Towards a Flexible Deep Learning Method for Automatic Detection of Clinically Relevant Multi-Modal Events in the Polysomnogram

Much attention has been given to automatic sleep staging algorithms in past years, but the detection of discrete events in sleep studies is also crucial for precise characterization of sleep patterns and possible diagnosis of sleep disorders. We propose here a deep learning model for automatic detection and annotation of arousals and leg movements. Both of these are commonly seen during normal sleep, while an excessive amount of either is linked to disrupted sleep patterns, excessive daytime sleepiness impacting quality of life, and various sleep disorders. Our model was trained on 1,485 subjects and tested on 1,000 separate recordings of sleep. We tested two different experimental setups and found optimal arousal detection was attained by including a recurrent neural network module in our default model with a dynamic default event window (F1 = 0.75), while optimal leg movement detection was attained using a static event window (F1 = 0.65). Our work show promise while still allowing for improvements. Specifically, future research will explore the proposed model as a general-purpose sleep analysis model.Comment: Accepted for publication in 41st International Engineering in Medicine and Biology Conference (EMBC), July 23-27, 201

Managing Resources by Grazing in Grasslands Dominated by Dominant Shrub Species

The European natural grasslands are attracting new attention because of their environmental value as habitats for threatened fauna and flora species and their contribution to the diversity of landscapes. Those responsible for the implementation of the European agri-environmental policy are hence encouraging livestock farmers to adopt grazing practices that contribute to the conservation of grassland biodiversity especially by limiting encroachment by dominant shrubs. However, current scientific knowledge and technical information are often insufficient to connect flock feeding and the impact of grazing on shrub dynamics and livestock farmers are not very enthusiastic about restoring or conserving “plant mosaics” including shrubs that support biodiversity in their fields. This paper presents results of an interdisciplinary study on interactions between small ruminant feeding strategy and population dynamics of dominant shrub species with the objective of managing by grazing the structure of plant community and thus to provide the renewal of resources on a multi-year scale

Development of a semi-automated image-based high-throughput drug screening system.

We previously reported that the innate sensing of the endosymbiont <i>Leishmania</i> RNA virus 1 (LRV1) within <i>Leishmania (Viannia) guyanensis</i> through Toll-like receptor 3, worsens the pathogenesis of parasite infection in mice. The presence of LRV1 has been associated with the failure of first-line treatment in patients infected with LRV1 containing - <i>L. guyanensis</i> and - <i>L. braziliensis</i> parasites. Here, we established a semi-automated image-based high-throughput drug screening (HTDS) protocol to measure parasiticidal activity of the Prestwick chemical library in primary murine macrophages infected with LRV1-containing <i>L. guyanensis</i> . The two-independent screens generated 14 hit compounds with over sixty-nine percent reduction in parasite growth compared to control, at a single dose in both screens. Our screening strategy offers great potential in the search for new drugs and accelerates the discovery rate in the field of drug repurposing against <i>Leishmania</i> . Moreover, this technique allows the concomitant assessment of the effect of drug toxicity on host cell number

New electronic orderings observed in cobaltates under the influence of misfit periodicities

We study with ARPES the electronic structure of CoO2 slabs, stacked with rock-salt (RS) layers exhibiting a different (misfit) periodicity. Fermi Surfaces (FS) in phases with different doping and/or periodicities reveal the influence of the RS potential on the electronic structure. We show that these RS potentials are well ordered, even in incommensurate phases, where STM images reveal broad stripes with width as large as 80\AA. The anomalous evolution of the FS area at low dopings is consistent with the localization of a fraction of the electrons. We propose that this is a new form of electronic ordering, induced by the potential of the stacked layers (RS or Na in NaxCoO2) when the FS becomes smaller than the Brillouin Zone of the stacked structure

High-resolution microwave frequency dissemination on an 86-km urban optical link

We report the first demonstration of a long-distance ultra stable frequency dissemination in the microwave range. A 9.15 GHz signal is transferred through a 86-km urban optical link with a fractional frequency stability of 1.3x10-15 at 1 s integration time and below 10-18 at one day. The optical link phase noise compensation is performed with a round-trip method. To achieve such a result we implement light polarisation scrambling and dispersion compensation. This link outperforms all the previous radiofrequency links and compares well with recently demonstrated full optical links.Comment: 11 pages, 5 figure

TEMPERATURE AND LEVEL DENSITY PARAMETER OF EVAPORATION RESIDUES PRODUCED IN THE REACTION 165Ho + 600 MeV 20Ne

Evaporative and preequilibrium neutrons emitted from evaporation residues in the reaction Ho + 600 MeV neon are exploited to deduce the thermal excitation energy E* and temperature T of the residues. From these quantities the level density parameter is deduced at a temperature of 4.1 MeV

First observation of feshbach resonances at very low magnetic field in a 133Cs fountain.

7 pagesOne of the main limitations of cesium atomic fountains has been the cold collision frequency shift. By using a method based on a transfer of population by adiabatic passage allowing to prepare cold atomic samples with a well defined ratio of atomic density as well as atom number the collisional shift is controlled at the 10E-3 of its value. A calibration of Zeeman sub-states contribution to the clock shift as a function of the field has been performed. Feshbach resonances have been observed for the first time at very low magnetic field and with a very good resolution. A Monte Carlo simulation has been performed and could fit properly some of experimental data. This constrains some parameters of the theory of collisions