43,631 research outputs found

    AN ANKLE SPRAIN RECOGNITION SYSTEM FOR IDENTIFYING ANKLE SPRAIN MOTION FROM OTHER NORMAL MOTION USING MOTION SENSOR

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    The purpose of this study was to develop an ankle sprain recognition system which identifies ankle sprain motions from other normal motions. Six healthy male subjects performed a total of 600 simulated ankle sprain motions and normal sports motions. Eight motion sensors were attached to cover the whole foot segment to monitor the linear velocity and angular accelerations of the segment. The data obtained from the motion sensor at the medial calcaneus selected to train up the Support Vector Machine (SVM). The trained SVM model was then verified by another 600 trials from other six healthy male subjects. Among the 300 sprain trials, 291 (97.0%) of them were identified correctly. However, there was still a 14.3% false alarm which normal trials being identified as sprain trails. In general, a good accuracy of 91.3% was achieved

    Iterative solution of perturbation equations

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    Iterative solution of perturbation equation

    The role of extracellular matrix in planarian regeneration

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    Poster Presentation - Theme 3: Development & stem cellsAs an important niche component, the role of extracellular matrix (ECM) in stem cell biology is well recognized, however, its role in tissue regeneration is not well understood. Planarians are able to regenerate any missing parts of the organism and this feat is thought to be contributing by its large population of stem cells, which are distributed throughout the inner mesenchymal region. Here we use planarian as the model system to study the dynamic protein expression changes during tissue regeneration in order to gain insights into the role of ECM in ...postprin

    Roles of progenitor cells for intervertebral disc regeneration in "healer" mice

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    Student Oral Presentation Session 1INTRODUCTION: Intervertebral disc (IVD) degeneration is a major cause of back pain that can also lead to sciatica, affecting the quality of life. Current treatments are limited to salvage surgical operations. Biological treatments to relieve symptoms or to restore disc are not available as we know little about the biology of IVD degeneration and its potential to regeneration. While most people will develop disc degeneration with aging, there are individuals who are protected even at the age (older than 50 years) when over 90% of the population would succumb to the problem, suggesting the presence of protective genes. Furthermore, maintenance of progenitor cells within the nucleus pulposus (NP) is thought …postprin

    Topological Bose-Mott Insulators in a One-Dimensional Optical Superlattice

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    We study topological properties of the Bose-Hubbard model with repulsive interactions in a one-dimensional optical superlattice. We find that the Mott insulator states of the single-component (two-component) Bose-Hubbard model under fractional fillings are topological insulators characterized by a nonzero charge (or spin) Chern number with nontrivial edge states. For ultracold atomic experiments, we show that the topological Chern number can be detected through measuring the density profiles of the bosonic atoms in a harmonic trap.Comment: 5 pages, published versio

    Structural basis for recruitment of mitochondrial fission complexes by Fis1

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    Mitochondrial fission controls mitochondrial shape and physiology, including mitochondrial remodeling in apoptosis. During assembly of the yeast mitochondrial fission complex, the outer membrane protein Fis1 recruits the dynamin-related GTPase Dnm1 to mitochondria. Fis1 contains a tetratricopeptide repeat (TPR) domain and interacts with Dnm1 via the molecular adaptors Mdv1 and Caf4. By using crystallographic analysis of adaptor-Fis1 complexes, we show that these adaptors use two helices to bind to both the concave and convex surfaces of the Fis1 TPR domain. Fis1 therefore contains two interaction interfaces, a binding mode that, to our knowledge, has not been observed previously for TPR domains. Genetic and biochemical studies indicate that both binding interfaces are important for binding of Mdv1 and Caf4 to Fis1 and for mitochondrial fission activity in vivo. Our results reveal how Fis1 recruits the mitochondrial fission complex and will facilitate efforts to manipulate mitochondrial fission
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