Development of Technologies for Active Wavefront Control of Advanced Gravitational Wave Detectors

The era of gravitational-wave astronomy started with the detection of a binary black hole coalescence on the 14th of September 2015 by the Advanced Laser Interferometer Gravitational-wave Observatory (aLIGO). By the end of 2017, a total number of 11 gravitational wave events have been detected by LIGO and Virgo detectors. One of these events, GW17081, produced by the coalescence of a binary neutron star signaled the dawn of multi-messenger gravitational astronomy, revealing invaluable information about the physics occurring in such cataclysmic event. The work presented in this thesis is part of the ongoing global effort to improve the sensitivity of current detectors and thus improve both the detection rates and the information that can be gleaned from each detection. The sensitivity of terrestrial interferometric detectors are broadly limited by coating thermal noise and quantum noise. Increasing the circulating laser power and injecting vacuum-squeezed light are employed to reduce the quantum noise. However, the ability to implement these measures and their efficacy is fundamentally limited by absorption-induced wavefront distortion within the interferometer. At the time of writing this thesis, aLIGO detectors are struggling to increase the input power above approximately 30 W and the current observed level of squeezing at aLIGO Livingston and Hanford Observatories are 3dB and 2.2 dB respectively, partly due to wavefront mismatch. New technologies are urgently required to diagnose these issues. In this thesis, I will will describe the development of a new technologies for the solution of this problem: an advanced “phase camera” that can examine individual RF sideband fields used to control and sense the interferometer and new adaptive optics for active wavefront control and mode-matching within the interferometer. The new phase camera measures the complex amplitude of a coherent field that is frequency-offset from a reference field, and records the transverse profile with high spatial and temporal resolution. Furthermore, it does so without the use of scanning mirrors and thus is suitable for use during both detector commissioning and low-noise operation. This thesis also describes the development of new thermally-actuated mirrors for adaptive wavefront control and mode matching in aLIGO. The two designs presented are the thermal-bimorph mirror and the compression-fit mirror. Both of which show a large and linear actuation range, and low higher-order aberrations. They are currently scheduled for deployment to assist with mode matching between the squeezed light source and the signal recycling cavity of aLIGO and can be extended to other optical interfaces during the detectors A+ upgrade.Thesis (Ph.D.) -- University of Adelaide, School of Physical Sciences, 201

Enhancing the dynamic range of deformable mirrors with compression bias

We report the design and testing of a compression-biased thermally-actuated deformable mirror that has a dynamic range larger than the limit imposed by pure-bending stress, negligible higher-order-mode scattering, and a linear defocus response and that is vacuum compatible. The optimum design principles for this class of actuator are described and a mirror with 370 mD dynamic range is demonstrated

Elevated Levels of Cell-Free Circulating DNA in Patients with Acute Dengue Virus Infection

BACKGROUND: Apoptosis is thought to play a role in the pathogenesis of severe dengue and the release of cell-free DNA into the circulatory system in several medical conditions. Therefore, we investigated circulating DNA as a potential biomarker for severe dengue. METHODS AND FINDINGS: A direct fluorometric degradation assay using PicoGreen was performed to quantify cell-free DNA from patient plasma. Circulating DNA levels were significantly higher in patients with dengue virus infection than with other febrile illnesses and healthy controls. Remarkably, the increase of DNA levels correlated with the severity of dengue. Additionally, multivariate logistic regression analysis showed that circulating DNA levels independently correlated with dengue shock syndrome. CONCLUSIONS: Circulating DNA levels were increased in dengue patients and correlated with dengue severity. Additional studies are required to show the benefits of this biomarker in early dengue diagnosis and for the prognosis of shock complication

The Association of Cytokines with Severe Dengue in Children

Background: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. Methods & Findings: In a hospital based-case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. Conclusion: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to shed further light on the function of these cytokines in severe dengue

A Cryogenic Silicon Interferometer for Gravitational-wave Detection

The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument able to detect gravitational waves at distances 5 times further away than possible with Advanced LIGO, or at greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby Universe, as well as observing the Universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke