INVESTIGATION OF TOOL WEARS IN HIGH SPEED TURNING OF EN 31 STEEL

Experiment is conducted on EN 31 alloy steel with carbide insert. Number of experiments and arrangement of process parameters are determined with the help of face centred central composite design. The input parameters are spindle speed, feed and depth of cut which is varied in three different levels. Response Surface Methodology is used to generate empirical relationship between the inputs and the responses which is validated by analysis of variance. The predicted values derived from Response Surface Methodology are compared with experimental data. Effects of input parameters on responses are analysed with the help of Response Surface Methodology. Multi-objective optimization of turning process parameters is done for Tool Wear

PHYSIO-ANATOMICAL EXPLORATION OF ROLE OF MENTAL HEALTH IN ANNAVAHA SROTAS DISORDERS

The good health is defined not only on basis of physical well being but rather also on mental well being. As told in Ayurveda texts- “Prasanna Atmendriya Manah Swasth Ityabhidheeyate”. In era of globalization, the fast & modernized lifestyle has taken toll on one’s health. Now a day, majority of population is suffering from digestive problems such as acidity, reflux, bloating, stomach pain, constipation, and anorexia. These digestive problems are mainly due to bad dietary habits like junk foods, lack of balanced diet etc and also due lack of proper sleep, stress etc. Stress shows both long term and short term effect on gut functions like gastric secretions, gut motility, mucosal permeability etc. Our Acharas were well aware about this factor for digestive disorders, as they included Shoka, Bhaya, Krodha etc. as Nidana (cause) of digestive disorders. These various Nidana of digestive disorders causes Agnidushti which is cause of Annvaha srotodushti and Mandagni. It is very important to understand the relationship between gut and mental health to know aetio-pathogenesis of disorders, which will help to develop holistic approach for better treatment of Annavaha Srotas Disorders

YK- 2038 Bug

This paper talks about the problem we all will be facing precisely   on 19th Jan.   2038.Digital world has been vulnerable by several bugs however, solely a couple of looked as if it would cause a good danger. The bug that got most famed was Y2K. Somehow, we tend to got over it, then, there was Y2K10. It too was resolved and currently we tend to have Y2K38. The Y2K38 bug, if not resolved, will make sure that the predictions that were created for the Y2K bug come true this point. On 19th Jan. 2038 within all UNIX supported Operating system Time and Date would began to work incorrectly. This    produces a big problem which is critical for all Software’s and basically a threat   to embedded systems. Hence afterwards   it   basically shows possible solutions   which we can take to avoid Unix Millennium 2038 problem. By doing research I have developed a patch. Now I have moved this    patch to GitHub. This patch can enable the 32bit S/W to use   64bit   time_t   on   a 32bit computer.  This  patch  is still under development but it is  current  state  has been shown in this paper along with  all  the  codes  and brief description of each and every function and files. I think to  quickies  way to solve this problem is by using patch which  Software  developers   who   are having 32bit S/w simply  needs  to  include  all  header   files   and implementation files within their software and use  the function I along with other open source community  has   made. Coding has been done in C language

Study of difference in cognitive functions after a single manic episode versus recurrent episodes in euthymic bipolar 1 patients

Background: Neurocognitive deficits have been substantially documented in patients with bipolar disorder in the euthymic state. The assessment of cognitive change from first episode mania is crucial in understanding whether cognitive deficits are progressive or already present from the first diagnostic episode of bipolar I disorder. The objective of the study is to assess and compare the cognitive function in bipolar I patients with one manic episode and recurrent episodes currently in remission.Methods: A cross sectional observational study consisting of 3 groups was carried on eighty cases each of bipolar 1 disorder patients in euthymic phase with one manic, more than 3 manic episodes and controls. These were subjected to the neuropsychological assessment and then compared.Results: The patients with recurrent episodes group shows poor performance upon digit span test, visuospatial memory test, verbal learning and memory test, color stroop test and trail making test than patients with single manic episode and healthy controls upon these cognitive tests.Conclusions: The present finding suggest that there is impairment in various cognitive domains like executive function, attention, memory even in bipolar patients after single manic episode

Efficiency of organic pesticides, turmeric (Curcuma longa) and neem (Azadirachta indica) against dry fish beetle (Dermestes sp.) during storage condition

Efficacy of turmeric (Curcuma longa) and neem (Azadirachta indica) or repelling dry fish insects (Dermestes sp. adult and larva) was investigated on the basis of their repellency rate, storage quality, sensory attributes of turmeric and neem treated dry fish and their cooked products. Pesticides prepared from turmeric and neem, were used in the form of extract and powder. The extracts were tested at the concentrations of 2%, 3%, 5% for turmeric and 3%, 5%, 7% for neem. Turmeric and neem powder were used for treatment at the rate of 2.0%, 3%, 4.0% upon 100 g dry fish. Repellency rate of Dermestes sp., adults was highest, where larvae showed mere resistance against herbal pesticides. Pesticides prepared from turmeric were more repellent than neem pesticides. Control and treated dry fish had almost similar sensory attributes after the 2nd month. However, odor, texture, general appearance and insect occurrence of control dry fish decreased significantly after 4th month of storage but all those parameter of treated dry fish were nearly unchanged. However, sensory quality of dry fish treated with turmeric and neem were remain unchanged after the 4th month. The results suggested that 3% extract and powder of turmeric or neem at the rate of 5% extract and 3% powder can be used as suitable field doses for direct application in dry fish to prevent insect infestation during storage of dry fish products

Extracellular acidification stimulates GPR68 mediated IL-8 production in human pancreatic β cells.

International audienceAcute or chronic metabolic complications such as diabetic ketoacidosis are often associated with extracellular acidification and pancreatic β-cell dysfunction. However, the mechanisms by which human β-cells sense and respond to acidic pH remain elusive. In this study, using the recently developed human β-cell line EndoC-βH2, we demonstrate that β-cells respond to extracellular acidification through GPR68, which is the predominant proton sensing receptor of human β-cells. Using gain- and loss-of-function studies, we provide evidence that the β-cell enriched transcription factor RFX6 is a major regulator of GPR68. Further, we show that acidic pH stimulates the production and secretion of the chemokine IL-8 by β-cells through NF-кB activation. Blocking of GPR68 or NF-кB activity severely attenuated acidification induced IL-8 production. Thus, we provide mechanistic insights into GPR68 mediated β-cell response to acidic microenvironment, which could be a new target to protect β-cell against acidosis induced inflammation

Differentiating functional human islet-like aggregates from pluripotent stem cells

Publisher Copyright: © 2022 The Author(s)We present here a robust and reliable protocol by which to differentiate pancreatic islet-like aggregates (SC-islets) from human pluripotent stem cells. The 7-stage protocol mimics developmental patterning factors that induce endocrine lineage formation and spans monolayer, microwell, and aggregate suspension culture. The SC-islets demonstrate dynamic glucose-sensitive insulin secretion and an endocrine cell composition similar to those of primary human islets. SC-islets generated using this optimized protocol are suitable for in vitro modeling of islet cell pathophysiology and therapeutic applications. For complete details on the use and execution of this protocol, please refer to Balboa et al. (2022).Peer reviewe

Influence of salt and herbal substance on the drying and reconstitution performance of Bombay duck, Harpodon nehereus

Effects of salt, chili and turmeric powder on the production of high quality dried fish products from Bombay duck (Harpodon nehereus) under open sun drying was investigated. Five different types of dried products (T1-T5) were produced and studied. Moisture content in T3 decreased more rapidly to below 16% within 28 hrs of drying compared to those treated with other treatments (temperature varies from 24.6°C to 34°C and relative humidity varies between  60% and 48%) . Drying process was very slow in control samples where it took 32 hrs for reaching the moisture level to 18.75%. Both turmeric and chili powders had strong repellency effect against insect infestation. Bombay duck treated with salt and herbal products were less infested by the blowfly whereas samples dried under control treatment were severely infested by blowfly