Una experiencia de creación de publicidad con uso de contendidos matemáticos en educación secundaria

En esta ponencia damos a conocer los resultados de una experiencia pedagógica de aula con estudiantes del primer año de Educación Secundaria del Colegio Proyección Siglo XXI de Osorno. Esta experiencia se centra en el análisis estadístico elemental del Índice de Masa Corporal (IMC) de los estudiantes de este colegio y la creación de afiches publicitarios a partir de los resultados obtenidos, para ello se dividió al curso en grupos para analizar el peso y la talla de los estudiantes desde pre-kínder a cuarto medio, correspondiendo 3 o 4 cursos a cada grupo de trabajo. Como resultado de esta experiencia pudimos confirmar: la necesidad de trabajar con datos reales en clases de matemática; que el uso de proyectos favorece en el proceso de enseñanza y aprendizaje de la disciplina; y que la matemática se puede aplicar en diferentes situaciones de la vida diaria (por ejemplo, en la publicidad), permitiendo fortalecer habilidades no matemáticas

Aplicación de la estadística en temáticas de administración de empresas

El presente artículo da cuenta de una experiencia de aula desarrollada en el Instituto de Educación Continua de la Universidad de Los Lagos de Osorno – Chile con alumnos y alumnas del primer año de la carrera Técnico Universitario en Administración de Empresas, quienes en el módulo de Estadística desarrollaron investigaciones en sus lugares de trabajo sobre temas propios de su profesión. Los estudiantes formaron equipos de trabajo y eligieron problemáticas relacionadas a sus carreras, luego aplicaron cuestionarios para recolectar información, presentaron los datos recopilados en tablas y gráficos de los cuales obtuvieron estadígrafos que permitieron establecer conclusiones. Para la descripción y análisis de los resultados, cada equipo realizó un informe escrito sobre la investigación. Como resultado de la experiencia se logró que los estudiantes se introdujeran en una problemática propia de su área laboral, investigaran y recopilaran información sobre el tema y pudieran visualizar a la estadística como una disciplina potencialmente útil para su formación profesional y futura vida laboral

Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction

The induction of both long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission entails pre- and postsynaptic Ca2+ signals, which represent transient increments in cytoplasmic free Ca2+ concentration. In diverse synapse types, Ca2+ release from intracellular stores contributes to amplify the Ca2+ signals initially generated by activation of neuronal Ca2+ entry pathways. Here, we used hippocampal slices from young male rats to evaluate whether pharmacological activation or inhibition of Ca2+ release from the endoplasmic reticulum (ER) mediated by ryanodine receptor (RyR) channels modifies LTD induction at Schaffer collateral-CA1 synapses. Pre-incubation of slices with ryanodine (1 μM, 1 h) or caffeine (1 mM, 30 min) to promote RyR-mediated Ca2+ release facilitated LTD induction by low frequency stimulation (LFS), but did not affect the amplitude of synaptic transmission, the profiles of field excitatory postsynaptic potentials (fEPSP) or the paired-pulse (PP) responses. Conversely, treatment with inhibitory ryanodine (20 μM, 1 h) to suppress RyR-mediated Ca2+ release prevented LTD induction, but did not affect baseline synaptic transmission or PP responses. Previous literature reports indicate that LTD induction requires presynaptic CaMKII activity. We found that 1 h after applying the LTD induction protocol, slices displayed a significant increase in CaMKII phosphorylation relative to the levels exhibited by un-stimulated (naïve) slices. In addition, LTD induction (1 h) enhanced the phosphorylation of the presynaptic protein Synapsin I at a CaMKII-dependent phosphorylation site, indicating that LTD induction stimulates presynaptic CaMKII activity. Pre-incubation of slices with 20 μM ryanodine abolished the increased CaMKII and Synapsin I phosphorylation induced by LTD, whereas naïve slices pre-incubated with inhibitory ryanodine displayed similar CaMKII and Synapsin I phosphorylation levels as naïve control slices. We posit that inhibitory ryanodine suppressed LTD-induced presynaptic CaMKII activity, as evidenced by the suppression of Synapsin I phosphorylation induced by LTD. Accordingly, we propose that presynaptic RyR-mediated Ca2+ signals contribute to LTD induction at Schaffer collateral-CA1 synapses

Nivel de felicidad en un grupo de adultos mayores de montería, pertenecientes a un programa de danza.

Objective. Describe the level of  happiness  of  a  group  of older adults belonging to the project of solidarity extension of the University of Cordoba “Dancing for my health”. Materials and method. Research of a quantitative nature, the sample consisted of 36 longevity selected for convenience to whom the General Happiness Scale was applied. Results. The predominant gender was female with 91%, the age range ranged from 60-90 years, after   a year of belonging to the program all without exception to a greater or lesser degree expressed  to  feel happy, the highest levels occurred in females, Nevertheless, in contrasting happiness level with having and being, this trend changes 86% showed low levels of happiness, stating that if they had less economic concerns they  could be happier. Conclusions. The high perception of happiness evidenced could be related to the fact that the older adults performed for a prolonged period and in a stable physical activity (dance) and participated actively in a program of solidarity extension with educational, welfare and recreational interventions in which Had the opportunity to share frequently with their counterparts, corroborating once again  the  importance  of  dance  as  a main strategy and integrating axis, a fundamental element to increase the socializing capacity, welfare, self care, health and happiness in the elderly; Therefore, it is necessary to reorient and optimize the Public Policies for the health and well-being of the longevity, expanding their opportunities of inclusion to integral health programs.Objetivo. Describir el nivel de felicidad de un grupo de adultos mayores perteneciente al proyecto de extensión solidaria  de  la  Universidad  de   Córdoba   “Bailando   por mi salud”. Materiales y métodos. Investigación de naturaleza cuantitativa, la muestra la constituyeron 36 longevos seleccionados por conveniencia a quienes se les aplicó la Escala General de la Felicidad. Resultados. El sexo predominante fue femenino con 91%, el rango de edad osciló entre 60 - 90 años, después de un año de pertenecer al programa todos sin excepción en mayor o menor grado expresaron sentirse felices, los niveles más altos se dieron en las mujeres, no obstante, al contrastar nivel de felicidad frente al tener y al ser, esta tendencia cambia en un 86% y alcanzó bajos niveles de felicidad, afirmando que si tuvieran menos preocupaciones económicas pudieran ser más felices. Conclusiones. La alta percepción de felicidad evidenciada, podría estar relacionada con el hecho de que los adultos mayores realizaron por un período prolongado y en forma estable actividad física (baile)  y  participaron  activamente  en  un programa de extensión solidaria con intervenciones educativas, asistenciales y recreativas en el cual tuvieron la oportunidad de compartir frecuentemente con sus homólogos, corroborando una vez más la importancia del baile como estrategia principal y eje integrador, elemento fundamental para aumentar la capacidad socializante, de bienestar, autocuidado, salud y felicidad en las personas mayores; por ello, es preciso reorientar y optimizar las Políticas Públicas en pro de la salud y bienestar de los longevos ampliando sus oportunidades de inclusión a programas integrales de salud

Estudio molecular de las proteínas p y t constituyentes del sistema de clivaje de la glicina en pacientes con diagnóstico presuntivo de hiperglicinemia no cetósica (hnc)

Analizar por medio de métodos moleculares el defecto enzimático en las proteínas P y T constituyentes del complejo enzimático del clivaje de la glicina. Establecer estrategias de biología molecular que permitan  identificar la mutación que afecta las proteínas P y T

Estudio molecular de las proteínas p y t constituyentes del sistema de clivaje de la glicina en pacientes con diagnóstico presuntivo de hiperglicinemia no cetósica (hnc)

Analizar por medio de métodos moleculares el defecto enzimático en las proteínas P y T constituyentes del complejo enzimático del clivaje de la glicina. Establecer estrategias de biología molecular que permitan  identificar la mutación que afecta las proteínas P y T

Detection of Neutralizing Antibodies against SARS-CoV-2 Post-Vaccination in Health Care Workers of a Large Tertiary Hospital in Spain by Using a Rapid Test LFIC and sVNT-ELISA

The presence of neutralizing antibodies (NAbs) against SARS-CoV-2 represent a surrogate marker of immunologic protection in populations at high risk of infection such as healthcare workers caring for hospitalized patients with COVID-19. As recommended by CDC and the European CDC, the use of rapid diagnostic tests during population-based evaluations offers an opportunity to identify individuals with serologic evidence of natural infection or who have undergone vaccination. We carried out a cross-sectional study to assess the presence of neutralizing antibodies against SARS-CoV-2 among medical providers at an intensive care unit of a large referral hospital in Alicante, Spain. In addition, we tested for the presence of neutralizing antibodies compared to serum of uninfected individuals from a Biobank. We were also interested in evaluating the use of a rapid lateral flow immunochromatography (LFIC) test against a surrogate ELISA viral neutralization test (sVNT). This rapid test demonstrated a specificity of 1.000 95% CI (0.91–1.00) and the sensitivity of 0.987 95% CI (0.93–1.00). The negative predictive value was 95%. After six months, this rapid test demonstrated that those immunized with two doses of BioNTech/Pfizer vaccine, maintained optimal levels of neutralizing antibodies. We concluded that all Health Care Workers develop NAbs and the use of this rapid immunochromatographic test represents a potential tool to be used in population-based studies to detect serological antibody responses to vaccination. Vaccination policies could benefit from this tool to assess additional doses of vaccine or boosters among high-risk populations.This work was supported by an advisory contract from the University of Alicante with reference WENZHOU-OJABIO1-21T and no one reports personal fees received from the biotech company

GW150914: First search for the electromagnetic counterpart of a gravitational-wave event by the TOROS collaboration

We present the results of the optical follow-up conducted by the TOROS collaboration of the first gravitational-wave event GW150914. We conducted unfiltered CCD observations (0.35-1 micron) with the 1.5-m telescope at Bosque Alegre starting ~2.5 days after the alarm. Given our limited field of view (~100 square arcmin), we targeted 14 nearby galaxies that were observable from the site and were located within the area of higher localization probability. We analyzed the observations using two independent implementations of difference-imaging algorithms, followed by a Random-Forest-based algorithm to discriminate between real and bogus transients. We did not find any bona fide transient event in the surveyed area down to a 5-sigma limiting magnitude of r=21.7 mag (AB). Our result is consistent with the LIGO detection of a binary black hole merger, for which no electromagnetic counterparts are expected, and with the expected rates of other astrophysical transients.Comment: ApJ Letters, in pres

Endocannabinoid regulation of amyloid-induced neuroinflammation

The modulation of endocannabinoid (EC) levels and the activation of cannabinoid receptors are seen as promising therapeutic strategies in a variety of diseases, including Alzheimer’s disease (AD). We aimed to evaluate the effect of the pharmacological and genetic inhibiton of anandamide (AEA)-degrading enzyme in a mouse model of AD (5xFAD). Pharmacological inhibition of the fatty acid amide hydrolase (FAAH) had little impact on the expression of key enzymes and cytokines as well as on the cognitive impairment and plaque deposition and gliosis in 5xFAD mice. CB1 blockade exacerbated inflammation in this transgenic mouse model of AD. The genetic inactivation of FAAH led to increases in the expression of inflammatory cytokines. At the same time, FAAH-null 5xFAD mice exhibited a behavioral improvement in spatial memory that was independent of the level of anxiety and was not CB1-mediated. Finally, mice lacking FAAH showed diminished soluble amyloid levels, neuritic plaques and gliosis. These data reinforce the notion of a role for the endocannabinoid system in neuroinflammation and open new perspectives on the relevance of modulating endocannabinoid levels in the inflammed brain.pre-print687 K