Ultrasound in the Evaluation of Radial Neuropathies at the Elbow

There are five sites at which radial nerve entrapment at the elbow has been commonly reported. These include the level of the fibrous bands within the extensor carpi radialis brevis, the thickened fascial tissue at the radiocapitellar joint, the leash of Henry, the arcade of Frohse, and the distal border of the supinator muscle. This review describes the anatomy of the radial nerve at the elbow and the surrounding structures, and then provides an overview of the literature supporting the use of ultrasound to assist in the evaluation of suspected radial neuropathy at the elbow. This review concludes with a suggested ultrasonographic approach for the systematic evaluation of suspected radial neuropathy at the elbow

Samples from Differentiated Asteroids; Regolithic Achondrites

Differentiated and partially differentiated asteroids preserve a glimpse of planet formation frozen in time from the early solar system and thus are attractive targets for future exploration. Samples of such asteroids arrive to Earth in the form of achondrite meteorites. Many achondrites, particularly those thought to be most representative of asteroidal regolith, contain a diverse assortment of materials both indigenous and exogenous to the original igneous parent body intermixed at microscopic scales. Remote sensing spacecraft and landers would have difficulty deciphering individual components at these spatial scales, potentially leading to confusing results. Sample return would thus be much more informative than a robotic probe. In this and a companion abstract [1] we consider two regolithic achondrite types, howardites and (polymict) ureilites, in order to evaluate what materials might occur in samples returned from surfaces of differentiated asteroids and what sampling strategies might be prudent

“It just makes me feel a little less alone” a qualitative exploration of the podcast “menopause unmuted” on women's perceptions of menopause

Objective: Menopause can negatively impact women's quality of life, with many women reporting inadequate information and support. Podcasts have grown in popularity in recent years and have been found to be accessible methods for increasing knowledge and challenging perceptions of stigmatized topics. The current research aimed to understand the impact of the podcast “menopause: unmuted” on women's menopause-related knowledge, understanding, and communication practices. Methods: A diverse sample of 30 women aged 40 to 60 years listened to the podcast series, which focused on menopause stories, before taking part in semistructured interviews to discuss the impact of the podcast on how they understood and communicated about menopause. The interviews were analyzed thematically. Results: Two overarching themes were identified in the data. A “journey of knowledge gain” explores participants’ understanding of menopause before listening to the podcast and describes how this is deepened by hearing and connecting with women's stories. “Reframing menopause” describes the impact of the podcast, where women reflect on the value of communication amongst women, challenge and re-evaluate the stigmatization of menopause, and discuss ways to make positive behavioral changes in their lives. Conclusions: The podcast “menopause: unmuted” helped women to learn about the menopause experience, have a greater sense of belonging to a community of women, and feel empowered to make changes in their own lives. Sharing stories via podcasts has potential as an accessible and impactful medium to educate women and reduce the widespread stigma associated with menopause

"You're more engaged when you're listening to somebody tell their story": A qualitative exploration into the mechanisms of the podcast 'menopause: unmuted' for communicating health information.

While health podcasts can be effective in reducing stigma and increasing knowledge, we know little about their mechanisms of action. This qualitative study explored the mechanisms of how women connected with the podcast 'menopause: unmuted', which presented menopause information in a storytelling format. A diverse sample of 30 women aged 40-60 years were interviewed after listening to the podcast. Interviews covered participant's views and perceptions of the stories presented. Transcripts were analyzed thematically. Two overarching themes were identified. 'Openness and authenticity' describes the value of personal stories told in an authentic way by real experts-by-experience. 'Relatability and representation' explores participants' emotional reaction to the podcast, influenced by the extent to which they identified with the stories and storytellers on the podcast. Authenticity and relatability were identified as key mechanisms through which participants connected with audio stories, consistent with Fisher's narrative theory. These findings have important implications for the application of storytelling in podcasts designed to influence health behaviors. Diverse stories representing a range of demographic characteristics and experiences are needed when creating podcasts about health information to increase listener's relatability and connection. [Abstract copyright: Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Red material on the large moons of Uranus: Dust from irregular satellites?

The large and tidally-locked classical moons of Uranus display longitudinal and planetocentric trends in their surface compositions. Spectrally red material has been detected primarily on the leading hemispheres of the outer moons, Titania and Oberon. Furthermore, detected H2O ice bands are stronger on the leading hemispheres of the classical satellites, and the leading/trailing asymmetry in H2O ice band strengths decreases with distance from Uranus. We hypothesize that the observed distribution of red material and trends in H2O ice band strengths results from infalling dust from Uranian irregular satellites. These dust particles migrate inward on slowly decaying orbits, eventually reaching the classical satellite zone, where they collide primarily with the outer moons. The latitudinal distribution of dust swept up by these moons should be fairly even across their southern and northern hemispheres. However, red material has only been detected over the southern hemispheres of these moons (subsolar latitude 81 S). Consequently, to test whether irregular satellite dust impacts drive the observed enhancement in reddening, we have gathered new ground-based data of the now observable northern hemispheres of these moons (sub-observer latitudes, 17 to 35 N). Our results and analyses indicate that longitudinal and planetocentric trends in reddening and H2O ice band strengths are broadly consistent across both southern and northern latitudes of these moons, thereby supporting our hypothesis. Utilizing a suite of numerical best fit models, we investigate the composition of the reddening agent detected on these moons, finding that both complex organics and amorphous pyroxene match the spectral slopes of our data. We also present spectra that span 2.9 to 4.1 microns, a previously unexplored wavelength range in terms of spectroscopy for the Uranian moons.Comment: Icarus [In Press]. 12 figures, 15 table

Ultrasound in the diagnosis of a median neuropathy in the forearm: case report

<p>Abstract</p> <p>Background</p> <p>Electrodiagnostic studies are traditionally used in the diagnosis of focal neuropathies, however they lack anatomical information regarding the nerve and its surrounding structures. The purpose of this case is to show that high-resolution ultrasound used as an adjunct to electrodiagnostic studies may complement this lack of information and give insight to the cause.</p> <p>Case presentation</p> <p>A 60-year-old male patient sustained a forearm traction injury resulting in progressive weakness and functional loss in the first three digits of the right hand. High-resolution ultrasound showed the presence of an enlarged nerve and a homogenous soft-tissue structure appearing to engulf the nerve. The contralateral side was normal. Surgery revealed fibrotic bands emanating from the flexor digitorum profundus muscle compressing the median nerve thus confirming the ultrasound findings.</p> <p>Conclusion</p> <p>A diagnostically challenging case of median neuropathy in the forearm is presented in which high-resolution ultrasound was valuable in establishing an anatomic etiology and directing appropriate management.</p

The distribution of extremal points of Gaussian scalar fields

We consider the signed density of the extremal points of (two-dimensional) scalar fields with a Gaussian distribution. We assign a positive unit charge to the maxima and minima of the function and a negative one to its saddles. At first, we compute the average density for a field in half-space with Dirichlet boundary conditions. Then we calculate the charge-charge correlation function (without boundary). We apply the general results to random waves and random surfaces. Furthermore, we find a generating functional for the two-point function. Its Legendre transform is the integral over the scalar curvature of a 4-dimensional Riemannian manifold.Comment: 22 pages, 8 figures, corrected published versio

Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells

In patients with bile acid malabsorption, high concentrations of bile acids enter the colon and stimulate Cl− and fluid secretion, thereby causing diarrhoea. However, deoxycholic acid (DCA), the predominant colonic bile acid, is normally present at lower concentrations where its role in regulating transport is unclear. Thus, the current study set out to investigate the effects of physiologically relevant DCA concentrations on colonic epithelial secretory function. Cl− secretion was measured as changes in short-circuit current across voltage-clamped T84 cell monolayers. At high concentrations (0.5–1 mM), DCA acutely stimulated Cl− secretion but this effect was associated with cell injury, as evidenced by decreased transepithelial resistance (TER) and increased lactate dehydrogenase (LDH) release. In contrast, chronic (24 hrs) exposure to lower DCA concentrations (10–200 μM) inhibited responses to Ca2+ and cAMP-dependent secretagogues without altering TER, LDH release, or secretagogue-induced increases in intracellular second messengers. Other bile acids – taurodeoxycholic acid, chenodeoxycholic acid and cholic acid – had similar antisecretory effects. DCA (50 μM) rapidly stimulated phosphorylation of the epidermal growth factor receptor (EGFr) and both ERK and p38 MAPKs (mitogen-activated protein kinases). The EGFr inhibitor, AG1478, and the protein synthesis inhibitor, cycloheximide, reversed the antisecretory effects of DCA, while the MAPK inhibitors, PD98059 and SB203580, did not. In summary, our studies suggest that, in contrast to its acute prosecretory effects at pathophysiological concentrations, lower, physiologically relevant, levels of DCA chronically down-regulate colonic epithelial secretory function. On the basis of these data, we propose a novel role for bile acids as physiological regulators of colonic secretory capacity

Thermodynamics, Disequilibrium, Evolution: Far-From-Equilibrium Geological and Chemical Considerations for Origin-Of-Life Research

The authors wish to thank the Earth-Life Science Institute of the Tokyo Institute of Technology for supporting and hosting the TDE Focus Group meeting on which this publication is based. The Thermodynamics, Disequilibrium, Evolution (TDE) Focus Group is supported by the NASA Astrobiology Institute (NAI). Parts of this work were carried out at the Jet Propulsion Laboratory, California Institute of Technology under a contract with the National Aeronautics and Space Administration; LMB and MJR are supported by NAI (Icy Worlds). ES thanks the ORIGINS COST Action (TD1308) for the STSM Reference Number: COST-STSM-TD1308-26973. ES is supported by Agreement ASI/INAF 2015 - 002 - R.O. JHEC acknowledges the financial support of the Spanish MINCINN project FIS2013-48444-C2-2-P

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understood. Using a heterogeneous population of peripheral blood mononuclear cells (PBMCs), we first undertook transcriptional profiling and found that PBMCs isolated from old individuals (≥ 65 years) exhibited a delayed and altered response to stimulation with TLR4, TLR7/8, and RIG-I agonists compared to cells obtained from adults (≤ 40 years). This delayed response to innate immune agonists resulted in the reduced production of pro-inflammatory and antiviral cytokines and chemokines including TNFα, IL-6, IL-1β, IFNα, IFNγ, CCL2, and CCL7. While the major monocyte and dendritic cell subsets did not change numerically with aging, activation of specific cell types was altered. PBMCs from old subjects also had a lower frequency of CD40+ monocytes, impaired up-regulation of PD-L1 on monocytes and T cells, and increased expression of PD-L2 and B7-H4 on B cells. The defective immune response to innate agonists adversely affected adaptive immunity as TLR-stimulated PBMCs (minus CD3 T cells) from old subjects elicited significantly lower levels of adult T-cell proliferation than those from adult subjects in an allogeneic mixed lymphocyte reaction (MLR). Collectively, these age-associated changes in cytokine, chemokine and interferon production, as well as co-stimulatory protein expression could contribute to the blunted memory B- and T-cell immune responses to vaccines and infections