Generating ring currents, solitons, and svortices by stirring a Bose-Einstein condensate in a toroidal trap

We propose a simple stirring experiment to generate quantized ring currents and solitary excitations in Bose-Einstein condensates in a toroidal trap geometry. Simulations of the 3D Gross-Pitaevskii equation show that pure ring current states can be generated efficiently by adiabatic manipulation of the condensate, which can be realized on experimental time scales. This is illustrated by simulated generation of a ring current with winding number two. While solitons can be generated in quasi-1D tori, we show the even more robust generation of hybrid, solitonic vortices (svortices) in a regime of wider confinement. Svortices are vortices confined to essentially one-dimensional dynamics, which obey a similar phase-offset--velocity relationship as solitons. Marking the transition between solitons and vortices, svortices are a distinct class of symmetry-breaking stationary and uniformly rotating excited solutions of the 2D and 3D Gross-Pitaevskii equation in a toroidal trapping potential. Svortices should be observable in dilute-gas experiments.Comment: 8 pages, 4 figures; accepted for publication in J. Phys. B (Letters

Selected Aspects of the Legal Status of the Public School Teacher in Oklahoma

Educational Administratio

Analysis and Modeling of Ground Operations at Hub Airports

Building simple and accurate models of hub airports can considerably help one understand airport dynamics, and may provide quantitative estimates of operational airport improvements. In this paper, three models are proposed to capture the dynamics of busy hub airport operations. Two simple queuing models are introduced to capture the taxi-out and taxi-in processes. An integer programming model aimed at representing airline decision-making attempts to capture the dynamics of the aircraft turnaround process. These models can be applied for predictive purposes. They may also be used to evaluate control strategies for improving overall airport efficiency.This research was supported in part by Honeywell, by an MIT teaching fellowship, and by NASA under grant NAG 2-1128 and through the National Center of Excellence for Aviation Operations Research (NEXTOR)

Pre- and Post Impoundment Ichthyoparasite Succession in a New Arkansas Reservoir

Helminth and crustacean parasites from 2,387 Micropterus dolomieui, M. punctulatus, and M. salmoides were utilized to monitor annual pre- and postimpoundment succession patterns spanning eight con- tinuous years in Beaver Reservoir, Arkansas. Incidence of infection by ichthyoparasites with direct life cycles (monogenetic trematodes, leeches, and crustaceans) generally increased following impoundment, although leeches remained relatively constant. Exceptions to this general pattern occurred. Incidence of ichthyoparasites with indirect life cycles (digenetic trematodes, cestodes, acanthocephalans, and nematodes) decreased immediately following impoundment with subsequent increases to a point equal or above that of preimpoundment, although exceptions occurred. Time for species adaptation to the reservoir environment varied, with some species disappearing and others occurring for the first time. Diversity indices indicated that a moderate parasite community was maintained in the White River two years prior to its impoundment to form Beaver Reservoir. During the first impoundment year the parasite community declined to the lowest postimpoundment level with the abrupt change in habitat. Throughout the following four post- impoundment years the parasite community gradually increased to become much larger and more complex than it was during preimpoundment. Parasite community succession stabilization occurred in the fifth postimpoundment year and continued the following year indicating the establishment of a climax ichthyoparasite community

A Flagellar A-Kinase Anchoring Protein with Two Amphipathic Helices Forms a Structural Scaffold in the Radial Spoke Complex

A-kinase anchoring proteins (AKAPs) contain an amphipathic helix (AH) that binds the dimerization and docking (D/D) domain, RIIa, in cAMP-dependent protein kinase A (PKA). Many AKAPs were discovered solely based on the AH–RIIa interaction in vitro. An RIIa or a similar Dpy-30 domain is also present in numerous diverged molecules that are implicated in critical processes as diverse as flagellar beating, membrane trafficking, histone methylation, and stem cell differentiation, yet these molecules remain poorly characterized. Here we demonstrate that an AKAP, RSP3, forms a dimeric structural scaffold in the flagellar radial spoke complex, anchoring through two distinct AHs, the RIIa and Dpy-30 domains, in four non-PKA spoke proteins involved in the assembly and modulation of the complex. Interestingly, one AH can bind both RIIa and Dpy-30 domains in vitro. Thus, AHs and D/D domains constitute a versatile yet potentially promiscuous system for localizing various effector mechanisms. These results greatly expand the current concept about anchoring mechanisms and AKAPs

Svortices and the fundamental modes of the "snake instability": Possibility of observation in the gaseous Bose-Einstein Condensate

The connection between quantized vortices and dark solitons in a long and thin, waveguide-like trap geometry is explored in the framework of the non-linear Schr\"odinger equation. Variation of the transverse confinement leads from the quasi-1D regime where solitons are stable to 2D (or 3D) confinement where soliton stripes are subject to a transverse modulational instability known as the ``snake instability''. We present numerical evidence of a regime of intermediate confinement where solitons decay into single, deformed vortices with solitonic properties, also called svortices, rather than vortex pairs as associated with the ``snake'' metaphor. Further relaxing the transverse confinement leads to production of 2 and then 3 vortices, which correlates perfectly with a Bogoliubov-de Gennes stability analysis. The decay of a stationary dark soliton (or, planar node) into a single svortex is predicted to be experimentally observable in a 3D harmonically confined dilute gas Bose-Einstein condensate.Comment: 4 pages, 4 figure

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer.

Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency1-5. Here, we surveyed genome-scale short hairpin RNA and CRISPR screening data on hundreds of cancer cell lines and identified MAGOH and MAGOHB, core members of the splicing-dependent exon junction complex, as top-ranked paralog dependencies6-8. MAGOHB is the top gene dependency in cells with hemizygous MAGOH deletion, a pervasive genetic event that frequently occurs due to chromosome 1p loss. Inhibition of MAGOHB in a MAGOH-deleted context compromises viability by globally perturbing alternative splicing and RNA surveillance. Dependency on IPO13, an importin-β receptor that mediates nuclear import of the MAGOH/B-Y14 heterodimer9, is highly correlated with dependency on both MAGOH and MAGOHB. Both MAGOHB and IPO13 represent dependencies in murine xenografts with hemizygous MAGOH deletion. Our results identify MAGOH and MAGOHB as reciprocal paralog dependencies across cancer types and suggest a rationale for targeting the MAGOHB-IPO13 axis in cancers with chromosome 1p deletion

Meaning behind measurement : self-comparisons affect responses to health related quality of life questionnaires

Purpose The subjective nature of quality of life is particularly pertinent to the domain of health-related quality of life (HRQOL) research. The extent to which participants’ responses are affected by subjective information and personal reference frames is unknown. This study investigated how an elderly population living with a chronic metabolic bone disorder evaluated self-reported quality of life. Methods Participants (n = 1,331) in a multi-centre randomised controlled trial for the treatment of Paget’s disease completed annual HRQOL questionnaires, including the SF-36, EQ-5D and HAQ. Supplementary questions were added to reveal implicit reference frames used when making HRQOL evaluations. Twenty-one participants (11 male, 10 female, aged 59–91 years) were interviewed retrospectively about their responses to the supplementary questions, using cognitive interviewing techniques and semi-structured topic guides. Results The interviews revealed that participants used complex and interconnected reference frames to promote response shift when making quality of life evaluations. The choice of reference frame often reflected external factors unrelated to individual health. Many participants also stated that they were unclear whether to report general or disease-related HRQOL. Conclusions It is important, especially in clinical trials, to provide instructions clarifying whether ‘quality of life’ refers to disease-related HRQOL. Information on selfcomparison reference frames is necessary for the interpretation of responses to questions about HRQOL.The Chief Scientist Office of the Scottish Government Health Directorates, The PRISM funding bodies (the Arthritis Research Campaign, the National Association for the Relief of Paget’s disease and the Alliance for Better Bone Health)Peer reviewedAuthor final versio