Feasibility and short-term outcomes in liver-first approach: a Spanish snapshot study (the RENACI project)

Producción CientíficaSimple Summary: Current evidence does not provide enough information for selecting a tailored approach pathway in patients with colorectal cancer and synchronous liver metastases. There are no randomized clinical trials or prospective series comparing the classical approach with the liver-first approach. In addition, information on the proportion of patients who actually complete the therapeutic regimen is limited. The RENACI Project was a prospective National Registry performed on patients with colorectal cancer and synchronous liver metastases undergoing the liver-first approach. This study aimed to present the data of feasibility and short-term outcomes of the Spanish National Registry of Liver First Approach (the RENACI Project).(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.Asociación Española de Cirujanos - (grant Research Projects 2020

Competitive Risaralda, generating research alliance for development

El presente libro lleva como título “Risaralda competitiva, generando alianzas en investigación para el desarrollo”, resultado del V encuentro de investigadores del departamento de Risaralda realizado en el mes de noviembre del año 2020. Evento en el cual se presentaron las últimas investigaciones realizadas en las diferentes instituciones educativas del departamento; quienes hacen parte de la Mesa de Investigaciones de Risaralda; ejercicio de gran interés que arroja resultados de investigaciones en diferentes áreas como son las Ciencias Agrícolas, Ciencias sociales, Ciencias de la salud, Ciencias de la tecnología y la información

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: A prospective observational study

Background: Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. Methods: In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with =2 clinical signs/symptoms of NP-C were considered ''suspected NP-C'' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI =70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. Results: In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores =70. Plasma 7-KC was higher than control cut-off values in all patients with two NPC1 mutations, and in the majority of patients with single mutations. Family studies identified three further NP-C patients. Conclusion: This approach may be very useful for laboratories that do not have mass spectrometry facilities and therefore, they cannot use other NP-C biomarkers for diagnosis

Nuevos escenarios para la docencia universitaria : entornos híbridos y pedagogías emergentes.

Memorias del IX Simposio Internacional de Docencia Universitaria (SIDU)Los trabajos reunidos en esta Memoria representan una contribución importante al campo de la educación y de la docencia universitaria, en tanto muestran distintas maneras de responder a las problemáticas educativas cotidianas y presentan propuestas para afrontar los retos emergentes en el campo de la educación superior. Invitamos a los lectores a realizar una lectura atenta y crítica de los trabajos compilados en esta publicación. Estamos seguros de que este acercamiento propiciará la reflexión y el análisis riguroso de los objetos de estudio abordados por los autores, y estimulará la generación de nuevos proyectos de investigación, intervención e innovación educativa que incidan en el desarrollo de mejores prácticas de docencia en educación media superior y superior.Pimera edición digitaldoi.org/10.56019/EDU-CETYS.2024.182

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Salud mental en estudiantes de medicina: un reto más allá del estrés académico

Introduction: Medical education poses challenges that can induce academic stress. The context of Covid-19, new virtual education models, and telemedicine attention, among other requirements, makes it essential to focus on enhancing the mental health of future professionals. The objective was to identify factors associated with the mental health of medical students at a private university in Colombia, adjusted for academic stress. Method: A cross-sectional study was conducted with 443 students. A questionnaire consisting of sociodemographic, lifestyle, and academic variables was completed, in addition to applying the Cognitive Systemic Inventory for the Study of Academic Stress (SISCO) and the Symptom Checklist-90-Revised (SCL-90-r) inventory. The risk factors that influence the severity index of mental health were analyzed using a Generalized Linear Model (GLM) by the Poisson family and log link. Results: It was found that 68.4% were women, and 48.8% were aged between 20 and 25 years. 50.6% of students presented severe academic stress. Protective factors related to the mental health index included regular physical activity (RRa=0.78) and extracurricular activities (RRa=0.75), while risk factors were severe stress (RRa=2.34), use of psychoactive substances (RRa=1.36), energy drinks (RRa=1.35), having an occupation alternative to studying (RRa=1.47). Conclussions: The current context demands the presence of mentally healthy physicians. The study provided information on the need for intervention in factors beyond academic stress, seeking to maintain student well-being and avoid academic dropout.Introducción: El proceso de enseñanza en medicina tiene desafíos que pueden inducir estrés académico. El contexto del Covid-19, los nuevos modelos de educación virtual y la atención en telemedicina, entre otros requisitos, hace imprescindible centrarse en potenciar la salud mental de los futuros profesionales. El objetivo fue identificar los factores asociados a la salud mental de estudiantes de medicina en una universidad privada en Colombia, ajustados al estrés académico. Método: Estudio transversal con 443 estudiantes. Se completó un cuestionario compuesto por variables sociodemográficas, de estilo de vida y académicas, además de aplicar el Inventario Cognitivo Sistémico para el Estudio del Estrés Académico (SISCO) y el inventario Symptom Checklist-90-Revised (SCL-90-r). Los factores de riesgo que influyen en el índice de gravedad de la salud mental se analizaron utilizando un Modelo Lineal Generalizado (GLM) por la familia de Poisson y log link. Resultados: Un 68,4% eran mujeres, 48,8% tenían edades entre 20 y 25 años y el 50,6% de los estudiantes presentaron estrés académico severo. Los factores protectores relacionados con el índice de salud mental incluyeron actividad física regular (RRa = 0,78) y actividades extracurriculares (RRa = 0,75), mientras que los factores de riesgo fueron estrés severo (RRa = 2,34), uso de sustancias psicoactivas (RRa = 1,36), bebidas energéticas (RRa = 1,35), tener una ocupación alternativa al estudio (RRa = 1,47). Conclusión: El contexto actual exige la presencia de médicos mentalmente sanos. El estudio proporcionó información sobre la necesidad de intervención en factores más allá del estrés académico, buscando mantener el bienestar de los estudiantes y así evitar el abandono académico

Desigualdades sociales relacionadas con la mortalidad por accidentes de tráfico

Resumen: Objetivo: Sintetizar las desigualdades sociales relacionadas con la mortalidad por accidentes de tráfico reportadas en publicaciones científicas. Método: Se realizó una revisión exploratoria de la literatura siguiendo la guía PRISMA-ScR. Utilizando el vocabulario MesH se hizo una búsqueda sistemática de artículos publicados en inglés, portugués y español en las bases de datos EBSCO, Scielo, Scopus, Ovid y PubMed. Resultados: Se identificaron 47.790 registros en la búsqueda inicial, de los cuales 35 artículos cumplieron los criterios de selección. Nueve de cada diez publicaciones son de países de altos ingresos y existe un mayor interés en el análisis de la mortalidad en ocupantes y conductores de automotores. La mitad de las publicaciones utilizan la raza, la etnia y la geolocalización como variables de posición socioeconómica. Los artículos incluidos en esta revisión indican que las agrupaciones de personas de baja posición socioeconómica presentan una mayor mortalidad por accidentes de tránsito. Conclusiones: La mayor mortalidad por accidentes de tránsito se presenta en personas de baja posición socioeconómica, lo que sugiere el desarrollo de acciones de seguridad vial que estén vinculadas con otras agendas políticas a fin de reducir su incidencia para 2030. A pesar de que la mortalidad por accidentes de tránsito es mayor en los países de medianos y bajos ingresos, son pocas las publicaciones realizadas en ellos, por lo que se requiere fortalecer las capacidades de investigación en tales países. Abstract: Objective: To synthesize the social inequalities related to mortality from traffic accidents reported in scientific publications. Method: A scoping review following the PRISMA-ScR guide was carried out. Using the MesH vocabulary, we systematically searched for articles in English, Portuguese and Spanish published in the EBSCO, Scielo, Scopus, Ovid, and PubMed databases. Results: We identified 47,790 records in the initial search, of which 35 articles met the selection criteria. Nine out ten publications are in high-income countries; there is a greater interest in analyzing mortality in occupants and drivers of vehicles and motorcyclists. Half of the publications use race-ethnicity and geolocation as socioeconomic position variables. The articles included in this review indicate that groups of people with low socioeconomic positions have higher mortality due to traffic accidents. Conclusions: The highest mortality from traffic accidents occurs in people with low socioeconomic positions which suggests the development of road safety actions from a comprehensive, integrative perspective and linked to other political agendas to reduce their incidence by 2030. Although road traffic fatalities are higher in low and middle-income countries, few publications are available in these countries. It is necessary to strengthen the research capacities in these countries