On Braids, Branched Covers and Transverse Invariants

In this work, we present a brief survey of knot theory supported by contact 3-manifolds. We focus on transverse knots and explore different ways of studying transverse knots. We define a new family of transverse invariants, this is accomplished by considering $n$-fold cyclic branched covers branched along a transverse knot and we then extend the definition of the BRAID invariant $t$ defined in cite{BVV} to the lift of the transverse knot. We call the new invariant the lift of the BRAID invariant and denote it by $t_n$. We then go on to show that $t_n$ satisfies a comultiplication formula and use this result to prove a vanishing theorem for $t_n$. We also re-prove a previously known result regarding the $n$-fold branched covers branched along stabilized transverse knot. We use this result to prove another vanishing result for $t_n$

Augmented Biracks and their Homology

We introduce augmented biracks and define a (co)homology theory associated to augmented biracks. The new homology theory extends the previously studied Yang-Baxter homology with a combinatorial formulation for the boundary map and specializes to $N$-reduced rack homology when the birack is a rack. We introduce augmented birack 2-cocycle invariants of classical and virtual knots and links and provide examples.Comment: 16 page

RNA foldings, Oriented Stuck Knots and State Sum Invariants

We extend the quandle cocycle invariant to the context of stuck links. More precisely, we define an invariant of stuck links by assigning Boltzmann weights at both classical and stuck crossings. As an application, we define a single-variable and a two-variable polynomial invariant of stuck links. Furthermore, we define a single-variable and two-variable polynomial invariant of arc diagrams of RNA foldings. We provide explicit computations of the new invariants

Alpine forbs rely on different photoprotective strategies during spring snowmelt

Snowmelt in alpine ecosystems brings ample water, and together with above-freezing temperatures, initiates plant growth. In this scenario, rapid activation of photosynthesis is essential for a successful life-history strategy. But, strong solar radiation in late spring enhances the risk of photodamage, particularly before photosynthesis is fully functional. We compared the photoprotective strategy of five alpine forbs: one geophyte not particularly specialised in subnival life (Crocus albiflorus) and four wintergreens differing in their degree of adaptation to subnival life, from least to most specialised: Gentiana acaulis, Geum montanum, Homogyne alpina and Soldanella alpina. We used distance to the edge of snow patches as a proxy to study time-dependent changes after melting. We postulated that the photoprotective response of snowbed specialists would be stronger than of more-generalist alpine meadow species. F-v/F-m was relatively low across wintergreens and even lower in the geophyte C. albiflorus. This species also had the largest xanthophyll-cycle pool and lowest tocopherol and flavonoid glycoside contents. After snow melting, all the species progressively activated ETR, but particularly the intermediate snowbed species G. acaulis and G. montanum. The photoprotective responses after snowmelt were idiosyncratic: G. montanum rapidly accumulated xanthophyll-cycle pigments, tocopherol and flavonoid glycosides; while S. alpina showed the largest increase in plastochromanol-8 and chlorophyll contents and the greatest changes in optical properties. Climate warming scenarios might shift the snowmelt date and consequently alter the effectiveness of photoprotection mechanisms, potentially changing the fitness outcome of the different strategies adopted by alpine forbs.Peer reviewe

PSO-PARSIMONY: A method for finding parsimonious and accurate machine learning models with particle swarm optimization. Application for predicting force–displacement curves in T-stub steel connections

[EN]We present PSO-PARSIMONY, a new methodology to search for parsimonious and highly accurate models by means of particle swarm optimization. PSO-PARSIMONY uses automatic hyperparameter optimization and feature selection to search for accurate models with low complexity. To evaluate the new proposal, a comparative study with multilayer perceptron algorithm was performed with public datasets and by applying it to predict two important parameters of the force–displacement curve in T-stub steel connections: initial stiffness and maximum strength. Models optimized with PSO-PARSIMONY showed an excellent trade-off between goodness-of-fit and parsimony. The new proposal was compared with GA-PARSIMONY, our previously published methodology that uses genetic algorithms in the optimization process. The new method needed more iterations and obtained slightly more complex individuals, but it performed better in the search for accurate models

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe