Which factors influence orthodontists in their decision to extract? A questionnaire survey

To evaluate the relative influence of different criteria in the choice between extraction and nonextraction treatment in current orthodontics, and to assess how the percentage of extractions has evolved over time. Pre-treatment records (panoramic radiograph, lateral cephalogram, study casts and photographs) of fourteen cases in permanent dentition (adult or adolescent) with class I molar relationship and moderate anterior crowding were evaluated by 28 orthodontists. For each case, each orthodontist filled out a questionnaire reporting his treatment plan proposal (extraction or nonextraction) and the importance of specific parameters in his decision-making process, using categorical scales. Orthodontists practicing for more than 15 years were also asked to compare this decision with the one they would have taken at the beginning of their professional career. The two most important factors in the decision-making were the soft tissue profile and the amount of crowding. The least important factor was the presence of third molars. In cases of nonextraction treatment, the lack of space was managed mostly by dental expansion and stripping. Twenty percent of the case evaluations revealed extraction(s) decisions. Among the orthodontists practicing for more than 15 years, the current extraction rate reached 24%, whereas the same orthodontists reported they would have extracted in 39% of the cases in the past. The present study suggests that soft tissue profile has a higher impact than traditional criteria such as cephalometric measurements in the extraction decision. This is associated with a decreased extractions rate compared to the past

Root repair after damage due to screw insertion for orthodontic miniplate placement

The aim of this investigation was to describe the healing reactions following root damage caused by placement of a miniplate anchorage system. In 4 beagle dogs, 4 titanium miniplates (2 self-tapping screws per miniplate) were placed in each maxilla, after drilling of pilot-holes. Six fixation screws were unintentionally inserted damaging the root of maxillary canines. Two weeks later, half of the miniplates were loaded with a coil spring. Two dogs were euthanized 7 weeks after placement of the miniplates, while the remaining two after 29 weeks. Histological sections were prepared, microradiographed, observed under U.V. light, then stained and analysed under ordinary light. Four screws caused direct root damage; one was damaged during the drilling process; one caused damage to the periodontal ligament only. Among these 6 screws, 2 were mobile and 4 were stable at sacrifice. Limited root damage showed some repair after 29 weeks, consisting in a thick layer of mineralized cementum including anchoring periodontal fibres. Tissue repair was not related to screw stability or loading status. Limited root damage has shown potential to heal, while extensive root damage has not. Precise position of insertion of the miniplates is thus of utmost importance

Topological BF Theories in 3 and 4 Dimensions

In this paper we discuss topological BF theories in 3 and 4 dimensions. Observables are associated to ordinary knots and links (in 3 dimensions) and to 2-knots (in 4 dimensions). The vacuum expectation values of such observables give a wide range of invariants. Here we consider mainly the 3-dimensional case, where these invariants include Alexander polynomials, HOMFLY polynomials and Kontsevich integrals.Comment: 25 pages, latex, no figures. Transmission problems have been solve

Restricted upper airway dimensions in patients with dentofacial deformity from juvenile idiopathic arthritis

BACKGROUND: This retrospective, cross-sectional study aimed to assess the pharyngeal airway dimensions of patients with juvenile idiopathic arthritis (JIA) and moderate/severe JIA-related dentofacial deformity (mandibular retrognathia/micrognathia), and compare the results with JIA patients with a normal mandibular appearance and a group of non-JIA patients. METHODS: Seventy-eight patients were retrospectively included in a 1:1:1 manner as specified below. All patients had previously been treated at the Section of Orthodontics, Aarhus University, Denmark. All had a pretreatment cone beam computed tomography (CBCT). Group 1 (JIA+); 26 JIA patients with severe arthritis-related dentofacial deformity and mandibular retrognathia/micrognathia. Group 2 (JIA-); 26 JIA patients with normal mandibular morphology/position. Group 3 (Controls); 26 non-JIA subjects. Dentofacial morphology and upper airway dimensions, excluding the nasal cavity, were assessed in a validated three-dimensional (3D) fashion. Assessment of dentofacial deformity comprised six morphometric measures. Assessment of airway dimensions comprised nine measures. RESULTS: Five morphometric measures of dentofacial deformity were significantly deviating in the JIA+ group compared with the JIA- and control groups: Posterior mandibular height, anterior facial height, mandibular inclination, mandibular occlusal inclination, and mandibular sagittal position. Five of the airway measurements showed significant inter-group differences: JIA+ had a significantly smaller nasopharyngeal airway dimension (ad2-PNS), a smaller velopharyngeal volume, a smaller minimal cross-sectional area and a smaller minimal hydraulic diameter than JIA- and controls. No significant differences in upper airway dimensions were seen between JIA- and controls. CONCLUSION: JIA patients with severe arthritis-related dentofacial deformity and mandibular micrognathia had significantly restricted upper airway dimensions compared with JIA patients without dentofacial deformity and controls. The restrictions of upper airway dimension seen in the JIA+ group herein were previously associated with sleep-disordered breathing in the non-JIA background population. Further studies are needed to elucidate the role of dentofacial deformity and restricted airways in the development of sleep-disordered breathing in JIA

The Origin of Line Emission in Massive z~2.3 Galaxies: Evidence for Cosmic Downsizing of AGN Host Galaxies

Using the Gemini Near-InfraRed Spectrograph (GNIRS), we have assembled a complete sample of 20 K-selected galaxies at 2.0<z<2.7 with high quality near-infrared spectra. As described in a previous paper, 9 of these 20 galaxies have strongly suppressed star formation and no detected emission lines. The present paper concerns the 11 galaxies with detected Halpha emission, and studies the origin of the line emission using the GNIRS spectra and follow-up observations with SINFONI on the VLT. Based on their [NII]/Halpha ratios, the spatial extent of the line emission and several other diagnostics, we infer that four of the eleven emission-line galaxies host narrow line active galactic nuclei (AGNs). The AGN host galaxies have stellar populations ranging from evolved to star-forming. Combining our sample with a UV-selected galaxy sample at the same redshift that spans a broader range in stellar mass, we find that black-hole accretion is more effective at the high-mass end of the galaxy distribution (~2.9x10^11 Msun) at z~2.3. Furthermore, by comparing our results with SDSS data, we show that the AGN activity in massive galaxies has decreased significantly between z~2.3 and z~0. AGNs with similar normalized accretion rates as those detected in our K-selected galaxies reside in less massive galaxies (~4.0x10^10 Msun) at low redshift. This is direct evidence for downsizing of AGN host galaxies. Finally, we speculate that the typical stellar mass-scale of the actively accreting AGN host galaxies, both at low and at high redshift, might be similar to the mass-scale at which star-forming galaxies seem to transform into red, passive systems.Comment: Accepted for publication in the Astrophysical Journa

The analog signal processor of the Auger fluorescence detector prototype

The Auger Fluorescence Detector will allow to determine the longitudinal development of atmospheric showers in the range 10 19 –10 21 eV. A detector module comprises an array of 20 � 22 PMTs at the focal surface of a large-aperture telescope. Thirty such modules will be used. The PMTs pixel signal is variable in shape depending on the shower-eye geometry. The sky background light (BL) is also variable. We have developed an analog signal processor to obtain best energy and timing resolution despite those constrains. The Head Electronics (HE) bias the PMTs and keeps its pulsegain constant even for large BL. This is measured using a current-monitor of novel design. Both the signal pulse and the BL DC level are sent via a single twisted pair to the Analog Board (AB). The AB performs the compression of the 15–16 bit signal dynamic range into 12 bits of the FADC which follows the AB. A three-pole Bessel filter was adopted for antialiasing. The AB includes 16 bit sigma-delta chips to readout the BL DC level, and a test-pulse distribution system. # 2001 Elsevier Science B.V. All rights reserved. PACS: 29.4

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice

Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons. This may be detrimental for neuronal function, especially given that locally synthesized cholesterol is implicated in synapse integrity and remodeling. Here, we used biodegradable and biocompatible polymeric nanoparticles (NPs) modified with glycopeptides (g7) and loaded with cholesterol (g7-NPs-Chol), which per se is not blood-brain barrier (BBB) permeable, to obtain high-rate cholesterol delivery into the brain after intraperitoneal injection in HD mice. We report that g7-NPs, in contrast to unmodified NPs, efficiently crossed the BBB and localized in glial and neuronal cells in different brain regions. We also found that repeated systemic delivery of g7-NPs-Chol rescued synaptic and cognitive dysfunction and partially improved global activity in HD mice. These results demonstrate that cholesterol supplementation to the HD brain reverses functional alterations associated with HD and highlight the potential of this new drug-administration route to the diseased brain

CALOCUBE: An approach to high-granularity and homogenous calorimetry for space based detectors

Future space experiments dedicated to the observation of high-energy gamma and cosmic rays will increasingly rely on a highly performing calorimetry apparatus, and their physics performance will be primarily determined by the geometrical dimensions and the energy resolution of the calorimeter deployed. Thus it is extremely important to optimize its geometrical acceptance, the granularity, and its absorption depth for the measurement of the particle energy with respect to the total mass of the apparatus which is the most important constraint for a space launch. The proposed design tries to satisfy these criteria while staying within a total mass budget of about 1.6 tons. Calocube is a homogeneous calorimeter instrumented with Cesium iodide (CsI) crystals, whose geometry is cubic and isotropic, so as to detect particles arriving from every direction in space, thus maximizing the acceptance; granularity is obtained by filling the cubic volume with small cubic CsI crystals. The total radiation length in any direction is more than adequate for optimal electromagnetic particle identification and energy measurement, whilst the interaction length is at least sufficient to allow a precise reconstruction of hadronic showers. Optimal values for the size of the crystals and spacing among them have been studied. The design forms the basis of a three-year R&amp;D activity which has been approved and financed by INFN. An overall description of the system, as well as results from preliminary tests on particle beams will be described

Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics