29 research outputs found

    Making sense of big data in health research: Towards an EU action plan.

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    Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health and healthcare for all Europeans

    Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

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    Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≄ II, EF ≀35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

    Collective efficacy and the built environment.

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    Collective efficacy is a prominent explanation for neighborhood crime concentrations. Just as crime is concentrated in particular neighborhoods, within-neighborhoods crime is concentrated in particular criminogenic locations. Research suggests criminogenic locations are determined by features of the built environment. This study links collective efficacy with situational opportunity to propose that collective efficacy facilitates the removal of criminogenic features of the built environment. I test this by examining associations 1) between past collective efficacy and present criminogenic features of the built environment, as well as 2) between those built environment features and crime, net of present collective efficacy. These are modeled using piecewise structural equations with generalized linear mixed-effect regressions on data from 1,641 blocks in 343 Chicago neighborhoods. Four types of police-reported crime are modeled using eight block-level built environment features in the 2003 Chicago Community Area Health Study (CCAHS; N = 3,074) and neighborhood collective efficacy from the CCAHS and the 1995 Project in Human Development in Chicago Neighborhoods (PHDCN) Community Survey (N = 7,672). Findings suggest neighborhoods with high collective efficacy maintain low rates of crime in part by limiting criminogenic built environment features, in particular, abandoned buildings. This crime control pathway is important because changes to the built environment are long lasting and reduce the need for future interventions against crime

    Disorder in the Neighborhood: A Large-Scale Field Experiment on Disorder, Norm Violation, and Pro-Social Behavior

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    Thesis (Master's)--University of Washington, 2017-09A highly-visible paper, published in Science, using field experiments in a Groningen neighborhood found strong support for the broken windows hypothesis: disorder increases norm violations (Keizer et al. 2008). The study has been replicated in several other European countries. We attempt to replicate this study in the U.S. by embedding a mailbox field experiment in six Seattle neighborhoods that vary in social capital and collective efficacy. Our experiment places a lost letter with a visible $5 bill near the mailbox. The treatment is graffiti and/or trash in the area. We examine three outcomes: passersby ignoring the letter, stealing the letter (a norm violation), or mailing the letter (a form of altruism). We use multinomial and nested logit methods to model the 2,786 cases. Results indicate physical disorder attenuates pro-social behavior while neighborhood collective efficacy and concentrated disadvantage are associated with rates of norm violation. Overall, we fail to replicate Keizer et al. but find evidence that disorder attenuates pro-social behavior

    Integrating Collective Efficacy and Criminal Opportunity: Disorder, the Built Environment, and Policing

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    Thesis (Ph.D.)--University of Washington, 2021This dissertation proposes an integrative theory that links social structural explanations of neighborhood crime to opportunity-based situational explanations for crime. The first chapter of this dissertation argues that the neighborhood-level theories of collective efficacy and broken windows may be unified into a multilevel theory of situations using Cohen and Felson’s (1979) routine activities theory and a pragmatist model of roles and perception. I discuss empirical implications of this integrated theory. The second chapter proposes that collective efficacy inhibits crime in part by permitting neighborhoods to remove and prevent built environment features that generate criminal opportunities. I find evidence collective efficacy is negatively related to the presence of abandoned buildings and mixed land use which, in turn, promote crime. The third chapter interrogates the role of police efficacy---resident perceptions of police effectiveness and legitimacy---in collective efficacy theory. In contrary to established research in this area, I find evidence that collective efficacy causally precedes police efficacy. In the conclusion I discuss implications for future research and advocate for situating collective efficacy in a multi-level crime, opportunity, and political economy framework
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