Metabolic response of endangered goats fed spineless cactus associated with Tifton-85 hay or Maniçoba hay

The aim of this study was to evaluate the effects of replacement of Tifton-85 hay by maniçoba hay, in spineless cactus-based diets, on markers of energy, protein, mineral metabolism and serum enzyme activity of Moxotó goats. Sixteen uncastrated male Moxotó breed goats, with 20 months old and initial body weight of 21.7 ± 3.92 kg were used in a randomized blocks design, using the initial weight as the criterion for the formation of blocks, with two treatments and eight replicates per treatment. The experimental treatments consisted of two diets: diets containing Miúda spineless cactus associated with Tifton-85 hay (1) or maniçoba hay (2), with roughage:concentrate ratio of 70:30. Blood samples were collected fortnightly (baseline, 15 days, 30 days and 45 days) during the feedlot period. There was a higher serum concentration of total protein and fructosamine (P < 0.05) in goats that received maniçoba hay. However, there was higher serum gamma-glutamyl transferase (GGT) enzyme activity in goats that ingested Tifton-85 hay (P < 0.05). Concerning to the profile of blood metabolites in the different fortnightly collections, it was possible to verify a significant effect for urea, fructosamine, GGT enzyme activity, K and Cl levels (P < 0.05). In conclusion, Tifton-85 hay and maniçoba hay combined with spineless cactus does not cause metabolic disorders in feedlot native goats

INGESTIVE BEHAVIOR OF BUFFALOES FED INCREASING LEVELS OF CONCENTRATE IN SUGARCANE BASED DIETS

The experiment was conducted to evaluate the ingestive behavior of buffalo fed sugarcane with different levels of concentrate. Twenty four Murrah buffaloes with body weight of 219±23 kg and nine months old were assigned to completely randomized design. Animals were placed in individual pens where they received diets ad libitum, twice a day. The experimental period has divided into 30 d for adaptation and 84 d for observations and samples collection. Four treatments were used: 1) 80% sugarcane (SC) + 20% concentrate (C); 2) 60% SC + 40% C; 3) 40% SC + 60% C; 4) 20% SC + 80% C. The diets were isoproteics and urea/ammonium sulfate was used at 9:1 ratio to correct the protein level of sugarcane. The evaluated variables were time spent feeding (TSF), ruminating (TSR), idle (TSI), dry matter intake (DMI), feeding efficiency of dry matter (FEDM), rumination efficiency of dry matter (REDM), number of meals, duration of meal and duration of breaks between meal. A regression analysis was performed using the MIXED procedure. DMI was positively affected (P0.05) on TSF. However, the TSR and number of meals decreased linearly (

Respostas fisiológicas de ovinos alimentados com genótipos de palma forrageira

Objetivou-se avaliar parâmetros fisiológicos de ovinos submetidos a dietas à base de palma forrageira e o grau de correlação entre estas variáveis e a ingestão de nutrientes digestíveis totais. Foram utilizados 36 cordeiros, com peso corporal inicial de 22.0±2.90 kg, idade média de seis meses, distribuídos em delineamento inteiramente casualizado, com três tratamentos e 12 repetições. O período experimental foi de 86 dias, sendo fornecida uma dieta base (controle) e dietas nas quais o feno de capim Tifton foi parcialmente substituído por palma miúda ou palma orelha de elefante mexicana. No 80º dia do período experimental, os animais foram submetidos à avaliação de respostas fisiológicas: frequência respiratória e cardíaca, temperatura retal e superficial, sendo esses dados coletados nos turnos da manhã e da tarde. Não houve interação significativa entre os fatores ‘dietas’ e ‘turno’, assim como não foi observado efeito das dietas sobre os parâmetros fisiológicos. Os valores de frequência respiratória e a temperatura superficial foram maiores no turno da manhã (98,73±32,30 respirações por minuto e 33,83ºC±0,81, respectivamente) em relação ao turno da tarde (78,79±24,53 respirações por minuto e 32,53ºC±0,89, respectivamente). Observaram-se significativos coeficientes de correlação positiva entre o consumo de energia e a frequência respiratória nos animais que receberam a dieta controle, no turno da manhã, e entre o consumo de energia e a temperatura corporal, no turno da tarde. Existe correlação positiva de moderada a forte magnitude entre o consumo de nutrientes digestíveis totais e a frequência respiratória e temperatura corporal de ovinos submetidos à dieta sem palma forrageira

Paracoccidioidomicose e infecção pelo virus da imunodeficiência humana

We present two cases of paracoccidioidorrvycosis, one occurring in an AIDS patient and the other in an HIV infected man. This is the first report of such association. The first patient, which was already followed for HIV infection (group IV-A) presented with high fever and hepatosplenomegaly. Plain X-ray, ultrasound and CT-scan of the abdomen showed solid nodules in the spleen, some of them with calcification. Both the direct smear and the culture of a bone marrow aspiration revealed Paracoccidioides brasiliensis. The patient died of acute disseminated Paracoccidioidomycosis. The second patient, a man anti-HIV seropositive presented with a mass on the right lower abdomen and inguinal region. A biopsy of the mass showed the association of Hodgkin's disease of the mixed cellularity type and paracoccidioidomycosis. With the expanding AIDS epidemic we believe this report emphasizes the need to consider Paracoccidioidomycosis in HIV infected persons in countries where this mycosis is endemic. We also suggest the inclusion of Paracoccidioidomycosis as a potential opportunistic infection in these areas.São apresentados dois casos de paracoccidioidomicose, um em paciente com a síndrome da imunodeficiência adquirida e o outro em paciente com infecção pelo HIV. Trata-se dos primeiros relatos em que esta associação é descrita na literatura. No primeiro, a micose se evidenciou durante o acompanhamento de paciente com AIDS, que passou a apresentar hépato-esplenomegalia e febre elevada. A ecografia, radiografia simples e tomografia computadorizada do abdômen, demonstraram nódulos sólidos, alguns calcificados, no parênquima esplénico. A punção aspirativa da medula óssea confirmou o diagnóstico; o conjunto dos achados caracterizou a forma aguda disseminada da paracoccidioidomicose, a qual levou o paciente ao óbito. No segundo relato, em paciente com infecção pelo HIV, a propósito de investigação de tumoração na região inguinal e fossa ilíaca à direita, constatou-se a associação de doença de Hodgkin, tipo celularidade mista e paracoccidioidomicose. Avalia-se a importância destes relatos frente a expansão da infecção pelo HIV e estima-se que mais casos venham a ser relatados em pacientes com AIDS, procedentes de áreas endêmicas desta micose. Propõe-se a inclusão da paracoccidioidomicose como infecção oportunística potencial em pacientes HIV positivos nestas áreas

Balanço hídrico e excreção renal de metabólitos em cabras leiteiras alimentadas com feno de alfafa e palma forrageira

Objetivou-se determinar os efeitos da substituição do feno de Tifton (Cynodon spp.) por feno de alfafa (Medicago Sativa) em dietas à base de palma forrageira (Nopalea cochenillifera) sobre o balanço hídrico, funções renais e excreção mineral de cabras leiteiras. Utilizou-se 12 cabras da raça Saanen, com peso vivo de 46,23±7,5kg, produção de 3,0 kg leite/dia. O delineamento experimental foi quadrado latino (4x4), com quatro tratamentos (0%; 33,3%; 66,7% e 100% de substituição) e quatro períodos para coleta de dados e amostras. O consumo de matéria seca (CMS), expresso em kg/dia e consumo de água total apresentaram aumento linear (p<0,05) em função da substituição do feno de Tifton pelo feno de alfafa, variando de 2,25 a 2,49 kg/dia e de 10,4 a 11,6 L/dia, para os níveis 0 a 100%, respectivamente. As perdas de água, taxa de depuração endógena de creatinina (TDECr), taxa de excreção de urina (TEU), Ca, P, Mg e ureia no plasma e urina, assim como índice de excreção urinária (IEUr) e taxas de excreção fracionadas (TEF) de cabras alimentadas com feno de alfafa em substituição ao feno de Tifton em dietas à base de palma forrageira, não foram influenciados (P>0,05) pelas dietas. A substituição do feno de Tifton por feno de alfafa em até 300 g/kg de matéria seca, em dietas à base de palma forrageira para cabras em lactação, influencia no consumo de água, sem alterar os índices de excreção urinária

Número de bolos ruminais e mastigação merícica de ovinos recebendo dieta a base de palma forrageira e fenos de Atriplex: Number of ruminal bolus and mericics mastications of sheep receiving diets the base spineless cactus by saltbush hay

Este trabalho teve por objetivo avaliar os efeitos da substituição da palma forrageira (Opuntia ficus-indica, Mill) por feno de erva sal (Atriplex nummularia Lind.) e farelo de milho sobre o número de bolos ruminais e variáveis da mastigação merícica de ovinos. Os níveis de substituição foram: 0,0; 15,3; 35,3; 62,9 e 100%. Foram utilizados cinco carneiros adultos, fistulados no rúmen, com peso vivo médio de 65 ± 2 kg; alojados em baias individuais, distribuídos em um delineamento quadrado latino 5 x 5 (5 dietas x 5 períodos). O número de bolos ruminados, tempo de mastigação merícica por bolo ruminal (MMtb) e número de mastigação merícica por bolo (MMnb) foram influenciados significativamente (P<0,05) pelo aumento no nível de substituição, ao contrário da mastigação merícica por minuto e número de mastigação merícica. Os resultados demonstraram que a substituição da palma forrageira modifica o número de bolos ruminados durante o dia, bem como algumas das variáveis da mastigação merícica

Carcass characteristics and meat quality of lambs that are fed diets with palm kernel cake

Objective The aim was to evaluate carcass characteristics, cut yield, and meat quality in lambs that were fed different inclusion levels of palm kernel cake. Methods Forty-five woolless castrated male Santa Inês crossbred sheep with an initial average body weight of 23.16±0.35 kg were used. The experimental design was a completely randomized design with five treatments, with palm kernel cake in the proportions of 0.0%, 7.5%, 15.0%, 22.5%, and 30.0% with nine replications per treatment. After slaughter, the gastrointestinal tract was weighed when it was full, after which it was then emptied. The heart, liver, kidney, pancreas perirenal fat were also collected and weighed. The carcass was split into two identical longitudinal halves and weighed to determine the quantitative and qualitative characteristics. Results The empty body weight, carcass weight and yield, and fat thickness decreased linearly (p0.05) for the rib eye area of animals that were fed palm kernel cake. There was a reduction in the commercial cut weight (p0.05). The sarcomere length decreased linearly (p<0.05), although an effect of the inclusion of palm kernel cake was not observed in other meat quality variables. It is worth noting that the red staining intensity, indicated as A, had a tendency to decrease (p = 0.050). Conclusion The inclusion of palm kernel cake up to 30% in the diet does not lead to changes in meat quality characteristics, except for sarcomere length. Nevertheless, carcass quantitative characteristics decrease with the use of palm kernel cake

A GUARDA COMPARTILHADA COMO MECANISMO DE PREVENÇÃO À ALIENAÇÃO PARENTAL

This research aims to examine custody according to the brazilian Law 13.058/2014, which makes it mandatorily joint, in order to identify if this can be an instrument to avoid parental alienation. It has been observed that usually in cases of contested divorce there is a dispute for the children’s custody, sometimes along with parental alienation and its syndrome (SAP). This confrontation can generate consequences and harm to the child's development. This study used the deductive method and was also supported by the principle of the best interest of the child. It was verified that joint custody, even when compulsory, brings great benefits, because besides approaching parents and children, it imposes to them that they have to make decisions together, breaking the paradigm of "possession" established in unilateralism. A change from inside to outside is necessary, one that is able to make people give up of their individuality in favor of the development and respect for the child’s human dignity.O artigo tem por objetivo analisar a guarda à luz da Lei 13.058/2014, que a torna compulsoriamente compartilhada entre os genitores, a fim de identificar se esse pode ser um instrumento ao combate da alienação parental. Comumente nota-se que, em casos de divórcio litigioso, há uma disputa pela guarda dos filhos, eventualmente caracterizada pela alienação parental e sua consequente síndrome (SAP). Este embate pode gerar consequências e prejuízos ao desenvolvimento da criança. O método utilizado na pesquisa foi o dedutivo, com respaldo no princípio do melhor interesse da criança. Verificou-se que a guarda compartilhada, mesmo “obrigatória”, traz grandes benefícios, porque além de aproximar pais e filhos, impõe àqueles que tomem decisões em conjunto, quebrando o paradigma de “posse” instaurado na unilateralidade. É preciso uma mudança de dentro para fora, tornando o homem capaz de abdicar de sua individualidade em prol do desenvolvimento e do respeito à dignidade humana da criança

COVID-19 outcomes in people living with HIV: Peering through the waves

Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to&nbsp;4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101&nbsp;COVID-19 patients were hospitalized, and 130&nbsp;(0.76%) of those were infected with HIV. The median age was&nbsp;54&nbsp;(IQR:&nbsp;43.0;64.0) years in&nbsp;2020 and 53&nbsp;(IQR:&nbsp;46.0;63.5) years in&nbsp;2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In&nbsp;2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9%&nbsp;vs.&nbsp;17.7%; p&nbsp;=&nbsp;0.049), but there was no difference in mortality between groups in&nbsp;2021 (25.0%&nbsp;vs.&nbsp;25.1%; p &gt; 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in&nbsp;2021, when the mortality rate is similar to the control group

Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.Introduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between patients with TR, IER, IRR, and no remission (NR). Results: 20.8% of CD patients presented TR, 23.3% IER, 13.6% IRR and 42.3% NR. TR was associated with lower risk of hospitalization (odds-ratio [OR] 0.244 [0.111-0.538], p < 0.001), surgery (OR 0.132 [0.030-0.585], p = 0.008), steroid use (OR 0.283 [0.159-0.505], p < 0.001), and treatment escalation (OR 0.088 [0.044-0.176], p < 0.001) compared to no NR. IRR resulted in lower risk of hospitalization (OR 0.333 [0.143-0.777], p = 0.011) and treatment escalation (OR 0.260 [0.125-0.540], p < 0.001), while IER reduced the risk of steroid use (OR 0.442 [0.262-0.745], p = 0.002) and treatment escalation (OR 0.490 [0.259-0.925], p = 0.028) compared to NR. Conclusions: TR improved clinical outcomes over 5 years of follow-up in CD patients. Distinct but significant benefits were seen with IER and IRR. This suggests that both endoscopic and radiologic remission should be part of the treatment targets of CD.info:eu-repo/semantics/publishedVersio