Effect of sonic boom on avalanches. Preparation for flight of a supersonic jet over the Lavay Valley

An experiment to determine the effect of sonic booms on the stability of the snow mantle in the Lavey Valley is proposed. It includes provisions for the aircraft trajectory, line of fucus, boom zone, as well as the determination of boom intensity levels for the whole valley

Characteristics Beyond In/Formality of Ways of Learning for Work: A Case of Knowledge-intense, Geographically-distributed Learning

Pharmaceutical-sales is a knowledge-intense, highly competitive and rapidly changing industry employing a geographically distributed workforce. The varied ways in which agents in this industry continue to learn for work are presented and examined. A framework is developed and employed for exploring and reporting fundamental characteristics of ways of learning beyond designation of in/formality. Findings include the importance of peer-learning for non-co-located peers, the identification of intentional incidental learning, and a non-traditional role for workplace learning in a knowledge-intense and competitive environment

Misperceiving and underestimating the ubiquitous chicken

Marino has provided an accurate and nuanced view about chickens’ complex capabilities as sentient individuals. I explore the implications of these findings for scholars as well as for activists in the protection of farmed animals

Taking exception to human exceptionalism

Chapman & Huffman refute common claims used to justify human species distinctions, and they critique the animal cruelty that has resulted from this privileged status. I raise related questions for further study of the roots of human exceptionalism and about whether aspiring to be more like our fellow animals might be part of the solution

The I in Autism:severity and social functioning in Autism is related to self-processing

It is well established that children with autism spectrum disorder (ASD) show impaired understanding of others and deficits within social functioning. However, it is still unknown whether self-processing is related to these impairments and to what extent self impacts social functioning and communication. Using an ownership paradigm, we show that children with ASD and chronological- and verbal-age-matched typically developing (TD) children do show the self-referential effect in memory. In addition, the self-bias was dependent on symptom severity and socio-communicative ability. Children with milder ASD symptoms were more likely to have a high self-bias, consistent with a low attention to others relative to self. In contrast, severe ASD symptoms were associated with reduced self-bias, consistent with an ‘absent-self’ hypothesis. These findings indicate that deficits in self-processing may be related to impairments in social cognition for those on the lower end of the autism spectrum

Estimating the reproductive number, total outbreak size, and reporting rates for Zika epidemics in South and Central America

As South and Central American countries prepare for increased birth defects from Zika virus outbreaks and plan for mitigation strategies to minimize ongoing and future outbreaks, understanding important characteristics of Zika outbreaks and how they vary across regions is a challenging and important problem. We developed a mathematical model for the 2015 Zika virus outbreak dynamics in Colombia, El Salvador, and Suriname. We fit the model to publicly available data provided by the Pan American Health Organization, using Approximate Bayesian Computation to estimate parameter distributions and provide uncertainty quantification. An important model input is the at-risk susceptible population, which can vary with a number of factors including climate, elevation, population density, and socio-economic status. We informed this initial condition using the highest historically reported dengue incidence modified by the probable dengue reporting rates in the chosen countries. The model indicated that a country-level analysis was not appropriate for Colombia. We then estimated the basic reproduction number, or the expected number of new human infections arising from a single infected human, to range between 4 and 6 for El Salvador and Suriname with a median of 4.3 and 5.3, respectively. We estimated the reporting rate to be around 16% in El Salvador and 18% in Suriname with estimated total outbreak sizes of 73,395 and 21,647 people, respectively. The uncertainty in parameter estimates highlights a need for research and data collection that will better constrain parameter ranges.Comment: 35 pages, 16 figure

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.

Lipid raft membrane compartmentalization and membrane-associated guanylate kinase (MAGUK) family molecular scaffolds function in establishing cell polarity and organizing signal transducers within epithelial cell junctions and neuronal synapses. Here, we elucidate a role for the MAGUK protein, Dlgh1, in polarized T cell synapse assembly and T cell function. We find that Dlgh1 translocates to the immune synapse and lipid rafts in response to T cell receptor (TCR)/CD28 engagement and that LckSH3-mediated interactions with Dlgh1 control its membrane targeting. TCR/CD28 engagement induces the formation of endogenous Lck-Dlgh1-Zap70-Wiskott-Aldrich syndrome protein (WASp) complexes in which Dlgh1 acts to facilitate interactions of Lck with Zap70 and WASp. Using small interfering RNA and overexpression approaches, we show that Dlgh1 promotes antigen-induced actin polymerization, synaptic raft and TCR clustering, nuclear factor of activated T cell activity, and cytokine production. We propose that Dlgh1 coordinates TCR/CD28-induced actin-driven T cell synapse assembly, signal transduction, and effector function. These findings highlight common molecular strategies used to regulate cell polarity, synapse assembly, and transducer organization in diverse cellular systems

Size tunable visible and near-infrared photoluminescence from vertically etched silicon quantum dots

Corrugated etching techniques were used to fabricate size-tunable silicon quantum dots that luminesce under photoexcitation, tunable over the visible and near infrared. By using the fidelity of lithographic patterning and strain limited, self-terminating oxidation, uniform arrays of pillar containing stacked quantum dots as small as 2 nm were patterned. Furthermore, an array of pillars, with multiple similar sized quantum dots on each pillar, was fabricated and tested. The photoluminescence displayed a multiple, closely peaked emission spectra corresponding to quantum dots with a narrow size distribution. Similar structures can provide quantum confinement effects for future nanophotonic and nanoelectronic devices

Diabetic Patients Foot Care Using Smart Materials to Prevent Ulcerations/Amputations

A major cause of illness and disability in diabetic patients is complications affecting the lower limbs, particularly the feet where loss of feeling may result in ulcerations, and ultimately to partial or total amputation. Traditional remedies for this problem still remains in measuring the foot pressures and then designing a passive shoe insert that absorbs the high pressures. This process may then be repeated multiple times during the lifetime of the patient. This paper describes the conceptual design of an automatic system that monitors and controls the pressure levels in diabetic patients’ feet in real time. The scheme is based on the constant measurement of pressure levels and then actively changing the shape of the shoe insert so as to decrease the high pressure levels. The sensing and the actuation is done by the use of smart materials powered by a battery pack in the insert. The sensing is done by using piezoceramic patches while the actuation is done by use of electroactive polymer (EAP) actuators. All the circuitry is envisioned to be on a single VLSI chip embedded in the shoe insert, hence making the shoe insert completely autonomous. The greatest strength of the system is that it is an active real time system that will adapt to changes in the locations of high stress points, and, hence, is far superior to currently used passive shoe inserts and other forms of diabetic foot care

Strategy management through quantitative modelling of performance measurement systems

This paper is based on previous works on performance measurement and on quantification of relationships between factors which affect performance. It demonstrates how tools and techniques developed can be used to evaluate the performance of alternative strategic choices through a quantitative approach to modelling of performance measurement systems. The paper provides a brief background to the research problem and preceding works. The tools and techniques used are briefly introduced. Use of these tools and techniques to evaluate the performance of alternative manufacturing strategies is demonstrated. Finally, the capability of the approach to deal with dynamic environments is demonstrated using sensitivity analysis