A light microscopic study: Conjunctiva-associated lymphoid tissue in camel

Konjunktiva ile iliĢkili lenfoid doku (CALT), gözün en önemli aksesuar bileĢenlerinden biridir. Bu çalıĢma, sağlıklı develerde konjunktiva ile iliĢkili lenfoid dokunun histolojik dağılımını ve karakteristik özelliklerini ıĢık mikroskobu tekniğiyle ortaya koymak amacıyla yapıldı. ÇalıĢmada toplam 5 adet (13-19 yaĢ aralığında) deveye ait alt ve üst göz kapağı kullanıldı. CALT’a ait genel makroskobik görünüm asetik asit uygulamasıyla ortaya konuldu. Tüm develerde CALT’ın en önemli elemanları olan ve soliter ve agregat lenf foliküllerinin varlığı tespit edildi. Foliküllerin üzerlerinin folikülle iliĢkili epitel (FAE) olarak bilinen ve intra epiteliyal lenfositleri barındıran, kadeh hücrelerinin görülmediği ince, yassılaĢmıĢ epitel ile örtülü olduğu görüldü. Buna ek olarak, lenf foliküllerinin germinal merkez, korona, dom bölgesi ve inter foliküler alanlardan meydana geldiği fark edildi. Ġnterfoliküler alanlarda CALT en önemli karakteristik özelliklerinden bir olan, yüksek endotelli venüllerin varlığı ortaya konuldu. Sonuç olarak, deve CALT’ının sahip olduğu belirleyici özellikleriyle diğer mukozal lenfoid dokularla oldukça yüksek benzelikler göterdiği ve oküler savunma mekanizması içerisinde önemli bir rol oynadığı kanısına varıldı.Conjunctiva-associated lymphoid tissue (CALT) is one of the most important accessory component of the eye. This study was undertaken to demostrate the histological distribution and characteristic features of CALT in healhty camels using light microscopy technique. A total upper and lower eyelids of 5 (age range, 13-19) camels were investigated. The gross appearance of CALT were revealed by acetic acid application. Fully intact solitary and aggregated lymphoid follicles were observed as members of CALT in all camels. These follicles were covered by a thin, flattened epitehelium called follicular-associated epithelium (FAE) that contained intra epithelial lymphocytes and lacked goblet cells. In addition germinal centers, corona, subepithelial dome region and interfolliculer areas were noticed within the lymphoid follicles. The presence of high endothelial venules (HEV), a highly distinctive feature of CALT, was confirmed in interfollicular areas. We conclude that CALT of camel closely resembles other mucosal lymphoid tissues and may serve as an important member of ocular defense mechanism with its determinative features

The occupational perceptions of the associate degree tourism students to the sector: Pamukkale University case

Turizm, günümüzün en önemli meslek alanlarından biri olmasına rağmen, turizm eğitimi alan öğrencilerin bu mesleğe yönelik algıları farklılık göstermektedir. Turizm faaliyetleri, ülkelere kazandırdığı gelir ve istihdama sağladığı katkı açısından değerlendirildiğinde, en yüksek derecede geliri elde etmek ve müşteri memnuniyetini sağlamak açısından kalifiye eleman yetiştirmek ve bu eğitimli işgücünü turizm sektörüne kazandırmak şarttır. Literatür incelendiğinde, turizm eğitimi alan öğrencilerin turizme yö-nelik meslek algısı konusunda birçok çalışmaya rastlanmaktadır. Öğrenim hayatı sonunda, turizm sek-töründe çalışmayı hedefleyen üniversite öğrencilerinin, mesleklerinin onlara sunduğu çalışma koşullarını, kendilerini geliştirme imkânlarını, kariyer olanaklarını nasıl algıladıkları ve sektörü nasıl gördük-leri ve bu mesleğin bir parçası olmak açısından önemlidir. Bu çalışmada turizm eğitimi alan önlisans öğrencilerinin demografik verilerine göre, turizm sektörüne yönelik algılarında farklılık olup olmadığı araştırılmıştır. Bu amaç doğrultusunda, Pamukkale Üniversitesi Denizli Sosyal Bilimler Meslek Yük-sekokulunda turizm eğitimi alan önlisans öğrencilerine yönelik bir anket uygulaması gerçekleştirilmiş-tir. Çalışma sonucunda öğrencilerin demografik özellikleri ile mesleğe yönelik algıları arasında farklılıklar tespit edilmiştir

On Rectifying Dual Space Curves

We give some characterizations of the rectifying curves in the dual space and show that rectifying dual space curves can be stated with the aid of dual unit spherical curves. Thus, we have a link between rectifying dual space curves and classical surfaces in the Euclidean three-space

The effect of time of day on Special Judo Fitness Test in active judokas: Evaluation in terms of chronotype

© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The present cross-sectional study aims to examine the effect of time of day on the judo-specific performance in judokas, considering their chronotypes. Twenty-four male judokas participated in the study where the Morningness-Eveningness Questionnaire was administered, and on it, they were divided into morning-type (MT:12-judokas) and evening-type groups (ET:12-judokas). Afterwards, the Special Judo Fitness Test (SJFT) was applied to both groups at three different times (morning: 09:00 h, afternoon: 13:00 h and evening: 17:00 h) with body temperature measured before and after every SJFT performance. As a result, the Group*Test Time interaction significantly affected overall throwing performance during SJFT [F(2,44) = 29.437, p = 0.001, η2p: .572]. Furthermore, a significant time effect was found for the SJFT index [F(2,44) = 5.118, p = 0.010, η2p: .189] and for the Group*Test Time interaction with the mean value of the index [F(2,44) = 24.424, p < 0.001, η2p: .526]. Furthermore, body temperature had a significant time effect [F(2,44) = 301.454, p < 0.001, η2p: .932] and the Group*Test Time interaction [F(2,44) = 5.802, p = 0.006, η2p: .209]. In conclusion, coaches and exercise experts should consider judo athletes’ chronotype when planning special training programs to improve judo-specific anaerobic capacity. Furthermore, to minimize the impact of time of day and chronotype on athletes’ performance in competitions, it is recommended that MT athletes develop their judo-specific anaerobic capacity in the evening hours, when their performance is lower, while ET athletes should do so in the morning hours when their performance is lower via randori training.Peer reviewe

MyProfessors: Mining Turkish Student Reviews

We introduce Hocalarim (MyProfessors), the largest student review dataset available for the Turkish language. It consists of over 5000 professor reviews left online by students, with different aspects of education rated on a scale of 1 to 5 stars. We investigate the properties of the dataset and present its statistics. We examine the impact of students' institution type on their ratings and the correlation of students' bias to give positive or negative feedback

Autism and Metabolic Cytopathy

Letter to the editor: Autism is a wide spectrum disorder and a lot of factors play role in the etiology. Autism may accompany some genetic disorders such as fragile X, tuberosclerosis, neurofibromatosis and phenylketonuria [1]. However, the absence of sufficient evidence on the etiological roles of environmental, neuroanatomical and biochemical factors has shifted the direction of research to genetics and cytology [2]

Antibacterial and antioxidant activities of traditional medicinal plants from the Erzurum region of Turkey

Background In this study, 13 different extracts were investigated which are grown in the region of Erzurum. Objective The aim of this study was to screen various plant extracts that are known and used for medicinal purposes such as Ferula communis L., Rumex patientia L., Gundelia tournefortii L., Rheum ribes L., Asphodeline taurica, Polygonum arenastrum, Allium schoenoprasum L., and Ferula orientalis L. Materials and methods Medicinal parts of plants such as leaves, flowers, and stems were investigated by 2,2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and cupric reducing antioxidant capacity assays: Centaury and Blackthorn. Total phenolic content, total flavonoid content, and antimicrobial properties were also determined. Antibacterial and antifungal activities were investigated by the microdilution method and the agar diffusion method respectively. Results Accordingly, the results of the Rheum ribes L. plant have the highest antioxidant activity among all analyses made. But in almost all antioxidant analysis methods, the lowest antioxidant activity was found in Ferula orientalis L. According to the antibacterial analysis applied, it was found that the plant extracts were generally more effective on yeast strains than the test bacteria used; that is, most of the plants have antifungal effect. Conclusions Due to their antimicrobial, antifungal, and antioxidant properties, the extracts of these plants might be used as natural sources in the pharmaceutical and cosmetic industries

CLIP-Guided StyleGAN Inversion for Text-Driven Real Image Editing

Researchers have recently begun exploring the use of StyleGAN-based models for real image editing. One particularly interesting application is using natural language descriptions to guide the editing process. Existing approaches for editing images using language either resort to instance-level latent code optimization or map predefined text prompts to some editing directions in the latent space. However, these approaches have inherent limitations. The former is not very efficient, while the latter often struggles to effectively handle multi-attribute changes. To address these weaknesses, we present CLIPInverter, a new text-driven image editing approach that is able to efficiently and reliably perform multi-attribute changes. The core of our method is the use of novel, lightweight text-conditioned adapter layers integrated into pretrained GAN-inversion networks. We demonstrate that by conditioning the initial inversion step on the CLIP embedding of the target description, we are able to obtain more successful edit directions. Additionally, we use a CLIP-guided refinement step to make corrections in the resulting residual latent codes, which further improves the alignment with the text prompt. Our method outperforms competing approaches in terms of manipulation accuracy and photo-realism on various domains including human faces, cats, and birds, as shown by our qualitative and quantitative results.Comment: Accepted for publication in ACM Transactions on Graphic

A rare neurodegenerative disorder with a novel mutation in ROGDI and Rett- like phenotype: Kohlschutter- Tönz syndrome

Kohlschutter-Tonz syndrome (KTZS) is a rare neurodegenerative disorder that presents with seizures, developmental delay, psychomotor regression, hypoplastic dental enamel morphology characteristic for amelogenesis imperfecta, and dysmorphologies. Genetic analysis has identified loss of function mutations within the coding region of the ROGDI and SLC13A5 genes in KTZS. In this report, we documented the clinical, radiological, electroencephalographic, and genetic results of a 3.5-year-old Turkish girl, born to nonconsanguineous parents, who was the first patient diagnosed with KTZS in Turkey. The patient presented with Rett syndrome-like phenotype, neurodevelopmental delay, refractory seizures, and amelogenesis imperfecta. After obtaining informed consent, chromosomal DNA was extracted from the peripheral blood of our patient and her parents. To investigate the molecular diagnosis of the patient, the clinical exome sequencing was performed. The Sanger sequencing analysis was performed for all of the family members for the validation and segregation of this mutation. Pub Med/Medline, Web of Science, and Google Scholar were also searched to find all of the published data on KTZS. The literature comprises 18 published studies about KTZS. The genetic analysis of our patient revealed a novel homozygous c.201-1G>T mutation in the ROGDI gene. The same mutation was also found to be heterozygous in her mother and father. The mutation caused alternative splicing of the ROGDI translation and resulted in a disruption of the ROGDI protein

Radioguided occult lesion localization versus wire-guided localization for non-palpable breast lesions: randomized controlled trial

AIM: This prospective randomized clinical study was conducted to compare radioguided occult lesion localization (ROLL) with wire-guided localization to evaluate optimum localization techniques for non-palpable breast lesions. METHODS: A total of 108 patients who were undergoing an excisional biopsy for non-palpable breast lesions requiring pathologic diagnosis were randomly assigned to the ROLL group (n = 56) and wire-guided localization group (n = 52). In the study, patients' characteristics, radiological abnormalities, radiological technique of localization, localization time, operation time, weight of the excised specimen, clearance margins, pathological diagnosis and perioperative complications were assessed. RESULTS: There were no differences between the two groups in terms of age, radiological abnormalities and localization technique (p = non-significant for all). ROLL techniques resulted in 100% retrieval of the lesions; for the wire-guided localization technique, 98%. Both localization time and operation time were significantly reduced with the ROLL technique (p = significant for all). The weight of the specimen was significantly lower in the ROLL group than in the wire-guided localization group (p = significant). The overall complication rate and pathological diagnosis were similar for both groups (p = non-significant for all). Clear margins were achieved in 91% of ROLL patients and in 53% of wire-guided localization patients, and the difference was significant. CONCLUSIONS: The present study indicated that the ROLL technique is as effective as wire-guided localization for the excision of non-palpable breast lesions. In addition, ROLL improved the outcomes by reducing localization and operation time, preventing healthy tissue excision and achieving clearer margins