΠΏΠ°ΡΠΈΠΈ ΠΈ ΡΠ°ΠΊΡΠΎΠΈΠ»Π΅ΠΈΡΠ°.
In this research we evaluated the nature of endothelial dysfunction and vascular adsorption-rheological properties of serum in patients with ankylosing spondylitis, determined its characteristics in the presence of angiopathy and established communication with the clinical and instrumental parameters of vascular disease and the state of immunity.
The study included 79 patients aged 15 to 66 years, among whom there were 95% of men and 5% of women. Endothelial vessels dysfunction occurs in each second patient with ankylosing spondylitis, which in the presence of clinical and instrumental vascular pathology accompanied by an increase in serum concentration of cyclic guanosine monophosphate and even greater reduction in prostacyclinemia parameters. The severity of disorders of vascular endothelial function in these patients is associated with disease duration, activity of the pathological process, the lesion of the peripheral nervous
system, the severity of spondylopathies and sacroiliitis
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