La música en la Educación Infantil. La canción como herramienta para el desarrollo global del niño

El presente trabajo de fin de grado recoge la investigación que he llevado a cabo sobre la importancia de la música en la etapa de infantil, profundizando en la utilización de las canciones infantiles como herramienta pedagógica para el desarrollo integral del niño. En lugar de la investigación directa con niños, basé mis hallazgos en el trabajo de otros grandes pedagogos, musicólogos, compositores y críticos musicales. Apoyándome en esta investigación, desarrollé una propuesta didáctica basada en canciones infantiles desde una perspectiva globalizada. Esta propuesta se fundamenta en los diferentes bloques reflejados en las tres áreas en las que se divide el currículo del segundo ciclo de Educación Infantil de la Comunidad de Castilla y León.Grado en Educación Infanti

Enantiomeric analysis of pyrethroids and organophosphorus insecticides

The use of pesticides has increased sharply in the last decades, not only in agriculture, but also in industry, public health, and other areas. Pyrethroids and organophosphorus insecticides are among the most employed pesticides. These chemicals usually contain asymmetric chiral atoms; thus, they are characterized by stereoisomerism. Although most of these chiral pesticides are produced, used, and released as racemic mixtures, the different enantiomers of these compounds can present different insecticidal activity, different toxicity against vertebrates and invertebrates, and also different persistence in the environment. In fact, in some cases, only one enantiomer is active, while the other can be less active or even toxic to non-target organisms. Therefore, the development of enantioselective analytical methodologies enabling their determination presents a high interest. Different separation techniques, including high performance liquid chromatography, gas chromatography, supercritical fluid chromatography, and capillary electrophoresis, have been employed to achieve the chiral analysis of pyrethroids and organophosphorus insecticides. This review presents the characteristics of the stereoselective analytical methodologies developed with this aim from 2010 to April 2019 and their applications to the analysis of real samples as well as for toxicity and biodegradation studies

The role of Artificial Intelligence and Distributed computing in IoT applications

[ES] La serie «El rol de la inteligencia artificial y la computación distribuida en las aplicaciones IoT» contiene publicaciones sobre la teoría y aplicaciones de la computación distribuida y la inteligencia artificial en el Internet de las cosas. Prácticamente todas las disciplinas como la ingeniería, las ciencias naturales, la informática y las ciencias de la información, las TIC, la economía, los negocios, el comercio electrónico, el medio ambiente, la salud y las ciencias de la vida están cubiertas. La lista de temas abarca todas las áreas de los sistemas inteligentes modernos y la informática como: inteligencia computacional, soft computing incluyendo redes neuronales, inteligencia social, inteligencia ambiental, sistemas auto-organizados y adaptativos, computación centrada en el ser humano y centrada en el ser humano, sistemas de recomendación, control inteligente, robótica y mecatrónica, incluida la colaboración entre el ser humano y la máquina, paradigmas basados en el conocimiento, paradigmas de aprendizaje, ética de la máquina, análisis inteligente de datos, gestión del conocimiento, agentes inteligentes, toma de decisiones inteligentes y apoyo, seguridad de la red inteligente, gestión de la confianza, entretenimiento interactivo, inteligencia de la Web y multimedia. Las publicaciones en el marco de «El rol de la inteligencia artificial y la computación distribuida en las aplicaciones IoT» son principalmente las actas de seminarios, simposios y conferencias. Abarcan importantes novedades recientes en la materia, tanto de naturaleza fundacional como aplicable. Un importante rasgo característico de la serie es el corto tiempo de publicación. Esto permite una rápida y amplia difusión de los resultados de las investigaciones[EN] The series «The Role of Artificial Intelligence and Distributed Computing in IoT Applications» contains publications on the theory and applications of distributed computing and artificial intelligence in the Internet of Things. Virtually all disciplines such as engineering, natural sciences, computer and information sciences, ICT, economics, business, e-commerce, environment, health and life sciences are covered. The list of topics covers all areas of modern intelligent systems and computer science: computational intelligence, soft computing including neural networks, social intelligence, ambient intelligence, self-organising and adaptive systems, human-centred and people-centred computing, recommendation systems, intelligent control, robotics and mechatronics including human-machine collaboration, knowledge-based paradigms, learning paradigms, machine ethics, intelligent data analysis, knowledge management, intelligent agents, intelligent decision making and support, intelligent network security, trust management, interactive entertainment, web intelligence, and multimedia. The publications in the framework of «The Role of Artificial Intelligence and Distributed Computing in IoT Applications» are mainly the proceedings of seminars, symposia and conferences. They cover important recent developments in the field, whether of a foundational or applicable character. An important feature of the series is the short publication time. This allows for the rapid and wide dissemination of research results

Multivariate analyses of soluble salts responsible for pathologies in granites of the roman aquecuct of Segovia, Spain.

8 páginas, 2 figuras, 3 tablasThe aim of this work is to characterize the main pathologies caused by salt crystallization in granitic monuments (crusts, salt efflorescence, disaggregation and disaggregation with salt efflorescence). Water soluble ions were determined quantitatively. Using the Canonical Biplot multivariate method it was determined that: a) there is a relationship between the content of water soluble salts and the different identified pathologies; b) sulphate and NO3 -, Cl-, Ca2+, Mg2+, K+ and Na+ ions are the major components of salt efflorescence; c) carbonate is a major component of the crust; and d) the disaggregated granites, with or without salt efflorescence, have a low proportion of soluble salts but no predominant ion composition.The authors are grateful for the funding received from the Town Hall of Segovia, and the National Plan project funded by the Ministry of Education and Science (CGL2007-62168BET and FEDER funds) and Ministry of Science and Innovation (MAT2010-20660)], which permitted this work to be carried out.Peer reviewe

Preface

[ES] La serie «El rol de la inteligencia artificial y la computación distribuida en las aplicaciones IoT» contiene publicaciones sobre la teoría y aplicaciones de la computación distribuida y la inteligencia artificial en el Internet de las cosas. Prácticamente todas las disciplinas como la ingeniería, las ciencias naturales, la informática y las ciencias de la información, las TIC, la economía, los negocios, el comercio electrónico, el medio ambiente, la salud y las ciencias de la vida están cubiertas. La lista de temas abarca todas las áreas de los sistemas inteligentes modernos y la informática como: inteligencia computacional, soft computing incluyendo redes neuronales, inteligencia social, inteligencia ambiental, sistemas auto-organizados y adaptativos, computación centrada en el ser humano y centrada en el ser humano, sistemas de recomendación, control inteligente, robótica y mecatrónica, incluida la colaboración entre el ser humano y la máquina, paradigmas basados en el conocimiento, paradigmas de aprendizaje, ética de la máquina, análisis inteligente de datos, gestión del conocimiento, agentes inteligentes, toma de decisiones inteligentes y apoyo, seguridad de la red inteligente, gestión de la confianza, entretenimiento interactivo, inteligencia de la Web y multimedia. Las publicaciones en el marco de «El rol de la inteligencia artificial y la computación distribuida en las aplicaciones IoT» son principalmente las actas de seminarios, simposios y conferencias. Abarcan importantes novedades recientes en la materia, tanto de naturaleza fundacional como aplicable. Un importante rasgo característico de la serie es el corto tiempo de publicación. Esto permite una rápida y amplia difusión de los resultados de las investigaciones[EN] The series «The Role of Artificial Intelligence and Distributed Computing in IoT Applications» contains publications on the theory and applications of distributed computing and artificial intelligence in the Internet of Things. Virtually all disciplines such as engineering, natural sciences, computer and information sciences, ICT, economics, business, e-commerce, environment, health and life sciences are covered. The list of topics covers all areas of modern intelligent systems and computer science: computational intelligence, soft computing including neural networks, social intelligence, ambient intelligence, self-organising and adaptive systems, human-centred and people-centred computing, recommendation systems, intelligent control, robotics and mechatronics including human-machine collaboration, knowledge-based paradigms, learning paradigms, machine ethics, intelligent data analysis, knowledge management, intelligent agents, intelligent decision making and support, intelligent network security, trust management, interactive entertainment, web intelligence, and multimedia. The publications in the framework of «The Role of Artificial Intelligence and Distributed Computing in IoT Applications» are mainly the proceedings of seminars, symposia and conferences. They cover important recent developments in the field, whether of a foundational or applicable character. An important feature of the series is the short publication time. This allows for the rapid and wide dissemination of research results

Silicon PV module customization using laser technology for new BIPV applications

It is well known that lasers have helped to increase efficiency and to reduce production costs in the photovoltaic (PV) sector in the last two decades, appearing in most cases as the ideal tool to solve some of the critical bottlenecks of production both in thin film (TF) and crystalline silicon (c-Si) technologies. The accumulated experience in these fields has brought as a consequence the possibility of using laser technology to produce new Building Integrated Photovoltaics (BIPV) products with a high degree of customization. However, to produce efficiently these personalized products it is necessary the development of optimized laser processes able to transform standard products in customized items oriented to the BIPV market. In particular, the production of semitransparencies and/or freeform geometries in TF a-Si modules and standard c-Si modules is an application of great interest in this market. In this work we present results of customization of both TF a-Si modules and standard monocrystalline (m-Si) and policrystalline silicon (pc-Si) modules using laser ablation and laser cutting processes. A discussion about the laser processes parameterization to guarantee the functionality of the device is included. Finally some examples of final devices are presented with a full discussion of the process approach used in their fabrication

Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying molecular mechanisms leading to EWS metastases remain poorly understood. Epigenetic changes have been implicated in EWS tumor growth and progression. Linking epigenetics and metastases may provide insight into novel molecular targets in EWS and improve its treatment. Here, we evaluated the effects of a selective G9a histone methyltransferase inhibitor (BIX01294) on EWS metastatic process. Our results showed that overexpression of G9a in tumors from EWS patients correlates with poor prognosis. Moreover, we observe a significantly higher expression of G9a in metastatic EWS tumor as compared to either primary or recurrent tumor. Using functional assays, we demonstrate that pharmacological G9a inhibition using BIX01294 disrupts several metastatic steps in vitro, such as migration, invasion, adhesion, colony formation and vasculogenic mimicry. Moreover, BIX01294 reduces tumor growth and metastases in two spontaneous metastases mouse models. We further identified the sialidase NEU1 as a direct target and effector of G9a in the metastatic process in EWS. NEU1 overexpression impairs migration, invasion and clonogenic capacity of EWS cell lines. Overall, G9a inhibition impairs metastases in vitro and in vivo through the overexpression of NEU1. G9a has strong potential as a prognostic marker and may be a promising therapeutic target for EWS patients

Barley-ß-glucans reduce systemic inflammation, renal injury and aortic calcification through ADAM17 and neutral-sphingomyelinase2 inhibition

In chronic kidney disease (CKD), hyperphosphatemia-induced inflammation aggravates vascular calcification (VC) by increasing vascular smooth muscle cell (VSMC) osteogenic differentiation, ADAM17-induced renal and vascular injury, and TNFα-induction of neutral-sphingomyelinase2 (nSMase2) to release pro-calcifying exosomes. This study examined anti-inflammatory β-glucans efficacy at attenuating systemic inflammation in health, and renal and vascular injury favoring VC in hyperphosphatemic CKD. In healthy adults, dietary barley β-glucans (Bβglucans) reduced leukocyte superoxide production, inflammatory ADAM17, TNFα, nSMase2, and pro-aging/pro-inflammatory STING (Stimulator of interferon genes) gene expression without decreasing circulating inflammatory cytokines, except for γ-interferon. In hyperphosphatemic rat CKD, dietary Bβglucans reduced renal and aortic ADAM17-driven inflammation attenuating CKD-progression (higher GFR and lower serum creatinine, proteinuria, kidney inflammatory infiltration and nSMase2), and TNFα-driven increases in aortic nSMase2 and calcium deposition without improving mineral homeostasis. In VSMC, Bβglucans prevented LPS- or uremic serum-induced rapid increases in ADAM17, TNFα and nSMase2, and reduced the 13-fold higher calcium deposition induced by prolonged calcifying conditions by inhibiting osteogenic differentiation and increases in nSMase2 through Dectin1-independent actions involving Bβglucans internalization. Thus, dietary Bβglucans inhibit leukocyte superoxide production and leukocyte, renal and aortic ADAM17- and nSMase2 gene expression attenuating systemic inflammation in health, and renal injury and aortic calcification despite hyperphosphatemia in CKD.A grant to A.S.D. and M.J.M. from IRBLleida and Agrotecnio Research collaborative projects from the Consell Social at Lleida University supported initial work, Instituto de Salud Carlos III and co-funded by European Union (ERDF/FEDER) (FIS PI11/00259, PI14/01452, PI17/02181), Plan de Ciencia, Tecnología e Innovación 2013–2017 y 2018–2022 del Principado de Asturias (GRUPIN14-028, IDI-2018-000152), RedInRen from ISCIII (ISCIII-RETIC REDINREN RD16/0009). Investigator support included: NC-L by GRUPIN14-028 and IDI-2018-000152, LM-A by GRUPIN14-028, SP by FICYT; MVA and PV by Educational Grant 2 A/2015 from ERA-EDTA CKD-MBD Working Group; PV and AC by ERA-EDTA fellowships 2011 and 2012; JR-C by MINECO (“Juan de la Cierva” program, FJCI-2015-23849); A.S.D. by Asociación Investigación de Fisiología Aplicada. A.S.D. and M.J.M. are members of the Campus Iberus (Ebro Valley Campus of International Excellence)

Abordaje de la insuficiencia cardiaca amiloidótica desde la pluripatología

A 88-year-old patient with personal clinical record of heart failure with left ventricular hypertrophy preserved ejection fraction and paroxysmal atrial flutter, is admitted due to a right heart failure, being diagnosed of natural transthyretin cardial amyloidosis. We approach the diagnostic process and its implications under the view of pluripathology which allows us to maintain the balance between nihilism and obstinacy upon the advances of the disease.  Paciente de 88 años con antecedentes de insuficiencia cardíaca, hipertrofia ventricular izquierda con fracción de eyección preservada y flutter auricular paroxístico. Ingresó por insuficiencia cardíaca de predominio derecho, siendo diagnosticada finalmente de amiloidosis cardíaca por transtiretina natural. Abordamos el proceso diagnóstico y las implicaciones del mismo desde una visión global e integradora que nos permite mantener el equilibrio entre el nihilismo y la obstinación ante los avances que se están produciendo en esta enfermedad