Outsourcing selective maintenance problem in failure prone multi-component systems

In many industrial settings, there are systems designed to perform consecutive missions interspersed with finite breaks during which only a set of component repairs can be carried out due to limited time, budget, or resources. The decision maker then has to decide which components to repair in order to guarantee a given performance level. This is known as the selective maintenance problem (SMP). This paper introduces a new variant of the SMP by specifically taking into account the maintenance outsourcing alternative. A novel integrated non-linear programming formulation where both the in-house and outsourcing maintenance alternatives are accounted for is developed and optimally solved. The effect of the outsourcing alternative on maintenance decisions is investigated through numerical experiments. The overall results obtained demonstrate the validity of the proposed approach. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved

Diversité spécifique de la macrofaune benthique dans la côte ouest de la baie de Tunis et la côte de l'île de Djerba (sud-ouest de la Méditerranée)

In this study, 21 stations were sampled, 11 in the Djerba island coast and 10 in the western coast of Tunis bay. Then, samples were sifted on a square mesh of 1 mm a side, and the animals collected were identified and counted. Lacking an efficient single index suitable for application in all situations, several traditional nonparametric indices of biodiversity were selected, calculated and discussed. Results show that the community composition is totally different in the two studied sites, and, within each site, several species are common, butthey exchange the leader ranks from one station to another. For biodiversity measurement and since results show varying values depending on indices at several stations, an arithmetic mean index was calculated at each station on the basis of the most similar indices. It shows that, overall, the biodiversity is significantly higher in Tunis bay coast than in Djerba coast. These results are more reliable considering the real environmental /anthropogenic constraints imposed on both sites. Indeed, Djerba coast is subject, these last decades, to strong industrial, urban and fishing activities, causing significant regression of benthic habitats, which can led to a reduction of the biodiversity.Dans cette étude, 21 stations ont été échantillonnées, 11 dans la côte de l'île de Djerba et 10 dans la côte ouest de la baie de Tunis. Ensuite, les échantillons ont été tamisés sur une maille carrée de 1 mm de côté, et les animaux capturés ont été identifiés et comptés. Faute d'un indice unique efficace et adapté à toutes les situations, plusieurs indices traditionnels de biodiversité ont été choisis, calculés et discutés. Les résultats montrent que la composition de la communauté est totalement différente dans les deux sites étudiés, et, à chaque site, plusieurs espèces sont communes, mais ils se substituent aux places des leaders d'une station à l’autre. Pour la mesure de la biodiversité et étant donné la grande différence dans les valeurs enregistrées par les indices retenus, une moyenne arithmétique a été calculée à chaque station sur la base des indices les plus cohérents. Elle montre que, globalement, la biodiversité est nettement plus élevée dans la baie de Tunis par rapport à la côte de Djerba. Ces résultats semblent être plus fiables tenant en compte les contraintes réelles environnementales et anthropiques imposées aux deux sites. En effet, la côte de Djerba est l'objet, ces dernières décennies, à de fortes activités urbaines et de pêche industrielle, entraînant une régression significative des habitats benthiques, ce qui peut conduire à la réduction de la biodiversité

A Neutron Elastic Diffuse Scattering Study of PMN

We have performed elastic diffuse neutron scattering studies on the relaxor Pb(Mg$_{1/3}$Nb$_{2/3}$)O$_3$ (PMN). The measured intensity distribution near a (100) Bragg peak in the (hk0) scattering plane assumes the shape of a butterfly with extended intensity in the (110) and (1$\bar{1}$0) directions. The temperature dependence of the diffuse scattering shows that both the size of the polar nanoregions (PNR) and the integrated diffuse intensity increase with cooling even for temperatures below the Curie temperature $T_C \sim 213$ K.Comment: Submitted to PR

Exploring the Pharmacological Potential of the Chemically Characterized Essential Oil from Clinopodium nepeta subsp. ascendens: A Combined In Vitro and In Silico Analysis

This thorough examination explores the various biological characteristics present in the essential oil derived from Clinopodium nepeta subsp. ascendens (CNEO), a subspecies previously unrecognized and indigenous to the eastern part of Morocco. This subspecies is distinguished from C. nepeta by the distinctive feature of having purple or pale pinkish-white flowers. The study initiates with a thorough scrutiny of the phytochemical composition of CNEO via gas chromatography-mass spectrometry (GC-MS), revealing a nuanced spectrum of 24 terpene compounds. Among these, noteworthy constituents such as linalyl acetate (23.28%), Trifluoroacetyl-α-terpineol (13.66%), camphor (13.28%), and menthol (9.22%) are identified. These compounds, acknowledged for their notable biological and pharmacological attributes, serve as focal points for subsequent analyses. Beyond compositional elucidation, the study systematically investigates the diverse biological activities of CNEO. The essential oil exhibits substantial antioxidant potential, as substantiated by robust total antioxidant capacity (TAC) of 315.07 μg AA/mg and effective inhibition of DPPH free radicals (IC50 = 112.97 ± 2.67 µg/ml). Demonstrating promising antibacterial efficacy against various strains, occasionally surpassing gentamicin, positions CNEO as a potential antibacterial agent. Equally notable antifungal efficacy, surpassing that of cycloheximide, with low minimum inhibitory concentrations (MIC) is obtained, underscoring its potent antifungal properties. The antidiabetic potential of CNEO manifests through significant inhibition of xanthine oxidase (IC50 = 30.82 ± 0.78 µg/ml), α-amylase (IC50 = 40.13 ± 1.60 µg/ml), and α-glucosidase (IC50 = 45.30 ± 0.69 µg/ml) activities, suggesting therapeutic prospects in glycemic regulation. Furthermore, the essential oil showcases compelling anti-tyrosinase activity (IC50 = 29.78 ± 1.01 µg/ml), indicating potential dermatoprotective applications in melanin regulation. The implications of these findings provide a robust foundation for future investigations, unraveling the full therapeutic potential of CNEO within medical, cosmetic, and industrial contexts

JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice

Oligodendrocytes are the primary target of demyelinating disorders, and progressive neurodegenerative changes may evolve in the CNS. DNA damage and oxidative stress are considered key pathogenic events, but the underlying molecular mechanisms remain unclear. Moreover, animal models do not fully recapitulate human diseases, complicating the path to effective treatments. Here we report that mice with cell-autonomous deletion of the nuclear COP9 signalosome component CSN5 (JAB1) in oligodendrocytes develop DNA damage and defective DNA repair in myelinating glial cells. Interestingly, oligodendrocytes lacking JAB1 expression underwent a senescence-like phenotype that fostered chronic inflammation and oxidative stress. These mutants developed progressive CNS demyelination, microglia inflammation, and neurodegeneration, with severe motor deficits and premature death. Notably, blocking microglia inflammation did not prevent neurodegeneration, whereas the deletion of p21CIP1 but not p16INK4a pathway ameliorated the disease. We suggest that senescence is key to sustaining neurodegeneration in demyelinating disorders and may be considered a potential therapeutic target

A multi-sensor network for the protection of cultural heritage

The paper presents a novel automatic early warning system to remotely monitor areas of archaeological and cultural interest from the risk of fire. Since these areas have been treasured and tended for very long periods of time, they are usually surrounded by old and valuable vegetation or situated close to forest regions, which exposes them to an increased risk of fire. The proposed system takes advantage of recent advances in multi-sensor surveillance technologies, using optical and infrared cameras, wireless sensor networks capable of monitoring different modalities (e.g. temperature and humidity) as well as local weather stations on the deployment site. The signals collected from these sensors are transmitted to a monitoring centre, which employs intelligent computer vision and pattern recognition algorithms as well as data fusion techniques to automatically analyze sensor information. The system is capable of generating automatic warning signals for local authorities whenever a dangerous situation arises, as well as estimating the propagation of the fire based on the fuel model of the area and other important parameters such as wind speed, slope, and aspect of the ground surface. © 2011 EURASIP