Colaniella, a late Permian Tethyan foraminifera: proposals for a simplified taxonomy, geographical distribution and environments,Colaniella, foraminifere index du Permien tardif tethysien: propositions pour une taxonomie simplifiee, repartition geographique et environnements

A simplified taxonomic classification in 3 groups of the genus Colaniella Likharev is proposed: Colaniella ex gr. parva. Colaniella ex gr. lepida. Colaniella ex gr. minima. The repartition of the eight main Colaniella biofacies is given and the paleogeographic distribution of this genus is presented on a late Permian map configuration

The Permian deposits of Hydra Island (Greece), micropaleontology, sedimentology and paleoenvironments,Le Permien de l'île d'Hydra (Grèce), micropalé ontologie, sédimentologie et paléoenvironnements

This study presents severa! analyses in micropaleontology and scdimentology of four sections of permian deposits in the Hydra Island (Grecce). The micropaleontological study is an inventory of foraminifers and aigne, which allow securnte datations to precise age assigncmcnts. Rcprcscntaûvc facies have bccn dcfined for the Permian deposits. Summary of these data pcrmitted to eharacterize successive paleocnvironments and to propose a reconstruction of Permian sequences in this arc

Mapping City Visions: Integrating Mega- projects in Urban Development

This policy brief explores the mapping of city visions in fast-growing cities in several emerging economies (Brazil, South Africa, India, Peru). As cities have to deal increasingly with both complexity and uncertainty in their development, they are concerned with the future pathways their cities can take. City visions on urban development portray idealized situations as goals for the future, and the maps portraying them are strongly idealized. To get behind these idealized versions of reality, policy makers need to understand how such visions are developed, by whom, and whose realities they reflect

Supplementary Prognostic Variables for Pleural Mesothelioma A Report from the IASLC Staging Committee

Introduction: The staging system for malignant pleural mesothelioma is controversial. To revise this system, the International Association for the Study of Lung Cancer Staging Committee developed an international database. This report analyzes prognostic variables in a surgical population, which are supplementary to previously published CORE variables (stage, histology, sex, age, and type of procedure). Methods: Supplementary prognostic variables were studied in three scenarios: (1) all data available, that is, patient pathologically staged and other CORE variables available (2) only clinical staging available along with CORE variables, and (3) only age, sex, histology, and laboratory parameters are known. Survival was analyzed by Kaplan– Meier, prognostic factors by log rank and stepwise Cox regression modeling after elimination of nonsignificant variables. p value less than 0.05 was significant. Results: A total of 2141 patients with best tumor, node, metastasis (TNM) stages (pathologic with/without clinical staging) had nonmissing age, sex, histology, and type of surgical procedure. Three prognostic models were defined. Scenario A (all parameters): best pathologic stage, histology, sex, age, type of surgery, adjuvant treatment, white blood cell count (WBC) (≥15.5 or not), and platelets (≥400 k or not) (n = 550). Scenario B (no surgical staging): clinical stage, histology, sex, age, type of surgery, adjuvant treatment, WBC, hemoglobin (<14.6 or not), and platelets (n = 627). Scenario C (limited data): histology, sex, age, WBC, hemoglobin, and platelets (n = 906). Conclusion: Refinement of these models could define not only the appropriate patient preoperatively for best outcomes after cytoreductive surgery but also stratify surgically treated patients after clinical and pathologic staging who do or do not receive adjuvant therapy

Melatonin Promotes Oligodendroglial Maturation of Injured White Matter in Neonatal Rats

OBJECTIVE:To investigate the effects of melatonin treatment in a rat model of white matter damage (WMD) in the developing brain. Additionally, we aim to delineate the cellular mechanisms of melatonin effect on the oligodendroglial cell lineage. METHODS:A unilateral ligation of the uterine artery in pregnant rat at the embryonic day 17 induces fetal hypoxia and subsequent growth restriction (GR) in neonatal pups. GR and control pups received a daily intra-peritoneal injection of melatonin from birth to post-natal day (P) 3. RESULTS:Melatonin administration was associated with a dramatic decrease in microglial activation and astroglial reaction compared to untreated GR pups. At P14, melatonin prevented white matter myelination defects with an increased number of mature oligodendrocytes (APC-immunoreactive) in treated GR pups. Conversely, melatonin was not found to be associated with an increased density of total oligodendrocytes (Olig2-immunoreactive), suggesting that melatonin is able to promote oligodendrocyte maturation but not proliferation. These effects appear to be melatonin-receptor dependent and were reproduced in vitro. INTERPRETATION:These data suggest that melatonin has a strong protective effect on developing damaged white matter through decreased microglial activation and oligodendroglial maturation leading to a normalization of the myelination process. Consequently, melatonin should be a considered as an effective neuroprotective candidate not only in perinatal brain damage but also in inflammatory and demyelinating diseases observed in adults

Auditory-Motor Mapping Training as an Intervention to Facilitate Speech Output in Non-Verbal Children with Autism: A Proof of Concept Study

Although up to 25% of children with autism are non-verbal, there are very few interventions that can reliably produce significant improvements in speech output. Recently, a novel intervention called Auditory-Motor Mapping Training (AMMT) has been developed, which aims to promote speech production directly by training the association between sounds and articulatory actions using intonation and bimanual motor activities. AMMT capitalizes on the inherent musical strengths of children with autism, and offers activities that they intrinsically enjoy. It also engages and potentially stimulates a network of brain regions that may be dysfunctional in autism. Here, we report an initial efficacy study to provide ‘proof of concept’ for AMMT. Six non-verbal children with autism participated. Prior to treatment, the children had no intelligible words. They each received 40 individual sessions of AMMT 5 times per week, over an 8-week period. Probe assessments were conducted periodically during baseline, therapy, and follow-up sessions. After therapy, all children showed significant improvements in their ability to articulate words and phrases, with generalization to items that were not practiced during therapy sessions. Because these children had no or minimal vocal output prior to treatment, the acquisition of speech sounds and word approximations through AMMT represents a critical step in expressive language development in children with autism

Delineating the molecular and phenotypic spectrum of the SETD1B-related syndrome

Purpose: Pathogenic variants in SETD1B have been associated with a syndromic neurodevelopmental disorder including intellectual disability, language delay, and seizures. To date, clinical features have been described for 11 patients with (likely) pathogenic SETD1B sequence variants. This study aims to further delineate the spectrum of the SETD1B-related syndrome based on characterizing an expanded patient cohort. Methods: We perform an in-depth clinical characterization of a cohort of 36 unpublished individuals with SETD1B sequence variants, describing their molecular and phenotypic spectrum. Selected variants were functionally tested using in vitro and genome-wide methylation assays. Results: Our data present evidence for a loss-of-function mechanism of SETD1B variants, resulting in a core clinical phenotype of global developmental delay, language delay including regression, intellectual disability, autism and other behavioral issues, and variable epilepsy phenotypes. Developmental delay appeared to precede seizure onset, suggesting SETD1B dysfunction impacts physiological neurodevelopment even in the absence of epileptic activity. Males are significantly overrepresented and more severely affected, and we speculate that sex-linked traits could affect susceptibility to penetrance and the clinical spectrum of SETD1B variants. Conclusion: Insights from this extensive cohort will facilitate the counseling regarding the molecular and phenotypic landscape of newly diagnosed patients with the SETD1B-related syndrome

The Courtepaille house (1959-2020), a history of architecture

La maison Courtepaille est un nouveau programme des Trente glorieuses, un restaurant-grill dédié aux usagers de la route qui circulent en automobile. La première ouvre le 15 août 1961, à Rouvray. Son architecture est reproduite en série jusqu’aux années 1990 plus d’une centaine de fois. Dans l’hexagone, son succès est quasi immédiat et reste inégalé. Mais hors de France, l’entreprise ne réussit pas à s’installer durablement. L’histoire de la maison Courtepaille révèle l’évolution de la société française dans cette période de croissance, de nouvelles mobilités, façons de consommer et de se restaurer ; et éclaire le processus par lequel cette transformation s’est opérée. Elle expose les mythologismes hérités du XIXe siècle et de l’école républicaine, et les modes qui ont fait son succès : le barbecue, les décorations rustiques et les chaumières. Elle dévoile l’expression d’une double utopie : celle d’une culture nationale unique, et celle d’une humanité « en même temps » archaïque et moderne.The Courtepaille house is a new program of the Trente glorieuses, a restaurant-grill dedicated to road users who travel by car. The first one opened on August 15, 1961, in Rouvray. Its architecture is reproduced in series until the 1990s more than a hundred times. In France, its success was almost immediate and remains unequalled. But outside France, the company did not succeed in establishing itself on a long-term basis. The history of the Courtepaille company reveals the evolution of French society in this period of growth, new mobilities, ways of consuming and eating; and sheds light on the process by which this transformation took place. It exposes the mythologies inherited from the 19th century and the republican school, and the fashions that made its success: the barbecue, country-style decorations and thatched cottages. It reveals the expression of a double utopia: that of a unique national culture, and that of a humanity « at the same time » archaic and modern

Colaniella, foraminifère index du Permien tardif téthysien: propositions pour une taxonomie simplifiée, répartition géographique et environnements

Une classification simplifiee du genre Colaniella LIKHAREV est proposee: Colaniella ex gr. parva, Colaniella ex gr. lepida, Colaniella ex gr. minima. Elle correspond a la division du taxon en trois groupes morphologiques. La repartition geographique de ce taxon est inventoriée de meme que les environnements sedimentaires et les microfaunes associees. Les nouvelles decouvertes de C. ex gr. parva dans Ie Permien superieur des coupes de Mesagros (ile d'Egine, Grece), d'Emarat (N Elbourz, Iran) et du Wadi Wasil dans les montagnes centrales d'Oman sont decrites en detail. L'importance des Colanielles dans la biostratigraphie du Permien superieur tethysien est analysee et clarifiee au vu des travaux recents et Ie problème des migrations est abordé. A simplified taxonomic classification in 3 groups of the genus Colaniella LIKHAREV is proposed: Colaniella ex gr. parva, Colaniella ex gr. lepida, Colaniella ex gr. minima. The repartition of the eight main Colaniella biofacies is given and the paleogeographic distribution of this genus is presented on a late Permian map configuration. New late Permian localities with Colaniella ex gr. parva have been found: Aegina island (Greece), Emmarat in the northern Alborz (Iran) and Wadi Wasit in the central Oman Mountains. The stratigraphic range of Colaniella ex gr. parva is much longer than previously accepted even by specialists. This range begins in the early Midian (Abadehian) and ends in the late Changhsingian (Dorashamian), very close to the range of the genus. For environmental reasons and slow eastward migration we have apparent shorter ranges in the Eastern part of the Tethyan domain