680 research outputs found
The implicit equation of a canal surface
A canal surface is an envelope of a one parameter family of spheres. In this
paper we present an efficient algorithm for computing the implicit equation of
a canal surface generated by a rational family of spheres. By using Laguerre
and Lie geometries, we relate the equation of the canal surface to the equation
of a dual variety of a certain curve in 5-dimensional projective space. We
define the \mu-basis for arbitrary dimension and give a simple algorithm for
its computation. This is then applied to the dual variety, which allows us to
deduce the implicit equations of the the dual variety, the canal surface and
any offset to the canal surface.Comment: 26 pages, to be published in Journal of Symbolic Computatio
Central IT or Shadow IT? Factors Shaping Users’ Decision to Go Rogue With IT
Shadow IT occurs when users develop systems outside of the central information technology department. It provides both benefits and risks- users procuring Shadow IT often do not consider integration with existing enterprise architecture, privacy and security protection, maintenance cost, and legal ramifications. Problems with shadow IT must often be resolved by central IT. It is, thus, important for central IT to determine when users will consider shadow IT, and how shadow IT can be managed. This research performs paired interviews with CIOs and senior users to identify factors causing Shadow IT. Two main arguments are advanced. First, the form the shadow IT/central IT duality takes is based on: (a) an alignment/non-alignment between the organization, central IT, and user function; and (b) the ability of user departments to procure IT independently. Second, top management support is not necessary for successful IT implementation, especially given the presence of enterprise shadow IT systems
Distance Geometry for Kissing Spheres
A kissing sphere is a sphere that is tangent to a fixed reference ball. We
develop in this paper a distance geometry for kissing spheres, which turns out
to be a generalization of the classical Euclidean distance geometry.Comment: 11 pages, 2 picture
CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells
Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1, a transmembrane protein with shared structural features to connexins and pannexins, has been implicated in ATP release from taste buds, but it has not been evaluated for a functional role in the airway. In the present study, Calhm1 knockout, Panx1 knockout, and wild-type mouse nasal septal epithelial cells were grown at an air-liquid interface (ALI) and subjected to light mechanical stimulation from an air puff. Apical ATP release was attenuated in Calhm1 knockout cultures following mechanical stimulation at a pressure of 55 mmHg for 50 milliseconds (p \u3c 0.05). Addition of carbenoxolone, a PANX1 channel blocker, completely abolished ATP release in Calhm1 knockout cultures but not in wild type or Panx1 knockout cultures. An increase in CBF was observed in wild-type ALIs following mechanical stimulation, and this increase was significantly lower (p \u3c 0.01) in Calhm1 knockout cultures. These results demonstrate that CALHM1 plays a newly defined role, complementary to PANX1, in ATP release and downstream CBF modulation following a mechanical stimulus in airway epithelial cells. © 2017 The Author(s)
Pre- and postnatal exposure to secondhand tobacco smoke and body composition at 12 years: periods of susceptibility
Objective: The study aimed to identify periods of heightened susceptibility to the effects of pre- and postnatal secondhand tobacco smoke (SHS) exposure on body composition at age 12 years. Methods: The study used data from 217 children from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort in Cincinnati, Ohio. Using multiple informant models, the study estimated associations of maternal serum cotinine (16 and 26 weeks of pregnancy) and child serum cotinine concentrations (at age 12, 24, 36, and 48 months) with measures of body composition obtained with anthropometry and dual-energy x-ray absorptiometry at 12 years. We examined whether there were differences between these associations for pre- and postnatal exposure periods and potential effect measure modification by sex.Results: Postnatal cotinine concentrations were associated with higher weight, BMI, body fat and lean mass, waist circumference, and visceral, android, and gynoid fat. Each 10-fold increase in postnatal cotinine was associated with 76% increased risk of overweight or obesity (95% CI: 1.13-2.75). Associations between prenatal concentrations and measures of body composition at 12 years were generally null.Conclusions: Postnatal exposure to SHS may increase adolescent adiposity and lean mass. Future studies should determine whether early-life exposures to SHS are associated with other cardiometabolic risk markers.Objective: The study aimed to identify periods of heightened susceptibility to the effects of pre- and postnatal secondhand tobacco smoke (SHS) exposure on body composition at age 12 years. Methods: The study used data from 217 children from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort in Cincinnati, Ohio. Using multiple informant models, the study estimated associations of maternal serum cotinine (16 and 26 weeks of pregnancy) and child serum cotinine concentrations (at age 12, 24, 36, and 48 months) with measures of body composition obtained with anthropometry and dual-energy x-ray absorptiometry at 12 years. We examined whether there were differences between these associations for pre- and postnatal exposure periods and potential effect measure modification by sex.Results: Postnatal cotinine concentrations were associated with higher weight, BMI, body fat and lean mass, waist circumference, and visceral, android, and gynoid fat. Each 10-fold increase in postnatal cotinine was associated with 76% increased risk of overweight or obesity (95% CI: 1.13-2.75). Associations between prenatal concentrations and measures of body composition at 12 years were generally null.Conclusions: Postnatal exposure to SHS may increase adolescent adiposity and lean mass. Future studies should determine whether early-life exposures to SHS are associated with other cardiometabolic risk markers.National Institute of Environmental Health Sciences. Grant Numbers: P01 ES011261, R01 ES014575, R01 ES015517National Institute of Environmental Health Sciences. Grant Numbers: P01 ES011261, R01 ES014575, R01 ES015517SIS
Gestational Exposure to Polybrominated Diphenyl Ethers and Social Skills and Problem Behaviors in Adolescents: The Home Study
Background: Polybrominated diphenyl ethers (PBDEs) are persistent environmental pollutants used as flame retardants. Gestational PBDE exposure has been associated with a variety of behavior problems in children, but little is known about its impact into adolescence, particularly on social skills, which are important for achieving social competence, establishing identity, and forming lasting relationships. Objective: We investigated associations between gestational exposure to PBDEs and social skills and problem behaviors in early adolescence in a longitudinal pregnancy and birth cohort in Cincinnati, Ohio (recruited 2003–2006). Methods: We measured maternal serum concentrations of five PBDE congeners during gestation. At age 12, we measured social skills and problem behaviors scores for 243 adolescents using self- and caregiver-report on the Social Skills Improvement System (SSiS). We used multivariable linear regression models to estimate associations between maternal PBDE concentrations and SSiS scores, controlling for potential covariates. We report associations for the five congeners and a summary exposure variable (∑5BDE: the sum of BDE- 28, 47, 99, 100, and 153, n = 197). Results: We found sex-specific associations of ∑5BDE concentrations with adolescent-reported Problem Behaviors (∑5BDE × sex pint = 0.02) and caregiver-reported Social Skills (∑5BDE × sex pint = 0.02). In sex-stratified models, log10 transformed data revealed increased maternal ∑5BDE concentration among males was associated with decreased caregiver-reported Social Skills composite score (β = -10.2, 95% CI: −19.5, −1.0), increased adolescent-reported Problem Behaviors composite score (β = 12.1, 95% CI: 5.4, 18.8), and increased caregiver-reported Problem Behaviors composite score (β = 6.2, 95% CI: 0.7, 11.7). Further analysis on SSiS subscales revealed similar patterns in significant associations among males. There were no statistically significant associations in stratified models among females despite higher ∑5BDE exposure (Female GM=40.15 ng/g lipid, GSE=1.10; Male GM=35.30 ng/g lipid, GSE=1.09). Discussion: We found gestational PBDE exposure in males was associated with poorer behavioral outcomes, extending previous findings among this cohort into early adolescence
Flame Retardants and Neurodevelopment: an Updated Review of Epidemiological Literature
Purpose of Review: Flame retardant (FR) compounds can adversely impact neurodevelopment. This updated literature review summarizes epidemiological studies of FRs and neurotoxicity published since 2015, covering historical (polybrominated biphenyls [PBBs], polychlorinated biphenyls [PCBs]), contemporary (polybrominated diphenyl ethers [PBDEs], hexabromocyclododecane [HBCD], and tetrabromobisphenol A [TBBPA]), and current-use organophosphate FRs (OPFRs) and brominated FRs (2-ethylhexyl 2,3,4,5-tetrabromobezoate [EH-TBB] TBB), bis(2-ethylhexyl) tetrabromophthalate [BEH-TEBP]), focusing on prenatal and postnatal periods of exposure. Recent Findings: Continuing studies on PCBs still reveal adverse associations with child cognition and behavior. Recent studies indicate PBDEs are neurotoxic, particularly for gestational exposures with decreased cognition and increased externalizing behaviors. Findings were suggestive for PBDEs and other behavioral domains and neuroimaging. OPFR studies provide suggestive evidence of reduced cognition and more behavioral problems in children. Summary: Despite a lack of studies of PBBs, TBBPA, EH-TBB, and BEH-TEBP, and only two studies of HBCD, recent literature of PCBs, PBDEs, and OPFRs are suggestive of developmental neurotoxicity, calling for more studies of OPFRs
The SINS/zC-SINF survey of z~2 galaxy kinematics: Outflow properties
Based on SINFONI Ha, [NII] and [SII] AO data of 30 z \sim 2 star-forming
galaxies (SFGs) from the SINS and zcSINF surveys, we find a strong correlation
of the Ha broad flux fraction with the star formation surface density of the
galaxy, with an apparent threshold for strong outflows occurring at 1 Msun
yr^-1 kpc^-2. Above this threshold, we find that SFGs with logm_\ast>10 have
similar or perhaps greater wind mass loading factors (eta = Mdotout/SFR) and
faster outflow velocities than lower mass SFGs. This trend suggests that the
majority of outflowing gas at z \sim 2 may derive from high-mass SFGs, and that
the z \sim 2 mass-metallicity relation is driven more by dilution of enriched
gas in the galaxy gas reservoir than by the efficiency of outflows. The mass
loading factor is also correlated with the SFR and inclination, such that more
star-forming and face-on galaxies launch more powerful outflows. For galaxies
that have evidence for strong outflows, we find that the broad emission is
spatially extended to at least the half-light radius (\sim a few kpc). We
propose that the observed threshold for strong outflows and the observed mass
loading of these winds can be explained by a simple model wherein break-out of
winds is governed by pressure balance in the disk. Using the ratio of the [SII]
doublet in a broad and narrow component, we find that outflowing gas has a
density of \sim10-100 cm^-3, significantly less than that of the star forming
gas (600 cm^-3).Comment: 7 pages, 3 figures, accepted by Ap
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