Guittone e le origini dell'epistolografia volgare

This essay examines the first collections of letters written in the Italian vernacular of the 13th and 14th centuries and explores the events and circumstances that gave birth to the epistolary genre. Common to all the epistles – from Guittone’s to Santa Caterina’s – is their Tuscan origins and, even more importantly, their Christian apologetics and deliberate suppression of specific references so as to raise the level of discourse to that of a moral treatise.

Minturno, Marino e un modulo oraziano

Nel sonetto proemiale delle Rime amorose, primo libro della vasta raccolta pubblicata nel 1602, Marino, coerentemente con l’argomento, enunciava il programma di astenersi dal genere eroico per dedicarsi al canto esclusivo dell’amore. L’opposizione acquisiva risalto per effetto dello schematico andamento delle due quartine. Nella prima il poeta formulava la rinuncia, in favore d’altri, alla poesia epica e nella seconda dichiarava la propria dedizione verso quella amorosa: Altri canti di Marte ..

Dovuto a Saba. Lettura di Settembre di Vittorio Sereni

La lettura prende in esame la poesia Settembre di Vittorio Sereni dapprima dal punto di vista tematico e delle varianti redazionali, per far emergere il senso di precarietà e di morte ingenerato nell’animo del poeta dalla fine dell’estate. In un secondo momento si richiama l’attenzione sull’affiorare di un ricordo preciso della poesia di Saba Il torrente mettendo di conseguenza in rilievo la funzione svolta dall’ammirazione per Saba nell’ispirazione del testo di Sereni

L'indeterminatezza nel racconto della Vita nova

The article focuses on Dante\u2019s characterisation of the city where the Vita nova is set as an almost unidentified location rather than as a place with a recognisable identity. In fact, Dante never provides any specific references to places or toponyms, nor does he name the persons appearing in the book, with the obvious exceptions of Beatrice and Giovanna. From this perspective, the article reexamines the controversial issue of the identification of the street where Dante sees the pilgrims on their way to Rome mentioned at the end of the book. In contrast with the realistic and individualising perspective that will prevail in the Commedia, this location is intentionally vague to stress the universal value of the story told in the Vita nova

Daclatasvir-based regimens in HCV cirrhosis: experience from the Italian early access program

We reported the efficacy and safety data for daclatasvir (DCV)-based all-oral antiviral therapy in patients treated in the Italian compassionate-use program. 275 patients were included (202 male-73.5%, mean age: 57.4 years, 62 HIV-coinfected, 94 with recurrence of hepatitis C post-OLT). Forty-nine patients (17.8%) had Child-Pugh B, Genotype(G) distribution was: G1a:72 patients (26.2%), G1b:137 (49.8%); G3:40 (14.5%) and G4:26 (9.5%). Patients received DCV with sofosbuvir(SOF) (n\u2009=\u2009221, 129 with ribavirin(RBV) or with simeprevir (SMV) or asunaprevir (ASU) (n\u2009=\u200954, 19 with RBV) for up to 24 weeks. Logistic regression was used to identify baseline characteristics associated with sustained virological response at week 12 post-treatment (SVR12). Liver function changes between baseline and follow up were assessed in 228 patients. 240 patients achieved SVR12 (87.3%), post transplant and HIV co-infected patients were equally distributed among SVR and no SVR (35% vs 34.3%; p\u2009=\u20090.56 and 24.2% vs 11.4%, p\u2009=\u20090.13, respectively). SVR rate was significantly higher with the combination DCV\u2009+\u2009SOF compared with DCV\u2009+\u2009SIM or ASU (93.2% vs 63.0%, p\u2009<\u20090.0001). Bilirubin value (OR: 0.69, CI95%: 0.54-0.87, p\u2009=\u20090.002) and regimen containing SOF (OR: 9.99, CI95%: 4.09-24.40; p\u2009<\u20090.001) were independently related with SVR. Mean albumin and bilirubin values significantly improved between baseline and follow-up week 12. DCV-based antiviral therapy was well tolerated and resulted in a high SVR when combined with SOF either in pre-transplant and in OLT patients and in "difficult to treat" HCV genotypes. Regimens containing DCV in combination with NS3 protease inhibitors obtained suboptimal results

Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

With the introduction of direct-acting antiviral agents (DAA), the rate of sustained virological response (SVR) in the treatment of hepatitis C virus (HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma (HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4% (maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4% (maximum "not well-defined" followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection. \ua9 2018 The Author(s). Published by Baishideng Publishing Group Inc. All rights reserved

Epistolari dal Due al Seicento. Modelli, questioni ecdotiche, edizioni, cantieri aperti (Gargnano del Garda, 29 settembre - 1° ottobre 2014)

Nei secoli passati, la lettera era l'unico mezzo di comunicazione: familiare, amichevole, d'ufficio o di servizio, ma anche strumento di dibattito politico e culturale. Lo studio degli epistolari dei singoli ma anche delle reti di comunicazione e di scambio è uno dei grandi temi della ricerca europea contemporanea. Vi si inserisce questo secondo volume dei "Quaderni di Gargnano", che - volgendosi sia alla produzione latina sia a quella volgare dal Due al Seicento - si sofferma su problemi metodologici e casi significativi, con impostazioni e tagli diversi: dall'ecdotica alla filologia, dall'archivistica, alla storia, alla storia delle discipline