Final report on the evaluation of RRM/CRRM algorithms

Deliverable public del projecte EVERESTThis deliverable provides a definition and a complete evaluation of the RRM/CRRM algorithms selected in D11 and D15, and evolved and refined on an iterative process. The evaluation will be carried out by means of simulations using the simulators provided at D07, and D14.Preprin

Desenvolupar competències ètiques a l'educació musical i corporal. Un estudi empíric als estudis de mestre en educació infantil a la Universitat de Barcelona

This paper presents an ongoing investigation regarding ethical competence, protective factors, strengths of character and coping strategies analyzed in a sample of students in Early Childhood Education Degree from the University of Barcelona. Along with a theoretical study will be an observational study using standardized instruments and standardized, which include the VIA-IS questionnaire Seligman. With all that is expected to draw conclusions to improve the training of teachers in kindergarten, especially since the subjects of musical expression and body where they develop these skills ethics

Pyomelanin synthesis in alternaria alternata inhibits DHN-Melanin synthesis and decreases cell wall chitin content and thickness

The genus Alternaria includes several of fungi that are darkly pigmented by DHNmelanin. These are pathogenic to plants but are also associated with human respiratory allergic diseases and with serious infections in immunocompromised individuals. The present work focuses on the alterations of the composition and structure of the hyphal cell wall of Alternaria alternata occuring under the catabolism of L-tyrosine and L-phenylalanine when cultured in minimal salt medium (MM). Under these growing conditions, we observed the released of a brown pigment into the culture medium. FTIR analysis demonstrates that the produced pigment is chemically identical to the pigment released when the fungus is grown in MM with homogentisate acid (HGA), the intermediate of pyomelanin, confirming that this pigment is pyomelanin. In contrast to other fungi that also synthesize pyomelanin under tyrosine metabolism, A. alternata inhibits DHN-melanin cell wall accumulation when pyomelanin is produced, and this is associated with reduced chitin cell wall content. When A. alternata is grown in MM containing L-phenylalanine, a L-tyrosine percursor, pyomelanin is synthesized but only at trace concentrations and A. alternata mycelia display an albino-like phenotype since DHN-melanin accumulation is inhibited. CmrA, the transcription regulator for the genes coding for the DHN-melanin pathway, is involved in the down-regulation of DHN-melanin synthesis when pyomelanin is being synthetized, since the CMRA gene and genes of the enzymes involved in DHN-melanin synthesis pathway showed a decreased expression. Other amino acids do not trigger pyomelanin synthesis and DHN-melanin accumulation in the cell wall is not affected. Transmission and scanning electron microscopy show that the cell wall structure and surface decorations are altered in L-tyrosine- and L-phenylalanine-grown fungi, depending on the pigment produced. In summary, growth in presence of L-tyrosine and L-phenylalanine leads to pigmentation and cell wall changes, which could be relevant to infection conditions where these amino acids are expected to be available.This study was partly supported by the FEDER funds through the Operational Programme Competitiveness Factors-COMPETE and national funds by FCT-Foundation for Science and Technology under the strategic projects UIDB/00285/2020 and UID/NEU/04539/2013 the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme under project CENTRO-01-0145-FEDER-000012 and project CENTRO-01-0145-FEDER-022095:ViraVector, and through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, under project UIDB/04539/2020, and the European Regional Development Fund (ERDF), through the Centro 2020 Regional Operational Programme: project CENTRO-01-0145-FEDER- 000012-HealthyAging 2020, the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation, and the Portuguese national funds via FCT—Fundação para a Ciência e a Tecnologia, I.P.: project POCI-01-0145-FEDER- 007440. IF thank the Foundation for Science and Technology (FCT, Portugal) and FEDER under Program PT2020 for financial support to CIMO (UID/AGR/00690/2013), LB (SFRH/BPD/107855/2015) and MD (SFRH/BD/84485/2012) grants. To POCI-01-0145-FEDER-006984 (LA LSRE-LCM), funded by ERDF, through POCI-COMPETE2020 and FCT. AC was supported in part by 5R01HL059842, 5R01AI033774, 5R37AI033142, and 5R01AI052733.info:eu-repo/semantics/publishedVersio

Gene expression analyses determine two different subpopulations in KIT-negative GIST-like (KNGL) patients

Introduction: there are limited findings available on KIT-negative GIST-like (KNGL) population. Also, KIT expression may be post-transcriptionally regulated by miRNA221 and miRNA222. Hence, the aim of this study is to characterize KNGL population, by differential gene expression, and to analyze miRNA221/222 expression and their prognostic value in KNGL patients. Methods: KIT, PDGFRA, DOG1, IGF1R, MIR221 and MIR222 expression levels were determined by qRT-PCR. We also analyzed KIT and PDGFRA mutations, DOG1 expression, by immunohistochemistry, along with clinical and pathological data. Disease-free survival (DFS) and overall survival (OS) differences were calculated using Log-rank test. Results: hierarchical cluster analyses from gene expression data identified two groups: group I had KIT, DOG1 and PDGFRA overexpression and IGF1R underexpression and group II had overexpression of IGF1R and low expression of KIT, DOG1 and PDGFRA. Group II had a significant worse OS (p = 0.013) in all the series, and showed a tendency for worse OS (p = 0.11), when analyzed only the localized cases. MiRNA222 expression was significantly lower in a control subset of KIT-positive GIST (p < 0.001). OS was significantly worse in KNGL cases with higher expression of MIR221 (p = 0.028) or MIR222 (p = 0.014). Conclusions: we identified two distinct KNGL subsets, with a different prognostic value. Increased levels of miRNA221/222, which are associated with worse OS, could explain the absence of KIT protein expression of most KNGL tumors

A DM1 family with interruptions associated with atypical symptoms and late onset but not with a milder phenotype

Carriage of interruptions in CTG repeats of the myotonic dystrophy protein kinase gene has been associated with a broad spectrum of myotonic dystrophy type 1 (DM1) phenotypes, mostly mild. However, the data available on interrupted DM1 patients and their phenotype are scarce. We studied 49 Spanish DM1 patients, whose clinical phenotype was evaluated in depth. Blood DNA was obtained and analyzed through triplet‐primed polymerase chain reaction (PCR), long PCR‐Southern blot, small pool PCR, AciI digestion, and sequencing. Five patients of our registry (10%), belonging to the same family, carried CCG interruptions at the 3’ end of the CTG expansion. Some of them presented atypical traits such as a very late onset of symptoms (&gt;50 years) and a severe axial and proximal weakness requiring walking assistance. They also showed classic DM1 symptoms including cardiac and respiratory dysfunction, which were severe in some of them. Sizes and interrupted allele patterns were determined, and we found a contraction and an expansion in two intergenerational transmissions. Our study contributes to the observation that DM1 patients carrying interruptions present with atypical clinical features that can make DM1 diagnosis difficult, with a later than expected age of onset and a previously unreported aging‐related severe disease manifestation

Desenvolupar competències ètiques a l'educació musical i corporal. Un estudi empíric als estudis de mestre en educació infantil a la Universitat de Barcelona

This paper presents an ongoing investigation regarding ethical competence, protective factors, strengths of character and coping strategies analyzed in a sample of students in Early Childhood Education Degree from the University of Barcelona. Along with a theoretical study will be an observational study using standardized instruments and standardized, which include the VIA-IS questionnaire Seligman. With all that is expected to draw conclusions to improve the training of teachers in kindergarten, especially since the subjects of musical expression and body where they develop these skills ethics

Desenvolupar competències ètiques a l'educació musical i corporal: un estudi empíric als estudis de mestre en educació infantil a la Universitat de Barcelona

This paper presents an ongoing investigation regarding ethical competence, protective factors, strengths of character and coping strategies analyzed in a sample of students in Early Childhood Education Degree from the University of Barcelona. Along with a theoretical study will be an observational study using standardized instruments and standardized, which include the VIA-IS questionnaire Seligman. With all that is expected to draw conclusions to improve the training of teachers in kindergarten, especially since the subjects of musical expression and body where they develop these skills ethics.Este trabajo presenta una investigación en curso respecto las competencias éticas, los factores de protección, las fortalezas de caràcter y las estrategias de afrontamiento analizadas en una muestra de estudiantes del Grado de Educación Infantil de la Universidad de Barcelona. Junto con un estudio teórico se realizará un estudio observacional mediante unos instrumentos normalizados y estandarizados, entre los que figura el cuestionario VIA-IS de Seligman. Con todo ello se espera sacar conclusiones para mejorar la formación de los maestros de Educación Infantil, especialmente a partir de las asignaturas de expresión musical y corporal donde deben desarrollarse dichas competencias éticas

La transició a la societat xarxa a Catalunya. Informe final de recerca (volum II)

Aquest estudi analitza les pràctiques diàries, els valors socials i les actituds de la població catalana en el procés de transició cap a la societat xarxa. Analitza el comportament de les persones a Internet i fora d'Internet, investigant el paper específic dels usos d'Internet a l'hora d'influenciar pràctiques i actituds. Es basa en les respostes a una enquesta de 3.005 individus, una mostra representativa de la població catalana el 2002. L'enquesta es va fer entre el febrer i el maig del 2002, i es basava en entrevistes cara a cara a partir d'un qüestionari de 179 preguntes. Es van utilitzar fonts secundàries per a situar els resultats catalans, particularment sobre els usos d'Internet, en el context global. L'anàlisi es va completar el 2007 incorporant-hi noves dades secundàries. L'estudi va cobrir pràctiques socials de treball, comunicació, sociabilitat, usos d'espai i temps, usos d'Internet, identitat cultural, pràctica política, associacionisme i formació de projectes d'autonomia. Es van construir diversos models estadístics per a proporcionar una anàlisi causal de cada una d'aquestes àrees d'estudi. El descobriment més significatiu fa referència a la relació entre els usos d'Internet i la construcció d'autonomia per part d'actors socials. Fent servir anàlisis factorial, l'estudi va definir cinc índexs d'autonomia que eren estadísticament independents: autonomia personal, autonomia professional, autonomia comunicativa, autonomia corporal i autonomia sociopolítica. Cada un d'aquests índexs d'autonomia independents estan fortament associats amb la freqüència i la intensitat de l'ús d'Internet, i les relacions observades es mantenen quan es controlen per variables sociodemogràfiques. A partir d'aquest estudi es pot afirmar que Internet és una plataforma important per a la construcció d'autonomia en la societat xarxa. En general, la societat catalana sembla que canviï de manera similar a altres societats en transició, amb l'èmfasi afegit del paper del territori i la família a l'hora d'enfortir les relacions socials, amb la contribució positiva d'Internet a un dens patró d'interacció social.El estudio analiza las prácticas diarias, los valores sociales y las actitudes de la población catalana en el proceso de transición hacia la sociedad red. Analiza el comportamiento de las personas en Internet y fuera de Internet, investigando el papel específico de los usos de Internet a la hora de influenciar prácticas y actitudes. Se basa en las respuestas a una encuesta de 3.005 individuos, una muestra representativa de la población catalana en el 2002. La encuesta se realizó entre febrero y mayo del 2002, y se basó en entrevistas cara a cara a partir de un cuestionario de 179 preguntas. Se utilizaron fuentes secundarias para situar los resultados catalanes, particularmente sobre los usos de Internet, en el contexto global. El análisis se completó en el 2007 incorporando nuevos datos secundarios. El estudio cubrió las prácticas sociales de trabajo, comunicación, sociabilidad, usos de espacio y tiempo, usos de Internet, identidad cultural, práctica política, asociacionismo y formación de proyectos de autonomía. Se construyeron varios modelos estadísticos para proporcionar un análisis causal de cada una de estas áreas de estudio. El descubrimiento más significativo hace referencia a la relación entre los usos de Internet y la construcción de autonomía por los actores sociales. Utilizando análisis factorial, el estudio definió cinco índices de autonomía que eran independientes estadísticamente: la autonomía personal, la autonomía profesional, la autonomía comunicativa, la autonomía corporal y la autonomía sociopolítica. Cada uno de estos índices de autonomía independientes están estrechamente asociados con la frecuencia y la intensidad del uso de Internet, y las relaciones asociadas se mantienen cuando se controlan por variables sociodemográficas. A partir de este estudio se puede afirmar que Internet es una plataforma importante para la construcción de autonomía en la sociedad red. En general, la sociedad catalana parece cambiar del mismo modo que otras sociedades en transición, con el énfasis añadido del papel del territorio y la familia a la hora de fortalecer las relaciones sociales, con la contribución positiva de Internet a un patrón muy denso de interacción social.This study analyzes the everyday practices, social values, and attitudes of the Catalan population in the process of transition towards the network society. It analyzes behavior online and off-line, investigating the specific role of Internet uses in influencing practices and attitudes. It is based on the answers to a survey of 3,005 individuals, a representative sample of the Catalan population in 2002. The survey was conducted between February and May 2002, and was based on face-to-face interviews using a questionnaire of 179 questions. Secondary sources were used to place the Catalan findings, particularly on the uses of the Internet, in the global context. The analysis was completed in 2007 by incorporating new secondary data. The study covered social practices of work, communication, sociability, uses of space and time, uses of the Internet, cultural identity, political practice, associationism, and formation of individual projects. A number of statistical models were built to provide a causal analysis of each one of these areas of study. The most striking finding refers to the relationship between Internet uses and the construction of autonomy by social actors. Using factor analysis, the study defined five indexes of autonomy that were statistically independent: personal autonomy, professional autonomy, communicative autonomy, body autonomy, and socio-political autonomy. Each one of these independent autonomy indexes were closely associated with frequency and intensity of Internet use, and the relationship when controlled by socio-demographic variables. On the basis of this study it is possible to claim that Internet is a significant platform for the construction of autonomy in the network society. Overall, Catalan society seems to be changing along paths similar to those of other societies in transition, with the added emphasis of the role of territory and family in strengthening social relations, with the positive contribution of the Internet to a very dense pattern of social interaction

La transición en la sociedad red en Catalunya. Informe final de investigación (volumen I)

Aquest estudi analitza les pràctiques diàries, els valors socials i les actituds de la població catalana en el procés de transició cap a la societat xarxa. Analitza el comportament de les persones a Internet i fora d'Internet, investigant el paper específic dels usos d'Internet a l'hora d'influenciar pràctiques i actituds. Es basa en les respostes a una enquesta de 3.005 individus, una mostra representativa de la població catalana el 2002. L'enquesta es va fer entre el febrer i el maig del 2002, i es basava en entrevistes cara a cara a partir d'un qüestionari de 179 preguntes. Es van utilitzar fonts secundàries per a situar els resultats catalans, particularment sobre els usos d'Internet, en el context global. L'anàlisi es va completar el 2007 incorporant-hi noves dades secundàries. L'estudi va cobrir pràctiques socials de treball, comunicació, sociabilitat, usos d'espai i temps, usos d'Internet, identitat cultural, pràctica política, associacionisme i formació de projectes d'autonomia. Es van construir diversos models estadístics per a proporcionar una anàlisi causal de cada una d'aquestes àrees d'estudi. El descobriment més significatiu fa referència a la relació entre els usos d'Internet i la construcció d'autonomia per part d'actors socials. Fent servir anàlisis factorial, l'estudi va definir cinc índexs d'autonomia que eren estadísticament independents: autonomia personal, autonomia professional, autonomia comunicativa, autonomia corporal i autonomia sociopolítica. Cada un d'aquests índexs d'autonomia independents estan fortament associats amb la freqüència i la intensitat de l'ús d'Internet, i les relacions observades es mantenen quan es controlen per variables sociodemogràfiques. A partir d'aquest estudi es pot afirmar que Internet és una plataforma important per a la construcció d'autonomia en la societat xarxa. En general, la societat catalana sembla que canviï de manera similar a altres societats en transició, amb l'èmfasi afegit del paper del territori i la família a l'hora d'enfortir les relacions socials, amb la contribució positiva d'Internet a un dens patró d'interacció social.El estudio analiza las prácticas diarias, los valores sociales y las actitudes de la población catalana en el proceso de transición hacia la sociedad red. Analiza el comportamiento de las personas en Internet y fuera de Internet, investigando el papel específico de los usos de Internet a la hora de influenciar prácticas y actitudes. Se basa en las respuestas a una encuesta de 3.005 individuos, una muestra representativa de la población catalana en el 2002. La encuesta se realizó entre febrero y mayo del 2002, y se basó en entrevistas cara a cara a partir de un cuestionario de 179 preguntas. Se utilizaron fuentes secundarias para situar los resultados catalanes, particularmente sobre los usos de Internet, en el contexto global. El análisis se completó en el 2007 incorporando nuevos datos secundarios. El estudio cubrió las prácticas sociales de trabajo, comunicación, sociabilidad, usos de espacio y tiempo, usos de Internet, identidad cultural, práctica política, asociacionismo y formación de proyectos de autonomía. Se construyeron varios modelos estadísticos para proporcionar un análisis causal de cada una de estas áreas de estudio. El descubrimiento más significativo hace referencia a la relación entre los usos de Internet y la construcción de autonomía por los actores sociales. Utilizando análisis factorial, el estudio definió cinco índices de autonomía que eran independientes estadísticamente: la autonomía personal, la autonomía profesional, la autonomía comunicativa, la autonomía corporal y la autonomía sociopolítica. Cada uno de estos índices de autonomía independientes están estrechamente asociados con la frecuencia y la intensidad del uso de Internet, y las relaciones asociadas se mantienen cuando se controlan por variables sociodemográficas. A partir de este estudio se puede afirmar que Internet es una plataforma importante para la construcción de autonomía en la sociedad red. En general, la sociedad catalana parece cambiar del mismo modo que otras sociedades en transición, con el énfasis añadido del papel del territorio y la familia a la hora de fortalecer las relaciones sociales, con la contribución positiva de Internet a un patrón muy denso de interacción social.This study analyzes the everyday practices, social values, and attitudes of the Catalan population in the process of transition towards the network society. It analyzes behavior online and off-line, investigating the specific role of Internet uses in influencing practices and attitudes. It is based on the answers to a survey of 3,005 individuals, a representative sample of the Catalan population in 2002. The survey was conducted between February and May 2002, and was based on face-to-face interviews using a questionnaire of 179 questions. Secondary sources were used to place the Catalan findings, particularly on the uses of the Internet, in the global context. The analysis was completed in 2007 by incorporating new secondary data. The study covered social practices of work, communication, sociability, uses of space and time, uses of the Internet, cultural identity, political practice, associationism, and formation of individual projects. A number of statistical models were built to provide a causal analysis of each one of these areas of study. The most striking finding refers to the relationship between Internet uses and the construction of autonomy by social actors. Using factor analysis, the study defined five indexes of autonomy that were statistically independent: personal autonomy, professional autonomy, communicative autonomy, body autonomy, and socio-political autonomy. Each one of these independent autonomy indexes were closely associated with frequency and intensity of Internet use, and the relationship when controlled by socio-demographic variables. On the basis of this study it is possible to claim that Internet is a significant platform for the construction of autonomy in the network society. Overall, Catalan society seems to be changing along paths similar to those of other societies in transition, with the added emphasis of the role of territory and family in strengthening social relations, with the positive contribution of the Internet to a very dense pattern of social interaction