ANALISIS PENERAPAN PEMBUKUAN DIGITAL AKUNTANSI SEDERHANA KEPADA PELAKU UMKM DI DESA TOAPAYA UTARA

Pembukuan digital adalah software untuk mencatat transaksi keuangan UMKM dengan lebih cepat, sederhana dan mudah. Tujuan dari kegiatan ini adalah untuk membantu UMKM khususnya UMKM di Desa Toapaya Utara dalam membuat pembukuan sederhana dengan menggunakan aplikasi pembukuan digital yaitu BukuKas. Kegiatan ini dilaksanakan karena berdasarkan hasil survei kelompok 17 ke lokasi UMKM, terdapat beberapa permasalahan yaitu kurangnya kemampuan pelaku UMKM dalam memisahkan uang pribadi dengan uang usaha yang mengakibatkan pelaporan keuangan yang tidak konsisten, dan keterbatasan pengetahuan akuntansi sederhana oleh pelaku UMKM. Metode yang dilaksanakan dibagi menjadi tiga tahap, yaitu tahap wawancara, tahap pemaparan materi, tahap cara penggunaan aplikasi "BukuKas" kepada para pelaku UMKM agar para pelaku UMKM dapat lebih jelas mengetahui laba rugi usahanya. Untuk itu kami memberikan penyuluhan mengenai pembukuan digital sederhana dengan menggunakan aplikasi digital "BukuKas"

PENERAPAN STRATEGI PEMASARAN, DIGITAL MARKETING MELALUI E-COMMERCE DAN MARKETPLACE UMKM TOAPAYA UTARA

Empowerment Activities Are A Form Of Community Service By Group 17 KKN Of The Tanjungpinang Development Economics College (STIE). Empowerment Activities Through Assistance For MSME Actors, Along With The Development Of Technology And The Need For Information, The Internet Is Also Experiencing Development. So Currently, A New Pattern Appears In Doing Business Processes That Is By Using The Internet. In Today's Business, Marketplace Or E- Commerce Is One Of The Places To Promote Products To Be More Efficient, Flexible, And Can Save Costs. The Non-Profit Partners In This Activity Are Micro, Small And Medium Enterprises (Msmes) That Produce Sweet Potato Rengginang In North Toapaya Village. This Business Has Been Established Since 2007 In North Toapaya Village, It Has Been About 15 Years That This Business Has Been Going On, But The Marketing Is Still Very Minimal, MSME Actors Still Need To Understand The Importance Of Using Digital Marketing To Improve The Marketing System So That They Can Expand Their Business Goals And Can Support Activities. Sales For Better. The Results Of This Service Are Expected That MSME Actors Can Understand The Importance Of Understanding Digital Marketing In Marketing Their Product

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Not AvailableProtandrous black porgy fish, Acanthopagrus schlegeli, have a striking life cycle with a male sex differenti ation at the juvenile stage and male-to-female sex change at 3 years of age. We had characterized the sex differentiation and sex change in this species by the integrative approaches of histology, endocrine and molecular genetics. The fish differentiated in gonad at the age around 4-months and the gonad further developed with a bisexual gonad for almost for 3 years and sex change at 3 year of age. An antagonistic relationship in the testicular and ovarian tissues was found during the development of the gonadal tissue. Male- (such as sf-1, dmrt1, dax-1 and amh) and female- (such as wnt4, foxl2 and cyp19a1a) promoting genes were associated with testicular and ovarian development, respectively. During gonadal sex differentiation, steroidogenic pathway and estrogen signaling were also highly expressed in the brain. The increased expression of sf-1 and wnt4, cyp19a1a in ovarian tissue and decreased expression of dax-1 in the ovarian tissue may play important roles in sex change from a male-to-female. Endocrine factors such as estradiol and luteinizing hormone may also involve in the natural sex change. Estradiol induced the expression of female-promoting genes and resulted in the precocious sex change in black porgy. Our series of studies shed light on the sex differentiation and sex change in protandrous black porgy and other animalsNot Availabl

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

general view, view to northeast across paving stone plaza (old roman forum) to church and campanile, 198

Breaking ground in cross-cultural research on the fear of being laughed at (gelotophobia): A multi-national study involving 73 countries

The current study examines whether the fear of being laughed at (gelotophobia) can be assessed reliably and validly by means of a self-report instrument in different countries of the world. All items of the GELOPH (Ruch and Titze, GELOPH46, University of Düsseldorf, 1998; Ruch and Proyer, Swiss Journal of Psychology 67:19–27, 2008b) were translated to the local language of the collaborator (42 languages in total). In total, 22,610 participants in 93 samples from 73 countries completed the GELOPH. Across all samples the reliability of the 15-item questionnaire was high (mean alpha of .85) and in all samples the scales appeared to be unidimensional. The endorsement rates for the items ranged from 1.31% through 80.00% to a single item. Variations in the mean scores of the items were more strongly related to the culture in a country and not to the language in which the data were collected. This was also supported by a multidimensional scaling analysis with standardized mean scores of the items from the GELOPH15. This analysis identified two dimensions that further helped explaining the data (i.e., insecure vs. intense avoidant-restrictive and low vs. high suspicious tendencies towards the laughter of others). Furthermore, multiple samples derived from one country tended to be (with a few exceptions) highly similar. The study shows that gelotophobia can be assessed reliably by means of a self-report instrument in cross-cultural research. This study enables further studies of the fear of being laughed at with regard to differences in the prevalence and putative causes of gelotophobia in comparisons to different cultures

Analysis of PTEN Complex Assembly and Identification of Heterogeneous Nuclear Ribonucleoprotein C as a Component of the PTEN-associated Complex*

PTEN (phosphatase and tensin homolog deleted on chromosome 10) is well characterized for its role in antagonizing the phosphoinositide 3-kinase pathway. Previous studies using size-exclusion chromatography demonstrated PTEN recruitment into high molecular mass complexes and hypothesized that PTEN phosphorylation status and PDZ binding domain may be required for such complex formation. In this study, we set out to test the structural requirements for PTEN complex assembly and identify the component(s) of the PTEN complex(es). Our results demonstrated that the PTEN catalytic function and PDZ binding domain are not absolutely required for its complex formation. On the other hand, PTEN phosphorylation status has a significant impact on its complex assembly. Our results further demonstrate enrichment of the PTEN complex in nuclear lysates, suggesting a mechanism through which PTEN phosphorylation may regulate its complex assembly. These results prompted further characterization of other protein components within the PTEN complex(es). Using size-exclusion chromatography and two-dimensional difference gel electrophoresis followed by mass spectrometry analysis, we identified heterogeneous nuclear ribonucleoprotein C (hnRNP C) as a novel protein recruited to higher molecular mass fractions in the presence of PTEN. Further analysis indicates that endogenous hnRNP C and PTEN interact and co-localize within the nucleus, suggesting a potential role for PTEN, alongside hnRNP C, in RNA regulation