Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders.

The attempts to clarify the origin of eating disorders (ED) have not been completely successful and their etiopathogenesis remains unknown. Current research shows an activation of the immune response in neuropsychiatric diseases, including ED. We aimed to investigate immune response parameters in patients with ED and to identify psychological factors influencing the inflammatory response. The relationship between inflammation markers and impulsivity and affective symptomatology was explored as well. Thirty-four adult female patients with current diagnosis of ED, none of them under psychopharmacological treatment (excluding benzodiazepines), were included in this study. Patients were compared with a healthy control group of fifteen adult females. The levels of inflammatory markers and indicators of oxidative/nitrosative stress were evaluated in plasma and/or in peripheral blood mononuclear cells (PBMCs). Subjects were assessed by means of different ED evaluation tools. Additionally, the Barratt Impulsiveness Scale, the Montgomery-Asberg Depression Rating Scale and the Hamilton Anxiety Rating Scale were also employed. Patients with ED shown increased plasma levels of the pro-inflammatory nuclear factor kappa B (NFκB) and the cytokine tumor necrosis factor-alpha (TNF-α), among other factors and an increment in the oxidative/nitrosative stress as well as increased glucocorticoid receptor (GR) expression levels in their PBMCs. Moreover, the inflammatory prostaglandin E2 (PGE2) correlated with impulsiveness and the anti-inflammatory prostaglandin J2 (15d-PGJ2) correlated with depressive symptomatology. Our results point towards a relationship between the immune response and impulsiveness and between the immune response and depressive symptomatology in female adult patients with ED.post-print1075 K

Un nuevo hospedero y distribución geográfica de Optatus palmaris Pascoe 1889 (Coleoptera: Curculionidae) en México.

The diurnal weevil Optatus palmaris Pascoe was found on Annona muricata L. (Anonaceae) fruits in Nayarit, Mexico which represents a new plant host record and extends the weevil distribution. Other plant hosts and damages produced are mentioned.

Enhanced Performance of Zn/Br Flow Battery Using N-Methyl-N-Propylmorpholinium Bromide as Complexing Agent

Redox flow batteries (RFB) are one of the most interesting technologies in the field of energy storage, since they allow the decoupling of power and capacity. Zinc–bromine flow batteries (ZBFB) are a type of hybrid RFB, as the capacity depends on the effective area of the negative electrode (anode), on which metallic zinc is deposited during the charging process. Gaseous bromine is generated at the positive electrode (cathode) during the charging process, so the use of bromine complexing agents (BCA) is very important. These BCAs are quaternary amines capable of complexation with bromine and generating an organic phase, immiscible with the aqueous electrolyte. One of the most commonly used BCAs in RFB technology is 4-methylethylmorpholinium bromide (MEM-Br). In this work, an alternative quaternary amine 4-methylpropylmorpholinium bromide (MPM-Br) was studied. MPM-Br was integrated into the electrolyte, and 200 charge–discharge cycles were performed on the resulting ZBFBs. The obtained results were compared with those when MEM-Br was used, and it was observed that the electrolyte with MPM-Br displays a higher resistance in voltage and higher energy efficiency, making it a promising alternative to MEM-Br

Nuevos registros y extensiones de distribución de mamíferos para Guanajuato, México

The objective of this study was to document new host plants and the geographical distributions of Melanagromyza floris Spencer, M. tomaterae Steyskal, M. viridis (Frost) and Ophiomyia lantanae (Froggatt). The study was carried out from August 2007 to August 2008. Puparia of these flies were collected on Tithonia sp. in Tonatico (state of Mexico); Physalis nicandroides Schltd in Atotonilco el Grande (state of Hidalgo); Tagetes erecta L. and Lantana camara L. in Huautla (state of Hidalgo) and Lantana camara L. in San Joaquin, state of Queretaro. Both flies and host plants were identified. T. erecta is a new host record for M. floris whereas P. nicandroides is a new host record for M. tomaterae. The flies M. floris and M. tomaterae are the first reports for these species in the state of Hidalgo. M. viridis is recorded from the southern part of the state of Mexico. Finally, O. lantanae is registered in two states: Hidalgo and Queretaro.El objetivo de este estudio fue documentar información sobre nuevas plantas hospederas y nuevos registros de distribución geográfica de Melanagromyza floris Spencer, M. tomaterae Steyskal, M. viridis (Frost) y Ophiomyia lantanae (Froggatt). Se realizaron colectas de puparios de agosto de 2007 a agosto de 2008 sobre Tithonia sp. en Tonatico, Estado de México, sobre Physalis nicandroides Schltdl en Atotonilco el Grande, sobre Tagetes erecta L. y Lantana camara L. en Huautla, ambos municipios del estado de Hidalgo y sobre Lantana camara L. en el municipio de San Joaquín, Querétaro. El material entomológico y vegetal se determinó taxonómicamente. Se registra por primera vez a T. erecta como nueva planta hospedera de M. floris, así como a P. nicandroides como nueva planta hospedera de M. tomaterae, a su vez también se adicionan nuevos registros de distribución para M. floris y M. tomaterae ambas especies amplían su distribución en el estado de Hidalgo, mientras que M. viridis amplía su distribución geográfica en la parte sur del estado de México. Finalmente se proporcionan para O. lantanae nuevos registros de distribución en los estados de Hidalgo y Querétar

Cuidado personal de niños, niñas y adolescentes en caso de separación de los padres en Chile: desde el cuidado único de la madre hasta la custodia compartida

This article presents the legislative evolution of the institution of sole custody of children in the Chilean legal system, showing the legal consecration of the institution and its legal modifications. Moreover, it goes further into the current situation of the said institution, addressing topics such as parental co-responsibility, shared custody, parents’ situations of inability and the exercise of sole custody by different people. Finally, a brief projective analysis of the issue is made in the light of international human rights law standards and the contemporary Chilean reality.El presente trabajo expone la evolución legislativa de la institución del cuidado personal de los hijos e hijas en el ordenamiento jurídico chileno, mostrando la consagración legal de la institución y sus modificaciones legales. Además, profundiza en la situación actual de la institución en comento, abordando tópicos como la corresponsabilidad parental, el cuidado personal compartido, las situaciones de inhabilidad de los padres y el ejercicio del cuidado personal por personas diferentes. Finalmente, se hace un breve análisis proyectivo de la cuestión a la luz de estándares establecidos por instrumentos internacionales de derechos humanos y la realidad chilena contemporánea

Plan de contingencia para los servicios de medicina intensiva frente a la pandemia COVID-19

In January 2020, the Chinese authorities identified a new virus of the Coronaviridae family as the cause of several cases of pneumonia of unknown aetiology. The outbreak was initially confined to Wuhan City, but then spread outside Chinese borders. On 31 January 2020, the first case was declared in Spain. On 11 March 2020, The World Health Organization (WHO) declared the coronavirus outbreak a pandemic. On 16 March 2020, there were 139 countries affected. In this situation, the Scientific Societies SEMICYUC and SEEIUC, have decided to draw up this Contingency Plan to guide the response of the Intensive Care Services. The objectives of this plan are to estimate the magnitude of the problem and identify the necessary human and material resources. This is to provide the Spanish Intensive Medicine Services with a tool to programme optimal response strategies

Riesgo quirúrgico tras resección pulmonar anatómica en cirugía torácica. Modelo predictivo a partir de una base de datos nacional multicéntrica

Introduction: the aim of this study was to develop a surgical risk prediction model in patients undergoing anatomic lung resections from the registry of the Spanish Video-Assisted Thoracic Surgery Group (GEVATS). Methods: data were collected from 3,533 patients undergoing anatomic lung resection for any diagnosis between December 20, 2016 and March 20, 2018. We defined a combined outcome variable: death or Clavien Dindo grade IV complication at 90 days after surgery. Univariate and multivariate analyses were performed by logistic regression. Internal validation of the model was performed using resampling techniques. Results: the incidence of the outcome variable was 4.29% (95% CI 3.6-4.9). The variables remaining in the final logistic model were: age, sex, previous lung cancer resection, dyspnea (mMRC), right pneumonectomy, and ppo DLCO. The performance parameters of the model adjusted by resampling were: C-statistic 0.712 (95% CI 0.648-0.750), Brier score 0.042 and bootstrap shrinkage 0.854. Conclusions: the risk prediction model obtained from the GEVATS database is a simple, valid, and reliable model that is a useful tool for establishing the risk of a patient undergoing anatomic lung resection

Derecho ex cathedra. 1847-1936 Diccionario de catedráticos españoles

Edición revisada 2020.Publicación de las entradas biográficas del Diccionario de catedráticos españoles de Derecho, accesible en http://www.uc3m.es/diccionariodecatedraticos. Al dar forma de libro al material hemos prescindido de algunos elementos informativos, que se mantienen en la página electrónica indicada. Se recogen ahora solamente a los ingresados en el cuerpo con anterioridad a la guerra civil.Publication of the biographical entries of the Diccionario de catedráticos españoles de Derecho, accessible at http://www.uc3m.es/diccionariodecatedraticos. By giving those material book form, we have dispensed with some informative elements, however kept on the web page. Only professors apointed prior to the Civil War are now included.Esta publicación forma parte del proyecto “La memoria del jurista español: génesis y desarrollo de las disciplinas jurídicas” (ref. DER2014-55035-C2-1-P/DER2014-55035-C2-2-P), financiado por el Ministerio de Economía, Industria y Competitividad (España)

Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease

Chronic kidney disease (CKD) is associated with an elevated risk of all-cause mortality, with cardiovascular death being extensively investigated. However, non-cardiovascular mortality represents the biggest percentage, showing an evident increase in recent years. Klotho is a gene highly expressed in the kidney, with a clear influence on lifespan. Low levels of Klotho have been linked to CKD progression and adverse outcomes. Single nucleotide polymorphisms (SNPs) of the Klotho gene have been associated with several diseases, but studies investigating the association of Klotho SNPs with noncardiovascular death in CKD populations are lacking. The main aim of this study was to assess whether 11 Klotho SNPs were associated with non-cardiovascular death in a subpopulation of the National Observatory of Atherosclerosis in Nephrology (NEFRONA) study (n ¼ 2185 CKD patients). After 48 months of follow-up, 62 cardiovascular deaths and 108 non-cardiovascular deaths were recorded. We identified a high non-cardiovascular death risk combination of SNPs corresponding to individuals carrying the most frequent allele (G) at rs562020, the rare allele (C) at rs2283368 and homozygotes for the rare allele (G) at rs2320762 (rs562020 GG/AG þ rs2283368 CC/CT þ rs2320762 GG). Among the patients with the three SNPs genotyped (n ¼ 1016), 75 (7.4%) showed this combination. Furthermore, 95 (9.3%) patients showed a low-risk combination carrying all the opposite genotypes (rs562020 AA þ rs2283368 TT þ rs2320762 GT/TT). All the other combinations [n ¼ 846 (83.3%)] were considered as normal risk. Using competing risk regression analysis, we confirmed that the proposed combinations are independently associated with a higher fhazard ratio [HR] 3.28 [confidence interval (CI) 1.51-7.12]g and lower [HR 6 × 10- (95% CI 3.3 × 10--1.1 × 10-)] risk of suffering a non-cardiovascular death in the CKD population of the NEFRONA cohort compared with patients with the normal-risk combination. Determination of three SNPs of the Klotho gene could help in the prediction of non-cardiovascular death in CKD