THE VALIDITY OF USING VIRTUAL REALITY HEAD-MOUNTED DISPLAY FOR AGILITY TRAINING

Virtual reality (VR) provides a fully controlled environment with the potential of making sports training easier. However, to date very few studies concerned creating a locomotion training environment enabling multi-directional movements for mimicking realistic locomotion. This study aims to investigate the validity of using low-cost VR head-mounted display (HMD) for agility training in a virtual environment (VE) for ‘real-walking’ locomotion. Three male college participants (age: 24.00±1.00years, height: 1.68±0.09m, weight: 65.63±4.65kg) participated in this study. They were asked to complete two agility ladder training tasks: the forward and backward icky shuffle, in the real environment (RE) and VE. The correlations of the segment trajectories in the RE and VE were calculated, respectively. Moreover, the correlations of the segment trajectories between the two environments were also calculated. The z-test results show that no significant difference has been obtained in the consistency of the movements between the two environments. Also, high correlations in the segment trajectories were obtained between the virtual and real training environment. The results indicate that it is feasible to use VR HMD for agility training

Facies Analysis, Sedimentology and Paleocurrent of The Quaternary Nenering Formation, Pengkalan Hulu, Malaysia

Nenering Formation is essentially made up of semi-consolidated sediments, which are divided into basal conglomerate beds, conglomeratic sandstone, cross-bedded sandstone, and siltstone to muddy layers facies. It is overlie unconformable to the Berapit Formation, but conformable to the Kroh and Grik Formations. The stratigraphy of Nenering Formation is a fining upwards sequence where the thickness of conglomerate beds become thinner upwards and become thicker for conglomeratic sandstone. The thickness varies from 0.5 m to tenths of meters. The more sandy in the upper portion (cross-bedded sandstone) overlie with thin siltstone and mudstone facies. The clast and grain composition suggested that the material making up the sedimentary sequence were derived predominantly from the erosion of granitoid rocks and sedimentary and metamorphic rocks constitute a minor provenance. Imbrications and the trend sizes of clasts indicate that the palaeo-current flow toward northeast. Cross bedding that was found in conglomerate and sandstone indicates the main channel depositional environment. The sequence stratigraphy of this area match with the Saskatchewan fluvial braided channel model. Formasi Nenering tersusun atas sedimen semi-terkonsolidasi yang terdiri atas lapisan basal konglomerat, batupasir konglomeratik, batupasir berlapisan silang siur, batulanau hingga fasies berlapisan lempung. Formasi Nenering terletak tidak selaras di atas Formasi Berapit, tetapi terletak selaras di atas Formasi Kroh dan Formasi Grik. Stratigrafi Formasi Nenering adalah menghalus ke atas, dimana ketebalan batuan konglomerat semakin menipis ke arah atas, sedangkan batupasir konglomeratik menjadi menebal ke arah atas. Ketebalan perlapisan berkisar pada 0,5 meter hingga puluhan meter. Komposisi pasir yang lebih dominan pada bagian atas (batupasir silang siur) terletak di atas fasies lapisan tipis batulanau dan batulempung. Komposisi butiran dan klastika menunjukkan bahwa material yang menyusun sekuen sedimen didominasi berasal dari erosi batuan granitik, batuan sedimen dan sedikit dari batuan metamorf. Indikasi imbrikasi dan kecenderungan perubahan ukuran material klastika menunjukkan bahwa aliran arus purba mengarah ke timur laut, sedangkan perlapisan silang siur pada batuan konglomerat dan batupasir mengindikasikan lingkungan pengendapan berupa sungai. Sekuen stratigrafi di daerah ini sesuai dengan model lingkungan pengendapan sungai teranyam fluvial Saskatchewan

An exchange-based AIoT platform for fast AI application development

AIoT is the combination of Internet of Things (IoT) and Artificial Intelligence (AI) technologies. While IoT emphasizes more on scalable and efficient communications, AI focuses more on reproducing human capabilities such as recognition and forecasting. An efficient AIoT platform may not be obtained directly from integrating existing IoT and AI serving platforms by considering the AIoT service reproduction and evolution. In this work, we propose an AIoT platform that empowers developers to build sophisticated and scalable applications. Our platform is derived based on exchange-based RabbitMQ broker and Advanced Message Queuing Protocol (AMQP) to facilitate the communications among heterogeneous data sources and AI models. By incorporating an AMQP broker, it supports diverse data exchanges, AI models chaining, and flexible message routing and processing. AI models can be deployed efficiently through containerization with flexible and shared data paths to facilitate computations. Hence, developers can focus on service and application requirements. We also present a case study in smart healthcare to validate our design

Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study

We examined interethnic differences in the prevalence of neuroimaging markers of cerebrovascular and neurodegenerative disease in 3 major Asian ethnicities (Chinese, Malays, and Indians), as well as their role in cognitive impairment. 3T MRI brain scans were acquired from 792 subjects (mean age: 70.0 ± 6.5years, 52.1% women) in the multi-ethnic Epidemiology of Dementia In Singapore study. Markers of cerebrovascular disease and neurodegeneration were identified. Cognitive performance was evaluated using Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and a neuropsychological assessment. Compared to Chinese, Malays had a higher burden of intracranial stenosis (OR: 2.28. 95%CI: 1.23-4.20) and cortical atrophy (β: -0.60. 95%CI: -0.78, -0.41), while Indians had a higher burden of subcortical atrophy (β: -0.23. 95%CI: -0.40, -0.06). Moreover, Malay and Indian ethnicities were likely to be cognitively impaired (OR for Malays: 3.79. 95%CI: 2.29-6.26; OR for Indians: 2.87. 95%CI: 1.74-4.74) and showed worse performance in global cognition (β for Malays: -0.51. 95%CI: -0.66, -0.37; and Indians: -0.32. 95%CI: -0.47, -0.17). A higher burden of cerebrovascular and neurodegenerative markers were found in Malays and Indians when compared to Chinese. Further research is required to fully elucidate the factors and pathways that contribute to these observed differences

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increase their intestinal lymphatic transport in rats. CBD concentrations in the lymph were 250-fold higher than in plasma, while THC concentrations in the lymph were 100-fold higher than in plasma. Since cannabinoids are currently in clinical use for the treatment of spasticity in multiple sclerosis (MS) patients and to alleviate nausea and vomiting associated with chemotherapy in cancer patients, lymphocytes from those patients were used to assess the immunomodulatory effects of cannabinoids. The levels of cannabinoids recovered in the intestinal lymphatic system, but not in plasma, were substantially above the immunomodulatory threshold in murine and human lymphocytes. CBD showed higher immunosuppressive effects than THC. Moreover, immune cells from MS patients were more susceptible to the immunosuppressive effects of cannabinoids than those from healthy volunteers or cancer patients. Therefore, administering cannabinoids with a high-fat meal or in lipid-based formulations has the potential to be a therapeutic approach to improve the treatment of MS, or indeed other autoimmune disorders. However, intestinal lymphatic transport of cannabinoids in immunocompromised patients requires caution

Two novel HLA-A*0201 T-cell epitopes in avian H5N1 viral nucleoprotein induced specific immune responses in HHD mice

The influenza A nucleoprotein (NP) is an attractive target for avian flu vaccine development because of its high conversancy in the evolutionary chain of the virus. Here we identified two novel HLA-A*0201 restricted NP epitopes, named H5N1 NP373-381 AMDSNTLEL (NP373) and NP458-466 FQGRGVFEL (NP458), using computational bioinformatic analysis. The NP peptides showed a high binding affinity to HLA-A*0201 on T2 cells, and were able to induce the activation of the cytotoxic T cells in the human peripheral blood mononuclear cells. We examined the potential of using NP373 and NP458 peptide sequences supplemented with a single-chain trimer as potential DNA vaccine candidates in an HHD transgenic mouse model. A gene gun delivery system was used for administrating the vaccine candidates into the animals. The results from cytotoxicity and ELISPOT assays indicated that a significant amount of IFN-γ was secreted by the T cells of the vaccinated mice, and the T cells were able to eliminate the corresponding peptide-loaded T2 cells. The discovery of these novel immunogenic NP peptides provides valuable information for avian flu vaccine design and construction

Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammatory and anti-oxidant effect of DC. The results showed that DC significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-activated RAW264.7 cells. The expression of pro-inflammatory proteins including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were also obviously inhibited by DC in LPS-activated RAW264.7 cells. Besides, the production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were also remarkably inhibited by DC in LPS-activated RAW264.7 cells. DC also suppressed inflammation indicators including COX-2, PGE2, TNF-α, and IL-6 in LPS-stimulated THP-1 macrophages. Furthermore, DC inhibited the macrophage M1 phenotype and the production of reactive oxygen species (ROS) in LPS-activated RAW264.7 cells. Mechanism studies showed that DC mainly activated nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, increased the level of anti-oxidant protein heme oxygenase-1 (HO-1) and thus produced the anti-inflammatory and anti-oxidant effects, which were abolished by Nrf2 siRNA and HO-1 inhibitor. These findings suggested that DC could be a new Nrf2 activator for the treatment and prevention of diseases related to inflammation and oxidative stress

Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in Hepatocellular carcinoma development

Background: The biological pathways and functional properties by which misexpressed microRNAs (miRNAs) contribute to liver carcinogenesis have been intensively investigated. However, little is known about the upstream mechanisms that deregulate miRNA expressions in this process. In hepatocellular carcinoma (HCC), hepatitis B virus (HBV) X protein (HBx), a transcriptional trans-activator, is frequently expressed in truncated form without carboxyl-terminus but its role in miRNA expression and HCC development is unclear. Methods: Human non-tumorigenic hepatocytes were infected with lentivirus-expressing full-length and carboxyl-terminal truncated HBx (Ct-HBx) for cell growth assay and miRNA profiling. Chromatin immunoprecipitation microarray was performed to identify the miRNA promoters directly associated with HBx. Direct transcriptional control was verified by luciferase reporter assay. The differential miRNA expressions were further validated in a cohort of HBV-associated HCC tissues using real-time PCR. Results: Hepatocytes expressing Ct-HBx grew significantly faster than the full-length HBx counterparts. Ct-HBx decreased while full-length HBx increased the expression of a set of miRNAs with growth-suppressive functions. Interestingly, Ct-HBx bound to and inhibited the transcriptional activity of some of these miRNA promoters. Notably, some of the examined repressed-miRNAs (miR-26a, -29c, -146a and -190) were also significantly down-regulated in a subset of HCC tissues with carboxyl-terminal HBx truncation compared to their matching non-tumor tissues, highlighting the clinical relevance of our data. Conclusion: Our results suggest that Ct-HBx directly regulates miRNA transcription and in turn promotes hepatocellular proliferation, thus revealing a viral contribution of miRNA deregulation during hepatocarcinogenesis. © 2011 Yip et al.published_or_final_versio

Interest-driven creator theory: towards a theory of learning design for Asia in the twenty-first century

Asian education is known for its examination-driven orientation, with the downsides of distorting the processes of learning and teaching, diminishing students’ interest in learning, and failing to nurture twenty-first century competencies among students. As a group of Asian researchers, we have been developing Interest-Driven Creator (IDC) Theory, a design theory based on three anchored concepts, namely interest, creation, and habit. Each of these anchored concepts is represented by a loop composed of three components. In the interest loop, the three components are triggering, immersing, and extending. The components of the creation loop are imitating, combining, and staging. The habit loop consists of cuing environment, routine, and harmony. These three loops are interconnected in various ways, with their characteristics revealed by the design process. We hypothesize that technology-supported learning activities that are designed with reference to IDC Theory will enable students to develop interest in learning, be immersed in the creation process, and, by repeating this process in their daily routines, strengthen habits of creation. Furthermore, students will excel in learning performance, develop twenty-first century competencies, and become lifelong interest-driven creators. To sharpen our understanding and further the development of the theory, we need more discussion and collaborative efforts in the community. Hypotheses arising from this theory can be tested, revised, or refined by setting up and investigating IDC Theory-based experimental sites. By disseminating the framework, foundations, and practices to the various countries and regions of Asia, we hope that it will bring about compelling examples and hence a form of quality education for the twenty-first century, which is an alternative to the examination-driven education system. In this paper, we present an overall introduction to IDC Theory and its history, and discuss some of the steps for advancing it in the future