The hypogeum from the Carrer París (Cerdanyola del Vallès, Barcelona): micromorphological study of a Late Neolithic and Bell-Beaker funeral deposit

This paper presents the contributions of micromorphology to the study of the hypogeum of Carrer Paris (Cerdanyola del Vallès, Barcelona), dated between 2878 and 2206 cal bc. The hypogeum of Carrer Paris was first used for a collective inhumation during the Late Neolithic. Afterward it was used again during the Bell-Beaker Chalcolithic for three different burial episodes including Bell-Beaker vessels.. The continued use of the sepulcher highlights the evolution of common funeral practices in the Neolithic towards a progressive tendency to individualize burials parallel to the adoption of bell- shaped vessels. /nThe study shows that the hypogeum was conceived and constructed well in advance of its use as well as the existence of a funeral ritual related to the use of fire prior to its use as a sepulchre. In addition, the sedimentary infilling of the structure by geogenic processes and identifies the post-depositional processes that the burials have suffered. In summary, soil micromorphology has proved to be an essential tool for the study and interpretation of funerary contexts. In this case, it has allowed us to identify and characterize better the constructive and funerary process of this type of prehistoric burials in the peninsular Northeast.En este artículo se presentan las principales aportaciones de la micromorfología al estudio del hipogeo del Carrer París (Cerdanyola del Vallès, Barcelona), datado entre 2878-2206 cal bc. El hipogeo del Carrer París comienza a utilizarse antes de la adopción del complejo campaniforme localizándose un primer nivel de inhumación colectiva propio del Neolítico Final-Calcolítico. Le seguirán tres episodios de inhumaciones asociadas a vasos campaniformes de diferentes tipologías. El uso continuado del sepulcro pone de manifiesto la evolución de las prácticas funerarias propias del Neolítico hacia una progresiva tendencia a la individualización de las inhumaciones paralela a la adopción de las cerámicas campaniformes./nDel estudio realizado se deduce que el hipogeo fue concebido y construido con suficiente antelación a su uso y existió un ritual funerario relacionado con el fuego anterior a su utilización como sepulcro. Además, la estructura se colmató por sedimentación geogénica y se han identificado los procesos ostdeposicionales que afectaron a las inhumaciones. En resumen, creemos que la micromorfología de suelos. En resumen, creemos que la micromorfología de suelos constituye una herramienta esencial para el estudio e interpretación de contextos funerarios. En este caso, ha permitido identificar y caracterizar mejor el proceso constructivo y funerario de este tipo de enterramientos prehistóricos en el ne peninsular

El hipogeo del Carrer París (Cerdanyola del Vallès, Barcelona): estudio micromorfológico de un depósito funerario del Neolítico final y Calcolítico Campaniforme.

[spa] En este artículo se presentan las principales aportaciones de la micromorfología al estudio del hipogeo del Carrer París (Cerdanyola del Vallès, Barcelona), datado entre 2878-2206 cal bc. El hipogeo del Carrer París comienza a utilizarse antes de la adopción del complejo campaniforme localizándose un primer nivel de inhumación colectiva propio del Neolítico Final-Calcolítico. Le seguirán tres episodios de inhumacio-nes asociadas a vasos campaniformes de diferentes tipologías. El uso continuado del sepulcro pone de manifiesto la evolución de las prácticas funerarias propias del Neolítico hacia una progresiva tendencia a la individualiza-ción de las inhumaciones paralela a la adopción de las cerámicas campaniformes.Del estudio realizado se deduce que el hipogeo fue concebido y construido con suficiente antelación a su uso y existió un ritual funerario relacionado con el fuego anterior a su utilización como sepulcro. Además, la estructura se colmató por sedimentación geogénica y se han identificado los procesos postdeposicionales que afectaron a las inhumaciones. En resumen, creemos que la micromorfología de suelos. En resumen, creemos que la micromorfología de suelos constituye una herramienta esencial para el estudio e interpretación de contex-tos funerarios. En este caso, ha permitido identificar y caracterizar mejor el proceso constructivo y funerario de este tipo de enterramientos prehistóricos en el ne peninsular.[eng] This paper presents the contributions of micromorphology to the study of the hypogeum of Carrer Paris (Cerdanyola del Vallès, Barcelona), dated between 2878 and 2206 cal bc. The hypogeum of Carrer Paris was first used for a collective inhumation during the Late Neolithic. Afterward it was used again during the Bell-Beaker Chalcolithic for three different burial episodes including Bell-Beaker vessels.. The continued use of the sepulcher highlights the evolution of common funeral practices in the Neolithic towards a progressive tendency to individualize burials parallel to the adoption of bell- shaped vessels. The study shows that the hypogeum was conceived and constructed well in advance of its use as well as the existence of a funeral ritual related to the use of fire prior to its use as a sepulchre. In addition, the sedimentary infilling of the structure by geogenic processes and identifies the post-depositional processes that the burials have suffered. In summary, soil micromorphology has proved to be an essential tool for the study and interpretation of funerary contexts. In this case, it has allowed us to identify and characterize better the constructive and funer-ary process of this type of prehistoric burials in the peninsular Northeast

Memorias de Agricultura y Artes, que se publican de orden de la Real Junta de Gobierno del Comercio de Cataluña ...

Menció dels autors responsables d'aquestes "Memorias" : Francesc Sampons, Francesc Carbonell i Joan Francesc Bahí, obtinguda de la introducció edit. del v. 1 (p. sign. A2)Nombre de v. de l'o.c. obtingut de PalauCada volum inclou: Escut calcogràfic de la Junta de Comerç de Barcelona a portada, ambl'escut coronat de la ciutat i la llegenda "Terra dabit merces undaque divitias", de Pere Pau Muntanya (dibuixant) i Blai Ametller Rotllan (gravador)Cada volum inclou 12 estampes calcogràfiques al textAl volum 8, una estampa signada per Francesc Sampons (dibuixant) i Josep Coromines i Faralt (gravador)Al volum 10, dues estampes signades per Pau Rigalt i Fargas (dibuixant) i Santiago Mª Folch (gravador)Forma part del projecte: Biblioteca Digital d'Història de l'Art Hispànic (UAB)Localització de l'original: Biblioteca de CatalunyaRevista editada per la Reial Junta de Comerç de Catalunya entre 1815 i 1821, amb articles relacionats amb l'agricultura i les arts, de periodicitat mensual en dotze volums. Cada volum conté dotze estampes calcogràfiques de temàtica científica com: obres d'enginyeria, aparells, instruments i maquinària, o procediments químics. En relació a les arts recull les primeres notícies sobre litogràfiaRevista editada por la Real Junta de Comercio de Cataluña entre 1815 y 1821, con artículos relacionados con la agricultura y las artes, de peridiocidad mensual, en doce volúmenes. Cada volumen contiene además doce estampas calcográficas con obras de ingeniería, aparatos, instrumentos y maquinaria diversa y procedimientos químicos. En relación a las artes reúne las primeras notícias sobre litografíaMagazine published by the Real Junta de Comercio de Cataluña between 1815 and 1821, with articles related to agriculture and the arts. Monthly magazine, consisting of twelve volumes. Each volume contains twelve science-themed chalcographic prints showing engineering, instruments and machinery, equipment, and chemical processes, all related directly to the text. Regarding the arts it contains the first news of the lithographic techniqu

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.

A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistance profile of a large cohort of patients failing DAA-based treatments, and investigate the relationship between HCV subtype and failure, as an aid to optimizing management of these patients. A new, standardized HCV-RAS testing protocol based on deep sequencing was designed and applied to 220 previously subtyped samples from patients failing DAA treatment, collected in 39 Spanish hospitals. The majority had received DAA-based interferon (IFN) α-free regimens; 79% had failed sofosbuvir-containing therapy. Genomic regions encoding the nonstructural protein (NS) 3, NS5A, and NS5B (DAA target regions) were analyzed using subtype-specific primers. Viral subtype distribution was as follows: genotype (G) 1, 62.7%; G3a, 21.4%; G4d, 12.3%; G2, 1.8%; and mixed infections 1.8%. Overall, 88.6% of patients carried at least 1 RAS, and 19% carried RAS at frequencies below 20% in the mutant spectrum. There were no differences in RAS selection between treatments with and without ribavirin. Regardless of the treatment received, each HCV subtype showed specific types of RAS. Of note, no RAS were detected in the target proteins of 18.6% of patients failing treatment, and 30.4% of patients had RAS in proteins that were not targets of the inhibitors they received. HCV patients failing DAA therapy showed a high diversity of RAS. Ribavirin use did not influence the type or number of RAS at failure. The subtype-specific pattern of RAS emergence underscores the importance of accurate HCV subtyping. The frequency of "extra-target" RAS suggests the need for RAS screening in all three DAA target regions