Obesidade Infantil: análises antropométricas, bioquímicas, alimentares e estilo de vida

Introdução: Hábitos alimentares inadequados na infância predispõem ao surgimento de doenças metabólicas na fase adulta, objetivando a identificar alterações de IMC em escolares no município de Poços de Caldas-MG-BR, com idades entre 6 a 12 anos, avaliar análises bioquímicas, dados antropométricos e padrão alimentar. Material e Métodos: Estudo quantitativo de campo, desenvolvido em três escolas, uma de ensino público e duas de ensino privado, no período de 2015 a 2016, com amostragem de 104 crianças. As variáveis de interesse foram dados antropométricos, amostragem sanguínea para exames laboratoriais e formulário de padrão alimentar. Resultados: A idade média da amostra foi 9,5±0,2, sendo 53,9% meninos e 46,2% meninas. Entre as prevalências encontradas, 51,0% das crianças tiveram algum tipo de alteração no IMC, sendo 29,2% de obesidade e 25,0% de sobrepeso na escola particular frente a 6,3% obesidade e 15,6% sobrepeso na escola pública. Observou que 60,6% apresentam alteração para glicemia em jejum (113,1±1,4 mg/dl). Colesterol 51,9% de alteração (196,0±2,9 mg/dl), HDL 43,3% mostram alterados (40,5±0,4 mg/dl), LDL percebe 19,2% das crianças apresentam aumento do valor normal (143,6±4,0 mg/dl) e TG 20,2% acima do valor recomendado (158,8±10,7 mg/dl). Foi possível observar ainda uma alta significantemente estatística na ingesta alimentar dando prioridade ao grupo de açúcares. Discussão: A amostra estudada apresenta alterações significativas para sobrepeso e obesidade, bem como para valores de porções alimentares, glicemia e dislipidemias. Conclusões: Mostra-se importante estudo na área a fim de mapear e melhorar o perfil nutricional para diminuir os riscos aos quais as crianças estão expostas. Como citar este artigo: Paiva ACT, Couto CC, Masson APL, Monteiro CAS, Freitas CF. Obesidade Infantil: análises antropométricas, bioquímicas, alimentares e estilo de vida. Rev Cuid. 2018; 9(3): 2387-99. http://dx.doi.org/10.15649/cuidarte.v9i3.57

Evaluation of salt intended for human consumption for the presence of physical contaminants: microplastics an emerging contaminant in the food area

Introduction: The presence of physical contaminants in food goes against the guarantee of the supply of safe products for consumption. Currently, there is an environmental concern with this type of contamination, especially with a class of plastic particles less than 5 mm, called microplastics. The impacts on human organisms are still under discussion, but there is already a relationship between the ingestion and inhalation of these particles and a possible health risk, since, in addition to being derived from macroplatic degradation processes with varied chemical compositions, they can still carry other contaminants. Objective: To value the presence of physical contaminants, such as microplastics in salt intended for human consumption. Method: A quantity of 8 salt samples was acquired in supermarkets in the city of Rio de Janeiro in 2019 and analyzed after dilution in water, according to the coefficient of salt dilution (36g/100mL), heated in plate at 100°C and filtered in filter 0.22μm. Detection was performed with the aid of stereoscope microscope and confirmation was performed under a scanning electron microscope (SEM). Results and Discussion: In 5 samples, the presence of physical contaminants was observed, which due to visual characteristics suggest to be microplastics. The possible presence of microplastics in salt samples is related to contamination of the oceans by microplastics. With this, it is observed the importance of monitoring the quality of human consumption, since it is a by-product of the oceans. Conclusion: Studies in Brazil regarding microplastic contamination is very focused on marine matrices, but it is necessary to think about the study and development of analytical methodologies for detection and identification of these contaminants in food, especially in products of marine origin

Tentativas reincidentes de autoextermínio em paciente com múltiplos transtornos psiquiátricos: entraves a um bom diagnóstico

The aim was to report the care of a patient with possible psychiatric disorders and a history of suicide attempts, in addition to evaluating diagnostic and therapeutic methods that can be used. Thus, this is a descriptive, critical-reflective and qualitative study, of the experience report type, carried out in a philanthropic hospital in the city of Caratinga, in the State of Minas Gerais. Data were collected through anamnesis and medical records of a 39-year-old female patient with major depression and bipolar affective disorder, with a history of several attempts at self-extermination. In this sense, the importance of an adequate diagnosis was evidenced in order to improve the patient's quality of life, as well as to avoid failures that harm her psychic condition. In addition, it was identified as essential the follow-up of a professional in the area who can offer appropriate support for the multiple psychiatric disorders reported.Objetivou-se relatar o atendimento à uma paciente com possíveis transtornos psiquiátricos e histórico de uma sorte de tentativas de suicídio, além de avaliar métodos de diagnósticos e terapêuticas que podem ser empregados. Destarte, trata-se de um estudo descritivo, crítico-reflexivo e qualitativo, do tipo relato de experiência, realizado em um hospital de caráter filantrópico na cidade de Caratinga, no Estado de Minas Gerais. Os dados foram coletados através de anamnese e do prontuário de uma paciente do sexo feminino, de 39 anos, com depressão maior e transtorno afetivo bipolar, com história de diversas tentativas de autoextermínio. Nesse sentido, evidenciou-se a importância de um diagnóstico adequado para que haja melhoria da qualidade de vida da paciente, bem como evitar falhas que prejudiquem sua condição psíquica. Ademais, identificou-se como essencial o acompanhamento de um profissional da área que possa oferecer suporte apropriado para os múltiplos transtornos psiquiátricos relatados

Proposal for screening of kidney disease in a random population based on World Kidney Day campaign

Despite the advances on early screening techniques, getting to know the chronic kidney disease (CKD) prevalence in Brazil and worldwide remains a challenge for researchers. Aging, diabetes and hypertension are the main CKD causes in Brazil. The aim of the study was to evaluate the presence of urinary dipstick abnormalities in World Kidney Day campaign. This is a cross-sectional studyconducted at FMABC. This study was based on the answers to a kidney disease questionnaire and urinary dipstick test. A total of 205 patients were randomly invited to collect urine samples on World Kidney Day 2013. Among the 205 studied patients, 66.34% were women with mean age of 46.32 years. Around 34.14% of the patients were hypertensive and 9.75% diabetic. Urinalysis alterations were observed in 28.29% of patients. The group with urine alterations had older individuals (51.36 years) andmore diabetes (18.96%) with higher levels of glucose (143.2 mg/dl).  Brazilian population is getting older and diabetic which represent risk factors for the onset of CKD. The necessity of an early detection by means of specific campaigns is thus of great importance. The use of dipstick test for screening is an important tool for kidney disease diagnosis. DOI: http://dx.doi.org/10.5281/zenodo.82692

Telemedicine-Based Management of Oral Anticoagulation Therapy:Systematic Review and Meta-analysis

BACKGROUND: Oral anticoagulation is the cornerstone treatment of several diseases. Its management is often challenging, and different telemedicine strategies have been implemented to support it. OBJECTIVE: The aim of the study is to systematically review the evidence on the impact of telemedicine-based oral anticoagulation management compared to usual care on thromboembolic and bleeding events. METHODS: Randomized controlled trials were searched in 5 databases from inception to September 2021. Two independent reviewers performed study selection and data extraction. Total thromboembolic events, major bleeding, mortality, and time in therapeutic range were assessed. Results were pooled using random effect models. RESULTS: In total, 25 randomized controlled trials were included (n=25,746 patients) and classified as moderate to high risk of bias by the Cochrane tool. Telemedicine resulted in lower rates of thromboembolic events, though not statistically significant (n=13 studies, relative risk [RR] 0.75, 95% CI 0.53-1.07; I2=42%), comparable rates of major bleeding (n=11 studies, RR 0.94, 95% CI 0.82-1.07; I2=0%) and mortality (n=12 studies, RR 0.96, 95% CI 0.78-1.20; I2=11%), and an improved time in therapeutic range (n=16 studies, mean difference 3.38, 95% CI 1.12-5.65; I2=90%). In the subgroup of the multitasking intervention, telemedicine resulted in an important reduction of thromboembolic events (RR 0.20, 95% CI 0.08-0.48). CONCLUSIONS: Telemedicine-based oral anticoagulation management resulted in similar rates of major bleeding and mortality, a trend for fewer thromboembolic events, and better anticoagulation quality compared to standard care. Given the potential benefits of telemedicine-based care, such as greater access to remote populations or people with ambulatory restrictions, these findings may encourage further implementation of eHealth strategies for anticoagulation management, particularly as part of multifaceted interventions for integrated care of chronic diseases. Meanwhile, researchers should develop higher-quality evidence focusing on hard clinical outcomes, cost-effectiveness, and quality of life. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42020159208; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=159208.</p

Análise de limite de galactosamina em hexosaminas totais em amostras injetáveis de heparina sódica suína

Introduction: Research, one of the core areas of health surveillance, has its importance justified by its search for answers to various health problems. Heparin, a biological product with anticoagulant and antithrombotic properties, has been related to adverse events between the years 2007–2008. Because of that, the official compendiums updated the monograph for raw material. However, there is a lack of monographs that evaluate the final product. Objective: The goal of this study is to propose a physicochemical method of analysis of the limits of galactosamine in total hexosamine from the finished product of porcine sodium heparin. Method: We developed an analytical method from the ionexchange high performance liquid chromatography with amperometric detection, with the appropriate evaluations of the system suitability for posterior analysis of three samples of porcine sodium heparin previously submitted to the sample preparation protocol through the Micro Bio-Spin column. Results: The samples were compared to the solution of the system suitability and raw material of porcine sodium heparin. We could detect the presence of galactosamine in one of the three analyzed samples in lower amounts than the limit stipulated by the American pharmacopeia. Conclusions: We concluded that the aforementioned method is efficient for the analysis of the finished product and that is the reason why it will be suggested to the Brazilian pharmacopeia.Introdução: A pesquisa, uma das vertentes da vigilância sanitária, tem sua importância justificada pela busca de respostas aos diversos prejuízos relativos à saúde. A heparina, produto biológico com propriedades anticoagulantes e antitrombóticas, esteve relacionada com eventos adversos entre 2007 e 2008. Diante do ocorrido, os compêndios oficiais atualizaram a monografia para matéria-prima. No entanto, há uma deficiência de monografias para avaliação do produto final. Objetivo: Propor método físico-químico de análise de limite de galactosamina em hexosaminas totais a partir do produto acabado de heparina sódica suína. Método: Foi desenvolvido método analítico a partir da cromatografia líquida de alta eficiência por troca iônica e detecção amperométrica, com as devidas avaliações de adequação do sistema para posterior análise de três amostras de heparina sódica suína, as quais foram previamente submetidas ao protocolo de preparo de amostra através da coluna Micro Bio-Spin™. Resultados: As amostras foram comparadas com a solução de adequação do sistema e matéria-prima de heparina sódica suína, sendo possível detectar presença de galactosamina em uma das três amostras analisadas em quantidade inferior ao limite estipulado pela Farmacopeia Americana. Conclusões: Conclui-se que o método é eficiente para análise do produto acabado e, por isso, será sugerido à Farmacopeia Brasileira

Predictors of cardiac involvement in idiopathic inflammatory myopathies

Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objectives: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. Results: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. Conclusion: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.info:eu-repo/semantics/publishedVersio

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Hydrogeochemistry of the Subaé River Impacted by Lead Smelting Activities, Bahia State, Brazil: Geochemical Characterization and Fluxes of Metals

International audienceThe Subaé river watershed is considered one of the most critical Pb-impacted environments in Brazil and around the world, due to pollutant dispersion during 33 years of lead ore purification in Santo Amaro da Purification. Severe damages have been reported in biota and population, which depends on the Subaé river watershed quality for agriculture, fishing, and shellfish harvesting. This study aims to understand the geochemical characteristics and dynamics of the river close to the former Pb smelter. The river was sampled at eight sites upstream and eight sites downstream the smelter, near the estuary in the Todos os Santos Bay, six times during a year. Immediate analyses were performed by multiprobe. Major ions were measured by chromatography, dissolved metals by ICP-OES in the filtrated samples (0.45 μm), and particulate metals > 0.45 μm by EDX spectrometry. The ions Na⁺ and HCO3⁻ are dominated in the river. Most of the samples (47.6%) were classified as sodic, due to oceanic saline intrusion during tide. Despite the high pollution caused by the smelter from 1960 to 1993, still observed in the surrounding soils, dissolved and particulate metals in the river remained low in all sites during the entire year. Only Cu presented some concentration above the threshold of the Brazilian regulations. The discharge of metals by the river into the Todos os Santos Bay appears to be low for Pb and Zn (2.2 and 14.3 kg km⁻¹ year⁻¹, respectively), but higher for Cu comparatively to other worldwide bays

Soil Chemistry after Irrigation with Treated Wastewater in Semiarid Climate

ABSTRACT Soil irrigation using treated wastewater in the Brazilian semiarid region is a promising practice as this area currently faces water scarcity and pollution of water resources by domestic sewage. The aim of this study was to evaluate the use of treated wastewater in drip irrigation and its effect on the chemistry of soil cultivated with squash (Cucurbita maxima Duch.) Coroa IAC and to verify whether there was an increase in soil salinity under a semiarid climate. The experiment was conducted for 123 days on a farm close to the sewage treatment plant, in a randomized block design with five treatments and four replications. The treatments consisted of two irrigation water depths (100 and 150 % of the evapotranspiration), two applications of gypsum to attenuate wastewater sodicity (0 and 5.51 g per plant), and a control treatment with no application of wastewater or gypsum. During the experiment, treated wastewater and soil gravitational water, at a depth of 0.40 m, were collected for measurement of Na+, K+, Ca2+, Mg2+, NO−3, NH4+, Cl− , alkalinity, electrical conductivity, pH and sodium adsorption ratio. At the end of the experiment, soil samples were collected at depths of 0.00-0.10, 0.10-0.20, and 0.20-0.40 m; and pH, total N, organic C, exchangeable cations and electrical conductivity of the saturation extract (CEs) were analyzed. Besides an increase in pH and a reduction in total N, the irrigation with wastewater reduces soil salinity of the naturally salt-rich soils of the semiarid climate. It also led to soil sodification, in spite of the added gypsum, which indicates that irrigation with wastewater might require the addition of greater quantities of gypsum to prevent physical degradation of the soil