Two-temperature accretion flows in magnetic cataclysmic variables: Structures of post-shock emission regions and X-ray spectroscopy

We use a two-temperature hydrodynamical formulation to determine the temperature and density structures of the post-shock accretion flows in magnetic cataclysmic variables (mCVs) and calculate the corresponding X-ray spectra. The effects of two-temperature flows are significant for systems with a massive white dwarf and a strong white-dwarf magnetic field. Our calculations show that two-temperature flows predict harder keV spectra than one-temperature flows for the same white-dwarf mass and magnetic field. This result is insensitive to whether the electrons and ions have equal temperature at the shock, but depends on the electron–ion exchange rate, relative to the rate of radiative loss along the flow. White-dwarf masses obtained by fitting the X-ray spectra of mCVs using hydrodynamic models including the two-temperature effects will be lower than those obtained using single-temperature models. The bias is more severe for systems with a massive white dwarf

Accretion in dipole magnetic fields: flow structure and X-ray emission of accreting white dwarfs

Field-channelled accretion flows occur in a variety of astrophysical objects, including T Tauri stars,magnetic cataclysmic variables and X-ray pulsars. We consider a curvilinear coordinate system and derive a general hydrodynamic formulation for accretion onto stellar objects confined by a stellar dipole magnetic field. The hydrodynamic equations are solved to determine the velocity, density and temperature profiles of the flow. We use accreting magnetic white-dwarf stars as an illustrative example of astrophysical applications. Our calculations show that the compressional heating due to the field geometry is as important as radiative cooling and gravity in determining the structure of the post-shock flow in accreting white-dwarf stars. The generalisation of the formulation to accretion flows channelled by higher-order fields and the applications to other astrophysical systems are discussed.Comment: Accepted A&

Influence of Compton scattering on the broad-band X-ray spectra of intermediate polars

The majority of cataclysmic variables observed in the hard X-ray energy band are intermediate polars where the magnetic field is strong enough to channel the accreting matter to the magnetic poles of the white dwarf. A shock above the stellar surface heats the gas to fairly high temperatures (10--100 keV). The post-shock region cools mostly via optically thin bremsstrahlung. We investigate the influence of Compton scattering on the structure and the emergent spectrum of the post-shock region. We also study the effect it has on the mass of the white dwarfs obtained from fitting the observed X-ray spectrum of intermediate polars. We construct the model of the post-shock region taking Compton scattering into account. The radiation transfer equation is solved in the plane-parallel approximation. The feedback of Compton scattering on the structure of the post-shock region is also accounted for. A set of the post-shock region model spectra for various white dwarf masses is calculated. We find that Compton scattering does not change the emergent spectra significantly for low accretion rates or low white dwarf masses. However, it becomes important at high accretion rates and high white dwarf masses. The time-averaged, broad-band X-ray spectrum of intermediate polar V709 Cas obtained by the RXTE and INTEGRAL observatories is fitted using the set of computed spectral models. We obtained the white dwarf mass of 0.91 +/- 0.02 M_sun and 0.88 +/- 0.02 M_sun using models with Compton scattering taken into account and without it, respectively.Comment: 5 pages, 4 figures, accepted for publication in A&A (minor changes following the referee's comments, five references added

XRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)

The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of the XRCC1 gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically significant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any impact on breast cancer susceptibility

XRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil)

The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of the XRCC1 gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this Brazilian sample. Although the 194Trp variant was overrepresented in women reporting familial cases of breast cancer, no statistically significant differences concerning genotype distribution or intragenic interactions were found between this group and the controls. Thus, in the population analyzed by us, variants Arg194Trp and Arg399Gln did not appear to have any impact on breast cancer susceptibility

X-Ray Repair Cross-Complementing Group 1 (XRCC1) Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: A Meta-Analysis

Background: Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effects of XRCC1 variants on childhood ALL risk. Methods: A meta-analysis was performed to examine the association between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and childhood ALL risk. We critically reviewed 7 studies with a total of 880 cases and 1311 controls for Arg399Gln polymorphism, 3 studies with a total of 345 cases and 554 controls for Arg280His polymorphism, and 6 studies with a total of 783 cases and 1180 controls for Arg194Trp polymorphism, respectively. Odds ratio (OR) and its 95% confidence interval (CI) were used. Results: Significant association between XRCC1 Arg399Gln polymorphism and childhood ALL risk was observed in total population analyses (OR additive model = 1.501, 95 % CI 1.112–2.026, P OR = 0.008; OR dominant model = 1.316, 95 % CI = 1.104–1.569, POR = 0.002) and Asian subgroup analyses (ORadditive model = 2.338, 95%CI = 1.254–4.359, POR = 0.008; ORdominant model = 2.108, 95%CI = 1.498–2.967, POR = 0.000). No association was detected in Caucasians, Metizo and mixed populations. Ethnicity was considered as a significant source of heterogeneity in the meta-regression model. For the other two XRCC1 polymorphisms, no association with childhood ALL risk was found

PEG−peptide conjugates

The remarkable diversity of the self-assembly behavior of PEG−peptides is reviewed, including self-assemblies formed by PEG−peptides with β-sheet and α-helical (coiled-coil) peptide sequences. The modes of self-assembly in solution and in the solid state are discussed. Additionally, applications in bionanotechnology and synthetic materials science are summarized