Production of electricity from energy cane in small tropical islands: an ex ante agro-environmental, economic and industrial

Interest in renewable energy from agricultural biomass has increased in recent years. Among renewable energy sources, biomass is considered indeed as an attractive option for sustainable energy production. This is particularly true in the case of small tropical island states, where energy demand is increasing and the energy mix currently heavily relies on fossil imported resources. Diversifying and orientating the energy mix toward locally grown energy crops could therefore be a promising sustainable option. However, the introduction of such bioenergy systems under existing conditions and current agricultural models is still rather uncertain and requires achieving several sustainable goals. In order to build new sustainable energy systems, assessing the conditions for a sustainable and profitable biomass supply is a critical step prior to industrial investment. In this paper we present the results of an interdisciplinary research program aimed at identifying the agro-environmental, economic and industrial conditions for producing electricity from energy cane in Guadeloupe

Item response theory and factor analysis as a mean to characterize occurrence of response shift in a longitudinal quality of life study in breast cancer patients.

International audienceBACKGROUND: The occurrence of response shift (RS) in longitudinal health-related quality of life (HRQoL) studies, reflecting patient adaptation to disease, has already been demonstrated. Several methods have been developed to detect the three different types of response shift (RS), i.e. recalibration RS, 2) reprioritization RS, and 3) reconceptualization RS. We investigated two complementary methods that characterize the occurrence of RS: factor analysis, comprising Principal Component Analysis (PCA) and Multiple Correspondence Analysis (MCA), and a method of Item Response Theory (IRT). METHODS: Breast cancer patients (n = 381) completed the EORTC QLQ-C30 and EORTC QLQ-BR23 questionnaires at baseline, immediately following surgery, and three and six months after surgery, according to the "then-test/post-test" design. Recalibration was explored using MCA and a model of IRT, called the Linear Logistic Model with Relaxed Assumptions (LLRA) using the then-test method. Principal Component Analysis (PCA) was used to explore reconceptualization and reprioritization. RESULTS: MCA highlighted the main profiles of recalibration: patients with high HRQoL level report a slightly worse HRQoL level retrospectively and vice versa. The LLRA model indicated a downward or upward recalibration for each dimension. At six months, the recalibration effect was statistically significant for 11/22 dimensions of the QLQ-C30 and BR23 according to the LLRA model (p ≤ 0.001). Regarding the QLQ-C30, PCA indicated a reprioritization of symptom scales and reconceptualization via an increased correlation between functional scales. CONCLUSIONS: Our findings demonstrate the usefulness of these analyses in characterizing the occurrence of RS. MCA and IRT model had convergent results with then-test method to characterize recalibration component of RS. PCA is an indirect method in investigating the reprioritization and reconceptualization components of RS

Prise en compte des problèmes de l'alimentation par la recherche

The author first examines how food problems could be taken into account by the research institutions for farm and food products, in particular (a) the knowledge and analysis of different human requirements and behaviour patterns, (b) the study of food characteristics related to these requirements. The potential of French research is then presented and its positive aspects as well as its shortcomings are evaluated. The conclusion is drawn that research in the field of farm and food products should be « integrated », combining technological and economic aspects with nutritional and socio-economic considerations. It could thus become one of the pillars of a food policy aiming at improving the quality of life and promoting French products on national and international markets

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer.

The 70-gene signature test (MammaPrint) has been shown to improve prediction of clinical outcome in women with early-stage breast cancer. We sought to provide prospective evidence of the clinical utility of the addition of the 70-gene signature to standard clinical-pathological criteria in selecting patients for adjuvant chemotherapy. In this randomized, phase 3 study, we enrolled 6693 women with early-stage breast cancer and determined their genomic risk (using the 70-gene signature) and their clinical risk (using a modified version of Adjuvant! Online). Women at low clinical and genomic risk did not receive chemotherapy, whereas those at high clinical and genomic risk did receive such therapy. In patients with discordant risk results, either the genomic risk or the clinical risk was used to determine the use of chemotherapy. The primary goal was to assess whether, among patients with high-risk clinical features and a low-risk gene-expression profile who did not receive chemotherapy, the lower boundary of the 95% confidence interval for the rate of 5-year survival without distant metastasis would be 92% (i.e., the noninferiority boundary) or higher. A total of 1550 patients (23.2%) were deemed to be at high clinical risk and low genomic risk. At 5 years, the rate of survival without distant metastasis in this group was 94.7% (95% confidence interval, 92.5 to 96.2) among those not receiving chemotherapy. The absolute difference in this survival rate between these patients and those who received chemotherapy was 1.5 percentage points, with the rate being lower without chemotherapy. Similar rates of survival without distant metastasis were reported in the subgroup of patients who had estrogen-receptor-positive, human epidermal growth factor receptor 2-negative, and either node-negative or node-positive disease. Among women with early-stage breast cancer who were at high clinical risk and low genomic risk for recurrence, the receipt of no chemotherapy on the basis of the 70-gene signature led to a 5-year rate of survival without distant metastasis that was 1.5 percentage points lower than the rate with chemotherapy. Given these findings, approximately 46% of women with breast cancer who are at high clinical risk might not require chemotherapy. (Funded by the European Commission Sixth Framework Program and others; ClinicalTrials.gov number, NCT00433589; EudraCT number, 2005-002625-31.)

Influence de l'ébullition domestique du lait sur son efficacité calcique

International audienc

Resultats des exploitations ovines en France. Un constat a partir du RICA

The decrease of mutton production in France and the difficulties of breeders during a few last years make necessary the analysis of sheep farms economic situation

Les étapes d’une expérience en économie expérimentale

This document applies to anybody who wants to understand what is Experimental Economics and the benefits that can profit from this approach for empirical works which validity and scope can be evaluated in a scientific work. In a pragmatic way are described in this document the different steps to be followed methodologically to set out an experiment. Our goal is to give our readers a broad view of an experimental process in economics. Further to the logistics aspects and data collection, this guide also tackles the tools used to work with data and the methodological referees that allow analysing the first results. It also reviews various animation support of the experimentalist community in France

How to Measure the Performance of Farms with Regard to Climate-Smart Agriculture Goals? A Set of Indicators and Its Application in Guadeloupe

Conceptualized by the Food and Agriculture Organization in 2010, climate-smart agriculture aims to simultaneously tackle three main objectives. These are increasing food security, building the resilience of agricultural systems for adaptation to climate change and mitigation of GHG. As much research focuses on one of these three objectives, our understanding of how agricultural systems address these three challenges simultaneously is limited by the lack of a comprehensive evaluation tool. In order to fill this gap, we have developed a generic evaluation framework that comprises 19 indicators that we measured in a sample of 12 representative farms of the North Basse-Terre region in Guadeloupe. The evaluation revealed clear differences in the performance of these farming systems. For example, nutritional performance varied from 0 to 13 people fed per hectare, the average potential impact of climatic conditions varied from 27% to 33% and the GHG emissions balance varied from +0.8 tCO(2eq)center dot ha(-1) to +3.6 tCO(2eq)center dot ha(-1). The results obtained can guide the design of innovative production systems that better meet the objectives of climate-smart agriculture for the study region. The evaluation framework is intended as a generic tool for a common evaluation basis across regions at a larger scale. Future prospects are its application and validation in different contexts

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis

Background Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could have therapeutic benefit. In order to establish whether changes in CDK5 activity are associated with oncogenesis one could quantify phosphorylation of CDK5 targets in disease tissue in comparison to appropriate controls. However the identity of physiological and pathophysiological CDK5 substrates remains the subject of debate, making the choice of CDK5 activity biomarkers difficult. Methods Here we use in vitro and in cell phosphorylation assays to identify novel features of CDK5 target sequence determinants that confer enhanced CDK5 selectivity, providing means to select substrate biomarkers of CDK5 activity with more confidence. We then characterize tools for the best CDK5 substrate we identified to monitor its phosphorylation in human tissue and use these to interrogate human tumour arrays. Results The close proximity of Arg/Lys amino acids and a proline two residues N-terminal to the phosphorylated residue both improve recognition of the substrate by CDK5. In contrast the presence of a proline two residues C-terminal to the target residue dramatically reduces phosphorylation rate. Serine-522 of Collapsin Response Mediator-2 (CRMP2) is a validated CDK5 substrate with many of these structural criteria. We generate and characterise phosphospecific antibodies to Ser522 and show that phosphorylation appears in human tumours (lung, breast, and lymphoma) in stark contrast to surrounding non-neoplastic tissue. In lung cancer the anti-phospho-Ser522 signal is positive in squamous cell carcinoma more frequently than adenocarcinoma. Finally we demonstrate that it is a specific and unusual splice variant of CRMP2 (CRMP2A) that is phosphorylated in tumour cells. Conclusions For the first time this data associates altered CDK5 substrate phosphorylation with oncogenesis in some but not all tumour types, implicating altered CDK5 activity in aspects of pathogenesis. These data identify a novel oncogenic mechanism where CDK5 activation induces CRMP2A phosphorylation in the nuclei of tumour cells