Diagnostiquer la proximité perçue en vente directe de produits alimentaires

Assessing the perceived proximity in direct selling of food products In line with the Editorial of Décisions Marketing "Is proximity a new marketing trend?", the aim of this article is to question the managerial relevance of the concept of proximity within the context of direct selling of food products. Through empirical studies in three supply chains - French CSA (AMAP), farm shops and direct selling on markets- we show the interest of assessing perceived proximity since it has a positive influence on consumers trust towards the studied supply chains and allows to discriminate them. The relevance of the concept of proximity being supported, recommendations are then emphasized on two points: which kinds of proximity to encourage and how to enhance proximity in food direct selling.Dans le prolongement de l'éditorial de Décisions Marketing : " La proximité est-elle une nouvelle mode du marketing ? ", cet article interroge la pertinence managériale du concept de proximité en vente directe de produits alimentaires. Via des études empiriques menées dans trois circuits - l'AMAP, le Point de Vente Collectif et le marché - nous montrons qu'il est pertinent de diagnostiquer la proximité perçue par les consommateurs car elle influence positivement la confiance à l'égard des circuits étudiés et permet de les discriminer. Une fois l'intérêt du concept démontré, des recommandations sont formulées autour de deux interrogations : quels types de proximité encourager et comment développer la proximité perçue en vente directe

Jean de Sponde (1557-1595.) Un humaniste dans la tourmente, études réunies par Véronique Duché-Gavet, Sabine Lardon et Guylaine Pineau

Construit autour des actes d’un Colloque organisé à l’Université de Pau et des Pays de l’Adour les 14 et 15 mars 2008, ce volume fait le point sur l’ensemble du travail accompli depuis quatre-vingts ans sur Jean de Sponde. Redécouvert en 1931 par Alan Boase qui l’avait d’abord édité seul, puis avec François Ruchon, Sponde avait, un demi-siècle plus tard, attiré l’attention de la critique universitaire française à l’occasion du programme de l’agrégation des Lettres de 1984 où figuraient ses Po..

Le Cabinet du curieux. Culture, savoirs, religion de l’Antiquité à l’Ancien régime, sous la direction de Witold Konstanty Pietrzak et Magdalena Kozluk

C’est un livre pluridisciplinaire, international, trans-séculaire et polyglotte, et donc à son image, que ses collègues ont ici préparé pour Jean-Paul Pittion, professeur émérite à l’Université de Tours et au Centre d’Études supérieures de la Renaissance de Tours, fellow du Trinity College, collaborateur de l’Université de Lodz, classiciste, anglicisant, comparatiste, spécialiste du livre du XVIe au XVIIIe siècle, féru d’histoire des idées, des religions et de la médecine, bref praticien d’un..

Guillaume Michel, Le Penser de royal memoire, éd. Lidia Radi

Il faut d’abord reconnaître que Le Penser de royal memoire n’est pas de ces textes que l’on connaît vraiment, d’autant qu’il n’a jamais été réédité depuis 1518 et que son auteur Guillaume Michel dit de Tours n’est souvent cité qu’en passant, même si quelques chercheurs (Elizabeth Armstrong, V.-L. Saulnier, Gérard Defaux, Pascale Chiron, Cynthia Brown) lui ont consacré depuis une cinquantaine d’années des travaux approfondis. La vie de Guillaume Michel, en dépit des efforts de Lidia Radi, l’éd..

Jean de Sponde (1557-1595.) Un humaniste dans la tourmente, études réunies par Véronique Duché-Gavet, Sabine Lardon et Guylaine Pineau

Construit autour des actes d’un Colloque organisé à l’Université de Pau et des Pays de l’Adour les 14 et 15 mars 2008, ce volume fait le point sur l’ensemble du travail accompli depuis quatre-vingts ans sur Jean de Sponde. Redécouvert en 1931 par Alan Boase qui l’avait d’abord édité seul, puis avec François Ruchon, Sponde avait, un demi-siècle plus tard, attiré l’attention de la critique universitaire française à l’occasion du programme de l’agrégation des Lettres de 1984 où figuraient ses Po..

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells

Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process. Ribosome biogenesis is a very complex process involving transcriptional a

Non-nociceptive roles of opioids in the CNS: opioids' effects on neurogenesis, learning, memory and affect.

Mortality due to opioid use has grown to the point where, for the first time in history, opioid-related deaths exceed those caused by car accidents in many states in the United States. Changes in the prescribing of opioids for pain and the illicit use of fentanyl (and derivatives) have contributed to the current epidemic. Less known is the impact of opioids on hippocampal neurogenesis, the functional manipulation of which may improve the deleterious effects of opioid use. We provide new insights into how the dysregulation of neurogenesis by opioids can modify learning and affect, mood and emotions, processes that have been well accepted to motivate addictive behaviours

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation