40 research outputs found

    The genetic epidemiology of joint shape and the development of osteoarthritis

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    Congruent, low-friction relative movement between the articulating elements of a synovial joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint formation or maintenance exist, mechanical overloading and osteoarthritis (OA) follow. The heritable component of OA accounts for ~ 50% of susceptible risk. Although almost 100 genetic risk loci for OA have now been identified, and the epidemiological relationship between joint development, joint shape and osteoarthritis is well established, we still have only a limited understanding of the contribution that genetic variation makes to joint shape and how this modulates OA risk. In this article, a brief overview of synovial joint development and its genetic regulation is followed by a review of current knowledge on the genetic epidemiology of established joint shape disorders and common shape variation. A summary of current genetic epidemiology of OA is also given, together with current evidence on the genetic overlap between shape variation and OA. Finally, the established genetic risk loci for both joint shape and osteoarthritis are discussed

    ‘Romanisation’ and the Body

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    Concrete’s memory

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    This paper explores the constraints upon archaeologists who working in the field of heritage studies who encounter tales of haunting, or have their own experiences with ghosts, during fieldwork. The discipline lacks the terminology to describe, analyse or understand such experiences, leading to either omissions, embarrassed anecdotes at the end of ‘serious’ discussions of fieldwork, or talking in metaphors. Using the case study of the Channel Islands, this paper explores ways in which archaeologists can talk and write about ghosts through recent understandings of the concept of ‘heritage’, through a rejection of UNESCO’s definitions of Intangible Cultural Heritage, and the adoption of the concept of ‘tangible intangibility’

    La mémoire du béton

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    Les habitants des Ăźles Anglo-Normandes sont confrontĂ©s quotidiennement aux fantĂŽmes de l’occupation allemande de la seconde guerre mondiale. Soldats et travailleurs forcĂ©s apparaissent dans les bunkers qui parsĂšment les cĂŽtes de ces Ăźles, offrant ainsi aux descendants des tĂ©moins de la guerre le moyen de cultiver la mĂ©moire d’une pĂ©riode historique critique qu’ils n’ont eux-mĂȘmes pas vĂ©cue. Insistant sur l’impossibilitĂ© de sĂ©parer ici le patrimoine immatĂ©riel et matĂ©riel, la mĂ©moire et le bĂ©ton, cet article examine les conditions d’intĂ©gration d’un type particulier de vestige – les fantĂŽmes – Ă  l’analyse archĂ©ologique
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