1,363 research outputs found
Algebraic structure of stochastic expansions and efficient simulation
We investigate the algebraic structure underlying the stochastic Taylor
solution expansion for stochastic differential systems.Our motivation is to
construct efficient integrators. These are approximations that generate strong
numerical integration schemes that are more accurate than the corresponding
stochastic Taylor approximation, independent of the governing vector fields and
to all orders. The sinhlog integrator introduced by Malham & Wiese (2009) is
one example. Herein we: show that the natural context to study stochastic
integrators and their properties is the convolution shuffle algebra of
endomorphisms; establish a new whole class of efficient integrators; and then
prove that, within this class, the sinhlog integrator generates the optimal
efficient stochastic integrator at all orders.Comment: 19 page
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Implications of moderate altitude training for sea level endurance in elite distance runners
Elite distance runners participated in one of
two studies designed to investigate the e ects of mod-
erate altitude training (inspiratory partial pressure of
oxygen »115±125 mmHg) on submaximal, maximal and
supramaximal exercise performance following return to
sea-level. Study 1 (New Mexico, USA) involved 14
subjects who were assigned to a 4-week altitude training
camp (1500±2000 m) whilst 9 performance-matched
subjects continued with an identical training programme
at sea-level (CON). Ten EXP subjects who trained at
1640 m and 19 CON subjects also participated in study 2
(Krugersdorp, South Africa). Selected metabolic and
cardiorespiratory parameters were determined with the
subjects at rest and during exercise 21 days prior to
(PRE) and 10 and 20 days following their return to sea-
level (POST). Whole blood lactate decreased by 23%
(P < 0.05 vs PRE) during submaximal exercise in the
EXP group only after 20 days at sea-level (study 1).
However, the lactate threshold and other measures of
running economy remained unchanged. Similarly, su-
pramaximal performance during a standardised track
session did not change. Study 2 demonstrated that
hypoxia per se did not alter performance. In contrast, in
the EXP group supramaximal running velocity de-
creased by 2% (P < 0.05) after 20 days at sea-level.
Both studies were characterised by a 50% increase in the
frequency of upper respiratory and gastrointestinal tract
infections during the altitude sojourns, and two male
subjects were diagnosed with infectious mononucleosis
following their return to sea-level (study 1). Group mean
plasma glutamine concentrations at rest decreased by
19% or 143 (74) lM (P < 0.001) after 3 weeks at alti-
tude, which may have been implicated in the increased
incidence of infectious illness
Optimal -beam at the CERN-SPS
A -beam with maximum (for \helio ions) or
(for \neon) could be achieved at the CERN-SPS. We study the sensitivity to
and of such a beam as function of , optimizing
with the baseline constrained to CERN-Frejus (130 km), and also with
simultaneous variation of the baseline. These results are compared to the {\it
standard} scenario previously considered, with lower , and also
with a higher option that requires a more powerful
accelerator. Although higher is better, loss of sensitivity to and is most pronounced for below 100.Comment: 22 page
Untangling CP Violation and the Mass Hierarchy in Long Baseline Experiments
In the overlap region, for the normal and inverted hierarchies, of the
neutrino-antineutrino bi-probability space for appearance,
we derive a simple identity between the solutions in the (, ) plane for the different hierarchies. The
parameter sets the scale of the
appearance probabilities at the atmospheric eV whereas controls the amount of CP
violation in the lepton sector. The identity between the solutions is that the
difference in the values of for the two hierarchies equals twice
the value of divided by the {\it critical} value
of . We apply this identity to the two proposed
long baseline experiments, T2K and NOA, and we show how it can be used to
provide a simple understanding of when and why fake solutions are excluded when
two or more experiments are combined. The identity demonstrates the true
complimentarity of T2K and NOA.Comment: 15 pages, Latex, 4 postscript figures. Submitted to New Journal of
Physics, ``Focus on Neutrino Physics'' issu
Lumen-oriented versus wall-oriented treatment strategies for intracranial aneurysms - A systematic review of suggested therapeutic concepts.
The development of new treatment strategies for intracranial aneurysms (IAs) has been and continues to be a major interest in neurovascular research. Initial treatment concepts were mainly based on a physical-mechanistic disease understanding for IA occlusion (lumen-oriented therapies). However, a growing body of literature indicates the important role of aneurysm wall biology (wall-oriented therapies) for complete IA obliteration. This systematic literature review identified studies that explored endovascular treatment strategies for aneurysm treatment in a preclinical setting. Of 5278 publications screened, 641 studies were included, categorized, and screened for eventual translation in a clinical trial. Lumen-oriented strategies included (1) enhanced intraluminal thrombus organization, (2) enhanced intraluminal packing, (3) bridging of the intraluminal space, and (4) other, alternative concepts. Wall-oriented strategies included (1) stimulation of proliferative response, (2) prevention of aneurysm wall cell injury, (3) inhibition of inflammation and oxidative stress, and (4) inhibition of extracellular matrix degradation. Overall, lumen-oriented strategies numerically still dominate over wall-oriented strategies. Among the plethora of suggested preclinical treatment strategies, only a small minority were translated into clinically applicable concepts (36 of 400 lumen-oriented and 6 of 241 wall-oriented). This systematic review provides a comprehensive overview that may provide a starting point for the development of new treatment strategies
Study of the eightfold degeneracy with a standard -Beam and a Super-Beam facility
The study of the eightfold degeneracy at a neutrino complex that includes a
standard -Beam and a Super-Beam facility is presented for the first time
in this paper. The scenario where the neutrinos are sent toward a Megaton water
Cerenkov detector located at the Fr\'{e}jus laboratory (baseline 130 Km) is
exploited. The performance in terms of sensitivity for measuring the continuous
( and ) and discrete ( and
) oscillation parameters for the -Beam
and Super-Beam alone, and for their combination has been studied. A brief
review of the present uncertainties on the neutrino and antineutrino
cross-sections is also reported and their impact on the discovery potential
discussed
The impact of biogenic VOC emissions on photochemical ozone formation during a high ozone pollution episode in the Iberian Peninsula in the 2003 summer season
Throughout Europe the summer of 2003 was exceptionally warm, especially July and August. The European Environment Agency (EEA) reported several ozone episodes, mainly in the first half of August. These episodes were exceptionally long-lasting, spatially extensive, and associated to high temperatures. In this paper, the 10$ndash;15 August 2003 ozone pollution event has been analyzed using meteorological and regional air quality modelling. During this period the threshold values of the European Directive 2002/3/EC were exceeded in various areas of the Iberian Peninsula. <br><br> The aim of this paper is to computationally understand and quantify the influence of biogenic volatile organic compound (BVOC) emissions in the formation of tropospheric ozone during this high ozone episode. Being able to differentiate how much ozone comes from biogenic emissions alone and how much comes from the interaction between anthropogenic and biogenic emissions would be helpful to develop a feasible and effective ozone control strategy. The impact on ozone formation was also studied in combination with various anthropogenic emission reduction strategies, i.e., when anthropogenic VOC emissions and/or NO<sub>x</sub> emissions are reduced. The results show a great dependency of the BVOC contribution to ozone formation on the antropoghenic reduction scenario. In rural areas, the impact due to a NO<sub>x</sub> and/or VOC reduction does not change the BVOC impact. Nevertheless, within big cities or industrial zones, a NO<sub>x</sub> reduction results in a decrease of the biogenic impact in ozone levels that can reach 85 &mu;g/m<sup>3</sup>, whereas an Anthropogenic Volatile Organic Compound (AVOC) reduction results in a decrease of the BVOC contribution on ozone formation that varies from 0 to 30 &mu;g/m<sup>3</sup> with respect to the contribution at the same points in the 2003 base scenario. On the other hand, downwind of the big cities, a decrease in NO<sub>x</sub> produces a minor contribution of biogenic emissions and a decrease in AVOCs results in greater contributions of BVOCs to the formation of ozone
Sensitivity analysis of surface ozone to modified initial and boundary conditions in both rural and industrial zones
International audienceA three-dimensional air quality model based on a set of chemical species mass conservation equations describes the time evolution of chemical species in the atmosphere. In order to solve this set of equations, proper choices of initial and boundary conditions are needed. Ideally, initial and boundary conditions should be determined on the basis of observations. However, since such high-resolution observations are generally not available, it becomes necessary to use other information sources to specify the initial and boundary values. The fact that both the initial and the boundary conditions are specified with some degree of presumption makes it important to evaluate their influence in the model results. In this paper we present a study of the impact of initial and boundary concentrations on the modelled surface ozone concentration over two environments: Huelva and Badajoz, an industrial and a rural zone, respectively. The impacts are analysed for the same meteorological period (10?15 August 2003)
Swallowing Activity Assessed by Ambulatory Impedance-pH Monitoring Predicts Awake and Asleep Periods at Night
Introduction: Voluntary muscle activity, including swallowing, decreases during the night. The association between nocturnal awakenings and swallowing activity is under-researched with limited information on the frequency of swallows during awake and asleep periods. Aim: The aim of this study was to assess nocturnal swallowing activity and identify a cut-off predicting awake and asleep periods. Methods: Patients undergoing impedance-pH monitoring as part of GERD work-up were asked to wear a wrist activity detecting device (Actigraph®) at night. Swallowing activity was quantified by analysing impedance changes in the proximal esophagus. Awake and asleep periods were determined using a validated scoring system (Sadeh algorithm). Receiver operating characteristics (ROC) analyses were performed to determine sensitivity, specificity and accuracy of swallowing frequency to identify awake and asleep periods. Results: Data from 76 patients (28male, 48 female; mean age 56±15years) were included in the analysis. The ROC analysis found that 0.33sw/min (i.e. one swallow every 3min) had the optimal sensitivity (78%) and specificity (76%) to differentiate awake from asleep periods. A swallowing frequency of 0.25sw/min (i.e. one swallow every 4min) was 93% sensitive and 57% specific to identify awake periods. A swallowing frequency of 1sw/min was 20% sensitive but 96% specific in identifying awake periods. Summary and Conclusion: Impedance-pH monitoring detects differences in swallowing activity during awake and asleep periods. Swallowing frequency noticed during ambulatory impedance-pH monitoring can predict the state of consciousness during nocturnal period
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