Aide aux choix d'orientation : actions de trois cégeps francophones

Un accompagnement dans les choix d'orientation peut favoriser le processus de prise de décision et influencer la poursuite et la réussite des études. Les mesures de soutien à la réussite mise en place en 2000 et évaluées en 2004 (Commission d'évaluation de l'enseignement collégial, 2004) se sont avérées satisfaisantes pour les établissements collégiaux. Maintenant que les collèges ont gagné en expérience dans ces mesures, il parait pertinent de dresser un portrait des mesures récemment adoptées en lien avec le soutien aux choix d'orientation dans les plans de réussite en début de première année d'études collégiales. Cet essai dresse ce portrait des actions récentes favorisant les choix d'orientation dans trois établissements d'enseignement collégial publics francophones. L'analyse des actions a été ensuite effectuée selon 1) les catégories d'actions soutenant la transition (Tinto, 1993); 2) la typologie du cheminement des élèves (CSÉ, 2002); 3) les trois établissements de l'échantillon (Cégep de Saint-Jean-sur-Richelieu; Cégep du Vieux-Montréal; Cégep de Trois-Rivières)

L'illustration des Métamorphoses d'Ovide au six-huitième siècle : l'édition de Dubois-Fontanelle (1767) et ses artistes

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.Pour respecter les droits d'auteur, la version électronique de cette thèse ou ce mémoire a été dépouillée, le cas échéant, de ses documents visuels et audio-visuels. La version intégrale de la thèse ou du mémoire a été déposée au Service de la gestion des documents et des archives de l'Université de Montréal

Organiser un débat argumenté en troisième (« Découverte professionnelle six heures »)

L’article offre aux praticiens de l’orientation un cadre d’intervention relatif à la pratique de débats argumentés en classe de troisième – « Découverte professionnelle six heures » –, dont l’objectif est d’enrichir les représentations des élèves sur l’école et le travail, mais aussi sur eux-mêmes et ainsi les aider à construire un point de vue argumenté sur leur orientation. Après nous être arrêtés, dans une première partie, sur la notion de débat (cadre général et objectifs), nous présentons, dans une seconde partie, le déroulé des trois séances formalisées à partir d’expérimentations de terrain.The article provides the experts of professional guidance with a framework of intervention for argumentative debates in fourth form classes –‘six hours of professional discovery’–, the aim of which is to enrich pupils’ representations of school and work, but also of themselves, and thus to help them build an argued point of view of their own orientation. In a first part, we focus on the concept of debate (general framework and objectives) and, in a second part, we present the method used for the three meetings based on practical experimentations

Physics of the frequency response of rectifying organic Schottky diodes

International audienceThe frequency response of unipolar organic Schottky diodes used in a rectifying circuit, such as an RFID tag, has been investigated in detail. The time dependent response of rectifying circuits has been simulated solving both the Drift Diffusion and Poisson equations to model the hole transport within the diode, coupled with time dependent circuit equations. Several approximations have also been discussed. It turns out that the cut off frequency of the rectifying circuit is indeed limited by the carrier time-of-flight and not by the diode equivalent capacitance. Simulations have also been confirmed by comparison with experiments, involving diodes with different mobilities and thicknesses. This work confirms that the 13.56MHz frequency can be reached using polymer semiconductors, as already experimentally demonstrated in the literature, by an adequate control of the active layer thicknes

BIOTEX-biosensing textiles for personalised healthcare management.

Textile-based sensors offer an unobtrusive method of continually monitoring physiological parameters during daily activities. Chemical analysis of body fluids, noninvasively, is a novel and exciting area of personalized wearable healthcare systems. BIOTEX was an EU-funded project that aimed to develop textile sensors to measure physiological parameters and the chemical composition of body fluids, with a particular interest in sweat. A wearable sensing system has been developed that integrates a textile-based fluid handling system for sample collection and transport with a number of sensors including sodium, conductivity, and pH sensors. Sensors for sweat rate, ECG, respiration, and blood oxygenation were also developed. For the first time, it has been possible to monitor a number of physiological parameters together with sweat composition in real time. This has been carried out via a network of wearable sensors distributed around the body of a subject user. This has huge implications for the field of sports and human performance and opens a whole new field of research in the clinical setting

Positron emission tomography-imaging assessment for guiding strategy in patients with relapsed/refractory large B-cell lymphoma receiving CAR T cells

The aim of this study was to evaluate the prognostic impact of the F-fluorodeoxyglucose positron emission tomography response at 1 month (M1) and 3 months (M3) after anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in a multicenter cohort of 160 patients with relapsed/refractory large B-cell lymphomas (R/R LBCL). In total, 119 (75%) patients reached M1 evaluation; 64 (53%, 64/119) had a complete response (CR); 91% were Deauville Score (DS) 1-3. Progressionfree survival (PFS) and overall survival (OS) were significantly worse in patients with DS-5 at M1, than in patients with DS 1-3 (PFS hazard ratio [HR]=6.37, 95% confidence interval [CI]: 3.5-11.5 vs. OS HR=3.79, 95% CI: 1.7-8.5) and DS-4 (PFS HR=11.99, 95% CI: 5.0-28.9 vs. OS HR=12.49, 95% CI: 2.8-55.8). The 1-year PFS rates were 78.9% (95% CI: 58.9-89.9) for DS-4 at M1, similar to 67.3% (95% CI: 51.8-78.8) for patients with DS 1-3 at M1, very different to 8.6% (95% CI: 1.8-22.4) for DS-5, respectively. Only eight of 30 (26%) patients with DS-4 progressed. Response at M3 evaluated in 90 (57%) patients was prognostic for PFS with lower discrimination (HR=3.28, 95% CI: 1.5-7.0; P=0.003) but did not predict OS (HR=0.61, 95% CI: 0.2-2.3; P=0.45). Patients with a high baseline total metabolic tumor volume (TMTV) >80 mL had worse PFS (HR=2.05, 95% CI: 1.2-3.5; P=0.009) and OS (HR=4.52, 95% CI: 2.5-8.1; P80 mL, and DS-5 at M1 for OS. In conclusion, baseline TMTV and response at M1 strongly predicts outcomes of patients with R/R LBCL undergoing CAR T-cell therapy

PpiA, a Surface PPIase of the Cyclophilin Family in Lactococcus lactis

Background: Protein folding in the envelope is a crucial limiting step of protein export and secretion. In order to better understand this process in Lactococcus lactis, a lactic acid bacterium, genes encoding putative exported folding factors like Peptidyl Prolyl Isomerases (PPIases) were searched for in lactococcal genomes. Results: In L. lactis, a new putative membrane PPIase of the cyclophilin subfamily, PpiA, was identified and characterized. ppiA gene was found to be constitutively expressed under normal and stress (heat shock, H2O2) conditions. Under normal conditions, PpiA protein was synthesized and released from intact cells by an exogenously added protease, showing that it was exposed at the cell surface. No obvious phenotype could be associated to a ppiA mutant strain under several laboratory conditions including stress conditions, except a very low sensitivity to H2O2. Induction of a ppiA copy provided in trans had no effect i) on the thermosensitivity of an mutant strain deficient for the lactococcal surface protease HtrA and ii) on the secretion and stability on four exported proteins (a highly degraded hybrid protein and three heterologous secreted proteins) in an otherwise wild-type strain background. However, a recombinant soluble form of PpiA that had been produced and secreted in L. lactis and purified from a culture supernatant displayed both PPIase and chaperone activities. Conclusions: Although L. lactis PpiA, a protein produced and exposed at the cell surface under normal conditions, displaye

A French multicentric prospective prognostic cohort with epidemiological, clinical, biological and treatment information to improve knowledge on lymphoma patients: study protocol of the "REal world dAta in LYmphoma and survival in adults" (REALYSA) cohort.

BACKGROUND: Age-adjusted lymphoma incidence rates continue to rise in France since the early 80's, although rates have slowed since 2010 and vary across subtypes. Recent improvements in patient survival in major lymphoma subtypes at population level raise new questions about patient outcomes (i.e. quality of life, long-term sequelae). Epidemiological studies have investigated factors related to lymphoma risk, but few have addressed the extent to which socioeconomic status, social institutional context (i.e. healthcare system), social relationships, environmental context (exposures), individual behaviours (lifestyle) or genetic determinants influence lymphoma outcomes, especially in the general population. Moreover, the knowledge of the disease behaviour mainly obtained from clinical trials data is partly biased because of patient selection. METHODS: The REALYSA ("REal world dAta in LYmphoma and Survival in Adults") study is a real-life multicentric cohort set up in French areas covered by population-based cancer registries to study the prognostic value of epidemiological, clinical and biological factors with a prospective 9-year follow-up. We aim to include 6000 patients over 4 to 5 years. Adult patients without lymphoma history and newly diagnosed with one of the following 7 lymphoma subtypes (diffuse large B-cell, follicular, marginal zone, mantle cell, Burkitt, Hodgkin, mature T-cell) are invited to participate during a medical consultation with their hematologist. Exclusion criteria are: having already received anti-lymphoma treatment (except pre-phase) and having a documented HIV infection. Patients are treated according to the standard practice in their center. Clinical data, including treatment received, are extracted from patients' medical records. Patients' risk factors exposures and other epidemiological data are obtained at baseline by filling out a questionnaire during an interview led by a clinical research assistant. Biological samples are collected at baseline and during treatment. A virtual tumor biobank is constituted for baseline tumor samples. Follow-up data, both clinical and epidemiological, are collected every 6 months in the first 3 years and every year thereafter. DISCUSSION: This cohort constitutes an innovative platform for clinical, biological, epidemiological and socio-economic research projects and provides an opportunity to improve knowledge on factors associated to outcome of lymphoma patients in real life. TRIAL REGISTRATION: 2018-A01332-53, ClinicalTrials.gov identifier: NCT03869619