The Photonic Band theory and the negative refraction experiment of metallic helix metamaterials

We develop a theory to compute and interpret the photonic band structure of a periodic array of metallic helices for the first time. Interesting features of band structure include the ingenuous longitudinal and circularly polarized eigenmodes, the wide polarization gap [Science 325, 1513 (2009)], and the helical symmetry guarantees the existence of negative group velocity bands at both sides of the polarization gap and band crossings pinned at the zone boundary with fixed frequencies. A direct proof of negative refraction via a chiral route [Science 306, 1353 (2004)] is achieved for the first time by measuring Gooshanchen shift through a slab of three dimensional bona fide helix metamaterial

Effective conductivity of composites of graded spherical particles

We have employed the first-principles approach to compute the effective response of composites of graded spherical particles of arbitrary conductivity profiles. We solve the boundary-value problem for the polarizability of the graded particles and obtain the dipole moment as well as the multipole moments. We provide a rigorous proof of an {\em ad hoc} approximate method based on the differential effective multipole moment approximation (DEMMA) in which the differential effective dipole approximation (DEDA) is a special case. The method will be applied to an exactly solvable graded profile. We show that DEDA and DEMMA are indeed exact for graded spherical particles.Comment: submitted for publication

Hurricanes Substantially Reduce the Nutrients in Tropical Forested Watersheds in Puerto Rico

Because nutrients including nitrogen and phosphorus are generally limited in tropical forest ecosystems in Puerto Rico, a quantitative understanding of the nutrient budget at a watershed scale is required to assess vegetation growth and predict forest carbon dynamics. Hurricanes are the most frequent disturbance in Puerto Rico and play an important role in regulating lateral nitrogen and phosphorus exports from the forested watershed. In this study, we selected seven watersheds in Puerto Rico to examine the immediate and lagged effects of hurricanes on nitrogen and phosphorous exports. Our results suggest that immediate surges of heavy precipitation associated with hurricanes accelerate nitrogen and phosphorus exports as much as 297 ± 113 and 306 ± 70 times than the long-term average, respectively. In addition, we estimated that it requires approximately one year for post-hurricane riverine nitrogen and phosphorus concentrations to recover to pre-hurricane levels. During the recovery period, the riverine nitrogen and phosphorus concentrations are 30 ± 6% and 28 ± 5% higher than the pre-hurricane concentrations on average

Basal Cell Carcinoma of the Head and Neck Region in Ethnic Chinese

Objectives. This study aims to report our experience in the management of HNBCC in ethnic Chinese over a 10-year period. Methods. A retrospective review of all ethnic Chinese patients with HNBCC treated in a tertiary centre from 1999 to 2009. Results. From 1999 to 2009, 225 patients underwent surgical excision for HNBCC. Majority were elderly female patients. Commonest presentation was a pigmented (76.2%) ulcer (64.8%) over the nose (31.6%). Median skin margin taken on tumour excision was 2.0 mm; primary skin closure was achieved in 51.8%. Postresection skin margin was clear in 75.4%. Of those with inadequate skin margins, 56.7% opted for further treatment, 43.4% for observation. Recurrence rates were 2.6% and 13.8%, respectively (P = 0.106). Overall recurrence rate was 5.5%. Conclusions. HNBCC commonly presented as pigmented ulcers over the nose of elderly female patients in our locality. Adequate tumour excision ± reconstruction offered the best chance of cure. Reexcision of those with inadequate skin margins improved local tumour control

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development.

Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV), mostly using murine CMV (MCMV) as the model system for preclinical animal tests. The recent publication (Yu et al., 2017, DOI: 10.1126/science.aam6892) of an atomic model for HCMV capsid with associated tegument protein pp150 has infused impetus for rational design of novel vaccines and drugs, but the absence of high-resolution structural data on MCMV remains a significant knowledge gap in such development efforts. Here, by cryoEM with sub-particle reconstruction method, we have obtained the first atomic structure of MCMV capsid with associated pp150. Surprisingly, the capsid-binding patterns of pp150 differ between HCMV and MCMV despite their highly similar capsid structures. In MCMV, pp150 is absent on triplex Tc and exists as a "Λ"-shaped dimer on other triplexes, leading to only 260 groups of two pp150 subunits per capsid in contrast to 320 groups of three pp150 subunits each in a "Δ"-shaped fortifying configuration. Many more amino acids contribute to pp150-pp150 interactions in MCMV than in HCMV, making MCMV pp150 dimer inflexible thus incompatible to instigate triplex Tc-binding as observed in HCMV. While pp150 is essential in HCMV, our pp150-deletion mutant of MCMV remained viable though with attenuated infectivity and exhibiting defects in retaining viral genome. These results thus invalidate targeting pp150, but lend support to targeting capsid proteins, when using MCMV as a model for HCMV pathogenesis and therapeutic studies

Broadband enhanced transmission through the stacked metallic multi-layers perforated with coaxial annular apertures

This paper theoretically and experimentally presents a first report on broadband enhanced transmission through stacked metallic multi-layers perforated with coaxial annular apertures (CAAs). Different from previous studies on extraordinary transmission that occurs at a single frequency, the enhanced transmission of our system with two or three metallic layers can span a wide frequency range with a bandwidth about 60% of the central frequency. The phenomena arise from the excitation and hybridization of guided resonance modes in CAAs among different layers. Measured transmission spectra are in good agreement with calculations semi-analytically resolved by modal expansion method.Comment: 9 pages,4 figure