Efectos del consumo de alcohol etílico en la cavidad oral: relación con el cáncer oral

El consumo de bebidas alcohólicas se encuentra asociado desde un punto de vista epidemiológico con un riesgo aumentado de desarrollar cáncer del tracto gastrointestinal superior. La realización de estudios que establezcan esa asociación resulta complicada, debido tanto a la confluencia de varios factores de riesgo en una misma persona, por ejemplo alcohol y tabaco, como a la falta de datos que puedan ser comprobables por el clínico. Por ello no se conoce con exactitud cual es el mecanismo patogénico responsable de este aumento de riesgo, ya que el etanol per se no ha demostrado ser carcinógeno. Se han propuesto distintas hipótesis que tratan de explicar como el etanol, ya sea por vía local o sistémica puede actuar como factor de riesgo en el desarrollo de un cáncer oral. Este trabajo supone una revisión de la situación actual de los potenciales mecanismos patogénicos, dividiéndolos en efectos locales y sistémicos. Dentro de los primeros se hace especial referencia a la alteración de la permeabilidad de la mucosa oral, a la acción del acetaldehído y al papel de los retinoidesIn an epidemiologic point of view the consumption of alcoholic beverages is found to be associated to an increased risk for developing an upper gastrointestinal tract cancer. The relation of the studies that establish this connection is complicated due to both the confluence of various risk factors within the same person such as alcohol and tobacco, and to the lack of data that can be verifiable by the clinician. For this reason the exact pathogenic mechanism responsible for this increase of risk is not known since ethanol per se was not confirmed to be carcinogenic. Different hypotheses have been proposed, explaining how ethanol, by oral or systemic route, can act as a risk factor for the development of oral cancer. This article serves as a review of the actual situation of the potential pathogenic mechanisms, dividing them in local and systemic effects. Within the aforementioned special reference is made on the alteration of the oral mucosa permeability, the action of acetaldehyde and the role of retinoids

Recursos didácticos para la docencia y mejora de la empleabilidad: aplicación a la asignatura Edición musical del Máster en Música Española e Hispanoamericana (II)

El objetivo principal es crear recursos didácticos para la mejora de la enseñanza de la edición de música, una de las actividades profesionales más habituales que realizan los músicos y los musicólogos pero apenas existen materiales ni recursos didácticos para su enseñanza

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Detection of persistent VHE gamma-ray emission from PKS 1510-089 by the MAGIC telescopes during low states between 2012 and 2017

Context. PKS 1510-089 is a flat spectrum radio quasar strongly variable in the optical and GeV range. To date, very high-energy (VHE, >100 GeV) emission has been observed from this source either during long high states of optical and GeV activity or during short flares. Aims. We search for low-state VHE gamma-ray emission from PKS 1510-089. We characterize and model the source in a broadband context, which would provide a baseline over which high states and flares could be better understood. Methods. PKS 1510-089 has been monitored by the MAGIC telescopes since 2012. We use daily binned Fermi-LAT flux measurements of PKS 1510-089 to characterize the GeV emission and select the observation periods of MAGIC during low state of activity. For the selected times we compute the average radio, IR, optical, UV, X-ray, and gammaray emission to construct a low-state spectral energy distribution of the source. The broadband emission is modeled within an external Compton scenario with a stationary emission region through which plasma and magnetic fields are flowing. We also perform the emissio-model-independent calculations of the maximum absorption in the broad line region (BLR) using two different models. Results. The MAGIC telescopes collected 75 hr of data during times when the Fermi-LAT flux measured above 1 GeV was below 3 x10(-8)cm(-2) s(-1) , which is the threshold adopted for the definition of a low gamma-ray activity state. The data show a strongly significant (9.50-sigma ) VHE gamma-ray emission at the level of (4.27 +/- 0.61(stat)) x 10(-12) cm(-2) s(-1) above 150 GeV, a factor of 80 lower than the highest flare observed so far from this object. Despite the lower flux, the spectral shape is consistent with earlier detections in the VHE band. The broadband emission is compatible with the external Compton scenario assuming a large emission region located beyond the BLR. For the first time the gamma-ray data allow us to place a limit on the location of the emission region during a low gamma ray state of a FSRQ. For the used model of the BLR, the 95% confidence level on the location of the emission region allows us to place it at a distance >74% of the outer radius of the BLR

Social theater as a form of Research, Participatory Action and learning of the Sociology of Work and Gener in the classroom

Artículo en revista Tendencias Sociales (aceptado), nº 6, septiembre 2020INSOCTEA III. Las dinámicas desarrolladas en el Aula-Laboratorio de Teatro Social UCM (INSOCTEA I-II) se ajustar a un marco de Investigación Acción Participativa (IAP) que podría garantizar el aprendizaje de la sociología del trabajo y el género.INSOCTEA III. The dynamics developed in the UCM Social Theater Classroom-Laboratory (INSOCTEA I-II) are a form of Participatory Action Research (PAR), this framework could guarantee learning about sociology of work and gender.Sección Deptal. de Sociología III (Estructura Social) (Sociología de la Educación)Fac. de Ciencias Económicas y EmpresarialesFALSEUniversidad Complutense de Madridsubmitte