Tumor de Wilms no adulto : case report

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2019O tumor de Wilms constitui uma das neoplasias renais malignas mais frequentes em idade pediátrica, correspondendo a 85-90% dos casos. A incidência em adultos é cerca de 0.2 por milhão por ano. Apesar de, em termos histológicos não existirem diferenças entre os grupos etários, a apresentação clinica em idade adulta é distinta. Dado o reduzido número de casos em idade adulta, existe uma escassa evidência sobre a estratégia terapêutica mais adequada, pelo que as opções terapêuticas são semelhantes independentemente da idade. O prognóstico é considerado pior nos adultos. Este trabalho descreve o caso de uma doente de 23 anos diagnosticada com Tumor de Wilms em estadio IV, que realizou nefrectomia citoredutora e quimioterapia neoadjuvante e adjuvante. Observou-se progressão da doença durante os 15 meses de seguimento, que culminou com o falecimento da doente.Wilms ' tumor is considered one of the most common malignant kidney neoplasms in pediatric age, corresponding to 85-90% of the cases. The incidence in adults is about 0.2 per million per year. In histologic terms there is no difference between the age groups. However, the clinical presentation in adults is not the same. Given the small number of adult cases, there is scant evidence on the most appropriate therapeutic strategy, so the therapeutic options are similar regardless of age. The prognosis is considered worse in adults. This work describes the case of a 23-year-old patient diagnosed with stage IV Wilms ' tumor, which held cytoreductive nephrectomy and pre-and postoperative chemotherapy. Disease progression was observed during the 15 months of follow-up, culminating in the death of the patient

A divulgação de alterações nos orgãos sociais e o seu impacto no mercado de capitais Português

A literatura financeira há muito que reconhece a influência que a liderança corporativa tem no desempenho de uma organização. Este facto faz com que as alterações na gestão de topo sejam um acontecimento marcante no dia-a-dia de uma empresa, reflectindo-se no preço das suas acções. No resto do mundo, este tema tem sido alvo de um estudo intenso. Contudo, em Portugal, este encontra-se pouco desenvolvido. O objectivo deste trabalho é aferir se o mercado de capitais português atribui valor informativo a alterações na gestão de topo. Para tal, aplicou-se a metodologia do estudo de eventos a 61 alterações no Conselho de Administração e no Conselho Geral e de Supervisão de 18 empresas pertencentes ao PSI-20, ocorridas entre 1 de Janeiro de 2005 e 31 de Dezembro de 2009. Os resultados obtidos sugerem que o mercado de capitais português reage e ajusta-se com rapidez à divulgação deste tipo de evento. Perante alterações nos titulares dos órgãos sociais, é possível verificar claramente a existência de rendibilidades anormais em torno do dia do evento, dando-se posteriormente a incorporação total da nova informação nos preços e, consequentemente, a sua estabilização. Assim sendo, o estudo realizado permite confirmar que o mercado de capitais português atribui valor informativo às alterações na gestão de topo, reflectindo-as nos preços das acções, o que vem comprovar a sua eficiência semi-forte ou informacional.Corporate leadership has been documented for a long time by the financial literature, as having a major influence on the performance of an organization. Changes in top management are a crucial event in the daily life of a company, which is reflected in the price of its shares. Overseas, this theme has been intensively researched. However, in Portugal, it still remains almost untouched. The goal of this paper is to assess if the Portuguese capital market recognizes informational value in top management turnover. To achieve it, the event study methodology was applied to 61 changes in the composition of the Board and the General Council and Supervisory Board of 18 companies belonging to the Portuguese Stock index, occurred between January 1, 2005 and December 31, 2009. The results suggest that the Portuguese stock market reacts and adjusts rapidly to the disclosure of this type of event. In the occurrence of top management changes, was possible to verify the existence of abnormal returns around the announcement day. Soon afterwards, the new information was fully incorporated in stock prices, which stabilized. Therefore, according to the results, the analysis undertaken confirmed that the Portuguese stock market assigns informational value to management changes, reflecting it in stock prices. This proves that in Portugal, the capital market is efficient in its semi-strong form

Vif- H3.3 interaction, a new Vif function?

Poster presented at the EMBO Workshop- Histone variants. Strasbourg, France, 2-4 June 2014

Rs266882 polymorphism analysis in KLK3 gene by RFLPPCR in cases of prostate cancer

Poster presented at the From Basic Sciences to Clinical Research - First International Congress of CiiEM. Egas Moniz, Caparica, Portugal, 27-28 November 2015"The prostate cancer (PC) is one of the most frequent neoplasia in men even though not the deadliest. Every year more than 1,1 million men are diagnose with PC worldwide. The principal risks factors are: age, diet, familiar predisposition, race and hormones. Gleason classification is use to graduate PC based upon the histologic pattern of tumoral growth. Additionally to this classification is use TNM that allow to describe the cancer severity for each individual. Prostate-specific antigen (PSA) has been used as biomarker of PC, however it isn´t a specific marker for cancer detection. This protein is coded by KLK3 gene (located at 19q13.41) and it is regulated by androgen receptors through ligation to consensus sequences in promoter region of KLK3 – Androgen Response Elements (ARE). In ARE-I, located at -158 position, there is a single polymorphism nucleotide (SNP) named rs266882, which consists of substitution of guanine (G) for adenine (A).

Distraction osteogenesis in dog with a tooth-borne device : histological and histomorphometric analysis

The distraction osteogenesis (DO) is the biological process of new bone formation between the surfaces of bone segments gradually separated by incremental traction. However, the lack of solid experimental studies using the tooth-borne distractor does not allow comparing this technique with the classical procedures. This study aimed to establish the effect of two different activation protocols in new bone formation, with a new intraoral tooth-borne device for dog mandibular distraction osteogenesis. Nine beagle dogs were split into 3 similar groups, Group A the control, Group B subjected to two daily activations of 0.5 mm and Group C subjected to a single daily activation of 1 mm. The distraction period was 10 days followed by a 12 weeks consolidation period. Samples where then processed and embedded in methylmethacrylate and ground to a thickness of 20µm. Toluidine blue stains were done on all specimens and histological and histomorphometric evaluation of bone tissue formed within distraction gap was performed. The statistical analysis in this manuscript was performed with IBM®-SPSS® v.20 statistics software and R software version 3.1.0. The level of significance adopted was 5 % (?=0.05). No statistically significant difference was detected by histomorphometric evaluation between the two experimental groups in what concerns the bone volume. However, significant differences were found in the coefficients of variation between the medial and buccal areas, and the buccal and lingual areas. This study shows that the mandible can be lengthened successfully using a tooth-borne distractor. Moreover, it suggested that a decrease from once to twice-daily activations might negatively change the quality and structure of newly formed bone and prompt it to instability

The feasibility of wavelength dispersive X-ray fluorescence spectrometry for the assessment of lead concentration in animal bone powder

"This work demonstrates the feasibility of wavelength dispersive X-ray fluorescence for the assessment of lead in animal bone powder.

Indoor air quality and atopic sensitization in primary schools: A follow-up study

Background: The onset and exacerbation of allergic diseases and asthma have been associated with poorindoor air quality (IAQ) inside classrooms.Objective: The aim was to investigate how IAQ changed in primary schools after applying indoor air qualityrecommendations, and to explore how these changes influenced allergic sensitization on children.Methods: Total volatile organic compounds, PM2.5, PM10, CO2, CO, temperature and relative humidity inthe indoor and outdoor air of 20 primary schools were measured in 2010–2012. The school staff receivedinstructions on how to improve IAQ in accordance with the SINPHONIE guidelines. Atopy status wasassessed in children attending the participating classrooms by skin prick tests and exhaled nitric oxide.A follow-up sampling campaign was performed in 2014–2015 in the same schools.Results: Indoor PM2.5and PM10concentrations were approximately 40% lower in the follow-up mea-surements (p < 0.05). There were no significant differences regarding outdoor PM concentrations.Nevertheless, PM levels from the follow-up campaign still exceeded the reference value established byPortuguese legislation. Moreover, there were no significant differences in atopic prevalence and FENOvalues between the campaigns.Conclusion: These findings suggest that adoption of the recommendations based on the SINPHONIE guide-lines was particularly successful in reducing PM2.5and PM10in primary schools of Porto. Nevertheless,the schools failed to reduce the levels of other IAQ pollutants, as well as the prevalence of atopic disease.This work was financed by the HEBE project (NORTE-01-0145-FEDER-000010), and by Fundação para a Ciência e Tecnologia through the ARIA project (PTDC/DTP-SAP/1522/2012, FCOMP-01-0124-FEDER-028709) and through the scholarships SFRH/BD/108605/2015, SFRH/BD/112269/2015 and SFRH/BPD/105100/2014.info:eu-repo/semantics/publishedVersio

Análise de polimorfismos no gene humano IGF-I

Poster apresentado nos Seminários de Ciências da Saúde, ISCSEM - Instituto Superior de Ciências da Saúde Egas Moniz, Caparica, Abril de 2013

Exposure of children to ultrafine particles in primary schools in Portugal

Children spend a large part of their time at schools, which might be reflected as chronic exposure. Ultrafine particles (UFP) are generally associated with a more severe toxicity compared to fine and coarse particles, due to their ability to penetrate cell membranes. In addition, children tend to be more susceptible to UFP-mediated toxicity compared to adults, due to various factors including undeveloped immune and respiratory systems and inhalation rates. Thus, the purpose of this study was to determine indoor UFP number concentrations in Portuguese primary schools. Ultrafine particles were sampled between January and March 2014 in 10 public primary schools (35 classrooms) located in Porto, Portugal. Overall, the average indoor UFP number concentrations were not significantly different from outdoor concentrations (8.69 × 10(3) vs. 9.25 × 10(3) pt/cm(3), respectively; considering 6.5 h of indoor occupancy). Classrooms with distinct characteristics showed different trends of indoor UFP concentrations. The levels of carbon dioxide were negatively correlated with indoor UFP concentrations. Occupational density was significantly and positively correlated with UFP concentrations. Although the obtained results need to be interpreted with caution since there are no guidelines for UFP levels, special attention needs to be given to source control strategies in order to reduce major particle emissions and ensure good indoor air quality.This study was performed in the framework of the ARIA project financed by Fundação para a Ciência e Tecnologia (PTDC/DTP-PA/1522/2012, FCOMP-01-0124-FEDER-028709), the project “E2BE” (NORTE-07-0124-FEDER-000036) financed by the Portuguese CCDR-N through the European Union FEDER programme, and the fellowship SFRH/BPD/65722/2009