BUSCA, RECUPERAÇÃO E VISUALIZAÇÃO DE RECURSOS ACADÊMICOS DISTRIBUÍDOS

Universities are reference when the subject is research and innovation. So much research creates a lot of related material (papers and videos for example), mostly this material is not shared with the community (of any nature: academic, scientific or public) because there is not a means with easy access and use. Don’t just researches create academic resources, the environment of a university by itself offer a wide range of activities that create academic resources: classes, scientific initiations, symposia, congress and others. The biggest problem of this scenario is that such a wealth of subjects doesn’t have any value when they are saved. As every university has a good IT infrastructure, the hosting and providing of such resources on Internet is trivial, the problem is that should know where the resources are to get them. This work pretends to take place in this context, allow the search of such resources in a transparent way to the final use

Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes

Antigen transport from the airway mucosa to the thoracic lymph nodes (TLNs) was studied in vivo by intratracheal instillation of fluorescein isothiocyanate (FITC)-conjugated macromolecules. After instillation, FITC+ cells with stellate morphology were found deep in the TLN T cell area. Using flow cytometry, an FITC signal was exclusively detected in CD11cmed-hi/major histocompatibility complex class II (MHCII)hi cells, representing migratory airway-derived lymph node dendritic cells (AW-LNDCs). No FITC signal accumulated in lymphocytes and in a CD11chiMHCIImed DC group containing a CD8αhi subset (non–airway-derived [NAW]-LNDCs). Sorted AW-LNDCs showed long MHCIIbright cytoplasmic processes and intracytoplasmatic FITC+ granules. The fraction of FITC+ AW-LNDCs peaked after 24 h and had reached baseline by day 7. AW-LNDCs were depleted by 7 d of ganciclovir treatment in thymidine kinase transgenic mice, resulting in a strong reduction of FITC-macromolecule transport into the TLNs. Compared with intrapulmonary DCs, AW-LNDCs had a mature phenotype and upregulated levels of MHCII, B7-2, CD40, and intracellular adhesion molecule (ICAM)-1. In addition, sorted AW-LNDCs from FITC-ovalbumin (OVA)–instilled animals strongly presented OVA to OVA-TCR transgenic T cells. These results validate the unique sentinel role of airway DCs, picking up antigen in the airways and delivering it in an immunogenic form to the T cells in the TLNs

Habitability: CAMELOT 4

During 1988 to 1989 the NASA/USRA Advanced Design Program sponsored research and design efforts aimed at developing habitability criteria and at defining a habitability concept as a useful tool in understanding and evaluating dwellings for prolonged stays in extraterrestrial space. The Circulating Auto sufficient Mars-Earth Luxurious Orbital Transport (CAMELOT) was studied as a case in which the students would try to enhance the quality of life of the inhabitants by applying architectural design methodology. The study proposed 14 habitability criteria considered necessary to fulfill the defined habitability concept, which is that state of equilibrium that results from the interaction between components of the Individual Architecture Mission Complex, which allows a person to sustain physiological homeostatis, adequate performance, and acceptable social relationships. Architecture, design development, refinements and revisions to improve the quality of life, new insights on artificial gravity, form and constitution problems, and the final design concept are covered

Efecto del drenaje ácido sobre el fraccionamiento de tierras raras ligeras en sedimentos: un caso de estudio en el estuario de los ríos Tinto y Odiel

The effect of acid drainage on light rare earth elements (LREE) has been studied in the estuarine sediment of the Tinto and Odiel system, where the fluvial and marine water mixing cause an important pH and chlorinity gradient inside. Due to the high influence of pH over the LREE partitioning from dissolved toparticulate phases, an anomalous behaviour has been found on La content in these sediments. Large removal of LREE takes place at low chlorinity zones in unaffected estuaries, but in the studied system this natural process is moved out the outer zones of the estuary. So, the relative La depletion in the estuarine mixing zone is due to the low pH values (< 6) that prevents LREE removal in low chlorinity zones. Once the acid neutralization (pH ~ 7) occurs, some La enrichment can be observed in sediments of the marine estuary.Versión de edito

Variaciones estacionales de tierras raras en la materia en suspensión y el agua del estuario del río Odiel (SO de España)

Seasonally distribution of the lanthanides in the suspended matter and dissolved phasehas been studied during a hydrological year in the estuary of the Odiel River. In his system affected by acid mine drainage take place the coexistence of two water mixture processes; a process salt-induced mixture typical in an estuary and a process of acid water neutralization. In the mixing zone of the estuary there is a removal of the dissolved phase to the suspended matter out of the system. REEs concentrations are controlled by the volume of discharge of the river and degree of neutralization process. Thus, during first rains after a dry period, the gradient in concentration of these elements in the mixing zone ismore pronounced in this system.Versión de edito

BUSCA, RECUPERAÇÃO E VISUALIZAÇÃO DE RECURSOS ACADÊMICOS DISTRIBUÍDOS

As universidades são referência quando o assunto é pesquisa e inovação. Tanta pesquisa gera muito material correlato (artigos e vídeos de experimentos por exemplo) e na maioria das vezes esse material não é compartilhado com a comunidade (seja qual for a natureza: acadêmica, científica ou pública) por falta de um meio que seja de fácil acesso e utilização. Vale lembrar que não apenas as pesquisas geram recursos acadêmicos, o ambiente de uma universidade oferece por si só um grande leque de atividades que geram recursos acadêmicos: aulas, iniciações científicas, simpósios, congressos, entre outros. O maior problema desse cenário é que tamanha riqueza de recursos não tem valor algum caso estes fiquem guardados. Como toda universidade dispõe de uma boa infra-estrutura em TI, a hospedagem e disponibilização de tais recursos na Internet é algo trivial, o problema é que deve-se conhecer onde os recursos estão para poder chegar até eles. É nesse contexto que este trabalho pretende desenrolar-se, permitir a busca destes recursos de um modo rápido e transparente ao usuário final

. A trophic latitudinal gradient revealed in anchovy and sardine from the Western Mediterranean Sea using a multi-proxy approach

This work combines state-of-the-art methods (DNA metabarcoding) with classic approaches (visual stomach content characterization and stable isotope analyses of nitrogen (δ15N) and carbon (δ13C)) to investigate the trophic ecology of anchovy (Engraulis encrasicolus) and sardine (Sardina pilchardus) at high taxonomic and spatial resolution in the Western Mediterranean Sea. Gut contents observed are in accordance with the dietary plasticity generally described for anchovy and sardine, suggesting a diet related to the opportunistic ingestion of available prey in a certain area and/or time. Genetic tools also showed modest inter-specific differences regarding ingested species. However, inter-specific and intra-specific differences in ingested prey frequencies and prey biomass reflected a latitudinal signal that could indicate a more effective predation on large prey like krill by anchovy versus sardine, as well as a generalized higher large prey ingestion by both species southwards. In fact, both species presented lower δ15N in the northernmost area. This latitudinal gradient indicates changes in the trophic ecology of anchovy and sardine that coincide with previously described better biological conditions for fish in the southern part of the study area as well as higher landings of both species in recent years.En prensa2,92

Efecto del nivel de fibra soluble y de la suplementación con celobiosa sobre los rendimientos productivos en conejos en cebo

El objetivo de este trabajo fue estudiar el efecto de la fibra soluble y la suplementación de con celobiosa en agua sobre los rencimientos productivos del gazapo tras el destete. A los gazapos se les suministró dos piensos que difirieron en el nivel de fibra soluble (7,7 vs.15,2%, sobre MS) y tres concentraciones de celobiosa en agua (0,0,75 y 1,5 fl). Los piensos y la celobiosa se suministraron a gazapos desde el destete (34 d edad 781±88 g, 44 gazapos/pienso) hasta los 48 d edad

Proteasome Dysfunction Associated to Oxidative Stress and Proteotoxicity in Adipocytes Compromises Insulin Sensitivity in Human Obesity

AIMS: Obesity is characterized by a low-grade systemic inflammatory state and adipose tissue (AT) dysfunction, which predispose individuals to the development of insulin resistance (IR) and metabolic disease. However, a subset of obese individuals, referred to as metabolically healthy obese (MHO) individuals, are protected from obesity-associated metabolic abnormalities. Here, we aim at identifying molecular factors and pathways in adipocytes that are responsible for the progression from the insulin-sensitive to the insulin-resistant, metabolically unhealthy obese (MUHO) phenotype. RESULTS: Proteomic analysis of paired samples of adipocytes from subcutaneous (SC) and omental (OM) human AT revealed that both types of cells are altered in the MUHO state. Specifically, the glutathione redox cycle and other antioxidant defense systems as well as the protein-folding machinery were dysregulated and endoplasmic reticulum stress was increased in adipocytes from IR subjects. Moreover, proteasome activity was also compromised in adipocytes of MUHO individuals, which was associated with enhanced accumulation of oxidized and ubiquitinated proteins in these cells. Proteasome activity was also impaired in adipocytes of diet-induced obese mice and in 3T3-L1 adipocytes exposed to palmitate. In line with these data, proteasome inhibition significantly impaired insulin signaling in 3T3-L1 adipocytes. INNOVATION: This study provides the first evidence of the occurrence of protein homeostasis deregulation in adipocytes in human obesity, which, together with oxidative damage, interferes with insulin signaling in these cells. CONCLUSION: Our results suggest that proteasomal dysfunction and impaired proteostasis in adipocytes, resulting from protein oxidation and/or misfolding, constitute major pathogenic mechanisms in the development of IR in obesity.IMIBIC/Universidad de Córdoba-SCAI (ProteoRed, PRB2-ISCIII)MINECO/FEDERJunta de Andalucía/FEDERCIBERobn(Instituto de Salud Carlos III