RoHS-direktiivin mukaisuuden kartoitus

Opinnäytetyön tavoitteena oli selvittää haitallisten aineiden määrä Merivaara Oyn tuotteissa. RoHS (Restriction of Hazardous Substances) -direktiivi eli Euroopan unionin haitallisten aineiden määrää rajoittava direktiivi on asettanut uudet rajat tiettyjen aineiden sallituille enimmäisarvoille tuotteissa. RoHS-direktiivi koskee vain sähköisiä tuotteita. Opinnäytetyön toimeksiantaja on Merivaara Oy. Merivaara Oy on suomalainen sairaalahuonekaluja valmistava yritys. Opinnäytetyössä tietoja kerättiin osien toimittajilta ja saatuja tietoja analysoitiin. Muutamia taulukoita uudelleenjärjesteltiin ja siistittiin lukemisen helpottamiseksi. Laskelmia ja arviointeja tehtiin tarpeellisten tulosten saamiseksi. Saaduista tuloksista voidaan päätellä, että Merivaara Oy:n tuotteet ovat RoHS-direktiivin mukaisia.The objective of this study was to evaluate the amount of hazardous substances in the products of a company. The RoHS (Restriction of Hazardous Substances) directive by the European Union has provided new limits for certain substances. The RoHS directive only applies to electronical products. This study was commisioned by Merivaara, which is Finnish company manufacturing hospital furniture. In this study, data was gathered and analyzed. Some charts were remodeled and cleaned for easier information access. Calculations and evaluations were conducted in order to reach the required results. From the results it is possible to state that Merivaara’s products conform to the RoHS directive

Analytical study of the thermal behaviour and stability of a small satellite

In this work the thermal analysis of a small satellite orbiting around the Earth has been approached by direct integration of the heat balance equations of a two-node reduced model, obtaining a linearized second order ODE problem, similar in form to the classical case of the forced vibration of a damped system. As the thermal loads (solar radiation, albedo, etc.) are harmonic, the problem is solved by means of Fourier analysis methods. Research on that field can be directly applied to the analysis of thermal problems and the results obtained are satisfactory. Working on the frequency domain streamlines the analysis, simplifies the study and facilitates the experimental testing. The transfer functions are obtained for the two-node case but the study can be extended to an n-node model

La casa y el recinto. Un proceso abierto a través del proyecto para la Residencia Peyrissac en una explotación agrícola en Argelia

[EN] The object of study of this research is the not built residential project designed by Le Corbusier in 1942 for a farm near Cherchell, Algeria. From the drawings that constitute the existing graphic documentation of this proposal, this study based its interest in describing the project as an open process of architectural reflection on the idea of the house within a bounded enclosure. A detailed analysis of the different mechanisms and project themes used by the architect through the developing of new interpretive drawings of the original documentation. In this way the invariants and different versions that built the development of the proposal are present. Finally we conclude with a critical synthesis where we relate the architectural areas studied with similar solutions from Le Corbusier works and paradigmatic examples of the architectural scene.[ES] El objeto de estudio de esta investigación es el proyecto residencial no construido que realiza Le Corbusier en 1942 para una explotación agrícola cerca de Cherchell, Argelia. A partir del conjunto de dibujos que constituye la documentación gráfica existente sobre esta propuesta, el estudio aquí desarrollado basa su interés en describir el proyecto como proceso abierto de reflexión arquitectónica sobre la idea de la casa dentro de un recinto acotado. Se realiza un análisis pormenorizado de los distintos mecanismos y temas de proyecto empleados por el arquitecto mediante el desarrollo de nuevos planos interpretativos de la documentación original. De este modo se encuentran tanto los invariantes como las distintas versiones que construyen el desarrollo de la propuesta. Finalmente se concluye mediante una síntesis crítica en la que se relacionan los ámbitos arquitectónicos estudiados con soluciones análogas dentro tanto dentro del conjunto de la obra de Le Corbusier como con ejemplos paradigmáticos del panorama arquitectónicoMartinez Arroyo, C.; Pemjean Muñoz, R.; Sanz Alarcón, JP. (2016). La casa y el recinto. Un proceso abierto a través del proyecto para la Residencia Peyrissac en una explotación agrícola en Argelia. En LE CORBUSIER. 50 AÑOS DESPUÉS. Editorial Universitat Politècnica de València. 1315-1329. https://doi.org/10.4995/LC2015.2015.628OCS1315132

The relationship between social support and self-reported health status in immigrants: an adjusted analysis in the Madrid Cross Sectional Study

<p>Abstract</p> <p>Background</p> <p>Social support is an important factor in the adaptation process of immigrants, helping for their integration in a new environment. The lack of social support may influence on well-being and health status. The aim of this study is to describe the social support of immigrant and native population and study the possible association between immigration and lack social support after adjusting for sociodemographic factors, income, stress and self-reported health status.</p> <p>Methods</p> <p>Cross-sectional population based study of immigrants and national patients without mental disorders of 15 urban primary health centers in the north-eastern area of Madrid. Participants provided information on social support, stress level, perceived health status and socio-economic characteristics. Descriptive and multiple logistic regression were conducted.</p> <p>Results</p> <p>The proportion of the global perception of social support among immigrants and natives was 79.2% and 94.2%, respectively. The lack of global social support adjusted prevalence ratio (PR) of immigrant was 2.72 (95% Confidence Interval = 1.81-4.09), showing a significant association with being male (PR = 2.26), having monthly income below 500 euros (PR = 3.81) and suffering stress (PR = 1.94). For the dimensions of lack of social support the higher association was being an immigrant and suffering stress.</p> <p>Conclusions</p> <p>We conclude that with regardless of the level of monthly income, stress level, self-reported health status, and gender, immigrant status is directly associated with lack social support. The variable most strongly associated with lack social support has been monthly income below 500 euros.</p

Estrategias metodológicas enfocadas a la mejora del aprendizaje en estudiantes con diversidad

Diseño y desarrollo de estrategias metodológicas que faciliten el aprendizaje de los estudiantes en general y que permitan a los estudiantes con diversidad funcional la integración y participación en el proceso de aprendizaje, que refuercen su inclusión y que favorezcan la adquisición de competencias

Tuberculosis prophylaxis with levofloxacin in liver transplant patients is associated with a high incidence of tenosynovitis: safety analysis of a multicenter randomized trial

This work was supported by the Ayudas para el fomento de la investigacion clinica independiente [EC 10-120] and Programa Intramural Consorcio de Apoyo a la Investigación Biomédica en Red 2010. Other funding sources: National R&D&I Plan 2008–2011 and the Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases [RD06/0008, RD12/0015] - co-financed by European Development Regional Fund “A way to achieve Europe” ERDF. Consorcio de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas is financed by the ISCIII.Background: It is necessary to develop a safe alternative to isoniazid for tuberculosis prophylaxis in liver transplant recipients. This study was designed to investigate the efficacy and safety of levofloxacin. Methods: An open-label, prospective, multicenter, randomized study was conducted to compare the efficacy and safety of levofloxacin (500 mg q24h for 9 months) initiated in patients awaiting liver transplantation and isoniazid (300 mg q24h for 9 months) initiated post-transplant when liver function was stabilized. Efficacy was measured by tuberculosis incidence at 18 months after transplantation. All adverse events related to the medication were recorded. Results: CONSORT guidelines were followed in order to present the results. The safety committee suspended the study through a safety analysis when 64 patients had been included (31 in the isoniazid arm and 33 in the levofloxacin arm). The reason for suspension was an unexpected incidence of severe tenosynovitis in the levofloxacin arm (18.2%). Although the clinical course was favorable in all cases, tenosynovitis persisted for 7 weeks in some patients. No patients treated with isoniazid, developed tenosynovitis. Only 32.2% of patients randomized to isoniazid (10/31) and 54.5% of patients randomized to levofloxacin (18/33, P = .094) completed prophylaxis. No patient developed tuberculosis during the study follow-up (median 270 days). Conclusions: Levofloxacin prophylaxis of tuberculosis in liver transplant candidates is associated with a high incidence of tenosynovitis that limits its potential utility.Ayudas para el fomento de la investigación clínica independiente [EC 10-120]Programa Intramural Consorcio de Apoyo a la Investigación Biomédica en Red 2010National R&D&I Plan 2008–2011Instituto de Salud Carlos III (ISCIII)Ministerio de Economía y Competitividad RD06/0008, RD12/0015European Development Regional Fun

Overproduction of a Trichoderma harzianum chitinase and analysis of its biotechnological potential to produce chitooligosaccharides

Trabajo presentado en la 7ª ed. del congreso internacional "FEMS" organizado por la Sociedad Española de Microbiología y la Federación Europea de Sociedades Microbiológicas en el Centro de Convenciones Feria Valencia (Valencia, España) durante los días 9 al 13 de julio de 2017.BACKGROUNDS: Chitooligosaccharides (COS) are β-(1,4)-linked oligomers of N-acetyl-glucosamine (GlcNAc) and glucosamine (GlcN) formed by chemical or enzymatic hydrolysis of chitosan or chitin. The growing biotechnological interest of COS in fields such as food or health increases the demand of the producing enzymes as well as their characterization and functional improvement. | OBJETIVES: Express a chitinase of 42 kDa from Trichoderma harzianum in a heterologous system, obtain protein levels compatible with its crystallization for the future protein structural resolution and evaluate the ability of the recombinant protein to produce COS. | METHODS: The chitinase gene cDNA from T. harzianum was expressed in Pichia pastoris using a restriction-free cloning strategy, production of heterologous protein was analysed and escalated up to a 5 L fermenter level. Recombinant protein was purified and some crystals were obtained which allows undertake the protein structural resolution. Synthesis of oligosaccharides from different substrates were evaluated and optimized using the recombinant enzyme. HPAEC-PAD on a Dionex ICS3000 system and Mass Spectrometry were used in the reaction studies and product characterization. | CONCLUSIONS: A chitinase of 42 kDa from T. harzianum was overexpressed in P. pastoris, the recombinant protein was purified, characterized and crystallized for the protein structural resolution. Production of COS mediated by this enzyme was evaluated and some of the molecules formed were characterized.N

Hypermedia : taller de configuración arquitectónica

El Grupo "Hypermedia. Taller de configuración arquitectónica" lo formamos un colectivo de profesores (doctores y asociados), doctorandos y becarios agrupados en la enseñanza del dibujo y el dibujar como herramienta para la elaboración profesional de proyectos de arquitectura en los primeros (1º y 2º año) semestres de la carrera de Arquitecto Superior. Algunos de nosotros empezamos hace más de 35 años alrededor de los ordenadores, estudiando y simulando procesos de generación de propuestas arquitectónicas. Trabajábamos en el Centro de Cálculo de la Universidad Complutense de Madrid (desde el año 1968, en un seminario denominado: "Análisis y generación de formas arquitectónicas"). Después, desde el 1974, en la Cátedra de Análisis de Formas Arquitectónicas, hemos participado y contribuido a la definición del Área de conocimiento denominada "Expresión Gráfica Arquitectónica" y hemos constituido la asociación de Departamentos del Área de todas las Escuelas de Arquitectura del Estado Español, que, en paralelo, ha creado una Revista especializada (EGA lleva editados 10 números anuales) y sostiene la convocatoria bianual de un Congreso Internacional sobre los temas propios de nuestra especialización. Hoy el Grupo, amplio por razón de la situación estratégica del dibujar (inespecífico, geométrico y arquitectónico) como medio indispensable en el trabajo de proyectar arquitectura, se organiza en varios subgrupos que se reparten puntualmente las preocupaciones y temáticas globales (colectivas) que sistemáticamente aparecen, produciendo gran cantidad de trabajos que, en forma de encargos subvencionados, tesis doctorales, monografías, ponencias y artículos aparecen año tras año en diversos medios de difusión (u edición). Nuestros trabajos no son todos estratégicos, pero son todos (sean o no aplicaciones) centrales en la formación arquitectónica, concernidos con la fundamentación teórica, social, científica y técnica de lo medio ambiental (lo arquitectónico entendido como lo envolvente adecuado al albergue de actividades humanas socializadas)

Walking family: Programme of parental skills during foster care and reunification. Summary of main findings of the Project I+D EDU2014-52921-C2. [Infographics]

Podeu consultar la versió castellana, francesa i portuguesa al recurs relacionat.Walking Family is a support programme for specific parenting skills in foster care and reunification. Its main aim is to promote the acceptance and involvement of the welfare measure and to foster and strengthen reunification. One of the most relevant aspects of the programme is its group methodology, as it can be used to convey effective coping strategies for everyday problems. Walking Family is characterised by three cornerstones of innovation: positive parenting and child welfare, child participation and family resilience. The programme is developed over 5 modules, each containing 3 sessions. Each session offers activities to do with the children, with the parents and with the family as a unit