Prestação de serviços em escritórios contábeis : um estudo aplicado com proposta de auditoria externa

Orientador: Mayla Cristina CostaMonografia(Especialização) - Universidade Federal do Paraná,Setor de Ciências Sociais Aplicadas, Curso de Especialização MBA em Auditoria Integra

Aplicabilidade e regulamentação sanitária da nanomedicina em grandes distúrbios do Sistema Nervoso Central (SNC)

In nanomedicine the nanocarriers are generally biocompatible, biodegradable with rapid biodistribution in the body and can be used to carry drugs or therapeutic genes. Thus, new drug delivery systems have been heavily exploited in the treatment of CNS disorders such as Parkinson's, Alzheimer's and glioma, since the CNS is a major challenge for therapeutic approaches due to the blood-brain barrier (BBB) and blood–cerebrospinal fluid (BCSFB). Thus, the scientific community together with government and private industry has added efforts to generate new formulations in nanoscale in order to achieve an appropriate therapeutic approach, satisfying, and that is within the principles of health monitoring for cerebral affections. This article aims to summarize the knowledge about the main barriers to drug delivery to the CNS, Nanomedicine, Glioma, Parkinson's, Alzheimer's and sanitary surveillance.Na nanomedicina, os nanocarreadores são geralmente, biocompatíveis, biodegradáveis de rápida biodistribuição pelo organismo e podem ser utilizados para transportar drogas ou genes terapêuticos. Assim, novos sistemas de liberação de fármacos têm sido altamente explorados no tratamento de doenças do Sistema Nervoso Central (SNC), como Parkinson, Alzheimer e gliomas, visto que o SNC representa um grande desafio para as abordagens terapêuticas devido às barreiras hemato-encefálica (BHE) e sangue-líquido cefalorraquidiano (BSLCR). Desse modo, a comunidade científica juntamente com instituições governamentais e indústrias privadas vem somando esforços para gerar novas formulações em escalas nanométricas com o intuito de alcançar uma abordagem terapêutica adequada, satisfatória e que esteja dentro dos princípios da vigilância sanitária para os acometimentos cerebrais. Este artigo visa sumarizar os conhecimentos sobre principais barreiras para entrega de fármacos ao SNC, Nanomedicina, Glioma, Parkinson, Alzheimer e vigilância sanitária

Use of cerebrospinal fluid and serum samples impregnated on FTA (TM) Elute filter paper for the diagnosis of infections caused by Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae

BACKGROUND:The lack of information regarding the burden of acute bacterial meningitis in Latin America leads to a reduction in the estimated incidence rates of the disease, and impairs public health decisions on the use and follow-up of preventive interventions, particularly, the evaluation of existing vaccination policies. The use of the real-time PCR in diagnostic routine procedures has resulted in a substantial increase in confirmed bacterial meningitis cases. However, in resource-poor countries, these assays are only available in reference laboratories. Sample transportation to these laboratories is a critical constraint, as it requires specialized, high cost courier services. To overcome this barrier we evaluated the use of FTATM Elute filter paper cards for the conservation and processing of samples under normal environmental conditions, as they would be when transported from remote and under-equipped healthcare facilities to the reference centers. A total of 401 samples received in 2015 as part of Sao Paulo's national surveillance for routine diagnosis were selected for this study. METHODS:The sensitivity and specificity of real-time PCR were evaluated using fresh serum and cerebrospinal fluid (CSF) samples processed using our laboratory's standard DNA extraction, and processing the same samples after being dried and stored on FTATM card, and DNA extracted following the manufacturer's instructions. RESULTS:The sensitivities for detection of Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae from CSF dried and stored on FTATM cards were 98%, 92%, and 100%, respectively, and with serum samples were 73%, 88%, and 100%, respectively. When compared to our laboratory's standard methodology, results showed high concordance, with Kappa index ranges of 0.9877-1.00 for CSF, and 0.8004-1.00 for serum samples. CONCLUSION:The use of FTATM cards for CSF and serum conservation and transport represents a rapid, reliable, and cost-effective alternative that will allow obtaining valuable epidemiological information that would otherwise be lost

O uso da natureza em ações urbanísticas: a privatização do acesso ao solo em Recife-Brasil

Neste artigo discute-se o uso da natureza, através do problema do acesso ao solo em Recife, na tentativa de compreender a complexidade das relações sociedade-natureza na cidade. Visando operacionalizar este objetivo, utilizou-se de uma abordagem metodológica ampla e aberta com base em resultados da revisão bibliográfica executada na construção de um projeto de pesquisa sobre o tema. Como principal contribuição, tem-se que a gestão urbana deve levar em conta o “princípio de natureza” como bem coletivo no processo permanente de produção do espaço urbano, senão os espaços das nossas cidades tornar-se-ão ainda mais insustentáveis à vid

Isolamento de actinomicetales aeróbios do gênero Nocardia de processos infecciosos dos animais domésticos

It was described the isolation of Actinomicetales, genus Nocardia, associated with veterinary pathology, mainly with bovine mastitis. From a total of 28 sample isolate 24 were identified as Nocardia asteroides, all of them isolated from milk sources. The other one were classified as Nocardia brasiliensis and they were obtained from: swine vaginal swab (1); tracheal mucus of a Holstein-Friesian P. O. with pulmonary affections (1) and bovine mastitis milk samples (2).Descreveu-se o isolamento de Actinomicetales do gênero Nocardia associados à patologia veterinária, principalmente à mastite bovina. Foi isolado um total de 28 amostras; destas, 24 identificadas como Nocardia asteroides, todas provenientes de leite de vacas com mastite; as outras 04 amostras classificadas como Nocardia brasiliensis foram isoladas de: "swab" vaginal de suíno, muco traqueal de bovino da raça Holstein-friesian P.O. com comprometimento pulmonar e as outras duas do Leite de vacas com mastite

FORMAÇÃO CONTINUADA EM PROJETOS E PROGRAMAS SOCIAIS ESPORTIVOS: UM ESTUDO DE CASO

This descriptive, documental research looks into the process of continuing education for the Brazilian Ministry of Sports’ Program Segundo Tempo. Data collection consisted of applying electronic questionnaires to 23 pedagogical coordinators, 267 teachers, and 198 sports monitors from partner organizations as well as consulting internal documents of the National Office for Sports, Education, Leisure and Social Inclusion. By indicating and examining positive and negative aspects, it verified the effectiveness of the process of continuing education triggered by pedagogical training and supported by the teaching material offered to personnel working in the program.Este estudio descriptivo y documental tuvo como objetivo analizar el proceso de formación continua que ofrece el Programa Segundo Tempo del Ministerio de Deportes de Brasil. La recolección de datos consistió en cuestionarios electrónicos, respondidos por 23 coordinadores pedagógicos, 267 profesores y 198 monitores de deportes de entidades asociadas, y en la consulta a documentos internos de la Secretaría Nacional de Deportes, Educación, Recreación e Inclusión Social. Apuntando y analizando aspectos positivos y negativos, se constató la eficacia del proceso de formación continua, iniciado en la formación pedagógica y con el apoyo de materiales didácticos puestos a disposición de los recursos humanos que trabajan en el programa.Esta pesquisa descritiva e documental objetivou analisar o processo de formação continuada do Programa Segundo Tempo, do Ministério do Esporte brasileiro. A coleta de dados consistiu na aplicação de questionários eletrônicos, respondidos por 23 coordenadores pedagógicos, 267 professores e 198 monitores de esportes de entidades convenentes, e na consulta a documentos internos da Secretaria Nacional de Esporte, Educação, Lazer e Inclusão Social. Sob o apontamento e a análise de aspectos positivos e negativos, verificou-se efetividade no processo de formação continuada, deflagrado na capacitação pedagógica e amparado pelo material didático disponibilizado aos recursos humanos atuantes no programa.

Formación continua en proyectos y programas sociales deportivos : un estudio de caso

Esta pesquisa descritiva e documental objetivou analisar o processo de formação continuada do Programa Segundo Tempo, do Ministério do Esporte brasileiro. A coleta de dados consistiu na aplicação de questionários eletrônicos, respondidos por 23 coordenadores pedagógicos, 267 professores e 198 monitores de esportes de entidades convenentes, e na consulta a documentos internos da Secretaria Nacional de Esporte, Educação, Lazer e Inclusão Social. Sob o apontamento e a análise de aspectos positivos e negativos, verificou-se efetividade no processo de formação continuada, deflagrado na capacitação pedagógica e amparado pelo material didático disponibilizado aos recursos humanos atuantes no programa.This descriptive, documental research looks into the process of continuing education for the Brazilian Ministry of Sports’ Program Segundo Tempo. Data collection consisted of applying electronic questionnaires to 23 pedagogical coordinators, 267 teachers, and 198 sports monitors from partner organizations as well as consulting internal documents of the National Office for Sports, Education, Leisure and Social Inclusion. By indicating and examining positive and negative aspects, it verified the effectiveness of the process of continuing education triggered by pedagogical training and supported by the teaching material offered to personnel working in the program.Este estudio descriptivo y documental tuvo como objetivo analizar el proceso de formación continua que ofrece el Programa Segundo Tempo del Ministerio de Deportes de Brasil. La recolección de datos consistió en cuestionarios electrónicos, respondidos por 23 coordinadores pedagógicos, 267 profesores y 198 monitores de deportes de entidades asociadas, y en la consulta a documentos internos de la Secretaría Nacional de Deportes, Educación, Recreación e Inclusión Social. Apuntando y analizando aspectos positivos y negativos, se constató la eficacia del proceso de formación continua, iniciado en la formación pedagógica y con el apoyo de materiales didácticos puestos a disposición de los recursos humanos que trabajan en el programa

Building a Portuguese Coalition for Biodiversity Genomics

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes, overexploitation or pathogen (re)emergence. The inventory, characterization and study of biodiversity at inter- and intra-specific levels using genomics is crucial to promote its preservation and recovery by informing biodiversity conservation policies, management measures and research. The participation of researchers from Portuguese institutions in the European Reference Genome Atlas (ERGA) initiative, and its pilot effort to generate reference genomes for European biodiversity, has reinforced the establishment of Biogenome Portugal. This nascent institutional network will connect the national community of researchers in genomics. Here, we describe the Portuguese contribution to ERGA’s pilot effort, which will generate high-quality reference genomes of six species from Portugal that are endemic, iconic and/or endangered, and include plants, insects and vertebrates (fish, birds and mammals) from mainland Portugal or the Azores islands. In addition, we outline the objectives of Biogenome Portugal, which aims to (i) promote scientific collaboration, (ii) contribute to advanced training, (iii) stimulate the participation of institutions and researchers based in Portugal in international biodiversity genomics initiatives, and (iv) contribute to the transfer of knowledge to stakeholders and engaging the public to preserve biodiversity. This initiative will strengthen biodiversity genomics research in Portugal and fuel the genomic inventory of Portuguese eukaryotic species. Such efforts will be critical to the conservation of the country’s rich biodiversity and will contribute to ERGA’s goal of generating reference genomes for European species.info:eu-repo/semantics/publishedVersio

CUBES : the Cassegrain U-band Efficient Spectrograph

In the era of Extremely Large Telescopes, the current generation of 8-10m facilities are likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (> 40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R >20, 000 (with a lower-resolution, sky-limited mode of R ~7, 000). With the design focusing on maximizing the instrument throughput (ensuring a Signal to Noise Ratio (SNR) ~20 per high-resolution element at 313 nm for U ~18.5 mag objects in 1h of observations), it will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the detailed design and construction phase. First science operations are planned for 2028

Climate seasonality limits leaf carbon assimilation and wood productivity in tropical forests

The seasonal climate drivers of the carbon cycle in tropical forests remain poorly known, although these forests account for more carbon assimilation and storage than any other terrestrial ecosystem. Based on a unique combination of seasonal pan-tropical data sets from 89 experimental sites (68 include aboveground wood productivity measurements and 35 litter productivity measurements), their associated canopy photosynthetic capacity (enhanced vegetation index, EVI) and climate, we ask how carbon assimilation and aboveground allocation are related to climate seasonality in tropical forests and how they interact in the seasonal carbon cycle. We found that canopy photosynthetic capacity seasonality responds positively to precipitation when rainfall is  < 2000 mm yr⁻¹ (water-limited forests) and to radiation otherwise (light-limited forests). On the other hand, independent of climate limitations, wood productivity and litterfall are driven by seasonal variation in precipitation and evapotranspiration, respectively. Consequently, light-limited forests present an asynchronism between canopy photosynthetic capacity and wood productivity. First-order control by precipitation likely indicates a decrease in tropical forest productivity in a drier climate in water-limited forest, and in current light-limited forest with future rainfall  < 2000 mm yr⁻¹