Status enxaquecoso em paciente com enxaqueca crônica: estratégias de manejo e profilaxia

Este estudo aborda a relação entre enxaqueca crônica e status enxaquecoso, destacando a importância da identificação precoce e do manejo eficaz dessas condições. Os objetivos foram definir essas condições, desenvolver estratégias de manejo e profilaxia, avaliar sintomas associados e investigar a eficácia das intervenções propostas. Utilizando abordagem explicativa e descritiva, foram analisados dados primários de um paciente e revisão de literatura secundária. Os resultados indicaram persistência da enxaqueca refratária a terapias convencionais, exigindo abordagens mais agressivas, como bloqueio de nervos cranianos. A profilaxia com venlafaxina foi prescrita para prevenir novos episódios. A discussão enfatizou a necessidade de colaboração entre médicos generalistas e neurologistas e apontou limitações do estudo, como sua natureza descritiva e tamanho da amostra. Conclui-se que a abordagem integrada é crucial para o manejo eficaz dessas condições, ressaltando a importância da pesquisa contínua para desenvolver terapias mais eficazes e personalizadas

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Genetic variants in RORA are associated with asthma and allergy markers in an admixed population

Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.O artigo encontra-se disponível em acesso aberto para download no site do Editor.Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-08-15T14:07:26Z No. of bitstreams: 1 Lima LC Genetic variants in RORA are associated .....pdf: 1052100 bytes, checksum: 5716ce205bb9f5085a139da0eecdb181 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-08-15T14:16:45Z (GMT) No. of bitstreams: 1 Lima LC Genetic variants in RORA are associated .....pdf: 1052100 bytes, checksum: 5716ce205bb9f5085a139da0eecdb181 (MD5)Made available in DSpace on 2018-08-15T14:16:45Z (GMT). No. of bitstreams: 1 Lima LC Genetic variants in RORA are associated .....pdf: 1052100 bytes, checksum: 5716ce205bb9f5085a139da0eecdb181 (MD5) Previous issue date: 2018CNPq National Research Council - Brazil and FAPESB State of Bahia, Brazil Research Council.Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA. The aim of this work was to identify genetic variants in RORA associated with asthma phenotypes and allergy markers. Genomic DNA samples of 1246 individuals participating from Social Changes Asthma and Allergy in Latin America Program (SCAALA) have been genotyped using Illumina Human 2.5 Omni Beadchip. Logistics regressions have been performed to analyze the association among RORA variants and asthma, skin prick tests (SPT), specific IgE and type 2 cytokine production. Twelve single nucleotide variants (SNVs) were significantly associated with atopy (P < 0.01), in which four of them, rs10162630, rs17191519, rs17270243, and rs55796775 and their haplotypes were strongly and positively associated (P < 0.001). Furthermore, these variants increased the RORA gene expression in silico analysis. Other SNVs in RORA were associated with allergy markers, atopic and non-atopic asthma. Therefore, it is believed that variants in RORA gene may influence immunologic features of asthma and allergies and could be possible targets for future treatment of allergic diseases

Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus

Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 &micro;M of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 &micro;M), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus

Das caixas da casa colonial às arcas do Museu Paulista

A partir de uma pesquisa desenvolvida no Museu Paulista da Universidade de São Paulo sobre o espaço doméstico e a cultura material em São Paulo colonial, buscaremos problematizar o ofício do historiador ao lidar com documentos de natureza diversa. Comentaremos como se estabeleceu e se conformou, ao longo do trabalho, um diálogo crítico entre as fontes tridimensionais - as peças do acervo - e as fontes textuais produzidas no contexto de origem dos artefatos domésticos - sobretudo inventários. Com base na catalogação de acervo, pretendemos discutir situações de aproximação e incompatibilidade colocadas, muitas vezes, entre os termos utilizados pelos coevos para designar determinadas peças de mobiliário nos séculos XVIII e XIX e a classificação das peças em instituições museológicas. Para tanto, jogaremos luzes sobre caixas e arcas, pois esses móveis de conter e de guardar eram onipresentes nas casas setecentistas do império português.This paper analyzes the way historians deal with different types of historical documents (considering their origins) based on a research conducted at the Paulista Museum of the University of São Paulo on the theme of domestic space and material culture in colonial São Paulo. We will discuss how a critical dialogue was established between the tridimensional sources - the pieces of the collection - and the textual sources produced in the original context of the domestic artifacts - especially inventories. Based on the cataloging of the collection, we analyze situations of approximation and incompatibility often created by the use of the terms by the contemporaries to designate certain pieces of furniture in the 18th and 19th centuries and the terms used in the process of pieces classification in museological institutions. In order to do so, we will shed light on boxes and chests, because these kind of furniture to contain and store were ubiquitous in the 18th century houses of the Portuguese Empire

Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients

Abstract Background Acute kidney injury (AKI) is frequently associated with COVID-19, and the need for kidney replacement therapy (KRT) is considered an indicator of disease severity. This study aimed to develop a prognostic score for predicting the need for KRT in hospitalised COVID-19 patients, and to assess the incidence of AKI and KRT requirement. Methods This study is part of a multicentre cohort, the Brazilian COVID-19 Registry. A total of 5212 adult COVID-19 patients were included between March/2020 and September/2020. Variable selection was performed using generalised additive models (GAM), and least absolute shrinkage and selection operator (LASSO) regression was used for score derivation. Accuracy was assessed using the area under the receiver operating characteristic curve (AUC-ROC). Results The median age of the model-derivation cohort was 59 (IQR 47–70) years, 54.5% were men, 34.3% required ICU admission, 20.9% evolved with AKI, 9.3% required KRT, and 15.1% died during hospitalisation. The temporal validation cohort had similar age, sex, ICU admission, AKI, required KRT distribution and in-hospital mortality. The geographic validation cohort had similar age and sex; however, this cohort had higher rates of ICU admission, AKI, need for KRT and in-hospital mortality. Four predictors of the need for KRT were identified using GAM: need for mechanical ventilation, male sex, higher creatinine at hospital presentation and diabetes. The MMCD score had excellent discrimination in derivation (AUROC 0.929, 95% CI 0.918–0.939) and validation (temporal AUROC 0.927, 95% CI 0.911–0.941; geographic AUROC 0.819, 95% CI 0.792–0.845) cohorts and good overall performance (Brier score: 0.057, 0.056 and 0.122, respectively). The score is implemented in a freely available online risk calculator ( https://www.mmcdscore.com/ ). Conclusions The use of the MMCD score to predict the need for KRT may assist healthcare workers in identifying hospitalised COVID-19 patients who may require more intensive monitoring, and can be useful for resource allocation