Los inicios de la economía de producción en el estuario Tinto-Odiel : el asentamiento prehistórico de Casa del Río (Aljaraque, Huelva)

La investigación arqueológica sobre el proceso de génesis y consolidación de estrategias productoras en el marco global del suroeste penínsular y en los contextos fluviomarítimos de la provincia de Huelva, en particular, apenas cuenta, hoy por hoy con resultados contrastados que puedan contribuir a esclarecer la cuestión. La excavación en el asentamiento de Casa del Río (Aljaraque, Huelva) ha aportado bases tanto para el análisis y definición del proceso histórico de aquellos grupos, su organización social, economía, etc., cuanto para el planteamiento de un modelo hipotético zonal del tránsito de sociedades cazadoras-recolectoras a productoras._______________________Nowadays, the archaeological research on the process of genesis and consolidation of producing strategies in the Southwest of the Iberian Peninsula, specially, on the fluvial and maritime context of the province of Huelva, hardly posseses contrasting results that clarify the isue. Anyway, thexcavations in the settlement of "Casa del Río" (Aljaraque, Huelva) have provided foundations for both the analysis and definition of the historical process, social organisation, economy, etc, for these groups. Besides, they have introduced a hypothetical model that enables the shift from hunting-farming societies to producing ones

Patterning of polymer nanofiber meshes by electrospinning for biomedical applications

The end-product of the electrospinning process is typically a randomly aligned fiber mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the collector. The developed electric field causes the stretching of the fibers and their random deposition. By judicious selection of the collector architecture, it is thus possible to develop other morphologies on the nanofiber meshes. The aim of this work is to prepare fiber meshes using various patterned collectors with specific dimensions and designs and to evaluate how those patterns can affect the properties of the meshes relevant to biomedical applications. This study aims at verifying whether it is possible to control the architecture of the fiber meshes by tailoring the geometry of the collector. Three different metallic collector topographies are used to test this hypothesis. Electrospun nonwoven patterned meshes of polyethylene oxide (PEO) and poly(ε-capro-lactone) (PCL) were successfully prepared. Those fiber meshes were analyzed by scanning electron microscopy (SEM). Both mechanical properties of the meshes and cell contacting experiments were performed to test the effect of the produced patterns over the properties of the meshes relevant for biomedical applications. The present study will evaluate cell adhesion sensitivity to the patterns generated and the effect of those patterns on the tensile properties of the fiber meshes

Fluorenylidene-pyrroline Biomimetic Light-driven Molecular Switches

A new family of biomimetic photoactivated molecular switches based in the retinal chromophore is described. Expedient synthesis allows a library of compounds with a different substitution pattern, including chiral substituents, to be obtained. The effect of substitution, solvent, and light source on the photoisomerization step has been assessed. The absorption maximum has been red-shifted ca. 50 nm with respect to related systems and rotation is now easily achieved by using visible light

Incorporation of industrial wastes in wood pellets

ABSTRACT: The present work evaluates the incorporation of industrial wastes (Refuse Derived Fuel-RDF) into biomass for pellet production. Its influence on parameters such as pellet production, combustion and gas emissions was studied for up to 10% of residues incorporation. This approach also deals with the diverting of industrial waste from landfills. The main objectives were: increasing the heat value of the final product, diverting industrial residues with energy potential from landfill and assess the quality of different types of pellets with incorporation of industrial residues. Its implementation was carried out in three phases: selection and characterization of the different industrial residues, production of pellets from different mixtures of wastes and combustion tests. For this purpose a comprehensive characterization of the pellets, the gaseous emissions during combustion and the chemical characterization of the resulting ashes was carried out. The study has shown that the application of industrial residues is a promising route for their incorporation in pellets which should be balanced by the reduction of wastes for landfill. However a few problems were identified: higher difficulty in pelletizing and likely excessive wear of the pellet mill for some of the residues; combustion equipment requiring air supply adjustment and higher ash contents

Compassion-based meditation quality practice and its impact on the positive attitudes toward others

Objectives: The authors report on the initial development and validation of the Compassion Practice Quality Scale (CPQS), a measure to assess the quality of compassion-based meditation (CBM). It is conceptualized and operationalized via two factors measuring mental imagery and somatic perception/response. Methods: The total sample was composed of 205 university students who underwent a CBM and completed pre-test/post-test assessment of compassion and related constructs. Results from a series of preliminary psychometric analyses of the CPQS were examined, including factor analysis, internal consistency, and convergent/discriminant validity. Results: The data supported a 12-item and 10-item (without reference to gestures and self-instructions) CPQS of which imagery and somatic perception emerged as two significant reliable subscales, with Cronbach’s alpha values of.90 and.88 respectively. Practice quality factors assessed by the CPQS correlated in expected ways with fear of compassion, imagery variables, and self-criticism, as well as predicted compassion outcome (i.e., feeling positive attitudes toward others). Conclusions: Our findings contribute to identifying two key components of high-quality meditation in CBM (i.e., mental imagery and somatic perception/response) for use in pedagogical development and further research and to offer a reliable self-report measure to assess them for the first time. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature

Predicting 6-Month Mortality in Incident Elderly Dialysis Patients: A Simple Prognostic Score

Aim: Mortality in end-stage renal disease (ESRD) remains high, particularly among elderly, who represents the most rapidly growing segment of the ESRD population in wealthier countries. We developed and validated a risk score in elderly patients to predict 6-month mortality after dialysis initiation. Methods: We used data from a cohort of 421 patients, aged 65 years and over who started dialysis between 2009 and 2016, in our Nephrology department. The predictive score was developed using a multivariable logistic regression analysis. A bootstrapping technique was used for internal validation. Results: The overall mortality within 6 months was 14.0%. Five independent predictors were identified, and a points system was constructed: age 75 years or older (2 points), coronary artery disease (2), cerebrovascular disease with hemiplegia (2), time of nephrology care before dialysis (<3.0 months [2]; ≥3 to <12 months [1]), and serum albumin levels (3.0-3.49 g/dL [1]; <3.0 g/dL [2]). A score of 6 identified patients with a 70% risk of 6-month mortality. Model performance was good in both discrimination (area under the curve of 0.793; [95% CI 0.73-0.86]) and validation (concordance statistics of 0.791 [95% CI 0.73-0.85]). Conclusions: We developed a simple prediction score based on readily available clinical and laboratory data that can be a practical and useful tool to assess short-term prognosis in elderly patients starting dialysis. It may help to inform patients and their families about ESRD treatment options and provide a more patient-centered overall approach to care.info:eu-repo/semantics/publishedVersio

Microrna-21 and colorectal cancer

Introducción. Los microRNAs son estructuras moleculares con actividad post-transcripcional que están implicados en la regulación de la expresión genética. Diversos estudios ponen de manifiesto la participación de los microRNAs con distintas funciones fisiológicas, así como con el proceso de la oncogénesis. La expresión de los microRNAs puede verse alterada en las neoplasias por su interacción bien con los genes supresores de tumores, bien con los oncogenes. Discusión. Llevamos a cabo una revisión de la literatura sobre el microRNA-21, poniendo de manifiesto la evidencia existente entre el microRNA-21 y la enfermedad neoplásica, de forma especial con el cáncer colorrectal. Conclusiones. El estado actual de los microRNAs hace necesario continuar con la investigación existente entre la etiopatogenia de las neoplasias y los microRNAs. El conocimiento de la verdadera implicación de los microRNAs en la fisiopatología de la enfermedad neoplásica, permitirá ampliar las supuestas aplicaciones clínicas del miR-21 no sólo a la determinación del pronóstico del cáncer colorrectal, sino también desde el punto de vista diagnóstico al poder diferenciar las lesiones de la mucosa colónicaIntroduction. MicroRNAs are molecular structures with post-transcriptional activity, involved in the gene expression regulation. Several studies have demonstrated the involvement of microRNAs in different physiological functions, as well as in the oncogenesis process. The expression of microRNAs may be altered in the tumors by either interaction with tumor suppressor genes or oncogenes. Discussion. A review of the medical literature on microRNA-21 has been conducted, showing the evidence between microRNA-21 and neoplastic disease, specially with colorectal cancer. Conclusion. The current status of microRNAs makes necessary to continue the investigation of the pathogenesis of cancer and microRNAs. The knowledge of the involvement of microRNAs in the pathophysiology of neoplastic disease, will allow to extend the supposed clinical applications of miR-21 not only to the determination of the prognosis of colorectal cancer, but also for the differential diagnosis of processes of colonic mucosa

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