56 research outputs found
SIRS Digues V2 : Le logiciel métier coopératif pour les professionnels de la gestion des digues (et cours d'eau)
La collecte et la gestion des donnĂ©es sont de nos jours devenues essentielles. Il est indispensable de pouvoir gĂ©rer, ordonner et pĂ©renniser lâinformation. Ă lâĂšre du Big data, la concatĂ©nation et la fiabilitĂ© des connaissances, associĂ©es Ă une analyse pointue, amĂ©liorent grandement lâexpertise gĂ©nĂ©rale. Par le biais dâune technologie toujours plus pertinente et pointue, la donnĂ©e se transforme aujourdâhui en hypothĂšses, en faits qui permettent de comprendre voire mĂȘme dâanticiper divers phĂ©nomĂšnes et activitĂ©s.
Il y a prĂšs de 9 000 km de digues en France. Ces constructions, sont, pour la plupart trĂšs anciennes, et la connaissance de leurs caractĂ©ristiques reste incomplĂšte. Ainsi La collecte et la gestion des donnĂ©es relatives aux endiguements reprĂ©sentent de vĂ©ritables enjeux pour leurs gestionnaires. Un besoin de restitution de cette donnĂ©e collectĂ©e et archivĂ©e, est aussi omniprĂ©sent. La donnĂ©e doit ĂȘtre accessible rapidement afin de procĂ©der Ă des diagnostics vĂ©loces et pertinents, dans lâobjectif dâune intervention, au jour le jour, adaptĂ©e, mais surtout de bĂ©nĂ©ficier dâune rĂ©activitĂ© opĂ©rationnelle face au risque dâinondation.
Lâoutil SIRS digues a Ă©tĂ© dĂ©veloppĂ© par et pour les gestionnaires dans ce sens. Il sâagit dâun logiciel libre dĂ©diĂ© Ă la gestion des digues et des cours dâeau, couplant base donnĂ©es, base documentaire et cartographie interactive. Il fait suite Ă une premiĂšre version devenue obsolĂšte qui Ă©tait utilisĂ© par un nombre restreint de gestionnaires qui souhaitait alors partager cet outil.
Câest lâhistoire du SIRS dans un premier temps, puis sa description dĂ©taillĂ©e ainsi que le rĂŽle de France Digues et les perspectives dâavenir, qui seront prĂ©sentĂ©es dans cet Ă©crit
Qualitative modelling and analysis of regulations in multi-cellular systems using Petri nets and topological collections
In this paper, we aim at modelling and analyzing the regulation processes in
multi-cellular biological systems, in particular tissues.
The modelling framework is based on interconnected logical regulatory
networks a la Rene Thomas equipped with information about their spatial
relationships. The semantics of such models is expressed through colored Petri
nets to implement regulation rules, combined with topological collections to
implement the spatial information.
Some constraints are put on the the representation of spatial information in
order to preserve the possibility of an enumerative and exhaustive state space
exploration.
This paper presents the modelling framework, its semantics, as well as a
prototype implementation that allowed preliminary experimentation on some
applications.Comment: In Proceedings MeCBIC 2010, arXiv:1011.005
Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish
The authors would like to thank the Royal Society of London, the National Eye Research Centre, the Visual Research Trust, Fight for Sight, the W.H. Ross Foundation, the Rosetrees Trust, and the Glasgow Childrenâs Hospital Charity for supporting this work. This work was also supported by the Deanship of Scientific Research at King Saud University for funding this research (Research Project) grant number âRGP â VPP â 219â.Mutations in the RPGR-interacting protein 1 (RPGRIP1) gene cause recessive Leber congenital amaurosis (LCA), juvenile retinitis pigmentosa (RP) and cone-rod dystrophy. RPGRIP1 interacts with other retinal disease-causing proteins and has been proposed to have a role in ciliary protein transport; however, its function remains elusive. Here, we describe a new zebrafish model carrying a nonsense mutation in the rpgrip1 gene. Rpgrip1homozygous mutants do not form rod outer segments and display mislocalization of rhodopsin, suggesting a role for RPGRIP1 in rhodopsin-bearing vesicle trafficking. Furthermore, Rab8, the key regulator of rhodopsin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants. The degeneration of rod cells is early onset, followed by the death of cone cells. These phenotypes are similar to that observed in LCA and juvenile RP patients. Our data indicate RPGRIP1 is necessary for rod outer segment development through regulating ciliary protein trafficking. The rpgrip1 mutant zebrafish may provide a platform for developing therapeutic treatments for RP patients.Publisher PDFPeer reviewe
Polymer Pipes for Distributing Mixtures of Hydrogen and Natural Gas: Evolution of their Transport and Mechanical Properties after an Ageing under an Hydrogen Environment
International audienc
Creep compression behaviour of a polyurethane foam from cryogenic temperatures: size effect and long-term prediction
The objective of this work was to predict the long term behavior of Polyurethane foam (PU) at very low-temperature, by applying the time-temperature superposition principle (TTSP). The experimental background of the TTSP was based on a Dynamical Mechanical Analysis technique. Two issues arise from this experimental approach: the relevance of the temperature range to apply the TTSP, and the possible size-effect associated to the small DMA samples. Firstly, on the studied temperature range (-170°C; +180°C) many transitions have been observed, particularly from -20°C. Thus to apply the TTSP, it would be necessary to limit the temperature range (between temperature of molecular transitions, i.e. from -20°C up to 80°C). At very low temperatures, DMA spectra did not evidence any viscoelastic domain. However a deformation has been measured during creep tests in the same temperature range. So it would be necessary to determine which micro-mechanism is responsible for the observed deformation. Secondly, it was important to determine if the volume of DMA sample was representative. Several techniques have shown that a representative volume would be reached between 8 and 12mm3
« LâĂ©valuation psychologique » en structure dâĂ©valuation et traitement de la douleur chronique : une nouvelle figure de la paradoxalitĂ© ?
International audienc
Creep compression behaviour of a polyurethane foam from cryogenic temperatures: size effect and long-term prediction
The objective of this work was to predict the long term behavior of Polyurethane
foam (PU) at very low-temperature, by applying the time-temperature
superposition principle (TTSP). The experimental background of the TTSP was
based on a Dynamical Mechanical Analysis technique. Two issues arise from this
experimental approach: the relevance of the temperature range to apply the TTSP,
and the possible size-effect associated to the small DMA samples. Firstly, on
the studied temperature range (-170°C; +180°C) many transitions have been
observed, particularly from -20°C. Thus to apply the TTSP, it would be necessary
to limit the temperature range (between temperature of molecular transitions,
i.e. from -20°C up to 80°C). At very low temperatures, DMA spectra did not
evidence any viscoelastic domain. However a deformation has been measured during
creep tests in the same temperature range. So it would be necessary to determine
which micro-mechanism is responsible for the observed deformation. Secondly, it
was important to determine if the volume of DMA sample was representative.
Several techniques have shown that a representative volume would be reached
between 8 and 12mm3
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