Pre-university education in terms of promoting Russian education on the world education market

Russia's advancement on the world education market is one of the foreign policy challenges. The pre-university stage is the milestone for the professional development of a foreign student. Such stage is of paramount importance for the Russia's integration into the world education market. Since the pre-university stage has been the first stage of training in the Russian education system, it should be a specific focal point for the educational service provider. Based on the footprint of pre-university education, foreigners shall have an understanding with respect to the educational system of a country the language whereof is studied

Pre-university education in terms of promoting Russian education on the world education market

Russia's advancement on the world education market is one of the foreign policy challenges. The pre-university stage is the milestone for the professional development of a foreign student. Such stage is of paramount importance for the Russia's integration into the world education market. Since the pre-university stage has been the first stage of training in the Russian education system, it should be a specific focal point for the educational service provider. Based on the footprint of pre-university education, foreigners shall have an understanding with respect to the educational system of a country the language whereof is studied

Semántica verbal en el contexto de la distribución actancial

This study is based on the theory of methods of verbal action (MVA), presented in the works by O.M. Sokolov. Prefixed Russian verbs are considered as part of a functional approach to language analysis. The authors prove that the verb prefixes in the Russian language should be considered as separate linguistic elements, which provide the characteristics of the subject or object actant.Este estudio se basa en la teor.a de los m.todos de acci.n verbal (AMEU), presentada en los trabajos de O.M. Sokolov. Los verbos rusos prefijados se consideran parte de un enfoque funcional para el an.lisis del lenguaje. Los autores prueban que los prefijos verbales en el idioma ruso deben considerarse como elementos lingü.sticos separados, que proporcionan las caracter.sticas del sujeto u objeto actante

Pre-university education in terms of promoting Russian education on the world education market

Russia's advancement on the world education market is one of the foreign policy challenges. The pre-university stage is the milestone for the professional development of a foreign student. Such stage is of paramount importance for the Russia's integration into the world education market. Since the pre-university stage has been the first stage of training in the Russian education system, it should be a specific focal point for the educational service provider. Based on the footprint of pre-university education, foreigners shall have an understanding with respect to the educational system of a country the language whereof is studied

Frequency of EGFR mutations in non-small cell lung cancer patients: screening data from West Siberia

BACKGROUN

Semántica verbal en el contexto de la distribución actancial

This study is based on the theory of methods of verbal action (MVA), presented in the works by O.M. Sokolov. Prefixed Russian verbs are considered as part of a functional approach to language analysis. The authors prove that the verb prefixes in the Russian language should be considered as separate linguistic elements, which provide the characteristics of the subject or object actant.Este estudio se basa en la teor.a de los m.todos de acci.n verbal (AMEU), presentada en los trabajos de O.M. Sokolov. Los verbos rusos prefijados se consideran parte de un enfoque funcional para el an.lisis del lenguaje. Los autores prueban que los prefijos verbales en el idioma ruso deben considerarse como elementos lingü.sticos separados, que proporcionan las caracter.sticas del sujeto u objeto actante

Pre-university education in terms of promoting Russian education on the world education market

Russia's advancement on the world education market is one of the foreign policy challenges. The pre-university stage is the milestone for the professional development of a foreign student. Such stage is of paramount importance for the Russia's integration into the world education market. Since the pre-university stage has been the first stage of training in the Russian education system, it should be a specific focal point for the educational service provider. Based on the footprint of pre-university education, foreigners shall have an understanding with respect to the educational system of a country the language whereof is studied.El avance de Rusia en el mercado mundial de la educación es uno de los desafíos de la política exterior. La etapa preuniversitaria es el hito para el desarrollo profesional de un estudiante extranjero. Esta etapa es de suma importancia para la integración de Rusia en el mercado mundial de la educación. Dado que la etapa preuniversitaria ha sido la primera etapa de formación en el sistema educativo ruso, debería ser un punto focal específico para el proveedor de servicios educativos. Con base en la huella de la educación preuniversitaria, los extranjeros deberán tener un conocimiento con respecto al sistema educativo de un país cuya lengua se estudie

Verbal Semantics in the Context of Actantial Distribution

This study is based on the theory of methods of verbal action (MVA), presented in the works by O.M. Sokolov. Prefixed Russian verbs are considered as part of a functional approach to language analysis. The authors prove that the verb prefixes in the Russian language should be considered as separate linguistic elements, which provide the characteristics of the subject or object actant

Frequency of EGFR mutations in non-small cell lung cancer patients: screening data from West Siberia

BACKGROUN

Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients

Background Integrins enable cell communication with the basal membrane and extracellular matrix, activating signaling pathways and facilitating intracellular changes. Integrins in circulating tumor cells (CTCs) play a significant role in apoptosis evasion and anchor-independent survival. However, the link between CTCs expressing different integrin subunits, their transcriptional profile and, therefore, their functional activity with respect to metastatic potential remains unclear. Methods Single-cell RNA sequencing of CD45-negative cell fraction of breast cancer patients was performed. All CTCs were divided into nine groups according to their integrin profile. Results СTCs without the gene expression of integrins or with the expression of non-complementary α and β subunits that cannot form heterodimers prevailed. Only about 15% of CTCs expressed integrin subunits which can form heterodimers. The transcriptional profile of CTCs appeared to be associated with the spectrum of expressed integrins. The lowest potential activity was observed in CTCs without integrin expression, while the highest frequency of expression of tumor progression-related genes, namely genes of stemness, epithelial-mesenchymal transition (EMT), invasion, proinflammatory chemokines and cytokines as well as laminin subunits, were observed in CTCs co-expressing ITGA6 and ITGB4. Validation on the protein level revealed that the median of integrin β4+ CTCs was higher in patients with more aggressive molecular subtypes as well as in metastatic breast cancer patients. One can expect that CTCs with ITGA6 and ITGB4 expression will have pronounced metastatic potencies manifesting in expression of EMT and stemness-related genes, as well as potential ability to produce chemokine/proinflammatory cytokines and laminins